scholarly journals Traveling cortical netwaves compose a mindstream

2019 ◽  
Author(s):  
Ernst Rudolf M. Hülsmann
Keyword(s):  
Time Space ◽  
Phase Images ◽  
Physical Response ◽  
Space Function ◽  
Spatio Temporal ◽  
Response Task ◽  
Vector Matrix ◽  
The Brain ◽  
Cortical Field ◽  
Resolving Functional

ABSTRACTThe brain creates a physical response out of signals in a cascade of streaming transformations. These transformations occur over networks, which have been described in anatomical, cyto-, myeloarchitectonic and functional research. The totality of these networks has been modelled and synthesised in phases across a continuous time-space-function axis, through ascending and descending hierarchical levels of association1-3 via changing coalitions of traveling netwaves4-6, where localised disorders might spread locally throughout the neighbouring tissues. This study quantified the model empirically with time-resolving functional magnetic resonance imaging of an imperative, visually-triggered, self-delayed, therefor double-event related response task. The resulting time series unfold in the range of slow cortical potentials the spatio-temporal integrity of a cortical pathway from the source of perception to the mouth of reaction in and out of known functional, anatomical and cytoarchitectonic networks. These pathways are consolidated in phase images described by a small vector matrix, which leads to massive simplification of cortical field theory and even to simple technical applications.

scholarly journals Cloning, Characterization, and Expression Features of Chicken CDS2 Splicing Variants

2020 ◽  
Author(s):  
Yuanyuan Xu ◽  
Shuping Zhang ◽  
Yujun Guo ◽  
Wen Chen ◽  
Yanqun Huang
Keyword(s):  
Adipose Tissue ◽  
Real Time ◽  
Real Time Pcr ◽  
Expression Patterns ◽  
Mrna Levels ◽  
Exogenous Insulin ◽  
Quantitative Real Time Pcr ◽  
Temporal Expression ◽  
Spatio Temporal ◽  
The Brain

Abstract Background: The CDS gene encodes the CDP-diacylglycerol synthase enzyme that catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid. At present, there are no reports of CDS2 in birds. Here, we identified chicken CDS2 transcripts by combining conventional RT- PCR amplification, 5' RACE (Fig. 1A), and 3' RACE, explored the spatio-temporal expression profiles of total CDS2 and the longest transcript variant CDS2-4, and investigated the effect of exogenous insulin on total the mRNA level of CDS2 by quantitative real-time PCR. Results: Four transcripts of chicken CDS2 (CDS2-1, -2, -3, and -4) were identified, which were alternatively spliced at the 3′-untranslated region (UTR). CDS2 was widely expressed in all tissues examined and the longest variant CDS2-4 was the major transcript. Both total CDS2 and CDS2-4 were prominently expressed in adipose tissue and the heart, and exhibited low expression in the liver and pectoralis of 49 day-old chickens. Quantitative real-time PCR revealed that total CDS2 and CDS2-4 had different spatio-temporal expression patterns in chicken. Total CDS2 exhibited a similar temporal expression tendency with a high level in the later period of incubation (embryonic day 19 [E19] or 1-day-old) in the brain, liver, and pectoralis. While CDS2-4 presented a distinct temporal expression pattern in these tissues, CDS2-4 levels peaked at 21 days in the brain and pectoralis, while liver CDS2-4 mRNA levels were highest at the early stage of hatching (E10). Total CDS2 (P < 0.001) and CDS2-4 (P = 0.0090) mRNA levels in the liver were differentially regulated throughout development of the chicken. Exogenous insulin significantly downregulated the level of total CDS2 at 240 min in the pectoralis of Silky chickens (P < 0.01). Total CDS2 levels in the liver of Silky chickens were higher than that of the broiler in the basal state and after insulin stimulation. Conclusion: Chicken CDS2 has multiple transcripts with variation at the 3′-UTR, which was prominently expressed in adipose tissue. Total CDS2 and CDS2-4 presented distinct spatio-temporal expression patterns, and they were differentially regulated with age in liver. Insulin could regulate chicken CDS2 levels in a breed- and tissue-specific manner.

scholarly journals New methods for retrieval of chlorophyll red fluorescence from hyper-spectral satellite instruments: simulations and application to GOME-2 and SCIAMACHY

2016 ◽  
Author(s):  
J. Joiner ◽  
Y. Yoshida ◽  
L. Guanter ◽  
E. M. Middleton
Keyword(s):  
Spatial Scales ◽  
Temporal Structure ◽  
Emission Feature ◽  
Ozone Monitoring Instrument ◽  
Additional Information ◽  
Time Space ◽  
Hyper Spectral ◽  
Spatio Temporal ◽  
Gas Measurements ◽  
Satellite Instruments

