scholarly journals Reproducible Tract Profiles (RTP): from diffusion MRI acquisition to publication

2019 ◽  
Author(s):  
Garikoitz Lerma-Usabiaga ◽  
Michael L. Perry ◽  
Brian A. Wandell
Keyword(s):  
Diffusion Weighted Imaging ◽  
Software Tools ◽  
List Type ◽  
Computational Tools ◽  
Server Side ◽  
Diffusion Weighted ◽  
Client Side ◽  
And Control ◽  
Diffusion Profiles ◽  
Complete Specification

AbstractReproducible Tract Profiles (RTP) comprises a set of methods to manage and analyze diffusion weighted imaging (DWI) data for reproducible tractography. The tools take MRI data from the scanner and process them through a series of analysis implemented as Docker containers that are integrated into a modern neuroinformatics platform (Flywheel). The platform guarantees that the entire pipeline can be re-executed, using the same data and computational parameters. In this paper, we describe (1) a cloud based neuroinformatics platform, (2) a tool to programmatically access and control the platform from a client, and (3) the DWI analysis tools that are used to identify the positions of 22 tracts and their diffusion profiles. The combination of these three components defines a system that transforms raw data into reproducible tract profiles for publication.Graphical abstractReproducible Tract Profiles (RTP) comprises a set of methods to manage and analyze diffusion weighted imaging (DWI) data for reproducible tractography. The RTP methods comprise two main parts. Server side software tools for storing data and metadata and managing containerized computations.Client side software tools that enable the researcher to read data and metadata and manage server-side computations.The server-side computational tools are embedded in containers that are linked to a JSON file with a complete specification of the computational parameters. The data and computational infrastructure on the server is fully reproducible.

Comparison of bi-exponential and mono-exponential models of diffusion-weighted imaging for detecting active sacroiliitis in ankylosing spondylitis

2017 ◽  
Vol 59 (4) ◽  
pp. 468-477 ◽  
Author(s):  
Haitao Sun ◽  
Kai Liu ◽  
Hao Liu ◽  
Zongfei Ji ◽  
Yan Yan ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Ankylosing Spondylitis ◽  
Diffusion Weighted Imaging ◽  
Active Group ◽  
Control Group ◽  
Imaging Method ◽  
Control Groups ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
And Control

Background There has been a growing need for a sensitive and effective imaging method for the differentiation of the activity of ankylosing spondylitis (AS). Purpose To compare the performances of intravoxel incoherent motion (IVIM)-derived parameters and the apparent diffusion coefficient (ADC) for distinguishing AS-activity. Material and Methods One hundred patients with AS were divided into active (n = 51) and non-active groups (n = 49) and 21 healthy volunteers were included as control. The ADC, diffusion coefficient ( D), pseudodiffusion coefficient ( D*), and perfusion fraction ( f) were calculated for all groups. Kruskal–Wallis tests and receiver operator characteristic (ROC) curve analysis were performed for all parameters. Results There was good reproducibility of ADC /D and relatively poor reproducibility of D*/f. ADC, D, and f were significantly higher in the active group than in the non-active and control groups (all P < 0.0001, respectively). D* was slightly but significant lower in the active group than in the non-active and control group ( P = 0.0064, 0.0215). There was no significant difference in any parameter between the non-active group and the control group (all P > 0.050). In the ROC analysis, ADC had the largest AUC for distinguishing between the active group and the non-active group (0.988) and between the active and control groups (0.990). Multivariate logistic regression analysis models showed no diagnostic improvement. Conclusion ADC provided better diagnostic performance than IVIM-derived parameters in differentiating AS activity. Therefore, a straightforward and effective mono-exponential model of diffusion-weighted imaging may be sufficient for differentiating AS activity in the clinic.

