scholarly journals The pace of life: Time, temperature, and a biological theory of relativity

2019 ◽  
Author(s):  
Anna B. Neuheimer

AbstractFor living things, time proceeds relative to body temperature. In this contribution, I describe the biochemical underpinnings of this “biological time” and formalize the Biological Theory of Relativity (BTR). Paralleling Einstein’s Special Theory of Relativity, the BTR describes how time progresses across temporal frames of reference, contrasting temperature-scaled biological time with our more familiar (and constant) “calendar” time measures. By characterizing the relationship between these two time frames, the BTR allows us to position observed biological variability on a relevant time-scale. In so doing, we are better able to explain observed variation (both temperature-dependent and -independent), make predictions about the timing of biological phenomena, and even manipulate the biological world around us. The BTR presents a theoretical framework to direct future work regarding an entire landscape of fundamental biological questions across space, time and species.

1988 ◽  
Vol 156 (9) ◽  
pp. 137-143 ◽  
Author(s):  
Anatolii A. Logunov ◽  
Yu.V. Chugreev

AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yanhua Yao ◽  
Guimei Zhou ◽  
Yonghui Lin ◽  
Xinqi Xu ◽  
Jie Yang

Abstract Laccases are a class of multi-copper oxidases with important industrial values. A thermotolerant laccase produced by a basidiomycete fungal strain Cerrena unicolor CGMCC 5.1011 was studied. With glycerin and peptone as the carbon and nitrogen sources, respectively, a maximal laccase activity of 121.7 U/mL was attained after cultivation in the shaking flask for 15 days. Transcriptomics analysis revealed an expressed laccase gene family of 12 members in C. unicolor strain CGMCC 5.1011, and the gene and cDNA sequences were cloned. A glycosylated laccase was purified from the fermentation broth of Cerrena unicolor CGMCC 5.1011 and corresponded to Lac2 based on MALDI-TOF MS/MS identification. Lac2 was stable at pH 5.0 and above, and was resistant to organic solvents. Lac2 displayed remarkable thermostability, with half-life time of 1.67 h at 70 ºC. Consistently, Lac2 was able to completely decolorize malachite green (MG) at high temperatures, whereas Lac7 from Cerrena sp. HYB07 resulted in accumulation of colored MG transformation intermediates. Molecular dynamics simulation of Lac2 was conducted, and possible mechanisms underlying Lac2 thermostability were discussed. The robustness of C. unicolor CGMCC 5.1011 laccase would not only be useful for industrial applications, but also provide a template for future work to develop thermostable laccases.


2002 ◽  
Vol 80 (12) ◽  
pp. 2235-2241 ◽  
Author(s):  
James A Schaefer ◽  
Chris C Wilson

The human perception of biological organization has profound implications for the study, management, and conservation of living things. Traditional methods of classification, which imply all-or-nothing group membership, are inconsistent with the modern synthesis, which stresses variability and unique individuals. We propose that fuzzy classification, which allows fractional membership in multiple clusters, can more realistically denote many forms of biological organization, such as populations. We used fuzzy clustering to depict the ambiguous structure of a migratory caribou (Rangifer tarandus) herd, based on affinities in space use, and walleye (Stizostedion vitreum) stocks, based on genetic dissimilarities among multilocus genotypes. In both cases, fuzzy memberships conveyed the degree of uncertainty of belonging while resolving cluster memberships for unambiguous and problematic individuals. Vagueness implies that borderline group identity cannot be remedied with more resolving power. Fuzzy classification is more in tune with the empirical and philosophical foundations of our discipline and can reconcile our need to classify with an inherently vague biological world.


2021 ◽  
Vol 11 (3) ◽  
pp. 43-49
Author(s):  
Hamdoon A. Khan ◽  

With the consideration of the light which carries the photon particles, the Lorentz transformation was constructed with an impressive mathematical approach. But the generalization of that equation for all the velocities of the universe is direct enforcement on other things not to travel faster than light. It has created serious issues in every scientific research that was done in the last century based on the special theory of relativity. This paper replaces the velocity of light with some other velocities and shows us the possible consequences and highlights the issues of special relativity. If I travel through my past or future and was able to see another me there, who would be the real Hamdoon I or the one I see there in the past or future! If the real one is only me, the one I saw, is not me, so, I could not travel through my or someone else's past or future. Therefore, no one can travel through time. If both of us are the same, can the key of personal identity be duplicated or be separated into two or more parts? These are some of the fundamental philosophical arguments that annihilate the concept of time travel which is one of the sequels of special relativity.


2021 ◽  
Vol 58 (4) ◽  
pp. 175-195
Author(s):  
Vladimir P. Vizgin ◽  

The article is based on the concepts of epistemic virtues and epistemic vices and explores A. Einstein’s contribution to the creation of fundamental physical theories, namely the special theory of relativity and general theory of relativity, as well as to the development of a unified field theory on the basis of the geometric field program, which never led to success. Among the main epistemic virtues that led Einstein to success in the construction of the special theory of relativity are the following: a unique physical intuition based on the method of thought experiment and the need for an experimental justification of space-time concepts; striving for simplicity and elegance of theory; scientific courage, rebelliousness, signifying the readiness to engage in confrontation with scientific conventional dogmas and authorities. In the creation of general theory of relativity, another intellectual virtue was added to these virtues: the belief in the heuristic power of the mathematical aspect of physics. At the same time, he had to overcome his initial underestimation of the H. Minkowski’s four-dimensional concept of space and time, which has manifested in a distinctive flexibility of thinking typical for Einstein in his early years. The creative role of Einstein’s mistakes on the way to general relativity was emphasized. These mistakes were mostly related to the difficulties of harmonizing the mathematical and physical aspects of theory, less so to epistemic vices. The ambivalence of the concept of epistemic virtues, which can be transformed into epistemic vices, is noted. This transformation happened in the second half of Einstein’s life, when he for more than thirty years unsuccessfully tried to build a unified geometric field theory and to find an alternative to quantum mechanics with their probabilistic and Copenhagen interpretation In this case, we can talk about the following epistemic vices: the revaluation of mathematical aspect and underestimation of experimentally – empirical aspect of the theory; adopting the concepts general relativity is based on (continualism, classical causality, geometric nature of fundamental interactions) as fundamental; unprecedented persistence in defending the GFP (geometrical field program), despite its failures, and a certain loss of the flexibility of thinking. A cosmological history that is associated both with the application of GTR (general theory of relativity) to the structure of the Universe, and with the missed possibility of discovering the theory of the expanding Universe is intermediate in relation to Einstein’s epistemic virtues and vices. This opportunity was realized by A.A. Friedmann, who defeated Einstein in the dispute about if the Universe was stationary or nonstationary. In this dispute some of Einstein’s vices were revealed, which Friedman did not have. The connection between epistemic virtues and the methodological principles of physics and also with the “fallibilist” concept of scientific knowledge development has been noted.


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