scholarly journals Lifestyle and biological factors influence the relationship between mental health and low-grade inflammation

2019 ◽  
Author(s):  
A Gialluisi ◽  
M Bonaccio ◽  
A Di Castelnuovo ◽  
S Costanzo ◽  
A De Curtis ◽  
...  
Keyword(s):  
Mental Health ◽  
Lifestyle Factors ◽  
Health Conditions ◽  
Depression Symptoms ◽  
Low Grade ◽  
Full Model ◽  
Biological Factors ◽  
Distribution Width ◽  
Low Grade Inflammation ◽  
The Relationship

AbstractMental health modulates the risk of common chronic conditions like cardiovascular disease, cancer and diabetes. Although inflammation is thought to partly explain this link, its relation with mental health is still unclear and largely unexplored.We investigated three scales assessing psychological resilience (CD-RISC), depression symptoms (PHQ8) and mental wellbeing (SF36-MCS) in an Italian adult population cohort (Nmax=16,952). We performed stepwise generalized linear models to test the association between each scale and INFLA-score, a composite blood-based inflammation index. At each step, a class of potential mediators was included in the model, namely health conditions, lifestyle factors, or both (full model). Full model analysis was also conducted on single blood markers involved in the inflammatory process.In the baseline model, we observed significant associations of PHQ8 (standardized β=0.024, p=8.9×10−3) and SF36-MCS (β = −0.021, p=7×10−3) with INFLA-score. These associations survived adjustment for health conditions but not for lifestyle factors, which explained 81% and 17% of the association with PHQ8 and SF36-MCS, respectively. Significant associations (p<4.2×10−3) after mediator adjustment were observed for single low-grade inflammation markers, including platelet distribution width (with PHQ8 and CD-RISC), granulocyte-and neutrophil-to-lymphocyte ratios, monocyte and lymphocyte fractions (with SF36-MCS).These findings suggest that the relationship between mental health and low-grade inflammation is largely influenced by lifestyle. However, the associations with specific biomarkers related to inflammation are partly independent and might be explained by biological factors. Interestingly, these associations are in line with recent blood transcriptomic analyses of depressed subjects, reporting up- and down-regulation of genes related to innate and adaptive immunity, respectively.

scholarly journals Lifestyle and biological factors influence the relationship between mental health and low-grade inflammation

2020 ◽  
Vol 85 ◽  
pp. 4-13 ◽  
Author(s):  
A. Gialluisi ◽  
M. Bonaccio ◽  
A. Di Castelnuovo ◽  
S. Costanzo ◽  
A. De Curtis ◽  
...  
Keyword(s):  
Mental Health ◽  
Low Grade ◽  
Biological Factors ◽  
Low Grade Inflammation ◽  
The Relationship

scholarly journals Should we increase the focus on diet when considering associations between lifestyle habits and deliberate self-harm?

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Elizabeth Berg ◽  
Kay Wilhelm ◽  
Tonelle Handley
Keyword(s):  
Mental Health ◽  
Suicidal Ideation ◽  
Multiple Linear Regression Model ◽  
Lifestyle Factors ◽  
Depression Symptoms ◽  
Deliberate Self Harm ◽  
Lifestyle Behaviours ◽  
Self Harm ◽  
Independent Association ◽  
The Relationship

Abstract Background Despite increasing awareness of high rates of physical illness and poor lifestyle behaviours among patients with a history of repeated deliberate self-harm (DSH), there is little research on specific lifestyle factors that are potentially problematic for this group. This paper aims to explore the relationship between lifetime repeated DSH and certain lifestyle factors, including balanced meals, eating breakfast, consumption of ‘junk’ food, weight, exercise, substance/alcohol use, smoking and social support, in a cohort of patients who presented to the Emergency Department (ED) with suicidal ideation or DSH. Methods From 2007 to 2016, data from lifestyle and mental health measures were collected from 448 attenders at an outpatient clinic for DSH or suicidal ideation following ED presentation. Lifestyle behaviours (Fantastic Lifestyle Checklist) and mental health (Depression and Anxiety Stress Scale), clinical diagnosis and number of previous DSH episodes were measured on arrival. The associations between lifestyle variables and the number of lifetime DSH episodes were examined. Results Sex, age, depression symptoms, poor diet, and smoking were all associated with a higher average number of deliberate self-harm episodes across the lifespan. There were non-significant positive trends for the other poor lifestyle behaviours. There was no association between DSH episodes and diagnosis of depression or anxiety disorder. In a multiple linear regression model, the only factors that remained significant were age, smoking and eating balanced meals, however, the relationship between smoking and lifetime DSH was moderated by more immediate DSH behaviours. Conclusion In this sample of patients referred to a service following presentation to the ED with acute mental health concerns, balanced meals and smoking were the lifestyle behaviours that were found to have the strongest independent association with repeated DSH across the lifespan.

Childhood Material Hardship and Adolescent Mental Health

2021 ◽  
pp. 0044118X2110018
Author(s):  
Chrisse Edmunds ◽  
Melissa Alcaraz
Keyword(s):  
Mental Health ◽  
Adolescent Depression ◽  
Adolescent Mental Health ◽  
Anxiety And Depression ◽  
Fragile Families ◽  
Depression Symptoms ◽  
Depression And Anxiety ◽  
Material Hardship ◽  
Critical Age ◽  
The Relationship

Adolescent mental health has implications for current and future wellbeing. While a link exists between poverty and mental health, little is known about how experiencing material hardship, such as insecurity of food, housing, utilities, and medical care, throughout early childhood affects adolescent mental health. We examine the relationship between material hardship in childhood and adolescent mental health. We use Poisson regression to examine the effect of material hardship experienced at different stages of childhood on adolescent depression and anxiety outcomes at age 15. We use longitudinal data from the Fragile Families and Child Wellbeing Study ( N = 3,222). We find that recently experiencing material hardship during childhood is positively and significantly associated with anxiety and depression symptoms at age 15, even when controlling for material hardship at age 15. Additionally, we find that insecurity during mid-childhood and the stress of lacking basic needs during a critical age may influence mental health in adolescence.