Abstract. Global satellite measurements of solar-induced fluorescence (SIF) from chlorophyll over land and ocean have proven useful for a number of different applications related to physiology, phenology, and productivity of plants and phytoplankton. Terrestrial chlorophyll fluorescence is emitted throughout the red and far-red spectrum, producing two broad peaks near 683 and 736 nm. From ocean surfaces, phytoplankton fluorescence emissions are entirely from the red region. Studies using satellite-derived SIF over land have focused almost exclusively on measurements in the far- red, since those are the most easily obtained with existing instrumentation. Here, we examine new ways to use existing hyper-spectral satellite data sets to retrieve red SIF over both land and ocean. Our approach offers noise reductions as compared with previously published solar line filling retrievals by making use of the oxygen (O2) γ-band that is not affected by SIF. The O2 γ-band in conjunction with solar Fraunhofer lines help to anchor the O2 B-band that provides additional information on red SIF. Biases due to instrumental artifacts that vary in time, space, and with instrument, must be addressed in order to obtain reasonable results. The satellite instruments that we use were designed to make atmospheric trace- gas measurements and are therefore not optimal for observing SIF; they have coarse spatial resolution and only moderate spectral resolution (∼0.5 nm). Nevertheless, these instruments offer a unique opportunity to compare red and far-red terrestrial SIF at regional spatial scales. Our eight year record of red SIF observations over land with the Global Ozone Monitoring Instrument 2 (GOME-2) allows for the first time reliable global mapping of monthly anomalies. These anomalies are shown to have similar spatio-temporal structure as those in the far-red, particularly for drought-prone regions. There is a somewhat larger percentage response in the red as compared with the far-red for these areas that are sensitive to soil moisture, although the differences are within the specified uncertainties that are dominated by systematic errors. We also demonstrate that high quality ocean fluorescence line height retrievals can be achieved with GOME-2 and similar instruments by utilizing the full complement of radiance measurements that span the red SIF emission feature.

scholarly journals RESEARCH ON CONSTRUCTION METHOD OF SPATIO-TEMPORAL DATA MODEL BASED ON BEHAVIOR-EVENT

2020 ◽  
Vol XLII-3/W10 ◽  
pp. 591-594
Author(s):  
J. W. Li ◽  
Y. Ma ◽  
J. W. Jiang ◽  
W. D. Chen ◽  
N. Yu ◽  
...  
Keyword(s):  
Data Model ◽  
Logical Structure ◽  
Physical Structure ◽  
Temporal Data ◽  
Model Based ◽  
Time Space ◽  
Before And After ◽  
Spatio Temporal ◽  
Temporal Objects ◽  
Organic Combination

Abstract. Starting from the object-oriented idea, this paper analyses the existing event-based models and the logical relationship between behavioral cognition and events, and discusses the continuity of behavioral cognition on the time axis from the perspective of temporal and spatial cognition. A geospatial data model based on behavioral-event is proposed. The physical structure and logical structure of the model are mainly designed, and the four-dimensional model of “time, space, attribute and event” is constructed on the axis. The organic combination of the four models can well describe the internal mechanism and rules of geographical objects. The expression of data model based on behavior-event not only elaborates the basic information of geospatial objects, but also records the changes of related events caused by the changes of geographic Entities' behavior, and expresses the relationship between spatial and temporal objects before and after the changes of behavior cognition. This paper also designs an effective method to organize spatio-temporal data, so as to realize the effective management and analysis of spatio-temporal data and meet the requirements of storage, processing and mining of large spatio-temporal data.

scholarly journals Análise da Variação Espaço-Temporal das Áreas Verdes e da Qualidade Ambiental em Áreas Urbanas, Recife-PE (Analysis of the Time-Space Variation of Green Areas and the Environmental Quality in Urban Areas, Recife-PE)

2015 ◽  
Vol 7 (6) ◽  
pp. 1196
Author(s):  
Tiago Henrique de Oliveira ◽  
José Gleidson Dantas ◽  
Josiclêda Domiciano Galvíncio ◽  
Rejane Magalhães de Mendonça Pimentel ◽  
Milton Botler
Keyword(s):  
Land Use ◽  
Environmental Quality ◽  
Urban Areas ◽  
Rapid Change ◽  
Large Temperature ◽  
Natural Soil ◽  
Area Index ◽  
Time Space ◽  
Green Areas ◽  
Spatio Temporal

