scholarly journals Superior temporal sulcus hypoperfusion in children with autism spectrum disorder: an arterial spin-labeling magnetic resonance study

2019 ◽  
Author(s):  
Ana Saitovitch ◽  
Elza Rechtman ◽  
Hervé Lemaitre ◽  
Jean-Marc Tacchella ◽  
Alice Vinçon-Leite ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Superior Temporal Sulcus ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Brain Functioning ◽  
Children With Asd

AbstractAdvances in neuroimaging techniques have significantly improved our understanding of the neural basis of autism spectrum disorder (ASD). Several attempts have been made to label the main neuroimaging phenotype of ASD, mostly by anatomical and functional activation studies, but none of the frameworks have been without controversy. Over the past decade, a renewed interest for rest brain functioning has emerged in the scientific community, reflected on a large number of resting state fMRI (rs-fMRI) studies, but results remain heterogeneous. It is possible today to investigate rest brain functioning by measuring rest cerebral blood flow (CBF) with MRI using arterial spin labeling (ASL). Here, we investigated rest CBF abnormalities using non-invasive ASL-MRI in 18 children with ASD without cognitive delay (10.4 ± 2.8 y) and 30 typically developing children (10.6 ± 3.0 y). Following quality control, images from a final sample of 12 children with ASD (11.2 ± 2.9 y) and 28 typically developing children (10.1 ± 2.5 y) were analyzed. Whole brain voxel-by-voxel analysis showed significant rest CBF decrease in temporal regions, mainly in the superior temporal sulcus (STS), in children with ASD. This hypoperfusion was individually detected in 83% of children with ASD. Finally, negative correlation was observed between ASD severity scores and rest CBF in the right posterior STS. Strikingly, despite the small sample studied here, our results are extremely similar to previous PET and SPECT findings describing decreased rest CBF in the same superior temporal regions at group and individual levels, as well as correlation with symptoms severity. The congruence between these results, with different methods and in different ASD profiles, reinforce the strength of rest functional abnormalities within these superior temporal regions in ASD and strongly indicates it might be a core characteristic of the disorder. Identifying a core dysfunctional region in ASD bears direct implications to the development of novel therapeutic interventions, such as transcranial magnetic stimulation. In addition, if confirmed in a larger sample, rest temporal hypoperfusion could become a reliable brain imaging biomarker in ASD.

The Use of Hand Gestures to Communicate About Nonpresent Objects in Mind Among Children With Autism Spectrum Disorder

2015 ◽  
Vol 58 (2) ◽  
pp. 373-382 ◽  
Author(s):  
Wing-Chee So ◽  
Ming Lui ◽  
Tze-Kiu Wong ◽  
Long-Tin Sit
Keyword(s):  
Autism Spectrum Disorder ◽  
Intervention Program ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Spatial Skills ◽  
Typically Developing Children ◽  
Visual Spatial ◽  
Children With Asd

Purpose The current study examined whether children with autism spectrum disorder (ASD), in comparison with typically developing children, perceive and produce gestures to identify nonpresent objects (i.e., referent-identifying gestures), which is crucial for communicating ideas in a discourse. Method An experimenter described the uses of daily-life objects to 6- to 12-year-old children both orally and with gestures. The children were then asked to describe how they performed daily activities using those objects. Results All children gestured. A gesture identified a nonpresent referent if it was produced in the same location that had previously been established by the experimenter. Children with ASD gestured at the specific locations less often than typically developing children. Verbal and spatial memory were positively correlated with the ability to produce referent-identifying gestures for all children. However, the positive correlation between Raven's Children Progressive Matrices score and the production of referent-identifying gestures was found only in children with ASD. Conclusions Children with ASD might be less able to perceive and produce referent-identifying gestures and may rely more heavily on visual–spatial skills in producing referent-identifying gestures. The results have clinical implications for designing an intervention program to enhance the ability of children with ASD to communicate about nonpresent objects with gestures.

