Evaluation of the possible association of Body Mass Index and four metabolic gene polymorphisms with longevity in an Italian cohort: a role forAPOE, eNOS, andFTOgene polymorphisms

2019 ◽  
Author(s):  
Alfredo Santovito ◽  
Gabriella Galli ◽  
Stefano Ruberto
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Gene Polymorphisms ◽  
Genetic Factors ◽  
Age Groups ◽  
Population Data ◽  
Allele Frequencies ◽  
Age Group ◽  
Italian Cohort

ABSTRACTBackgroundlongevity is considered the result of interactions between environmental and genetic factors.Aimwe investigated the possible association of body mass index and the frequencies ofAPOE, ACE, eNOS, andFTOgene polymorphisms with longevity.Subjects and Method1,100 healthy volunteers aged 10-100 were recruited. We genotyped subjects forAPOE, ACE, eNOS, andFTOgene polymorphisms. Data about height and weight were also collected. The sample was split in four age groups: 1-24, 25-49, 50-85 and 86-100.Resultssignificant differences were found in BMI values between age groups, with exception of 1-24 with respect to 86-100. A significant decrease of theAPO E4, eNOS 393andFTO Aand allele frequencies was observed in the 86-100 age group with respect to younger groups. ForACEgene, no significant differences were found in the allele frequencies between groups. A similar trend was also observed subdividing the sample in two main age groups: 1-85 and 86-100.Conclusionthis study provides evidences for a role ofAPOE, eNOS, andFTOgene polymorphisms in longevity. It has been estimated that the number of centenarians worldwide will double each decade until 2100, making population data about gene polymorphisms relevant for further studies about longevity.

scholarly journals Is age group a predictive factor for satisfaction among patients undergoing sympathectomy to treat hyperhidrosis?

2011 ◽  
Vol 10 (4) ◽  
pp. 284-288 ◽  
Author(s):  
José Ribas Milanez de Campos ◽  
Nelson Wolosker ◽  
Marco Antonio Soares Munia ◽  
Guilherme Yazbek ◽  
Paulo Kauffman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Body Mass Index ◽  
Body Mass ◽  
Age Groups ◽  
Age Group ◽  
Compensatory Hyperhidrosis ◽  
Thoracic Sympathectomy ◽  
Video Assisted ◽  
Primary Hyperhidrosis

OBJECTIVE: Video-assisted thoracic sympathectomy is currently the procedure of choice for the definitive treatment of primary hyperhidrosis, because it is an effective, safe, and minimally invasive method. In the search for better quality of life indexes, all researchers look for predictive factors indicating better surgical outcomes. Failure in the primary treatment, postoperative compensatory hyperhidrosis, body mass index over 25, level of resection of the sympathetic chain, and extent of resection are some of the factors that may negatively influence the results. The objective of this study was to compare, according to the age group, the quality of life after bilateral thoracic sympathectomy for treatment of primary hyperhidrosis in a cohort of 1,644 patients. METHODS: From February 2000 to October 2008, data were collected from 1,644 patients with palmar (71%) or axillary (29%) hyperhidrosis who underwent video-assisted thoracic sympathectomy. The patients were divided into three groups according to their ages. The first group consisted of patients up to 17 years-old, the second from 18 to 30 years-old, and the third of over 30 years-old. All patients had a body mass index of less than 25. RESULTS: In the evaluation 30 days after surgery, improvement of the quality of life in the three groups was observed. There was no significant difference between the age groups. In the present study, 91.9% of the patients presented compensatory hyperhidrosis, with no difference between the age groups. CONCLUSIONS: Patients with primary hyperhidrosis experience quality of life improvement after thoracic sympathectomy regardless of their age.

scholarly journals Cardiorespiratory Fitness Normative Values in Latin-American Adolescents: Role of Fatness Parameters

2019 ◽  
Vol 16 (20) ◽  
pp. 3889 ◽  
Author(s):  
Robinson Ramírez-Vélez ◽  
Antonio García-Hermoso ◽  
Alicia María Alonso-Martínez ◽  
César Agostinis-Sobrinho ◽  
Jorge Enrique Correa-Bautista ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Cardiorespiratory Fitness ◽  
Latin American ◽  
Age Groups ◽  
Specific Reference ◽  
Z Score ◽  
Anthropometric Parameters ◽  
Age And Sex

The aim of this study was to provide percentile values for a cardiorespiratory fitness (CRF) field test for Latin-American adolescents (34,461 girls and 38,044 boys) aged 13 to 15 years. The role of fatness parameters on the CRF level across age groups was also examined, with a focus on non-obese (healthy) and obese groups. CRF was assessed using the 20-meter shuttle run test protocol. Anthropometric parameters were measured using body mass index z-score (body mass index (BMI) z-score), BMI, waist circumference (WC), and waist-to-height ratio (WHtR). Participants were categorized according to the BMI z-score, WC, and WHtR international cut-off points as healthy and obese. Age- and sex-specific reference tables for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th centile scores were calculated using Cole’s lambda, mu, and sigma method. The prevalence of obesity according to the BMI z-score, WC, and WHtR was 9.6%, 11.2%, and 15.0%, respectively. Across all age and sex groups, a negative association was found between relative peak oxygen uptake ( V ˙ O2peak) and BMI, WC, and WHtR. In boys and girls there were higher levels of performance across all age groups, with most apparent gains between the ages of 13 and 14 years old. Overall, participants categorized in the healthy group had shown to have significantly higher V ˙ O2peak than their obese counterparts (p < 0.001; Cohen’s d > 1.0). In conclusion, our study provides age- and sex-specific reference values for CRF ( V ˙ O2peak, mL·kg−1·min−1). The anthropometric parameters were inversely associated with CRF in all ages in both sexes. The obese group had worse CRF than their healthy counterparts independent of anthropometric parameters used to determine obesity.

