scholarly journals Discovery of functional alternatively spliced PKM transcripts in human cancers

2019 ◽  
Author(s):  
Xiangyu Li ◽  
Cheng Zhang ◽  
Woonghee Kim ◽  
Muhammad Arif ◽  
Chunxia Gao ◽  
...  
Keyword(s):  
Clear Cell ◽  
Treatment Strategies ◽  
Renal Clear Cell Carcinoma ◽  
Protein Product ◽  
Efficient Treatment ◽  
Prognostic Effect ◽  
Alternatively Spliced ◽  
The Right ◽  
Cancer Studies

ABSTRACTThe association of pyruvate kinase muscle type (PKM) with survival of cancer patients is controversial. Here, we focus on different transcripts of PKM and investigate the association between their mRNA expression and the clinical survival of the patients in 25 different cancers. We find that the transcript encoding PKM2, and three other functional transcripts are prognostic in multiple cancers. Our integrative analysis shows that the functions of these four transcripts are highly conservative in different cancers. Next, we validate the prognostic effect of these transcripts in an independent kidney renal clear-cell carcinoma (KIRC) cohort and identify a prognostic signature which could distinguish high- and low-risk KIRC patients. Finally, we reveal the functional role of alternatively spliced PKM transcripts in KIRC, and discover the protein products of different transcripts of PKM. Our analysis demonstrated that alternatively spliced transcripts of not only PKM but also other genes should be considered in cancer studies, since it may enable the discovery and targeting of the right protein product for development of the efficient treatment strategies.

scholarly journals Thymic Cavernous Hemangioma Misdiagnosed as Thymoma: A Case Report and Review of the Literature

2021 ◽  
Author(s):  
Yi Chen ◽  
Liping Yan ◽  
Fangbiao zhang ◽  
Shaosong Tu ◽  
Zhijun Wu
Keyword(s):  
Cavernous Hemangioma ◽  
Renal Carcinoma ◽  
Mediastinal Mass ◽  
Clear Cell ◽  
Renal Clear Cell Carcinoma ◽  
Anterior Mediastinal Mass ◽  
Abdominal Ct ◽  
Case Presentation ◽  
Ct Evaluation ◽  
The Right

Abstract Introduction: Thymic cavernous hemangioma, a rare mediastinal tumor, is difficult to diagnose by imaging examinations. Case presentation: We treated a 63-year-old woman with thymic cavernous hemangioma. She was found to have an anterior mediastinal mass during a routine examination, and enhanced chest CT showed that it was approximately 3.5×2.4×2.1 cm in size. Enhanced abdominal CT indicated a 2.5cm space-occupying lesion in the right kidney. We considered it to be thymoma and renal carcinoma, so we resected it by using thoracoscope and laparoscope. The postoperative pathological reports showed that the mass was thymic cavernous hemangioma and renal clear cell carcinoma. Twenty months postsurgery, the patient was alive with no evidence of tumor recurrence.Conclusions: We report a rare case of thymic cavernous hemangioma misdiagnosed as thymoma. It is difficult to obtain pathological results by needle biopsy before surgery because the location of the anterior mediastinal mass is very challenging to reach. Therefore, a thorough CT evaluation before the operation can prevent inappropriate operations from being performed.

scholarly journals High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Yun-Qian Cui ◽  
Fei Meng ◽  
Wen-Li Zhan ◽  
Zhou-Tong Dai ◽  
Xinghua Liao
Keyword(s):  
Potential Role ◽  
Clear Cell ◽  
Cell Cancer ◽  
Progression Free Survival ◽  
Renal Clear Cell Carcinoma ◽  
High Expression ◽  
Poor Survival ◽  
Free Survival

This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment.

scholarly journals Nasopharyngeal Hyalinizing Clear Cell Carcinoma: A Case Report and Review of the Literature

2019 ◽  
Vol 10 ◽  
pp. 215265671988903 ◽  
Author(s):  
Madison J. Malfitano ◽  
Meghan N. Norris ◽  
Wesley H. Stepp ◽  
Griffin D. Santarelli ◽  
T. Danielle Samulski ◽  
...  
Keyword(s):  
Case Report ◽  
Salivary Glands ◽  
Clear Cell ◽  
Malignant Tumors ◽  
Treatment Strategies ◽  
Low Grade ◽  
Minor Salivary Glands ◽  
Presenting Symptoms ◽  
Nasopharyngeal Mass ◽  
The Right

