scholarly journals Temporal complexity of fMRI is reproducible and correlates with higher order cognition

2019 ◽  
Author(s):  
Amir Omidvarnia ◽  
Andrew Zalesky ◽  
Sina Mansour ◽  
Dimitri Van De Ville ◽  
Graeme D. Jackson ◽  
...  
Keyword(s):  
Time Series ◽  
Temporal Resolution ◽  
Resting State ◽  
Brain Function ◽  
Fluid Intelligence ◽  
Global Network ◽  
Normal Brain ◽  
Temporal Complexity ◽  
Multi Scale ◽  
Human Connectome Project

AbstractIt has been hypothesized that resting state networks (RSNs) likely display unique temporal complexity fingerprints, quantified by their multi-scale entropy patterns [1]. This is a hypothesis with a potential capacity for developing digital biomarkers of normal brain function, as well as pathological brain dysfunction. Nevertheless, a limitation of [1] was that resting state functional magnetic resonance imaging (rsfMRI) data from only 20 healthy individuals was used for the analysis. To validate this hypothesis in a larger cohort, we used rsfMRI datasets of 1000 healthy young adults from the Human Connectome Project (HCP), aged 22-35, each with four 14.4-minute rsfMRI recordings and parcellated into 379 brain regions. We quantified multi-scale entropy of rsfMRI time series averaged at different cortical and sub-cortical regions. We performed effect-size analysis on the data in 8 RSNs. Given that the morphology of multi-scale entropy is affected by the choice of its tolerance parameter (r) and embedding dimension (m), we repeated the analyses at multiple values ofrandmincluding the values used in [1]. Our results reinforced high temporal complexity in the default mode and frontoparietal networks. Lowest temporal complexity was observed in the sub-cortical areas and limbic system. We investigated the effect of temporal resolution (determined by the repetition timeTR) after downsampling of rsfMRI time series at two rates. At a low temporal resolution, we observed increased entropy and variance across datasets. Test-retest analysis showed that findings were likely reproducible across individuals over four rsfMRI runs, especially when the tolerance parameterris equal to 0.5. A strong relationship was observed between temporal complexity of RSNs and fluid intelligence (people’s capacity to reason and think flexibly) through step-wise regression analysis suggesting that complex dynamics of the human brain is an important attribute of high-level brain function. Finally, the results confirmed that the relationship between functional brain connectivity strengths and rsfMRI temporal complexity changes over time scales, likely due to the regulation of neural synchrony at local and global network levels.

Multiscale Jensen-Shannon Divergence Based Analysis of Beta Wave Attention EEG

2014 ◽  
Vol 574 ◽  
pp. 723-727
Author(s):  
Zheng Xia Zhang ◽  
Si Qiu Xu ◽  
Er Ning Zhou ◽  
Xiao Lin Huang ◽  
Jun Wang
Keyword(s):  
Time Series ◽  
Brain Function ◽  
Complexity Analysis ◽  
Function Parameter ◽  
Function Evaluation ◽  
Eeg Signals ◽  
Multi Scale ◽  
Eyes Closed ◽  
Statistical Complexity ◽  
Jensen Shannon Divergence

The article adopted the multiscale Jensen - Shannon Divergence analysis method for EEG complexity analysis, then the study found that this method can distinguish between three different status (Eyes closed, count, in a daze) acquisition of Beta EEG time series, shows three different states of Beta EEG time series have significant differences. In each state of the three different states (Eyes closed, count, in a daze),we are aimed at comparing and analyzing the statistical complexity of EEG time series itself and the statistical complexity of EEG time series shuffled data, finding that there are large amounts of nonlinear time series in the Beta EEG signals. This method is also fully proved that the multi-scale JSD algorithm can be used to analyze EEG signals, attention statistical complexity can be used as a measure of brain function parameter, which can be applied to the auxiliary clinical brain function evaluation in the future.

scholarly journals Dynamic mode decomposition of resting-state and task fMRI

2018 ◽  
Author(s):  
Jeremy Casorso ◽  
Xiaolu Kong ◽  
Wang Chi ◽  
Dimitri Van De Ville ◽  
B.T. Thomas Yeo ◽  
...  
Keyword(s):  
Time Series ◽  
Resting State ◽  
Motor Task ◽  
Component Analysis ◽  
Temporal Organization ◽  
Fmri Data ◽  
Dynamic Component ◽  
Human Connectome Project ◽  
Fmri Time Series

