scholarly journals Threat imminence dictates the role of the bed nucleus of the stria terminalis in contextual fear

2019 ◽  
Author(s):  
Travis D. Goode ◽  
Gillian M. Acca ◽  
Stephen Maren
Keyword(s):  
Unconditioned Stimulus ◽  
Fear Conditioning ◽  
Stria Terminalis ◽  
Conditioning Procedure ◽  
Conditioned Stimuli ◽  
Reversible Inactivation ◽  
Bed Nucleus ◽  
Contextual Fear ◽  
Context Dependent

ABSTRACTPrevious work indicates that the bed nucleus of the stria terminalis (BNST) is involved in defensive freezing to unpredictable Pavlovian conditioned stimuli (Goode et al., 2019). Here we show that the BNST mediates freezing to contexts paired with remote (unpredictable), but not imminent (predictable), footshock. Rats underwent a fear conditioning procedure in which a single footshock unconditioned stimulus (US) was delivered either 1 (imminent) or 9 minutes (remote) after placement in the context; each rat received a total of four conditioning trials over two days. Contexts associated with either imminent or remote USs produced distinct patterns of freezing and shock-induced activity but freezing in each case was context-dependent. Reversible inactivation of the BNST reduced the expression of contextual freezing in the context paired with remote, but not imminent, footshock. Implications of these data are discussed in light of recent conceptualizations of BNST function, as well as for anxiety behaviors.

scholarly journals Role of the bed nucleus of the stria terminalis in the acquisition of contextual fear at long or short context-shock intervals.

2015 ◽  
Vol 129 (5) ◽  
pp. 673-678 ◽  
Author(s):  
Sayamwong E. Hammack ◽  
Travis P. Todd ◽  
Margaret Kocho-Schellenberg ◽  
Mark E. Bouton
Keyword(s):  
Stria Terminalis ◽  
Bed Nucleus ◽  
Contextual Fear

Cannabidiol injected into the bed nucleus of the stria terminalis reduces the expression of contextual fear conditioning via 5-HT1Areceptors

2010 ◽  
Vol 26 (1) ◽  
pp. 104-113 ◽  
Author(s):  
Felipe V Gomes ◽  
Daniel G Reis ◽  
Fernando HF Alves ◽  
Fernando MA Corrêa ◽  
Francisco S Guimarães ◽  
...  
Keyword(s):  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Contextual Fear

Bed nucleus of the stria terminalis β1, but not β2-adrenoceptors, are involved with expression of contextual fear conditioning of rats

2011 ◽  
Vol 163 (1-2) ◽  
pp. 55
Author(s):  
S.C. Hott ◽  
D.R.S. Fabri ◽  
F.V. Gomes ◽  
D.G. Reis ◽  
F.M.A. Corrêa ◽  
...  
Keyword(s):  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Contextual Fear

scholarly journals Bed nucleus of the stria terminalis regulates fear to unpredictable threat signals

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Travis D Goode ◽  
Reed L Ressler ◽  
Gillian M Acca ◽  
Olivia W Miles ◽  
Stephen Maren
Keyword(s):  
Conditioned Fear ◽  
Stria Terminalis ◽  
Conditioned Stimuli ◽  
Variable Intensity ◽  
Reversible Inactivation ◽  
Bed Nucleus ◽  
Defensive Behaviors ◽  
The Us ◽  
Specific Factors ◽  
Fear And Anxiety

The bed nucleus of the stria terminalis (BNST) has been implicated in conditioned fear and anxiety, but the specific factors that engage the BNST in defensive behaviors are unclear. Here we examined whether the BNST mediates freezing to conditioned stimuli (CSs) that poorly predict the onset of aversive unconditioned stimuli (USs) in rats. Reversible inactivation of the BNST selectively reduced freezing to CSs that poorly signaled US onset (e.g., a backward CS that followed the US), but did not eliminate freezing to forward CSs even when they predicted USs of variable intensity. Additionally, backward (but not forward) CSs selectively increased Fos in the ventral BNST and in BNST-projecting neurons in the infralimbic region of the medial prefrontal cortex (mPFC), but not in the hippocampus or amygdala. These data reveal that BNST circuits regulate fear to unpredictable threats, which may be critical to the etiology and expression of anxiety.

Bed nucleus of the stria terminalis NMDA receptors and nitric oxide modulate contextual fear conditioning in rats

2017 ◽  
Vol 112 ◽  
pp. 135-143 ◽  
Author(s):  
Sara C. Hott ◽  
Felipe V. Gomes ◽  
Daniela L. Uliana ◽  
Gabriel T. Vale ◽  
Carlos R. Tirapelli ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nmda Receptors ◽  
Fear Conditioning ◽  
Contextual Fear Conditioning ◽  
Stria Terminalis ◽  
Bed Nucleus ◽  
Contextual Fear

Role of dorsal and ventral hippocampal muscarinic receptor activity in acquisition and retention of contextual fear conditioning.

2020 ◽  
Vol 134 (5) ◽  
pp. 460-470
Author(s):  
Claudia C. Pinizzotto ◽  
Nicholas A. Heroux ◽  
Colin J. Horgan ◽  
Mark E. Stanton
Keyword(s):  
Fear Conditioning ◽  
Muscarinic Receptor ◽  
Contextual Fear Conditioning ◽  
Receptor Activity ◽  
Contextual Fear
Sign in / Sign up

Export Citation Format

Share Document