Psychopharmacological treatment of ADHD symptoms in children with autism spectrum disorder

2011 ◽  
Vol 23 (3) ◽  
Author(s):  
Benjamin L. Handen ◽  
Johanna Taylor ◽  
Rameshwari Tumuluru
Keyword(s):  
Autism Spectrum Disorder ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Adhd Symptoms ◽  
Typically Developing Children ◽  
Psychopharmacological Treatment ◽  
Children With Asd ◽  
Appropriate Treatment

Abstract One of the most frequently reported behavioral concerns among children with autism spectrum disorder (ASD) is high rates of activity and inattention, symptoms that are often associated with attention deficit hyperactivity disorder (ADHD). Although there is a considerable body of research regarding the appropriate treatment of ADHD symptoms among typically developing children, the research among children with ASD is more limited. The evidence to date suggests that medication response rates among children with ASD are considerably lower than among typically developing children and that children with ASD tend to be at greater risk for experiencing side effects. The purpose of the present paper is to review the available research on the treatment of ADHD symptoms in children with ASD. This paper summarizes the data on a range of pharmacological options and provides specific recommendations for how best to clinically manage these symptoms.

Participation of Children With ASD Using an Adapted Structured Preschool Participation Observation and Comparison With Typically Developing Children

2021 ◽  
Vol 75 (Supplement_2) ◽  
pp. 7512500056p1-7512500056p1
Author(s):  
Anat Golos ◽  
Sophi Itkin ◽  
Hadas Ben-Zur
Keyword(s):  
Autism Spectrum Disorder ◽  
Content Validity ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Children With Asd ◽  
Preschool Participation ◽  
Primary Author

Abstract Date Presented Accepted for AOTA INSPIRE 2021 but unable to be presented due to online event limitations. Participation of children with autism spectrum disorder (ASD) is limited compared with their typically developing (TD) peers. This study examined the participation of children with ASD using an adapted observation in comparison with TD children. Content validity was evaluated by 21 experts, and 70 children were observed. Children with ASD scored significantly lower than TD children in most areas. More structured settings enabled higher participation scores. Further studies are needed. Primary Author and Speaker: Anat Golos Contributing Authors: Sophi Itkin, Hadas Ben-Zur

Action coordination during a real-world task: Evidence from children with and without autism spectrum disorder

2020 ◽  
pp. 1-11
Author(s):  
Dominic A. Trevisan ◽  
James T. Enns ◽  
Elina Birmingham ◽  
Grace Iarocci
Keyword(s):  
Autism Spectrum Disorder ◽  
Real World ◽  
Joint Action ◽  
Social Process ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Children With Asd ◽  
Action Coordination

Abstract “Joint action”—the ability to coordinate actions with others—is critical for achieving individual and interpersonal goals and for our collective success as a species. Joint actions require accurate and rapid inferences about others’ goals, intentions, and focus of attention, skills that are thought to be impaired in individuals with autism spectrum disorder (ASD). Research to date has not investigated joint action abilities in individuals with ASD during real-world social interactions. We conducted an experimental study that required children with ASD and typically developing children to move tables by themselves or collaboratively through a maze. This involved developing innovative methodologies for measuring action coordination—a critical component of the joint action process. We found that children with ASD are less likely to benefit from the collaboration of a peer than are typically developing children, and they are less likely to synchronize their steps when moving the table. However, these differences were masked when scaffolded by an adult. There was no evidence that ASD differences were due to gross motor delays in the participants with ASD. We argue that action coordination is a highly adaptive social process that is intrinsic to successful human functioning that manifests as atypical synchronization of mind and body in children with ASD.

Imitation Recognition by Minimally Verbal Young Children: A Comparison Between Down Syndrome and Autism Spectrum Disorder

2021 ◽  
pp. 108835762110350
Author(s):  
Gökhan Töret
Keyword(s):  
Autism Spectrum Disorder ◽  
Down Syndrome ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Minimally Verbal ◽  
Typically Developing Children ◽  
Children With Asd ◽  
Minimally Verbal Children

Research has shown that children with autism spectrum disorder (ASD) display limited imitation recognition behaviors in comparison with typically developing children. However, the levels of imitation recognition of minimally verbal children with ASD relative to those with developmental disabilities are unknown. The purpose of this study was to compare the imitation recognition behaviors of 20 minimally verbal children with ASD and 20 minimally verbal children with Down syndrome (DS) when imitated by an adult in a play context. Results showed that children with ASD display more limited imitation recognition than children with DS. These results indicate that children with ASD are weaker in displaying imitation recognition. On the contrary, both groups display an association between imitation recognition and a variety of play actions in both groups.

scholarly journals Parent-Child Reminiscing: Relationships between Parent Elaborations, Emotion Talk and Memory Contributions of Children with Autism Spectrum Disorder

2021 ◽  
Author(s):  
◽  
Wendy Faust
Keyword(s):  
Autism Spectrum Disorder ◽  
Developmental Process ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Children With Asd ◽  
Emotion Talk ◽  
Parent Child

