scholarly journals Precision-targeted metabolomics method characterizes differential metabolomes in multiple-biological matrixes and cell-mitochondria

2019 ◽  
Author(s):  
Xialin Luo ◽  
Rui Guo ◽  
Jingjing Liu ◽  
Aihua Zhang ◽  
Xijun Wang ◽  
...  
Keyword(s):  
New Method ◽  
Plant Tissues ◽  
Targeted Metabolomics ◽  
Rat Urine ◽  
Classification Of Diseases ◽  
Diagnosis And Classification ◽  
Insight Into ◽  
Key Questions

This new method has the capacity to dynamically analyse the metabolome of interest in diverse biological matrixes by offering coverage of rat urine, plasma, liver, brain, intestine, stomach, heart, spleen, lung, faeces, fresh plant tissues, cells and microbes. In addition, this new method enables specific and efficient analysis of microdontia metabolomes, non-microdontia and whole cell metabolomes, as well as can engage in absolute determination of 84 key clinical-wide metabolites in different biological matrixes, to enable the complementary support of clinical diagnosis and classification of diseases. To demonstrate the applicable capacity of this new method, multiple-matrixes differential metabolomes were firstly characterized using this new method to coordinate metabolic modifications underlie hepatitis induced by carbon tetrachloride (CCL4) in rats, such finding provides novel insight into the pathogenesis and therapeutics of hepatitis in clinic. Altogether, we are fully confident that this new metabolomics method will be widely welcomed by scientists in different niches to solve their key questions accordingly.

Depression

2017 ◽  
Author(s):  
Philip Cowen
Keyword(s):  
International Classification Of Diseases ◽  
Behavioural Therapy ◽  
Historical Background ◽  
Cognitive Behavioural ◽  
Classification Of Diseases ◽  
Icd 10 ◽  
Diagnosis And Classification ◽  
Modern Experience ◽  
Symptoms And Signs

This chapter discusses the symptomatology, diagnosis, and classification of depression. It begins with a brief historical background on depression, tracing its origins to the classical term ‘melancholia’ that describes symptoms and signs now associated with modern concepts of the condition. It then considers the phenomenology of the modern experience of depression, its diagnosis in the operational scheme of ICD-10 (International Classification of Diseases, tenth edition), and current classificatory schemes. It looks at the symptoms needed to meet the criteria for ‘depressive episode’ in ICD-10, as well as clinical features of depression with ‘melancholic’ features or ‘somatic depression’ in ICD-10. It also presents an outline of the clinical assessment of an episode of depression before concluding with an overview of issues that need to be taken into account when addressing approaches to treatment, including cognitive behavioural therapy and the administration of antidepressants.

Effect of urine storage on urinary uric acid concentrations

2000 ◽  
Vol 37 (3) ◽  
pp. 355-359 ◽  
Author(s):  
Jun-Ichi Yamakita ◽  
Tetsuya Yamamoto ◽  
Yuji Moriwaki ◽  
Sumio Takahashi ◽  
Zenta Tsutsumi ◽  
...  
Keyword(s):  
Uric Acid ◽  
Acid Concentration ◽  
Storage Temperature ◽  
Accurate Determination ◽  
Uric Acid Concentration ◽  
Serum Samples ◽  
Diagnosis And Classification ◽  
Urine Storage

Accurate determination of serum and urinary uric acid concentrations is essential for the diagnosis and classification of gout according to uric acid metabolism derangement. Urine and/or serum samples are often kept at either 4°C or 20°C until assayed, when a large number of samples are handled simultaneously. Our preliminary study indicated a significant decrease in urinary uric acid concentration after preservation, regardless of the storage temperature. Uric acid crystals were often observed in these cases which showed a marked decrease in urinary uric acid concentration after storage. In the present study, we sought the factor(s) that might cause this decrease in urinary uric acid concentration, as well as measures to overcome the problem. High urinary uric acid concentration and low pH proved to play major roles in the decrease in urinary uric acid concentration after storage. In contrast, dilution of the urine samples before storage resulted in no significant change in urinary uric acid concentration. Based on these results, we recommend diluting urine before storage for determination of uric acid concentration and avoiding underestimation.

Electrochemical immunoplatform to assist in the diagnosis and classification of breast cancer through the determination of matrix-metalloproteinase-9

Talanta ◽  
2021 ◽  
Vol 225 ◽  
pp. 122054
Author(s):  
Beatriz Arévalo ◽  
Amira ben Hassine ◽  
Alejandro Valverde ◽  
Verónica Serafín ◽  
Ana Montero-Calle ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Diagnosis And Classification ◽  
Metalloproteinase 9

Medicare Billing Update

2010 ◽  
Vol 20 (1) ◽  
pp. 7-15
Author(s):  
Mark Kander
Keyword(s):  
Web Sites ◽  
International Classification Of Diseases ◽  
International Classification ◽  
Current Procedural Terminology ◽  
Private Practitioners ◽  
Physician Office ◽  
Classification Of Diseases ◽  
Special Rules

Abstract As of July 2009, speech-language pathologists (SLPs) may bill for Medicare services as private practitioners. This article directs SLPs to the rules for enrollment, necessary approvals by physicians and certain physician substitutes, and proper current procedural terminology (CPT) and International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM) coding when submitting claims. Guidance for determination of the exact payment amount for specific geographic areas is covered as well as determination of local Medicare Administrative Contractor (MAC) Web sites and their local coverage policies for speech-language-voice and dysphagia services. Special rules apply to SLPs who are employees or contractors of physician groups, and these SLPs also may function as private practitioners in physician office settings if they follow certain rules that insulate SLPs from kickback accusations. The rules governing these SLPs are summarized in this article. Questions regarding reimbursement should be directed to the Division 3 Reimbursement Committee or to [email protected] .

scholarly journals Has the incidence of empyema in Scottish children continued to increase beyond 2005?

