scholarly journals Dysregulation of Sterol Regulatory Element-Binding Protein 2 Gene in HIV Treatment-Experienced Individuals

2019 ◽  
Author(s):  
Anuoluwapo Sopeyin ◽  
Lei Zhou ◽  
Min Li ◽  
Lydia Barakat ◽  
Elijah Paintsil
Keyword(s):  
Binding Protein ◽  
Regulatory Element ◽  
Cholesterol Biosynthesis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hiv Treatment ◽  
Density Lipoprotein Receptor ◽  
Element Binding Protein ◽  
Sterol Regulatory Element ◽  
Lipid Abnormalities

AbstractWe investigated the effects of antiretroviral therapy (ART) on cholesterol biosynthesis in a case-control study. mRNA and protein expressions of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) and ATP binding cassette transporter A1 (ABCA1) were significantly upregulated in cases (HIV+) compared to controls (HIV-). We observed dysregulation between sterol regulatory element-binding protein 2 (SREBP-2, sensory control) and HMGCR and low-density lipoprotein receptor (LDLR) pathways. Dysregulation of cholesterol biosynthesis genes may predate clinical manifestation of ART-induced lipid abnormalities.

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