AbstractComponent analysis is a powerful tool to identify dominant patterns of interactions in multivariate datasets. In the context of fMRI data, methods such as principal component analysis or independent component analysis have been used to identify the brain networks shaping functional connectivity (FC). Importantly, these approaches are static in the sense that they ignore the temporal information contained in fMRI time series. Therefore, the corresponding components provide a static characterization of FC. Building upon recent findings suggesting that FC dynamics encode richer information about brain functional organization, we use a dynamic extension of component analysis to identify dynamic modes (DMs) of fMRI time series. We demonstrate the feasibility and relevance of this approach using resting-state and motor-task fMRI data of 730 healthy subjects of the Human Connectome Project (HCP). In resting-state, dominant DMs have strong resemblance with classical resting-state networks, with an additional temporal characterization of the networks in terms of oscillatory periods and damping times. In motor-task conditions, dominant DMs reveal interactions between several brain areas, including but not limited to the posterior parietal cortex and primary motor areas, that are not found with classical activation maps. Finally, we identify two canonical components linking the temporal properties of the resting-state DMs with 158 behavioral and demographic HCP measures. Altogether, these findings illustrate the benefits of the proposed dynamic component analysis framework, making it a promising tool to characterize the spatio-temporal organization of brain activity.

scholarly journals Typicality of Functional Connectivity robustly captures motion artifacts in rs-fMRI across datasets, atlases and preprocessing pipelines

2020 ◽  
Author(s):  
Jakub Kopal ◽  
Anna Pidnebesna ◽  
David Tomeček ◽  
Jaroslav Tintěra ◽  
Jaroslav Hlinka
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Resting State Fmri ◽  
Motion Artifacts ◽  
Connectivity Pattern ◽  
Head Motion ◽  
Connectivity Matrix ◽  
Normal Brain ◽  
Functional Connections ◽  
Human Connectome Project

AbstractFunctional connectivity analysis of resting state fMRI data has recently become one of the most common approaches to characterizing individual brain function. It has been widely suggested that the functional connectivity matrix, calculated by correlating signals from regions of interest, is a useful approximate representation of the brain’s connectivity, potentially providing behaviorally or clinically relevant markers. However, functional connectivity estimates are known to be detrimentally affected by various artifacts, including those due to in-scanner head motion. Treatment of such artifacts poses a standing challenge because of their high variability. Moreover, as individual functional connections generally covary only very weakly with head motion estimates, motion influence is difficult to quantify robustly, and prone to be neglected in practice. Although the use of individual estimates of head motion, or group-level correlation of motion and functional connectivity has been suggested, a sufficiently sensitive measure of individual functional connectivity quality has not yet been established. We propose a new intuitive summary index, the Typicality of Functional Connectivity, to capture deviations from normal brain functional connectivity pattern. Based on results of resting state fMRI for 245 healthy subjects we show that this measure is significantly correlated with individual head motion metrics. The results were further robustly reproduced across atlas granularity and preprocessing options, as well as other datasets including 1081 subjects from the Human Connectome Project. The Typicality of Functional Connectivity provides individual proxy measure of motion effect on functional connectivity and is more sensitive to inter-individual variation of motion than individual functional connections. In principle it should be sensitive also to other types of artifacts, processing errors and possibly also brain pathology, allowing wide use in data quality screening and quantification in functional connectivity studies as well as methodological investigations.

scholarly journals A macaque connectome for large-scale network simulations in TheVirtualBrain

2018 ◽  
Author(s):  
Kelly Shen ◽  
Gleb Bezgin ◽  
Michael Schirner ◽  
Petra Ritter ◽  
Stefan Everling ◽  
...  
Keyword(s):  
Resting State ◽  
Brain Function ◽  
Large Scale ◽  
Spatial And Temporal Scales ◽  
Multi Scale ◽  
Large Scale Network ◽  
Scale Network ◽  
Network Simulations ◽  
Dynamical Function ◽  
The Brain

AbstractModels of large-scale brain networks that are informed by the underlying anatomical connectivity contribute to our understanding of the mapping between the structure of the brain and its dynamical function. Connectome-based modelling is a promising approach to a more comprehensive understanding of brain function across spatial and temporal scales, but it must be constrained by multi-scale empirical data from animal models. Here we describe the construction of a macaque connectome for whole-cortex simulations in TheVirtualBrain, an open-source simulation platform. We take advantage of available axonal tract-tracing datasets and enhance the existing connectome data using diffusion-based tractography in macaques. We illustrate the utility of the connectome as an extension of TheVirtualBrain by simulating resting-state BOLD-fMRI data and fitting it to empirical resting-state data.