2014 ◽  
Vol 100 (3) ◽  
pp. 255-258 ◽  
Author(s):  
Stuart Nath ◽  
Matt Thomas ◽  
David Spencer ◽  
Steve Turner
Keyword(s):  
Hospital Admissions ◽  
Incidence Rate Ratio ◽  
Pneumococcal Vaccination ◽  
International Classification Of Diseases ◽  
Diagnostic Codes ◽  
Classification Of Diseases ◽  
Icd 10 ◽  
The Relationship ◽  
Insight Into

BackgroundThe incidence of empyema increased dramatically in children during the 1990s and early 2000s. We investigated the relationship between changes in the incidence of childhood empyema in Scotland following the 2006 introduction of routine heptavalent conjugate pneumococcal vaccination (PCv-7) and the 2010 introduction of the 13-valent (PCV-13) vaccine.MethodsThis was a whole-population study of Scottish hospital admissions between 1981 and 2013 using ICD (International Classification of Diseases)-9 and ICD-10 diagnostic codes for empyema. The number of admissions for pneumonia and croup was also captured to give insight into secular trends in admissions with other related and unrelated respiratory presentations.ResultsThere were 217 admissions with empyema between 1981 and 2005 (mean incidence 9 cases/million/year) and 323 between 2006 and 2013 (mean incidence 47 cases/million/year), p<0.001. The introduction of conjugate vaccines in 2006 was associated with an overall increase in admissions for empyema of 2.0 (95% CI 1.4 to 2.8) per 100 000 children, however, the incidence rate ratio for empyema admission between 2010 and 2013 was lower relative to 2006–2009 (0.78 (95% CI 0.63 to 0.98)). Secular changes in pneumonia, but not croup, were comparable with those for empyema.ConclusionsThe incidence of empyema in Scottish children initially rose in children aged 1 to 9 years after the introduction of routine conjugate pneumococcal vaccination, however, empyema incidence has fallen since 2010 when the PCV-13 was introduced.

scholarly journals Are new diagnostic criteria and classification of diabetes necessary?

1999 ◽  
Vol 45 (3) ◽  
pp. 21-25
Author(s):  
M. I. Balabolkin ◽  
V. M. Kreminskaya
Keyword(s):  
Diagnostic Criteria ◽  
Clinical Picture ◽  
Diagnostic Algorithm ◽  
Classification Of Diseases ◽  
Diagnosis And Classification

The issues of diagnosis and classification of diseases are given priority. This is understandable, since each classification reflects the level of our knowledge and ideas about the pathogenesis of the disease for a certain period of time. The classification of diseases, therefore, is a kind of tool that helps practitioners navigate the diverse clinical picture of the same disease and correctly conduct the diagnostic algorithm. Ultimately, the classification of the disease, based on current pathogenesis data, provides practical assistance to the doctor in matters of both diagnosis and therapeutic tactics of the disease.

Electron Microscopy of Carcinomas of the Lung

1974 ◽  
Vol 32 ◽  
pp. 16-17
Author(s):  
B. Mackay ◽  
M. Mandavia ◽  
J. M. Lukeman ◽  
C. F. Mountain
Keyword(s):  
Electron Microscopy ◽  
Poor Prognosis ◽  
Light And Electron Microscopy ◽  
Malignant Neoplasm ◽  
Therapeutic Modalities ◽  
The Poor ◽  
Diagnosis And Classification ◽  
Methods Of Treatment ◽  
Insight Into

Carcinoma of the lung is the most common malignant neoplasm in males and the incidence continues to rise. The inadequacy of current methods of treatment is reflected in the poor prognosis: only 5% of patients survive for more than five years following diagnosis.In order to assess the effectiveness of new therapeutic modalities, accurate pathologic diagnosis is essential, and it is recognized that a proportion of these tumors can not be accurately classified by light microscopy alone. We have now studied over one hundred lung carcinomas with correlated light and electron microscopy, and our findings indicate that electron microscopy can be an invaluable aid in the diagnosis and classification of the tumors. Study of the fine structure of the tumor cells can provide the basis for a more precise classification than is currently used in clinical studies, and additionally give insight into problems of histogenesis.

Blended Models for Nearest Neighbour Algorithms for High Dimensional Smart Medical Data

2020 ◽  
pp. 48-75
Author(s):  
Sandhya Harikumar
Keyword(s):  
Nearest Neighbor ◽  
Window Size ◽  
High Dimensional ◽  
Massive Datasets ◽  
Parzen Window ◽  
Classification Of Diseases ◽  
Diagnosis And Classification ◽  
Generative Algorithms ◽  
Neighbor Classifier

Nearest neighbor algorithms like kNN and Parzen Window are generative algorithms that are used extensively for medical diagnosis and classification of diseases. The data generated or collected in healthcare is high dimensional and cannot be assumed to follow a particular distribution. The conventional approaches fail due to computational complexity, curse of dimensionality, and varying distributions. Hence, this chapter deals with a blending technique for evaluation of nearest neighbor algorithms based on various parameters such as the size of data, dimensions of data, window size, and number of nearest neighbors to make it suitable for massive datasets. Dimensionality reduction and clustering are combined with nearest neighbor classifier such as kNN and Parzen Window to observe the performance of the blended models on various types of datasets. Experimental results on 15 real datasets with various models reveal the efficacy of the proposed blends.

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