scholarly journals Bone Fracture Detection by Electrical Bioimpedance: First Non-Invasive Measurements in Ex-Vivo Mammalian Femur

2019 ◽  
Author(s):  
A. H. Dell’Osa ◽  
A. Concu ◽  
F. R. Dobarro ◽  
J. C. Felice
Keyword(s):  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Bone Fractures ◽  
Ex Vivo ◽  
Fracture Site ◽  
Electrical Impedance Spectroscopy ◽  
X Rays ◽  
Fracture Detection ◽  
Real Component ◽  
Non Invasive

AbstractThe fracture of long bones is one of the pathologies of greater demand of systems of medical emergencies, the method used for the diagnosis, the radiology of X-rays, produces damages to the patients and to the hospitals environment. For these reasons, our group is studying the implementation of a new diagnostic technique for the detection of bone fractures by bioimpedance measurements. To simulate a limb, two phantom of bovine femurs (the one with an entire bone and the other with a sawn bone) were constructed and non-invasive Electrical Impedance Spectroscopy measurements were taken on them in order to identify differences in their respective Cole Cole diagrams. Impedance spectroscopy was performed by a frequency sweep between 1 Hz and 65 kHz at a fixed current of 1 mA. The results obtained show wide differences in the Cole Cole diagrams of both phantoms (entire and fractured bone), especially concerning the real component of the, which latter, around the bones section corresponding to that of the lesion in both femurs, was always lower in the fractured femur than the entire one. These first superficial (non-invasive) measurements correspond to the electrical impedance spectroscopy bases and these could -in turn- correspond to what occurs in mammals immediately after the fracture happens, i. e. a dramatic increase in electrical conductivity due to diffusion into the fracture site of more conductive materials such as the blood and the extravascular fluids.

scholarly journals Bioimpedance and Bone Fracture Detection: A State of the Art

2019 ◽  
Author(s):  
Antonio Dell'Osa ◽  
Franco Simini ◽  
Jose C. Felice
Keyword(s):  
Bone Fracture ◽  
Electrical Impedance ◽  
Ex Vivo ◽  
New Technology ◽  
Electrical Impedance Spectroscopy ◽  
Long Bone ◽  
Fracture Detection ◽  
Impedance Tomography ◽  
Non Invasive

Bioimpedance measurements are used increasingly in health applications because bioelectric parameters have been associated with anatomical and physiological properties, thus enabling to distinguish medical conditions. For bone fracture diagnostics, nevertheless, there is no established non-invasive method. Ex vivo studies and In vivo bioimpedance procedures, both invasive and non-invasive, on mammalians long bones are associated with promising results. In this work, out of a total of 568 papers, we reviewd 59 articles that mention long bone integrity by electric properties, be it Bioimpedance Analysis, Electrical Impedance Spectroscopy or Electrical Impedance Tomography. The papers are described in three sections, “Ex vivo measurements”, “In vivo invasive measurements” and “In vivo non-invasive measurements”. This review allows to establish the basics to planning the development of new technology to detect bone fracture via bioimpedance measurements.

Ex-vivo biological tissue differentiation by the Distribution of Relaxation Times method applied to Electrical Impedance Spectroscopy

2018 ◽  
Vol 276 ◽  
pp. 214-222 ◽  
Author(s):  
R.G. Ramírez-Chavarría ◽  
C. Sánchez-Pérez ◽  
D. Matatagui ◽  
N. Qureshi ◽  
A. Pérez-García ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Biological Tissue ◽  
Electrical Impedance ◽  
Ex Vivo ◽  
Relaxation Times ◽  
Tissue Differentiation ◽  
Electrical Impedance Spectroscopy

scholarly journals Virtual Biopsy by Electrical Impedance Spectroscopy in Barrett’s Carcinoma

2021 ◽  
Author(s):  
Sandra Blößer ◽  
Andrea May ◽  
Lukas Welsch ◽  
Michael Ast ◽  
Susanne Braun ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Endoscopic Resection ◽  
Electrical Impedance ◽  
Ex Vivo ◽  
Electrical Impedance Spectroscopy ◽  
Esophageal Mucosa ◽  
Impedance Measurements ◽  
Four Quadrant ◽  
Suspicious Lesions ◽  
Targeted Biopsies

Abstract Purpose Early detection of adenocarcinomas in the esophagus is crucial for achieving curative endoscopic therapy. Targeted biopsies of suspicious lesions, as well as four-quadrant biopsies, represent the current diagnostic standard. However, this procedure is time-consuming, cost-intensive, and examiner-dependent. The aim of this study was to test whether impedance spectroscopy is capable of distinguishing between healthy, premalignant, and malignant lesions. An ex vivo measurement method was developed to examine esophageal lesions using impedance spectroscopy immediately after endoscopic resection. Methods After endoscopic resection of suspicious lesions in the esophagus, impedance measurements were performed on resected cork-covered tissue using a measuring head that was developed, with eight gold electrodes, over 10 different measurement settings and with frequencies from 100 Hz to 1 MHz. Results A total of 105 measurements were performed in 60 patients. A dataset of 400 per investigation and a total of more than 42,000 impedance measurements were therefore collected. Electrical impedance spectroscopy (EIS) was able to detect dysplastic esophageal mucosa with a sensitivity of 81% in Barrett’s esophagus. Conclusion In summary, EIS was able to distinguish different tissue characteristics in the different esophageal tissues. EIS thus holds potential for further development of targeted biopsies during surveillance endoscopy. Trial Registration NCT04046601

Non-invasive assessment of radiation injury with electrical impedance spectroscopy

2004 ◽  
Vol 49 (5) ◽  
pp. 665-683 ◽  
Author(s):  
K Sunshine Osterman ◽  
P Jack Hoopes ◽  
Christine DeLorenzo ◽  
David J Gladstone ◽  
Keith D Paulsen
Keyword(s):  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Radiation Injury ◽  
Electrical Impedance Spectroscopy ◽  
Non Invasive
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