scholarly journals A light-dependent molecular link between competition cues and defense responses in plants

2019 ◽  
Author(s):  
G. L. Fernández-Milmanda ◽  
C. D. Crocco ◽  
M. Reichelt ◽  
C. A. Mazza ◽  
T. G. Köllner ◽  
...  
Keyword(s):  
Plant Immunity ◽  
Plant Competition ◽  
Growth Inhibitor ◽  
Defense Responses ◽  
Shade Avoidance ◽  
Hormone Signaling ◽  
Accelerate Growth ◽  
Potent Growth ◽  
Potent Growth Inhibitor ◽  
Ja Signaling

ABSTRACTOne of the principal internal signals controlling plant growth and defense is jasmonate (JA), a potent growth inhibitor that is simultaneously a central regulator of plant immunity to herbivores and pathogens. When shade-intolerant plants perceive the proximity of competitors using the photoreceptor phytochrome B (phyB), they accelerate growth and down-regulate JA responses. However, the mechanisms by which photoreceptors relay light cues to the JA signaling pathway are not understood. Here we identify a sulfotransferase (ST2a) that is strongly up-regulated by plant proximity perceived by phyB via the phyB-Phytochrome Interacting Factor (PIF) signaling module. By catalyzing the formation of a sulfated JA derivative, ST2a acts to degrade bioactive forms of JA and represents a direct molecular link between photoreceptors and hormone signaling in plants. The enzyme provides a molecular mechanism for prioritizing shade avoidance over defense under close plant competition.

Aberrant responses to growth-regulatory signals by variant kidney epithelial cells

1988 ◽  
Vol 254 (5) ◽  
pp. F747-F753
Author(s):  
M. M. Walsh-Reitz ◽  
R. I. Feldman ◽  
F. G. Toback
Keyword(s):  
Epithelial Cells ◽  
Growth Regulation ◽  
Growth Inhibitor ◽  
Soft Agar ◽  
Isoenzyme Analysis ◽  
Variant Cell ◽  
Kidney Epithelial Cells ◽  
Potent Growth ◽  
Potent Growth Inhibitor ◽  
Low K

Cultures that achieved a higher cell density than expected were noted during study of growth regulation in monkey kidney epithelial cells of the BSC-1 line. Multiplication of the variant cells was accelerated, compared with parental cells, as the cultures approached confluence. Cytogenetic analysis, immunofluorescence antibody reactions with specific monkey serum, isoenzyme analysis, microbiological studies, and lack of growth in soft agar indicated that the variant cells were not a contaminating cell type, lacked new isoenzymes, were free of microbial contamination, and were not transformed. Confluent variant cultures did not respond to a purified growth inhibitor protein produced by BSC-1 cells that inhibits multiplication and reduces cell Na content in subconfluent variant and parental cells. Vasopressin, which is a mitogen for parental cells, was a potent growth inhibitor for confluent cultures of variant cells. Low-K or high-Na media, which stimulate proliferation of parental cells, had no effect on growth of the variant cell line. These results suggest that enhanced multiplication of the variant cells is mediated by altered signal transduction pathways and/or receptors for growth-regulatory molecules.

Isolation and Structure Elucidation of a Potent Growth Inhibitor, Helian, from Blue Light-Illuminated Sunflower (Helianthus annuus) Hypocotyls

Heterocycles ◽  
2007 ◽  
Vol 71 (3) ◽  
pp. 609 ◽  
Author(s):  
Kosumi Yamada ◽  
Tsuyoshi Hasegawa ◽  
Shigenori Togo ◽  
Yosuke Hisamatsu ◽  
Kiyotake Suenaga ◽  
...  
Keyword(s):  
Helianthus Annuus ◽  
Blue Light ◽  
Structure Elucidation ◽  
Growth Inhibitor ◽  
Potent Growth ◽  
Potent Growth Inhibitor

Identification of dasatinib as an in vitro potent growth inhibitor of canine histiocytic sarcoma cells

2013 ◽  
Vol 196 (3) ◽  
pp. 536-540 ◽  
Author(s):  
Keita Ito ◽  
Shiori Kuroki ◽  
Masato Kobayashi ◽  
Kenichiro Ono ◽  
Tsukimi Washizu ◽  
...  
Keyword(s):  
Growth Inhibitor ◽  
Histiocytic Sarcoma ◽  
Potent Growth ◽  
Potent Growth Inhibitor ◽  
Sarcoma Cells