Background Hyalinizing clear cell carcinomas (HCCCs) are rare, low-grade, malignant tumors which most often arise from the minor salivary glands primarily in palate and tongue but can arise in any location with minor salivary glands including the nasopharynx. Methods A case report of primary nasopharyngeal HCCC is presented. Because of the rarity of this tumor and location, a literature search was conducted to determine the most common presenting symptoms, treatment strategies, and outcomes. Results A 48-year-old man underwent biopsy of a 4.5 cm mass of the right nasopharynx with pathology suggesting an intermediate grade mucoepidermoid carcinoma. After discussing management with the patient, an endoscopic resection was performed. Final pathology revealed an HCCC which was confirmed after negative Mastermind-like 2 (MAML2) and positive Ewing sarcoma breakpoint region 1 (ESWR1) gene rearrangements on fluorescence in situ hybridization (FISH) studies. Literature review of other nasopharyngeal HCCC cases shows diverse presentation and overall excellent prognosis through surgical and radiation therapy. Conclusion HCCCs are rare, low-grade malignant tumors of the minor salivary glands and can present as a nasopharyngeal mass. Presenting symptoms are diverse but frequently involve otologic and sinonasal disturbances. HCCC is an indolent tumor with an excellent prognostic outcome when treated appropriately with surgical resection and adjuvant radiotherapy.

scholarly journals The critical role of BAP1 mutation in the prognosis and treatment selection of kidney renal clear cell carcinoma

2020 ◽  
Vol 9 (4) ◽  
pp. 1725-1734
Author(s):  
Guobin Tan ◽  
Zijun Xuan ◽  
Zhiqin Li ◽  
Shuitong Huang ◽  
Guangming Chen ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Critical Role ◽  
Renal Clear Cell Carcinoma ◽  
Treatment Selection ◽  
Selection Of

scholarly journals Identification, analysis and improvement of red meat supply chain strategies considering the impact of COVID-19 pandemic: a hybrid SWOT-QSPM approach in an emerging economy

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Farshid Riahi Dorcheh ◽  
Seyed Hossein Razavi Hajiagha ◽  
Misagh Rahbari ◽  
Vahid Jafari-Sadeghi ◽  
Hannan Amoozad Mahdiraji
Keyword(s):  
Supply Chain ◽  
Strategic Planning ◽  
Protein Product ◽  
Red Meat ◽  
Competitive Strategies ◽  
Content Type ◽  
The Right ◽  
The Impact ◽  
Beef Supply Chain

PurposeIn recent years, and especially during the coronavirus disease 2019 (COVID-19) pandemic, the significant role of agriculture, specifically red meat, in household consumption has been increased. On the other hand, the lack of proper policymaking in the production and pricing of red meat and the lack of a comprehensive study on the beef supply chain has led to a reduction in the role of this protein product in the household food basket. Thus, in this research, comprehensive strategic planning considering the effect of the COVID-19 pandemic has been illustrated to overcome the aforementioned problems.Design/methodology/approachTo study the intended objectives, first, using qualitative methods, the strengths, weaknesses, opportunities and threats (SWOT) to the studied company's supply chain in Iran were identified and then using the SWOT-Quantitative Strategic Planning Matrix (QSPM) technique, the surrounding strategies have been analysed.FindingsThe results indicate that the most important strength of the studied company is the “access to the red meat market of the retirement plan”; the most important weakness is the “lack of required and on-time funding, especially in the condition of the COVID-19 pandemic”; the highest-ranked opportunity is the “access to banking facilities” and the main threat to the company is the “COVID-19 pandemic limitations and health protocols”. In the same vein, by examining the attractiveness score of internal and external factors, it was observed that diversity and competitive strategies would have a higher priority. Finally, the QSPM illustrated that activating the full capacity of existing infrastructure has the highest priority.Originality/valueAccording to the red meat supply chain and the link amongst different market levels, identifying, analysing and improving the beef supply chain is of particular importance. One of the threats facing the international community is the emergence of events such as the COVID-19 pandemic, which requires businesses to choose the right strategy to deal with the issue. Therefore, the main distinction of this study is to identify, analyse and improve the red meat supply chain of a real case due to the condition of the COVID-19 pandemic.

scholarly journals Prognostic Effect of Preoperative Apolipoprotein B Level in Surgical Patients with Renal Clear Cell Carcinoma

2019 ◽  
Author(s):  
Kun Wang ◽  
Tingchun Wu ◽  
Yiming Chen ◽  
Guanglai Song ◽  
Xiaozhou He ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Partial Nephrectomy ◽  
Apolipoprotein B ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Surgical Patients ◽  
Apo B ◽  
Apob Level ◽  
Prognostic Effect

