scholarly journals Singular manifolds of proteomic drivers to model the evolution of inflammatory bowel disease status

2019 ◽  
Author(s):  
Ian Morilla ◽  
Thibaut Léger ◽  
Assiya Marah ◽  
Isabelle Pic ◽  
Hatem Zaag ◽  
...  
Keyword(s):  
Riemannian Manifolds ◽  
Disease Status ◽  
Graph Laplacian ◽  
Complex Structures ◽  
Geometric Framework ◽  
Topological Overlap ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Different Levels ◽  
Singular Manifolds

The conditions who denotes the presence of an immune disease are often represented by interaction graphs. These informative, but complex structures are susceptible to being perturbed at different levels. The mode in which that perturbation occurs is still of utmost importance in areas such as reprogramming therapeutics. In this sense, the overall graph architecture is well characterise by module identification. Topological overlap-related measures make possible the localisation of highly specific module regulators that can perturb other nodes, potentially causing the entire system to change behaviour or collapse. We provide a geometric framework explaining such situations in the context of inflammatory bowel diseases (IBD). IBD are important chronic disorders of the gastrointestinal tract which incidence is dramatically increasing worldwide. Our approach models different IBD status as Riemannian manifolds defined by the graph Laplacian of two high throughput proteome screenings. Identifies module regulators as singularities within the manifolds (the so-called singular manifolds). And reinterprets the characteristic IBD nonlinear dynamics as compensatory responses to perturbations on those singularities. Thus, we could control the evolution of the disease status by reconfiguring particular setups of immune system to an innocuous target state.

scholarly journals Singular manifolds of proteomic drivers to model the evolution of inflammatory bowel disease status

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ian Morilla ◽  
Thibaut Léger ◽  
Assiya Marah ◽  
Isabelle Pic ◽  
Hatem Zaag ◽  
...  
Keyword(s):  
Riemannian Manifolds ◽  
Disease Status ◽  
Graph Laplacian ◽  
Immune Disease ◽  
Geometric Framework ◽  
Topological Overlap ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Different Levels ◽  
Singular Manifolds

Abstract The conditions used to describe the presence of an immune disease are often represented by interaction graphs. These informative, but intricate structures are susceptible to perturbations at different levels. The mode in which that perturbation occurs is still of utmost importance in areas such as cell reprogramming and therapeutics models. In this sense, module identification can be useful to well characterise the global graph architecture. To help us with this identification, we perform topological overlap-related measures. Thanks to these measures, the location of highly disease-specific module regulators is possible. Such regulators can perturb other nodes, potentially causing the entire system to change behaviour or collapse. We provide a geometric framework explaining such situations in the context of inflammatory bowel diseases (IBD). IBD are severe chronic disorders of the gastrointestinal tract whose incidence is dramatically increasing worldwide. Our approach models different IBD status as Riemannian manifolds defined by the graph Laplacian of two high throughput proteome screenings. It also identifies module regulators as singularities within the manifolds (the so-called singular manifolds). Furthermore, it reinterprets the characteristic nonlinear dynamics of IBD as compensatory responses to perturbations on those singularities. Then, particular reconfigurations of the immune system could make the disease status move towards an innocuous target state.

Metabolomic Analysis in Inflammatory Bowel Disease: A Systematic Review

2020 ◽  
Author(s):  
Kate Gallagher ◽  
Alexandra Catesson ◽  
Julian L Griffin ◽  
Elaine Holmes ◽  
Horace R T Williams
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Disease Status ◽  
Microbial Metabolism ◽  
Microbial Dysbiosis ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Branched Chain ◽  
Secondary Bile Acids

Abstract Background and aims The inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis, are chronic, idiopathic gastrointestinal (GI) diseases. Whilst their precise etiology is unknown, it is thought to involve a complex interaction between genetic predisposition and an abnormal host immune response to environmental exposures, likely microbial. Microbial dysbiosis has frequently been documented in IBD. Metabolomics (the study of small molecular intermediates and end products of metabolism in biological samples) provides a unique opportunity to characterize disease-associated metabolic changes and may be of particular use in quantifying gut microbial metabolism. Numerous metabolomic studies have been undertaken in inflammatory bowel disease populations, identifying consistent alterations in a range of molecules across several biological matrices. This systematic review aims to summarize these findings. Methods A comprehensive, systematic search was carried out using Medline and EMBASE. All studies were reviewed by two authors independently using predefined exclusion criteria. A total of sixty-four relevant papers were quality assessed and included in the review. Results Consistent metabolic perturbations were identified, including increases in levels of branched chain amino acids and lipid classes across stool, serum, plasma and tissue biopsy samples, and reduced levels of microbially modified metabolites in both urine (such as hippurate) and stool (such as secondary bile acids). Conclusions This review provides a summary of metabolomic research in IBD to date, highlighting underlying themes of perturbed gut microbial metabolism and mammalian-microbial co-metabolism associated with disease status.

scholarly journals P010 Precision Dosing Tool Forecasts Trough Infliximab and Associates With Disease Status in Inflammatory Bowel Diseases

2021 ◽  
Vol 116 (1) ◽  
pp. S3-S3
Author(s):  
Dervieux Thierry ◽  
Primas Christian ◽  
Panetta John ◽  
Mould Diane ◽  
Eser Alexander ◽  
...  
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Disease Status ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Extraintestinal manifestations of inflammatory bowel diseases and their management

2011 ◽  
Vol 152 (17) ◽  
pp. 663-671 ◽  
Author(s):  
Mária Garamszegi
Keyword(s):  
Inflammatory Bowel Diseases ◽  
Bowel Disease ◽  
Intestinal Inflammation ◽  
Coagulation System ◽  
Favorable Effect ◽  
Extraintestinal Manifestations ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Different Levels

Extraintestinal manifestations of ulcerative colitis and Crohn’s disease are symptoms of variegated organ injuries due to systemic inflammatory process. Bowel disease seems to be primary but upon genetic disposition disturbed immune regulation may result in inflammation of other organs that may appear simultaneously, precede bowel disease or follow it in the quiescent phase. As far as possible extraintestinal manifestations have to be distinguished from the complications of the intestinal inflammation and also from side effects of drugs for its treatment. Involvement of bones and joints, skin, eyes, liver and biliary tract is more common but disease of blood coagulation system, lung, kidneys and nervous system may also appear. Treatment of extraintestinal manifestations is influenced by their association with the activity of the bowel disease. Beyond some specific interventions, to achieve improvement of manifestations independent from activity long lasting anti-inflammatory therapy or immunomodulation is almost always needed. Clinical evidence of different levels from reports support the favorable effect of biologic therapy in different extraintestinal manifestations of inflammatory bowel diseases as well. Care and follow-up of patients is a multidisciplinary task. Orv. Hetil., 2011, 152, 663–671.

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