scholarly journals PKMYT1 is a computationally predicted target for kidney cancer

2019 ◽  
Author(s):  
Denis Torre ◽  
Nicolas F. Fernandez ◽  
Avi Ma’ayan
Keyword(s):  
Protein Kinase ◽  
Kidney Cancer ◽  
Protein Kinase Family ◽  
Development Level ◽  
Kinase Family ◽  
Bioinformatics Tools ◽  
Druggable Genome

AbstractProtein Kinase Membrane Associated Tyrosine/Threonine 1 (PKMYT1) is an understudied member of the serine/threonine protein kinase family. PKMYT1 is listed as a dark kinase according to the Illuminating the Druggable Genome (IDG) target development level classification. Using a combination of bioinformatics tools that we developed, we predict that targeting PKMYT1 is potentially beneficial for treating kidney cancer.

scholarly journals Molecular Physiology of SPAK and OSR1: Two Ste20-Related Protein Kinases Regulating Ion Transport

2012 ◽  
Vol 92 (4) ◽  
pp. 1577-1617 ◽  
Author(s):  
Kenneth B. Gagnon ◽  
Eric Delpire
Keyword(s):  
Protein Kinase ◽  
Multiple Organ ◽  
Genetically Engineered ◽  
Related Protein ◽  
Molecular Physiology ◽  
Cancer Proliferation ◽  
Protein Kinase Family ◽  
Kinase Family ◽  
Organ Systems ◽  
And Migration

SPAK (Ste20-related proline alanine rich kinase) and OSR1 (oxidative stress responsive kinase) are members of the germinal center kinase VI subfamily of the mammalian Ste20 (Sterile20)-related protein kinase family. Although there are 30 enzymes in this protein kinase family, their conservation across the fungi, plant, and animal kingdom confirms their evolutionary importance. Already, a large volume of work has accumulated on the tissue distribution, binding partners, signaling cascades, and physiological roles of mammalian SPAK and OSR1 in multiple organ systems. After reviewing this basic information, we will examine newer studies that demonstrate the pathophysiological consequences to SPAK and/or OSR1 disruption, discuss the development and analysis of genetically engineered mouse models, and address the possible role these serine/threonine kinases might have in cancer proliferation and migration.

cAMP-dependent protein kinase and the protein kinase family

1992 ◽  
Vol 93 ◽  
pp. 143 ◽  
Author(s):  
Susan S. Taylor ◽  
Daniel R. Knighton ◽  
Jianhua Zheng ◽  
Lynn F. Ten Eyck ◽  
Janusz M. Sowadski
Keyword(s):  
Protein Kinase ◽  
Dependent Protein Kinase ◽  
Camp Dependent Protein Kinase ◽  
Protein Kinase Family ◽  
Kinase Family ◽  
Dependent Protein

scholarly journals Pulmonary arterial hypertension associated with protein kinase inhibitors: a pharmacovigilance–pharmacodynamic study

2019 ◽  
Vol 53 (5) ◽  
pp. 1802472 ◽  
Author(s):  
Lucie Cornet ◽  
Charles Khouri ◽  
Matthieu Roustit ◽  
Christophe Guignabert ◽  
Marie-Camille Chaumais ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Pulmonary Arterial Hypertension ◽  
Protein Kinase ◽  
Arterial Hypertension ◽  
Kinase Inhibitors ◽  
Protein Kinase Inhibitors ◽  
World Health ◽  
Protein Kinase Family ◽  
Kinase Family ◽  
Pulmonary Arterial

The pathophysiology of pulmonary arterial hypertension (PAH) induced by protein kinase inhibitors (PKIs) remains unclear. To gain knowledge into this rare and severe pathology we performed a study combining a pharmacovigilance approach and the pharmacodynamic properties of PKIs.A disproportionality analysis on the World Health Organization pharmacovigilance database VigiBase using the reporting odds ratio (ROR) and 95% confidence interval was first performed. Then, we identified the most relevant cellular targets of interest through a systematic literature review and correlated the pharmacovigilance signals with the affinity for the different PKIs. We further performed a hierarchical cluster analysis to assess patterns of binding affinity.A positive disproportionality signal was found for dasatinib, bosutinib, ponatinib, ruxolitinib and nilotinib. Five non-receptor protein kinases significantly correlate with disproportionality signals: c-Src (r=0.79, p=0.00027), c-Yes (r=0.82, p=0.00015), Lck (r=0.81, p=0.00046) and Lyn (r=0.80, p=0.00036), all belonging to the Src protein kinase family, and TEC (r=0.85, p=0.00006). Kinases of the bone morphogenetic protein signalling pathway also seem to play a role in the pathophysiology of PKI-induced PAH. Interestingly, the dasatinib affinity profile seems to be different from that of other PKIs in the cluster analysis.The study highlights the potential role of the Src protein kinase family and TEC in PAH induced by PKIs. This approach combining pharmacovigilance and pharmacodynamics data allowed us to generate some hypotheses about the pathophysiology of the disease; however, the results have to be confirmed by further studies.

scholarly journals ERK8, a New Member of the Mitogen-activated Protein Kinase Family

2002 ◽  
Vol 277 (19) ◽  
pp. 16733-16743 ◽  
Author(s):  
Mark K. Abe ◽  
Matthew P. Saelzler ◽  
Rafael Espinosa ◽  
Kristopher T. Kahle ◽  
Marc B. Hershenson ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Protein Kinase Family ◽  
Kinase Family ◽  
Mitogen Activated Protein

scholarly journals Multiple Members of the Mitogen-activated Protein Kinase Family Are Necessary for PED/PEA-15 Anti-apoptotic Function

2002 ◽  
Vol 277 (13) ◽  
pp. 11013-11018 ◽  
Author(s):  
Gerolama Condorelli ◽  
Alessandra Trencia ◽  
Giovanni Vigliotta ◽  
Anna Perfetti ◽  
Umberto Goglia ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Mitogen Activated Protein Kinase ◽  
Protein Kinase Family ◽  
Kinase Family ◽  
Mitogen Activated Protein
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