Abstract Objectives To assess the prognostic value of preoperative apolipoprotein B level in surgical patients with renal clear cell carcinoma (ccRCC). Materials and Methods The study included 308 ccRCC patients receiving radical or partial nephrectomy between 2003 and 2012 in our center. The correlations among the preoperative ApoB, clinico -pathological parameters, and overall survival (OS) were evaluated. Results A total of 193 men (62.9%) and 114 women (37.1%) with ccRCC underwent radical or partial nephrectomy were enrolled in the present study. The OS at five years after operation was 90.6% for all patients, 87.4% for the lower ApoB group, and 97.0% for the higher ApoB group. The CSS at 5 years after surgery was 90.2% for all patients, 86.7% for the lower ApoB group, and 97.0% for the higher ApoB group. A higher ApoB level was related to a better OS and CSS in ccRCC patients (P = 0.001 and P < 0.001, respectively). In multivariate analysis, age >60 (P=0.008 and P=0.023), lower Apo B level (P= 0.019 and P= 0.018), were independent prognostic factors for OS and CSS, respectively. Conclusions In the Apo apolipoprotein family, the preoperative ApoB level has an important clinical significance for predicting the prognosis survival rate of the ccRCC patients.

scholarly journals Expression and Prognostic Role of MEKK3 and pERK in Patients with Renal Clear Cell Carcinoma

2015 ◽  
Vol 16 (6) ◽  
pp. 2495-2499 ◽  
Author(s):  
Qi Chen ◽  
Hong-sheng Lu ◽  
Mei-fu Gan ◽  
Lan-xi Chen ◽  
Kai He ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Renal Clear Cell Carcinoma ◽  
Prognostic Role

scholarly journals Pseudogene HSPA7 is a Poor Prognostic Biomarker in Kidney Renal Clear Cell Carcinoma (KIRC) and Correlated With Immune Infiltrates

2021 ◽  
Author(s):  
Chunjin Ding ◽  
Rundong He ◽  
Jinghan Zhang ◽  
Zhan Dong ◽  
Jun Wu
Keyword(s):  
Cox Regression ◽  
Clear Cell ◽  
Prognostic Biomarker ◽  
Renal Clear Cell Carcinoma ◽  
Database Analysis ◽  
Kaplan Meier ◽  
Tumor Tissues ◽  
Infiltrating Cells ◽  
Cox Analysis

Abstract Background: Pseudogenes played important roles in tumorigenesis, while there are nearly no reports about the expression and roles of HSPA7 in the cancer. Methods: Firstly,we used Logistic regression,the KS test, the GEPIA database, UALCAN database and qRT-PCR to analyze the level of HSPA7 expressed in KIRC,then we used the Cox regression and the Kaplan-Meier curve to analyze the overall survival(OS) of KIRC patients with different Clinico-pathological parameters. Thirdly, we used the multivariate Cox analysis of influencing factors to compare the correlation between the HSPA7 expression level and the clinical parameters. Finally, we used multi-GSEA analysis and the Tumor Immunoassay Resource (TIMER) database to explore the functional role of HSPA7 in KIRC. Results: The HSPA7 is highly expressed in KIRC tumor tissues, and its expression is related to clinico-pathological features and survival in KIRCpatints.GSEA analysis displayed the high expression of HSPA7 in KIRC were related to several tumor-related and immune-related pathways. With the TIMER database analysis we showed that HSPA7 levels were correlated with the CD4+ T cells, neutrophils and Dendritic Cell.Conclusions: Our study showed that HSPA7 is very important in the tumor progression and may act as a poor prognostic biomarker for KIRC tumor by modulating immune infiltrating cells.

scholarly journals Granulomatous Lesion in Inserted Gum-Metastasis of Renal Clear Cell Carcinoma. Case Presentation

2019 ◽  
pp. 125-134
Author(s):  
Francisco Germán Villanueva Sánchez DDS,MSc,PhD ◽  
David Fonseca Lozada DDS ◽  
Claudia Ivonne Rojas Sánchez DDS ◽  
Lilia Haidé Escalante Macías DDS, MSc
Keyword(s):  
Oral Cavity ◽  
Clear Cell ◽  
Left Lung ◽  
Treatment Protocol ◽  
Renal Clear Cell Carcinoma ◽  
Biological Behavior ◽  
Case Presentation ◽  
Granulomatous Lesions ◽  
History Of ◽  
The Right

Worldwide, renal carcinoma constitutes 3% of all forms of cancer in the human body. Its biological behavior is variable depending on the biology of each individual; it tends to metastasize to contiguous sites such as adrenal glands, liver, lung, bone, lymph nodes, however, remote presentation in the oral cavity is less frequent, even in inserted gums. Granulomatous lesions of the periodontium include pyogenic granulomas, giant cell granulomas among others. The main objective of this clinical case is to describe the clinical and histopathological characteristics of oral cavity metastases as granulomatous lesions. The case of a 60-year-old female patient with a history of renal cell papillary carcinoma in the right kidney treated by nephrectomy in 2017 is presented, in 2019 she presented metastases to the left lung and oral cavity. It is currently under treatment protocol for renal clear cell metastases.

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