Associação entre obesidade e resultados graves do tratamento em pacientes com COVID-19

2021 ◽  
Vol 12 (47) ◽  
pp. 138-142
Author(s):  
Giordana Gregório Fritsch ◽  
Michael Wesley Schmidt ◽  
Antônio Carlos Gargioni Filho ◽  
Hussein Nasser Fares
Keyword(s):  
Metabolic Disorders ◽  
Distress Syndrome ◽  
Obesity Paradox ◽  
Low Grade ◽  
Double Burden ◽  
Death Rates ◽  
Worldwide Population ◽  
Low Grade Inflammation ◽  
The Relationship ◽  
Activation Component

The worldwide population is facing a double burden of epidemic, the COVID-19and obesity. This is even more alarming as obesity increases the COVID-19 severity. However, the relationship between obesity and COVID-19 severity is more complex than a simple association with BMI. In particular, obesity has been associated with low death rates in patients with acute respiratory distress syndrome, a fatal comorbidity to COVID-19, possibly due to the obesity paradox. Also, visceral adiposity could be a major risk factor for COVID- -19severity, due to its immune activation component, release of ACE2 and involvement in the cytokine storm, It is also known to correlate with metabolic disorders, low-grade inflammation and higher mortality rates.

Age moderates the relationship between source of social support and mental health in racial minority lesbian, gay, and bisexual youth

2017 ◽  
Vol 24 (7) ◽  
pp. 888-897
Author(s):  
Anna E Wise ◽  
Brian C Smith ◽  
Aaron P Armelie ◽  
Jessica M Boarts ◽  
Douglas L Delahanty
Keyword(s):  
Mental Health ◽  
Social Support ◽  
Posttraumatic Stress Disorder ◽  
Posttraumatic Stress ◽  
Low Socioeconomic Status ◽  
Stress Disorder ◽  
Racial Minority ◽  
Depression Symptoms ◽  
And Bisexual ◽  
The Relationship

We examined the relationship between source of social support and mental health (and the moderating impact of age) in 64 low socioeconomic status, racial minority lesbian, gay, and bisexual adolescents/young adults. Social support from family ( β = −.302, p = .03; β = −.364, p = .008), but not friends or significant others, was independently related to posttraumatic stress disorder and depression symptoms, respectively. Family social support was associated with lower posttraumatic stress disorder and depression symptoms in participants aged 16–19 years, while friend social support was associated with lower symptoms for participants aged over 20 years. Friend social support was also associated with lower posttraumatic stress disorder symptoms in participants aged 16–17 years. Interventions should target age-appropriate sources of social support.

scholarly journals Trauma and Mental Health in Resettled Refugees: Mediating Effect of Host Language Acquisition on Posttraumatic Stress Disorder, Depressive and Anxiety Symptoms

2018 ◽  
Vol 56 (1) ◽  
pp. 3-23 ◽  
Author(s):  
Dzenana Kartal ◽  
Nathan Alkemade ◽  
Litza Kiropoulos
Keyword(s):  
Mental Health ◽  
Language Acquisition ◽  
Posttraumatic Stress ◽  
Community Sample ◽  
Anxiety Symptoms ◽  
Mediating Effect ◽  
Depression Symptoms ◽  
Indirect Pathway ◽  
Traumatic Exposure ◽  
The Relationship

This study examined the relationship between traumatic exposure, host language acquisition and mental health (posttraumatic stress, depressive and anxiety symptoms) in long-term resettled refugees. Participants included a community sample of Bosnian refugees ( N = 138, 55% male, mean age of 40 years old) that had resettled in Australia and Austria on average 18 years prior. Two mediation models were tested based on two competing theories. Model A examined whether language acquisition mediates the relationship between traumatic exposure and mental health problems experienced by refugees. Model B examined whether mental health symptoms mediate the relationship between exposure to traumatic events and the acquisition of host language. Model A fit the data well (CFI = 1.00, SRMR = .017, RMSEA < .001, χ2 p = .526), while Model B was rejected as an acceptable model for the data (CFI = .556, SRMR = .136, RMSEA = .352). In Model A, the indirect pathway from trauma to mental health via language acquisition was significant for PTSD ( β = .067, p = .028) and anxiety symptoms ( β = .063, p = .026) but not depression symptoms ( β = .048, p = .071). Intervention strategies aimed at improving host language acquisition may be important not only in successful adaptation to daily living in the host country, but also to improve the mental health of traumatized refugees.

F48INVESTIGATING THE RELATION BETWEEN MENTAL HEALTH AND LOW GRADE INFLAMMATION

2019 ◽  
Vol 29 ◽  
pp. S1135
Author(s):  
Alessandro Gialluisi ◽  
Marialaura Bonaccio ◽  
Augusto Di Castelnuovo ◽  
Simona Costanzo ◽  
Amalia De Curtis ◽  
...  
Keyword(s):  
Mental Health ◽  
Low Grade ◽  
Low Grade Inflammation
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