<p>How parents of children with Autism Spectrum Disorder (ASD) engage their children in reminiscing about the past was investigated in a sample of 12 children with ASD and 12 matched typically developing children. Analysis of parent elaboration styles and emotion talk during reminiscing revealed no significant differences between parents of children with ASD and parents of typically developing children. The elaboration style and emotion talk of parents of children with ASD was associated with their children's memory contributions and emotion talk during conversations. The discussion addresses why the social and language difficulties, characteristic of ASD, may not have impacted on parent-child reminiscing. It considers this specifically in relation to the role that parents of children with ASD play in 'scaffolding' their children through the critical developmental process of parent-child reminiscing.</p>

scholarly journals Parent-Child Reminiscing: Relationships between Parent Elaborations, Emotion Talk and Memory Contributions of Children with Autism Spectrum Disorder

2021 ◽  
Author(s):  
◽  
Wendy Faust
Keyword(s):  
Autism Spectrum Disorder ◽  
Developmental Process ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Typically Developing Children ◽  
Children With Asd ◽  
Emotion Talk ◽  
Parent Child

<p>How parents of children with Autism Spectrum Disorder (ASD) engage their children in reminiscing about the past was investigated in a sample of 12 children with ASD and 12 matched typically developing children. Analysis of parent elaboration styles and emotion talk during reminiscing revealed no significant differences between parents of children with ASD and parents of typically developing children. The elaboration style and emotion talk of parents of children with ASD was associated with their children's memory contributions and emotion talk during conversations. The discussion addresses why the social and language difficulties, characteristic of ASD, may not have impacted on parent-child reminiscing. It considers this specifically in relation to the role that parents of children with ASD play in 'scaffolding' their children through the critical developmental process of parent-child reminiscing.</p>

scholarly journals Developmental Language Disorder and Autism: Commonalities and Differences on Language

2021 ◽  
Vol 11 (5) ◽  
pp. 589
Author(s):  
Natasa Georgiou ◽  
George Spanoudis
Keyword(s):  
Autism Spectrum Disorder ◽  
Language Impairment ◽  
Language Disorder ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
Developmental Language Disorder ◽  
Typically Developing Children ◽  
Autism Group ◽  
Developmental Conditions

Language and communication deficits characterize both autism spectrum disorder and developmental language disorder, and the possibility of there being a common profile of these is a matter of tireless debate in the research community. This experimental study addresses the relation of these two developmental conditions in the critical topic of language. Α total of 103 children (79 males, 24 females) participated in the present study. Specifically, the study’s sample consisted of 40 children with autism, 28 children with developmental language disorder, and 35 typically developing children between 6 and 12 years old. All children completed language and cognitive measures. The results showed that there is a subgroup inside the autism group of children who demonstrate language difficulties similar to children with developmental language disorder. Specifically, two different subgroups were derived from the autism group; those with language impairment and those without. Both autism and language-impaired groups scored lower than typically developing children on all language measures indicating a common pathology in language ability. The results of this study shed light on the relation between the two disorders, supporting the assumption of a subgroup with language impairment inside the autism spectrum disorder population. The common picture presented by the two developmental conditions highlights the need for further research in the field.

scholarly journals Early screening of autism spectrum disorder using cry features

2020 ◽  
Author(s):  
Aida Khozaei ◽  
Hadi Moradi ◽  
Reshad Hosseini ◽  
Hamidreza Pouretemad ◽  
Bahareh Eskandari
Keyword(s):  
Autism Spectrum Disorder ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Typically Developing ◽  
New Classification ◽  
Early Screening ◽  
Classification Approach ◽  
Children With Asd ◽  
Sensitivity Specificity

AbstractDue to the importance of automatic and early autism screening, in this paper, a cry-based screening approach for children with Autism Spectrum Disorder (ASD) is introduced. During the study, we realized that the ASD specific features are not necessarily observable among all children with ASD and among all instances of each child. Therefore, we proposed a new classification approach to be able to find such features and their corresponding instances. We tested the proposed approach and found two features that can be used to distinguish groups of children with ASD from Typically Developing (TD) children. In other words, these features are present in subsets of children with ASD not all of them. The approach has been tested on a dataset including 14 boys and 7 girls with ASD and 14 TD boys and 7 TD girls, between 18 to 53 months old. The sensitivity, specificity, and precision of the proposed approach for boys were 85.71%, 100%, and 92.85%, respectively. These measures were 71.42%, 100%, and 85.71% for girls, respectively.

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