As rápidas mudanças do uso e cobertura do solo em ambiente urbano apresentam grande impacto nas relações entre os ciclos energéticos e hidrológicos sobre a superfície. O município do Recife, através da Lei de Uso e Ocupação do Solo de 1996 (Lei nº 16.176/96) define área verde como “toda área de domínio público ou privado, em solo natural,onde predomina qualquer forma de vegetação, distribuída em seus diferentes estratos: Arbóreo, Arbustivo e Herbáceo /Forrageira, nativa ou exótica”. O objetivo deste artigo é analisar a variação espacial das áreas verdes disponíveis no município do Recife e a evolução espaço-temporal da qualidade ambiental na RPA 4 através do computo do Índice de umidade (NDWI), Índice de Área Foliar (IAF) e Temperatura da superfície em imagens TM Landsat. Foi realizada uma classificação supervisionada na ortofotocarta Recife onde as áreas verdes foram exportadas para polígonos, permitindo a sua quantificação. Para as imagens TM foi aplicada parte da metodologia SEBAL. As áreas verdes ocupam 45,58% do Recife. Os transectos lineares e perfis permitiram visualizar mais facilmente as mudanças espaço-temporais ocorridos na RPA-4. Foi visualizada grande diferença de temperatura entre as áreas vegetadas e as áreas mais urbanizadas. Palavras-chave: Uso e ocupação do solo; área urbana, áreas vegetadas, sensoriamento remoto; MAXVER. A B S T R A C T The rapid change of use and land cover in urban environment poses great impact on relations between energy and hydrological cycles on the surface. The municipality of Recife, through the Land Use Legislation from 1996 (Law No. 16.176/96) defines green area as ";;;;;;any public or private domain area, in natural soil, where overcrows any form of vegetation, distributed in its different layers: Arboreal, shrubby and Herbaceous Forage, native or exotic";;;;;;. The goal of this paper is to analyze the spatial variation of available green areas in the city of Recife and the spatio-temporal evolution of environmental quality in the Political Administrative Region 4, known as RPA-4, through the calculation of moisture content (NDWI), leaf area index (LAI) and the surface temperature from Landsat TM images. Supervised classification was performed on orthophoto Reef where the green areas were exported to polygons, allowing its quantification. For the TM images, it has been applied the methodology SEBAL. The green areas occupy 45.58% of Recife. The linear transects and profiles allowed to show more easily space-time changes occurring in the RPA-4. Large temperature differences have been displayed between the most vegetated areas and more urbanized areas. Key-words: Land use; urban areas; vegetated area, remote sensing; MAXVER.

Plague Time: Space, Fear, and Emergency Statecraft in Early Modern Italy

2021 ◽  
Vol 44 (2) ◽  
pp. 87-111
Author(s):  
Nicholas A. Eckstein
Keyword(s):  
Eighteenth Century ◽  
Seventeenth Century ◽  
Early Modern ◽  
Analytical Framework ◽  
Temporal Dimension ◽  
Early Modern Italy ◽  
Time Space ◽  
Contingent Response ◽  
Spatio Temporal ◽  
Historical Examination

Michel Foucault argued famously that early modern European governors responded to plague by quarantining entire urban populations and placing citizens under minute surveillance. For Foucault, such sixteenth- and seventeenth-century policies were the first steps towards an authoritarian paradigm that would only emerge in full in the eighteenth century. The present article argues that Foucault’s model is too abstracted to function as a tool for the historical examination of specific emergencies, and it proposes an alternative analytical framework. Addressing itself to actual events in early modern Italy, the article reveals that when plague threatened, Florentine and Bolognese health officials projected themselves into a spatio-temporal dimension in which official actions and perceptions were determined solely by the spread of contagion. This dimension, “plague time,” was not a stage on the irresistible journey towards Foucault’s “utopia of the perfectly governed city.” A contingent response to a recurrent existential menace, plague time rose and fell in response to events, and may be understood as a season.

Neuroethics

2021 ◽  
pp. 405-420
Author(s):  
Georg Northoff
Keyword(s):  
Deep Brain Stimulation ◽  
Psychiatric Disorders ◽  
Brain Stimulation ◽  
Empirical Data ◽  
Moral Agency ◽  
Ethical Issues ◽  
Spatio Temporal ◽  
The Brain ◽  
Deep Brain