scholarly journals Resting-state functional brain connectivity best predicts the personality dimension of openness to experience

2017 ◽  
Author(s):  
Julien Dubois ◽  
Paola Galdi ◽  
Yanting Han ◽  
Lynn K. Paul ◽  
Ralph Adolphs
Keyword(s):  
Personality Traits ◽  
Resting State ◽  
Fluid Intelligence ◽  
Small Sample ◽  
Openness To Experience ◽  
Personality Factors ◽  
Personality Factor ◽  
Personality Dimension ◽  
Human Connectome Project ◽  
Neuroimaging Data

AbstractPersonality neuroscience aims to find associations between brain measures and personality traits. Findings to date have been severely limited by a number of factors, including small sample size and omission of out-of-sample prediction. We capitalized on the recent availability of a large database, together with the emergence of specific criteria for best practices in neuroimaging studies of individual differences. We analyzed resting-state functional magnetic resonance imaging data from 884 young healthy adults in the Human Connectome Project (HCP) database. We attempted to predict personality traits from the “Big Five”, as assessed with the NEO-FFI test, using individual functional connectivity matrices. After regressing out potential confounds (such as age, sex, handedness and fluid intelligence), we used a cross-validated framework, together with test-retest replication (across two sessions of resting-state fMRI for each subject), to quantify how well the neuroimaging data could predict each of the five personality factors. We tested three different (published) denoising strategies for the fMRI data, two inter-subject alignment and brain parcellation schemes, and three different linear models for prediction. As measurement noise is known to moderate statistical relationships, we performed final prediction analyses using average connectivity across both imaging sessions (1 h of data), with the analysis pipeline that yielded the highest predictability overall. Across all results (test/retest; 3 denoising strategies; 2 alignment schemes; 3 models), Openness to experience emerged as the only reliably predicted personality factor. Using the full hour of resting-state data and the best pipeline, we could predict Openness to experience (NEOFAC_O: r=0.24, R2=0.024) almost as well as we could predict the score on a 24-item intelligence test (PMAT24_A_CR: r=0.26, R2=0.044). Other factors (Extraversion, Neuroticism, Agreeableness and Conscientiousness) yielded weaker predictions across results that were not statistically significant under permutation testing. We also derived two superordinate personality factors (“α” and “β”) from a principal components analysis of the NEO-FFI factor scores, thereby reducing noise and enhancing the precision of these measures of personality. We could account for 5% of the variance in the β superordinate factor (r=0.27, R2=0.050), which loads highly on Openness to experience. We conclude with a discussion of the potential for predicting personality from neuroimaging data and make specific recommendations for the field.

scholarly journals Computing personalized brain functional networks from fMRI using self-supervised deep learning

2021 ◽  
Author(s):  
Hongming Li ◽  
Srinivasan Dhivya ◽  
Zaixu Cui ◽  
Chuanjun Zhuo ◽  
Raquel E. Gur ◽  
...  
Keyword(s):  
Deep Learning ◽  
Resting State ◽  
Brain Function ◽  
Resting State Fmri ◽  
Fmri Data ◽  
Functional Networks ◽  
Brain Functional Networks ◽  
Human Connectome Project ◽  
Functional Homogeneity ◽  
Decoder Architecture

ABSTRACTA novel self-supervised deep learning (DL) method is developed for computing bias-free, personalized brain functional networks (FNs) that provide unique opportunities to better understand brain function, behavior, and disease. Specifically, convolutional neural networks with an encoder-decoder architecture are employed to compute personalized FNs from resting-state fMRI data without utilizing any external supervision by optimizing functional homogeneity of personalized FNs in a self-supervised setting. We demonstrate that a DL model trained on fMRI scans from the Human Connectome Project can identify canonical FNs and generalizes well across four different datasets. We further demonstrate that the identified personalized FNs are informative for predicting individual differences in behavior, brain development, and schizophrenia status. Taken together, self-supervised DL allows for rapid, generalizable computation of personalized FNs.

scholarly journals Resting-state activity in development and maintenance of normal brain function

2011 ◽  
Vol 108 (28) ◽  
pp. 11638-11643 ◽  
Author(s):  
C. E. Pizoli ◽  
M. N. Shah ◽  
A. Z. Snyder ◽  
J. S. Shimony ◽  
D. D. Limbrick ◽  
...  
Keyword(s):  
Resting State ◽  
Brain Function ◽  
Normal Brain ◽  
State Activity ◽  
Normal Brain Function
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