Recalculating growth and defense strategies under competition: key roles of photoreceptors and jasmonates

2019 ◽  
Vol 70 (13) ◽  
pp. 3425-3434 ◽  
Author(s):  
Carlos L Ballaré ◽  
Amy T Austin
Keyword(s):  
Defense Responses ◽  
Plant Biology ◽  
Leaf Mass Per Area ◽  
Functional Explanation ◽  
Shade Avoidance ◽  
Defense Strategies ◽  
Trade Offs ◽  
Survival And Reproduction ◽  
Ja Signaling ◽  
Defense Syndrome

AbstractThe growth–defense trade-off in plant biology has gained enormous traction in the last two decades, highlighting the importance of understanding how plants deal with two of the greatest challenges for their survival and reproduction. It has been well established that in response to competition signals perceived by informational photoreceptors, shade-intolerant plants typically activate the shade-avoidance syndrome (SAS). In turn, in response to signals of biotic attack, plants activate a suite of defense responses, many of which are directed to minimize the loss of plant tissue to the attacking agent (broadly defined, the defense syndrome, DS). We argue that components of the SAS, including increased elongation, apical dominance, reduced leaf mass per area (LMA), and allocation to roots, are in direct conflict with configurational changes that plants require to maximize defense. We hypothesize that these configurational trade-offs provide a functional explanation for the suppression of components of the DS in response to competition cues. Based on this premise, we discuss recent advances in the understanding of the mechanisms by which informational photoreceptors, by interacting with jasmonic acid (JA) signaling, help the plant to make intelligent allocation and developmental decisions that optimize its configuration in complex biotic contexts.

Isolation and Structure Elucidation of a Potent Growth Inhibitor, Helian, from Blue Light-Illuminated Sunflower (Helianthus annuus) Hypocotyls.

ChemInform ◽  
2007 ◽  
Vol 38 (31) ◽  
Author(s):  
Tsuyoshi Hasegawa ◽  
Shigenori Togo ◽  
Yosuke Hisamatsu ◽  
Kosumi Yamada ◽  
Kiyotake Suenaga ◽  
...  
Keyword(s):  
Helianthus Annuus ◽  
Blue Light ◽  
Structure Elucidation ◽  
Growth Inhibitor ◽  
Potent Growth ◽  
Potent Growth Inhibitor

scholarly journals Triflumuron Effects on the Physiology and Reproduction ofRhodnius prolixusAdult Females

2016 ◽  
Vol 2016 ◽  
pp. 1-11 ◽  
Author(s):  
Bianca Santos Henriques ◽  
Fernando Ariel Genta ◽  
Cícero Brasileiro Mello ◽  
Lucas Rangel Silva ◽  
Thaís Franco Codogno ◽  
...  
Keyword(s):  
Topical Treatment ◽  
Biological Effects ◽  
Oral Treatment ◽  
Growth Inhibitor ◽  
Egg Hatching ◽  
Continuous Contact ◽  
Control Programs ◽  
Adult Females ◽  
Potent Growth ◽  
Potent Growth Inhibitor

We evaluated the efficacy of the growth regulator triflumuron (TFM) in inducing mortality and disrupting both oviposition and egg hatching inRhodnius prolixusadult females. TFM was administered via feeding, topically or by continuous contact with impregnated surfaces. Feeding resulted in mild biological effects compared with topical and impregnated surfaces. One day after treatment, the highest mortality levels were observed with topical surface and 30 days later both topical and impregnated surfaces induced higher mortalities than feeding. Oral treatment inhibited oviposition even at lower doses, and hatching of eggs deposited by treated females was similarly affected by the three delivery modes. Topical treatment of eggs deposited by nontreated females significantly reduced hatching. However, treatment per contact of eggs oviposited by untreated females did not disrupt eclosion. Additionally, oral treatment increased the number of immature oocytes per female, and topical treatment reduced the mean size of oocytes. TFM also affected carcass chitin content, diuresis, and innate immunity of treated insects. These results suggest that TFM acts as a potent growth inhibitor ofR. prolixusadult females and has the potential to be used in integrated vector control programs against hematophagous triatomine species.