Neuroethics, located at the interface of conceptual and empirical dimensions, carries major implications for psychiatry, such as the neuroscientific basis of ethical concepts as moral agency. Drawing on data in neuroscience, this chapter highlights issues central to psychiatric ethics. First, it addresses a reductionistic model of the brain, often conceived as purely neuronal, and then it discusses empirical data suggesting that the brain’s activity is strongly aligned to its respective social (e.g., relation to others) and ecological (e.g., relation to the environment and nature) contexts; this implies a relational rather than reductionist model. Second, it suggests that self (e.g., the experience or sense of a self) and personhood (e.g., the person as existent independent of experience) must also be understood in such a social and ecological and, therefore, relational and spatio-temporal sense. Ethical concepts like agency, therefore, cannot be limited solely to the person and brain, but must rather be understood in a relational and neuro-ecological/social way. Third, it discusses deep brain stimulation as a treatment that promotes enhancement. In sum, this chapter presents findings in neuroscience that carry major implications for our view of brain, mental features, psychiatric disorders, and ethical issues like agency, responsibility, and enhancement.

scholarly journals Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Kanchan Bisht ◽  
Kenneth A. Okojie ◽  
Kaushik Sharma ◽  
Dennis H. Lentferink ◽  
Yu-Yo Sun ◽  
...  
Keyword(s):  
Myeloid Cell ◽  
Structure And Function ◽  
Pannexin 1 ◽  
Vascular Physiology ◽  
Blood Flow Increase ◽  
Bona Fide ◽  
Spatio Temporal ◽  
And Function ◽  
The Brain

AbstractMicroglia are brain-resident immune cells with a repertoire of functions in the brain. However, the extent of their interactions with the vasculature and potential regulation of vascular physiology has been insufficiently explored. Here, we document interactions between ramified CX3CR1 + myeloid cell somata and brain capillaries. We confirm that these cells are bona fide microglia by molecular, morphological and ultrastructural approaches. Then, we give a detailed spatio-temporal characterization of these capillary-associated microglia (CAMs) comparing them with parenchymal microglia (PCMs) in their morphological activities including during microglial depletion and repopulation. Molecularly, we identify P2RY12 receptors as a regulator of CAM interactions under the control of released purines from pannexin 1 (PANX1) channels. Furthermore, microglial elimination triggered capillary dilation, blood flow increase, and impaired vasodilation that were recapitulated in P2RY12−/− and PANX1−/− mice suggesting purines released through PANX1 channels play important roles in activating microglial P2RY12 receptors to regulate neurovascular structure and function.

scholarly journals STAB: a spatio-temporal cell atlas of the human brain

2020 ◽  
Vol 49 (D1) ◽  
pp. D1029-D1037
Author(s):  
Liting Song ◽  
Shaojun Pan ◽  
Zichao Zhang ◽  
Longhao Jia ◽  
Wei-Hua Chen ◽  
...  
Keyword(s):  
Human Brain ◽  
Single Cell ◽  
Temporal Dynamics ◽  
Cell Types ◽  
Brain Regions ◽  
Molecular Characteristics ◽  
Great Effort ◽  
Brain Functions ◽  
Spatio Temporal ◽  
The Brain

Abstract The human brain is the most complex organ consisting of billions of neuronal and non-neuronal cells that are organized into distinct anatomical and functional regions. Elucidating the cellular and transcriptome architecture underlying the brain is crucial for understanding brain functions and brain disorders. Thanks to the single-cell RNA sequencing technologies, it is becoming possible to dissect the cellular compositions of the brain. Although great effort has been made to explore the transcriptome architecture of the human brain, a comprehensive database with dynamic cellular compositions and molecular characteristics of the human brain during the lifespan is still not available. Here, we present STAB (a Spatio-Temporal cell Atlas of the human Brain), a database consists of single-cell transcriptomes across multiple brain regions and developmental periods. Right now, STAB contains single-cell gene expression profiling of 42 cell subtypes across 20 brain regions and 11 developmental periods. With STAB, the landscape of cell types and their regional heterogeneity and temporal dynamics across the human brain can be clearly seen, which can help to understand both the development of the normal human brain and the etiology of neuropsychiatric disorders. STAB is available at http://stab.comp-sysbio.org.

scholarly journals Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases

NeuroImage ◽  
2008 ◽  
Vol 39 (4) ◽  
pp. 1682-1692 ◽  
Author(s):  
Kathryn E. Hammond ◽  
Janine M. Lupo ◽  
Duan Xu ◽  
Meredith Metcalf ◽  
Douglas A.C. Kelley ◽  
...  
Keyword(s):  
Neurological Diseases ◽  
Robust Method ◽  
Normal Volunteers ◽  
Phase Images ◽  
The Brain

A 3-D spatio-temporal deconvolution approach for MR perfusion in the brain

2014 ◽  
Vol 18 (1) ◽  
pp. 144-160 ◽  
Author(s):  
Carole Frindel ◽  
Marc C. Robini ◽  
David Rousseau
Keyword(s):  
Mr Perfusion ◽  
Spatio Temporal ◽  
The Brain
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