MRT des Prostatakarzinoms: Diffusion Weighted Imaging im Vergleich mit der Histologie

2009 ◽  
Vol 181 (S 01) ◽  
Author(s):  
J Yamamura ◽  
G Salomon ◽  
J Graessner ◽  
A Hohenstein ◽  
M Graefen ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Diffusion Weighted

CHROMATOGRAPHY OF THE 17-KETOGENIC STEROIDS IN THE DIAGNOSIS AND CONTROL OF CONGENITAL ADRENAL HYPERPLASIA

1960 ◽  
Vol XXXIII (II) ◽  
pp. 230-250 ◽  
Author(s):  
Eileen E. Hill
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
List Type ◽  
Adrenal Hyperplasia ◽  
Normal Children ◽  
Paediatric Practice ◽  
The Mean ◽  
Cortisone Therapy ◽  
And Control ◽  
Clinical Problems ◽  
Stimulation Of

ABSTRACT A method for the fractionation of the urinary 17-ketogenic steroids with no oxygen grouping at C11 and those oxygenated at C11, is applied to the clinical problems of congenital adrenal hyperplasia. In normal children the mean ratio of the non-oxygenated to oxygenated steroids is 0.24. In childrern with congenital adrenal hyperplasia the ratio is 2.3. The reason for this difference in ratio is discussed. The changes in ratio found under stimulation of the adrenal gland with exogenous or endogenous corticotrophin and the suppression with cortisone therapy are studied. This test can be applied to isolated samples of urine, a major advantage in paediatric practice, and can be carried out in routine laboratories. It is found to be reliable in the diagnosis and sensitive in the control of congenital adrenal hyperplasia.

Dynamic Load-balancing and Control for Server-Side Rendering on Ajax-GIS

2013 ◽  
Vol 133 (4) ◽  
pp. 891-898
Author(s):  
Takeo Sakairi ◽  
Masashi Watanabe ◽  
Katsuyuki Kamei ◽  
Takashi Tamada ◽  
Yukio Goto ◽  
...  
Keyword(s):  
Load Balancing ◽  
Dynamic Load ◽  
Dynamic Load Balancing ◽  
Server Side ◽  
And Control

Diffusion-Weighted Imaging Features of Urachal Abscess

2008 ◽  
Author(s):  
Ozgur Kilickesmez ◽  
Arda Kayhan ◽  
Bengi Gürses ◽  
Neslihan Tasdelen ◽  
Baki Ekci ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Imaging Features ◽  
Diffusion Weighted ◽  
Urachal Abscess

DYNAMIC REST SERVICES ORCHESTRATION USING THE KNOWLEDGE BASE

2019 ◽  
Author(s):  
Kostyantyn Kharchenko
Keyword(s):  
Knowledge Base ◽  
Service Oriented Architecture ◽  
Main Idea ◽  
The Real ◽  
Server Side ◽  
Service Oriented ◽  
Services Orchestration ◽  
Client Side ◽  
Abstract Operation ◽  
Microservice Architecture

The approach to organizing the automated calculations’ execution process using the web services (in particular, REST-services) is reviewed. The given solution will simplify the procedure of introduction of the new functionality in applied systems built according to the service-oriented architecture and microservice architecture principles. The main idea of the proposed solution is in maximum division of the server-side logic development and the client-side logic, when clients are used to set the abstract computation goals without any dependencies to existing applied services. It is proposed to rely on the centralized scheme to organize the computations (named as orchestration) and to put to the knowledge base the set of rules used to build (in multiple steps) the concrete computational scenario from the abstract goal. It is proposed to include the computing task’s execution subsystem to the software architecture of the applied system. This subsystem is composed of the service which is processing the incoming requests for execution, the service registry and the orchestration service. The clients send requests to the execution subsystem without any references to the real-world services to be called. The service registry searches the knowledge base for the corresponding input request template, then the abstract operation description search for the request template is performed. Each abstract operation may already have its implementation in the form of workflow composed of invocations of the real applied services’ operations. In case of absence of the corresponding workflow in the database, this workflow implementation could be synthesized dynamically according to the input and output data and the functionality description of the abstract operation and registered applied services. The workflows are executed by the orchestrator service. Thus, adding some new functions to the client side can be possible without any changes at the server side. And vice versa, adding new services can impact the execution of the calculations without updating the clients.

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