Oxyrane derivative of α-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms

2006 ◽  
Vol 99 (4) ◽  
pp. 429-433 ◽  
Author(s):  
Alessandra Jorqueira ◽  
Robson M. Gouvêa ◽  
Vitor F. Ferreira ◽  
Milton N. da Silva ◽  
Maria C. B. V. de Souza ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Growth Inhibitor ◽  
Potent Growth ◽  
Potent Growth Inhibitor

scholarly journals IQD1 involvement in hormonal signaling and general defense responses against Botrytis cinerea

2021 ◽  
Author(s):  
Omer Barda ◽  
Maggie Levy
Keyword(s):  
Plant Defense ◽  
Botrytis Cinerea ◽  
Defense Responses ◽  
Hormone Signaling ◽  
Hormone Regulation ◽  
Calmodulin Binding ◽  
Plant Hormone Signaling ◽  
Transcriptome Expression ◽  
Ja Signaling ◽  
Knockout Line

IQ Domain 1 (IQD1) is a novel calmodulin-binding protein in A. thaliana, which was found to be a positive regulator of glucosinolate (GS) accumulation and plant defense responses against insects. We demonstrate here that the IQD1 overexpressing line (IQD1OXP) is more resistant also to the necrotrophic fungus Botrytis cinerea, whereas an IQD1 knockout line (iqd1-1) is much more sensitive. Furthermore, we show that IQD1 is upregulated by Jasmonic acid (JA) and downregulated by Salicylic acid (SA). Comparison of whole transcriptome expression between iqd1-1 and wild type revealed a substantial downregulation of genes involved in plant defense and hormone regulation. Further examination revealed a marked reduction of SA/JA signaling and increase in ethylene signaling genes in the iqd1-1 line. Moreover, quantification of SA, JA and abscisic acids in IQD1OXP and iqd1-1 lines compared to WT showed a significant reduction in endogenous JA levels in the knockout line simultaneously with increased SA levels. Epistasis relations between IQD1OXP and mutants defective in plant-hormone signaling indicated that IQD1 acts upstream or parallel to the hormonal pathways (JA/ET and SA) in defense response against B. cinerea and in regulating GS accumulation and it is dependent on JAR1 controlling indole glucosinolate accumulation. As a whole, our results suggest that IQD1 is an important defensive protein against Botrytis cinerea in A. thaliana and is integrated into several important pathways such as plant microbe perception and hormone signaling.

A screening system using minimal media identifies a flavin-competing inhibitor of Porphyromonas gingivalis growth

2019 ◽  
Vol 366 (16) ◽  
Author(s):  
Keitarou Saiki ◽  
Yumiko Urano-Tashiro ◽  
Kiyoshi Konishi ◽  
Yukihiro Takahashi
Keyword(s):  
Porphyromonas Gingivalis ◽  
Wild Type Strain ◽  
Flavin Adenine Dinucleotide ◽  
Growth Inhibitor ◽  
Flavin Mononucleotide ◽  
Wild Type ◽  
Minimal Media ◽  
Potent Growth ◽  
Potent Growth Inhibitor ◽  
Effective Drugs

ABSTRACT Chronic periodontitis is caused by dysbiosis of human oral commensals and especially by increase in Porphyromonas gingivalis. Inhibitors of P. gingivalis growth are expected to serve as effective drugs for the periodontal therapy. In the present study, we isolated new growth inhibitors of P. gingivalis using minimal media for P. gingivalis. The minimal media included the previously reported Globulin–Albumin (GA) and the newly developed Lactalbumin-Ferric chloride (LF) and Globulin-Calcium chloride (GC); all supported growth of the wild-type strain of P. gingivalis but did not support the growth of a mutant defective for a type IX secretion system. GC contains CaCl2, indicating that P. gingivalis requires a calcium ion for growth. Using LF and GA, we screened about 100 000 compounds and identified 73 that strongly inhibited the growth of P. gingivalis. More than half of these candidates would not have been obtained if these minimal media had not been used in our screen. One of our candidate inhibitors was diphenyleneiodonium chloride (DPIC), which showed strong bactericidal activity against P. gingivalis. Excess amounts of flavin adenine dinucleotide or flavin mononucleotide suppressed the inhibitory activity of DPIC, suggesting that DPIC would be a novel potent growth inhibitor.

Sign in / Sign up

Export Citation Format

Share Document