scholarly journals Accuracy of serological tests for diagnosis of chronic pulmonary aspergillosis: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Cláudia Elizabeth Volpe Chaves ◽  
Sandra Maria do Valle Leone de Oliveira ◽  
James Venturini ◽  
Antonio Jose Grande ◽  
Tatiane Fernanda Sylvestre ◽  
...  
Keyword(s):  
Systematic Review ◽  
Operating Characteristic ◽  
Meta Analysis ◽  
Elisa Test ◽  
Reference Test ◽  
Summary Receiver Operating Characteristic ◽  
Pulmonary Aspergillosis ◽  
Serological Tests ◽  
Receiver Operating Characteristic Curves ◽  
Chronic Pulmonary Aspergillosis

AbstractChronic pulmonary aspergillosis (CPA) is a disease that benefits from cavities as after-effects of tuberculosis, presenting a high mortality rate. Serological tests like double agar gel immunodiffusion test (DID) or the counterimmunoelectrophoresis (CIE) test have been routinely used for CPA diagnosis in the absence of positive cultures; however, they have been replaced by enzyme-linked immunoassay (ELISA), with a variety of methods.This systematic review aims to compare the accuracy of the ELISA test with the reference test (DID and/or CIE) in CPA diagnosis. It was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyzes (PRISMA).The study was registered in PROSPERO under the registration number CRD42016046057. We searched the electronic databases MEDLINE (PubMed), EMBASE (Elsevier), LILACS (VHL), Cochrane library, and ISI Web of Science. Gray literature was researched in Google Scholars and conference abstracts. We included articles with patients or serum samples from CPA patients who underwent two serological tests: ELISA (index test) and IDD and/or CIE (reference test), using the accuracy of the tests as a result. Original articles were considered without a restriction of date or language. The pooled sensitivity, specificity, and summary receiver operating characteristic curves were estimated.We included 13 studies in the review, but only four studies were included in the meta-analysis. The pooled sensitivities and specificities were 0.93 and 0.97 for the ELISA test. For the reference test (DID and/or CIE), these values were 0.64 and 0.99. Analyses of summary receiver operating characteristic curves yielded 0.99 for ELISA and 0.99 for the reference test (DID and/or CIE). Our meta-analysis suggests that the diagnostic accuracy of ELISA is greater than that of the reference tests (DID and/or CIE) in early detection of CPA.

scholarly journals Accuracy of serological tests for diagnosis of chronic pulmonary aspergillosis: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0222738 ◽  
Author(s):  
Cláudia Elizabeth Volpe Chaves ◽  
Sandra Maria do Valle Leone de Oliveira ◽  
James Venturini ◽  
Antonio Jose Grande ◽  
Tatiane Fernanda Sylvestre ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Pulmonary Aspergillosis ◽  
Serological Tests ◽  
Chronic Pulmonary Aspergillosis

Intravenous therapy for chronic pulmonary aspergillosis: A systematic review and meta‐analysis

Mycoses ◽  
2020 ◽  
Vol 63 (9) ◽  
pp. 921-927 ◽  
Author(s):  
Felix Bongomin ◽  
Lucy Grace Asio ◽  
Ronald Olum ◽  
David W. Denning
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Intravenous Therapy ◽  
Pulmonary Aspergillosis ◽  
Chronic Pulmonary Aspergillosis

scholarly journals The Diagnostic Accuracy of Direct Agglutination Test for Serodiagnosis of Human Visceral Leishmaniasis: A Systematic Review with Meta-analysis

2020 ◽  
Author(s):  
Mehdi Mohebali ◽  
Hossein Keshavarz ◽  
Sedigheh Shirmohammad ◽  
Behnaz Akhoundi ◽  
Alireza Borjian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Visceral Leishmaniasis ◽  
Diagnostic Accuracy ◽  
Receiver Operating Characteristic ◽  
Sensitivity And Specificity ◽  
Operating Characteristic ◽  
Meta Analysis ◽  
Agglutination Test ◽  
Direct Agglutination Test ◽  
Summary Receiver Operating Characteristic

Abstract Background: Direct agglutination test (DAT) as a simple, accurate and reliable method, has been widely used for serodiagnosis of visceral leishmaniasis (VL) during the last three decades. The present study is a systematic review and meta-analysis to evaluate the diagnostic accuracy of DAT for serodiagnosis of human VL.Methods: Electronic databases, including MEDLINE (via PubMed), SCOPUS, Web of Science, SID and Mag Iran (two Persian scientific search engines) were searched from December 2004 to April 2019. We determined the pooled sensitivity and specificity rates of DAT for the diagnosis of human VL, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic (ROC) curves parameters across the eligible studies.Results: Of the 2928 records identified in the mentioned electronic databases and after examining reference lists of articles, 24 articles met inclusion criteria and were enrolled in the systematic review and out of them 20 records qualified for meta-analysis. The pooled sensitivity and specificity rates of DAT was 96% [95% CI, 92–98] and 98% [95 % CI, 86–99], respectively. The likelihood ratio of a positive test (LR+) was found to be 21 [CI95%, 6.6–66.5] and the likelihood ratio of a negative test (LR−) was found to be 0.04 [(CI95%, 0.02–0.08]. The combined estimate of the diagnostic odds ratio for DAT was high [467 (CI95%, 114-1912]). We found that the summary receiver operating characteristic curve (SROC) is positioned near the upper left corner of the curve and the area under curve (AUC) was 0.98 (95% CI, 0.97 to 0.99).Conclusion: Referring to our analysis, we determined that DAT can be considered as a valuable tool for the serodiagnosis of human VL with high sensitivity and specificity. As DAT is a simple, accurate and efficient serological test, it can be recommended for serodiagnosis of human VL particularly in endemic areas.

