scholarly journals Highly reliable, targeted photothermal cancer therapy combined with thermal dosimetry using indocyanine green lactosome

2019 ◽  
Author(s):  
Shinsuke Nomura ◽  
Yuji Morimoto ◽  
Hironori Tsujimoto ◽  
Manabu Harada ◽  
Daizoh Saitoh ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Cancer Cell Line ◽  
Colon Cancer Cell Line ◽  
Infrared Light ◽  
Irradiation Site ◽  
Tumor Mouse Model ◽  
Novel Drug ◽  
Murine Colon

AbstractIndocyanine green (ICG) is a near-infrared light-absorbing substance. Thus, when a tumor in which ICG has accumulated is irradiated with a near-infrared (NIR) laser, only the tumor can be heated by a photothermal reaction. We developed ICG lactosome, a novel drug delivery system (DDS) composed of polymeric micelles and ICG that shows selective accumulation in tumor based on an enhanced permeability and retention (EPR) effect. We showed that ICG lactosome accumulated in a tumor by using an intradermal tumor mouse model of a murine colon cancer cell line (Colon26) transfected with Nano lantern luminescent protein (NLC26). Two days after the administration of ICG lactosome, the tumor was irradiated with an 808-nm diode-laser while monitoring tumor temperature. The results showed that the treated tumors were cured when the peak of tumor temperature during NIR irradiation reached 43°C or higher. To verify these results, photothermal therapy (PTT) using ICG lactosome was carried out using a newly developed system that can control the temperature at the NIR irradiation site at a constant level. All of the tumors that had been kept at 43°C during irradiation were cured, while 2 of 5 tumors that had been kept at 42°C were not cured, and none of tumors that had been kept at a temperature below 41°C were cured. ICG lactosome-assisted PTT combined with thermal dosimetry is a highly reliable method for cancer treatment and may afford further clinical opportunities for PTT.

Evaluation of brain toxicity following near infrared light exposure after indocyanine green dye injection

2002 ◽  
Vol 117 (1) ◽  
pp. 23-31 ◽  
Author(s):  
Emanuela Keller ◽  
Hideyuki Ishihara ◽  
Andreas Nadler ◽  
Peter Niederer ◽  
Burkhardt Seifert ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Light Exposure ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Indocyanine Green Dye

Determinants of differential liver-colonizing potential of variants of the MCA-38 murine colon cancer cell line

1995 ◽  
Vol 13 (2) ◽  
pp. 141-150 ◽  
Author(s):  
James J. Piscatelli ◽  
Stephan A. Cohen ◽  
Charles S. Berensont ◽  
Peter Lance
Keyword(s):  
Colon Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Colon Cancer Cell Line ◽  
Colon Cancer Cell ◽  
Murine Colon

scholarly journals Role of Indocyanine Green in Fluorescence Imaging with Near-Infrared Light to Identify Sentinel Lymph Nodes, Lymphatic Vessels and Pathways Prior to Surgery – A Critical Evaluation of Options

2018 ◽  
Vol 78 (01) ◽  
pp. 54-62 ◽  
Author(s):  
Andreas Hackethal ◽  
Markus Hirschburger ◽  
Sven Eicker ◽  
Thomas Mücke ◽  
Christoph Lindner ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Indocyanine Green ◽  
Functional Imaging ◽  
Near Infrared ◽  
Critical Evaluation ◽  
Surgical Techniques ◽  
Sentinel Lymph Nodes ◽  
Infrared Light ◽  
Oncologic Surgery ◽  
Detection Rates

AbstractModern surgical strategies aim to reduce trauma by using functional imaging to improve surgical outcomes. This reviews considers and evaluates the importance of the fluorescent dye indocyanine green (ICG) to visualize lymph nodes, lymphatic pathways and vessels and tissue borders in an interdisciplinary setting. The work is based on a selective search of the literature in PubMed, Scopus, and Google Scholar and the authorsʼ own clinical experience. Because of its simple, radiation-free and uncomplicated application, ICG has become an important clinical indicator in recent years. In oncologic surgery ICG is used extensively to identify sentinel lymph nodes with promising results. In some studies, the detection rates with ICG have been better than the rates obtained with established procedures. When ICG is used for visualization and the quantification of tissue perfusion, it can lead to fewer cases of anastomotic insufficiency or transplant necrosis. The use of ICG for the imaging of organ borders, flap plasty borders and postoperative vascularization has also been scientifically evaluated. Combining the easily applied ICG dye with technical options for intraoperative and interventional visualization has the potential to create new functional imaging procedures which, in future, could expand or even replace existing established surgical techniques, particularly the techniques used for sentinel lymph node and anastomosis imaging.

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