scholarly journals The Diagnostic Accuracy of Direct Agglutination Test for Serodiagnosis of Human Visceral Leishmaniasis: A Systematic Review with Meta-analysis

2020 ◽  
Author(s):  
Mehdi Mohebali ◽  
Hossein Keshavarz ◽  
Sedigheh Shirmohammad ◽  
Behnaz Akhoundi ◽  
Alireza Borjian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Visceral Leishmaniasis ◽  
Diagnostic Accuracy ◽  
Receiver Operating Characteristic ◽  
Likelihood Ratio ◽  
Operating Characteristic ◽  
Meta Analysis ◽  
Agglutination Test ◽  
Direct Agglutination Test ◽  
Summary Receiver Operating Characteristic

Abstract Background: Direct agglutination test (DAT) as simple, accurate and non-expensive tool that has been used widely for serodiagnosis of visceral leishmaniasis (VL) during the last three decades. We conducted a systematic review and meta-analysis to evaluate the diagnostic accuracy of DAT for serodiagnosis of human VL. Methods: Electronic databases, including MEDLINE (via PubMed), SCOPUS, Web of Science, SID and Mag Iran (two Persian scientific search engines) were searched from December 2004 to April 2019. The study quality was evaluated using the QUADAS checklist. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR-), and constructed summary receiver operating characteristic(ROC) curves parameters. Results: Of the 2928 records identified in the mentioned electronic databases and through articles’ reference lists, 25 articles met inclusion criteria and enrolled into the systematic review and among them 22 records were qualified for meta-analysis. The pooled sensitivity and specificity of DAT was 96% [(95% CI, 93–98])and 95% [(95% CI, 88–98]), respectively. The likelihood ratio of a positive test (LR+) was found to be 19.8 [CI95%, 7.6–51.8] and the likelihood ratio of a negative test (LR−) was found to be 0.04 [CI95%, 0.02–0.08]. The combined estimate of the diagnostic odds ratio for DAT was high [454)136-1561]) ].We found that the summary receiver operating characteristic curve (SROC) is positioned near the upper left corner of the curve and the area under curve (AUC) was 0.98 (95% CI, 0.97 to 0.99). Conclusion: Based on our analysis, we find DAT can be considered as valuable tool for the serodiagnosis and seroprevalence of human VL with high sensitivity and specificityrates. As DAT is simple, accurate, non-invasive and efficient serological test, it can be used for serodiagnosis of human VL particularly in endemic areas of the disease.

Diagnostic Performance of Magnetic Resonance Imaging for Detecting Meniscal Ramp Lesions in Patients With Anterior Cruciate Ligament Tears: A Systematic Review and Meta-analysis

2019 ◽  
Vol 48 (8) ◽  
pp. 2051-2059 ◽  
Author(s):  
Boyeon Koo ◽  
Sun Hwa Lee ◽  
Seong Jong Yun ◽  
Jae Gwang Song
Keyword(s):  
Systematic Review ◽  
Diagnostic Performance ◽  
Operating Characteristic ◽  
Cruciate Ligament ◽  
Meta Analysis ◽  
Summary Receiver Operating Characteristic ◽  
Acl Tear ◽  
Knee Position ◽  
Ramp Lesion ◽  
Anterior Cruciate

Background: The clinical importance of meniscal ramp lesions in patients with anterior cruciate ligament (ACL) tear has emerged as a major issue. However, the diagnostic accuracy of magnetic resonance imaging (MRI) for detecting ramp lesions has a wide range. Purpose: To perform a systematic review and meta-analysis of the diagnostic performance of MRI for diagnosing ramp lesion in patients with ACL tear. Study Design: Systematic review and meta-analysis. Methods: A literature search of PubMed, EMBASE, and the Cochrane Library was performed based on the revised guidelines for the PRISMA DTA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses of Diagnostic Accuracy Studies) statement. Diagnostic performance studies using MRI as the index test and arthroscopy as the reference standard for ramp lesion were included. Bivariate and hierarchical summary receiver operating characteristic modeling was used to evaluate the diagnostic performance. Meta-regression analyses were performed to identify potential sources of heterogeneity. Results: The review and meta-analysis included 9 studies from 8 articles (883 patients with ACL tear and reconstruction). The summary sensitivity, summary specificity, and area under the hierarchical summary receiver operating characteristic for ramp lesion were 0.71 (95% CI, 0.59-0.81), 0.94 (95% CI, 0.88-0.97), and 0.90 (95% CI, 0.87-0.92), respectively. Among the potential covariates, magnet strength ( P < .01), patient knee position ( P = .04), and MRI interpreter ( P = .04) were associated with heterogeneity in terms of sensitivity, whereas magnet strength ( P = .03) was associated with heterogeneity in terms of specificity. Conclusion: MRI demonstrated moderate sensitivity and excellent specificity for diagnosing ramp lesion. Routine arthroscopic assessment is recommended for the presence of ramp lesion, regardless of whether it is suspected on MRI. Further clinicoradiological studies of diagnostic algorithms are needed for identifying ramp lesion, including high-resolution MRI with appropriate knee position.

scholarly journals Tolerability of oral itraconazole and voriconazole for the treatment of chronic pulmonary aspergillosis: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240374
Author(s):  
Ronald Olum ◽  
Joseph Baruch Baluku ◽  
Andrew Kazibwe ◽  
Laura Russell ◽  
Felix Bongomin
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Pulmonary Aspergillosis ◽  
Oral Itraconazole ◽  
Chronic Pulmonary Aspergillosis
Sign in / Sign up

Export Citation Format

Share Document