scholarly journals Role of age of incidence, parity, body mass index and socioeconomic class in endometrial carcinoma

2020 ◽  
Vol 9 (2) ◽  
pp. 762
Author(s):  
Neha A. Nimbark
Keyword(s):  
Body Mass Index ◽  
Endometrial Carcinoma ◽  
Body Mass ◽  
Descriptive Statistics ◽  
Age Group ◽  
Socioeconomic Class ◽  
Frequency Table ◽  
Number Of Patients ◽  
A Prospective Study

Background: Endometrial carcinoma is the most common gynecologial malignancy in world. The main aim is to study epidemiological factors of Ca body uterus in our hospital. The present study was designed to evaluate the age of incidence of carcinoma body uterus and study role of parity, body mass index and socioeconomic class in carcinoma body.Methods: This is a prospective study of 50 cases of endometrial carcinoma who were treated in a single unit of the hospital from April 2010 to March 2012 (2 years) conducted at the department of gynaecological oncology G. C. R. I., Ahmedabad. Observational study was done. All these data were combined and tabulated in frequency table simple percentage analysis is used for frequency and percentage analysis is applied to create a contingency table from the frequency distribution and represent the collected data for better understanding. Descriptive statistics were obtained for all variable.Results: Maximum number of patients were in age group of 50-59 years. Mean age was 58 years. Maximum patients were multiparous (54%). 4 patients were nulligravida (9%). 70% were overweight and obese. Majority of patients (72%) belong to middle and higher socio-economic class.Conclusions: It was noted that the incidence for ca endometrium is related to age, parity, BMI and socioeconomic class at our centre.

scholarly journals Comparison of Nutritional Status between Kindergarten Groups in Split

2021 ◽  
Vol 1 (2) ◽  
pp. 99-103
Author(s):  
Nela Židić ◽  
Nada Tomasović Mrčela
Keyword(s):  
Body Mass Index ◽  
Nutritional Status ◽  
Body Mass ◽  
Age Groups ◽  
The Body ◽  
Age Group ◽  
Average Value ◽  
Percentile Curves ◽  
Gender And Age ◽  
Nutritional Status Of Children

AIM: to determine whether there is a difference in the level of nutritional status of children across age groups, which would indicate the need for a change in caloric values of daily menus that are currently the same for all age groups in kindergartens in Split. PARTICIPANTS AND METHODS: The study was conducted during June 2020 in “Grigor Vitez” kindergarten in Split. All parents were asked to voluntarily complete a questionnaire with a guarantee of anonymity. The data on height and weight of children were used to calculate the nutritional indicators: the body mass index (BMI) and the percentile curves of the body mass index (% BMI), defined by gender and age. RESULTS: Data for 128 children aged 3 - 6.99 of the kindergarten "Grigor Vitez" were analyzed. Children in the selected kindergartens did not differ significantly in relation to the level of their nutritional status across age groups (3 – 3.99 years, 4 – 4.99 years, 5 – 5.99 years, 6 – 6.99 years). The highest average percentile was determined (60.30) in the age group of children aged 6.00 - 6.99, which is 12.89 points higher than the average value of the percentile of children aged 3.00 - 3.99 years, while no difference was found by testing (F = 0.936; p = 0.426). CONCLUSION: Only percentile values were compared between kindergarten groups, and so it can be concluded that meals may have appropriate energy values, which should be checked by analyzing the menus, and comparing them with the recommendations.

scholarly journals Association of Metabolic and DNA-repair gene polymorphisms with Longevity: a role for GSTT1, GSTP and XPC genes

2020 ◽  
Author(s):  
Manuel Scarfò ◽  
Chiara Sciandra ◽  
Alfredo Santovito
Keyword(s):  
Dna Repair ◽  
Gene Polymorphisms ◽  
Age Groups ◽  
Age Group ◽  
Repair Gene ◽  
Complex Processes ◽  
Dna Repair Gene ◽  
Genetic Level ◽  
Exon 9 ◽  
Italian Cohort

AbstractAging and longevity are complex processes controlled at different levels, including genetic level. We evaluated the association of seven drug and DNA-repair gene polymorphisms with longevity in an Italian cohort. A sample of 756 subjects aged 18-98 was genotyped for CYP1A1 exon 7 A>G, GSTT1 null, GSTM1 null, GSTP A>G, XRCC1 exon 6 C>T, XRCC1 exon 9 A> G and XPC exon 15 A>C gene polymorphisms. The association between the analyzed gene polymorphisms and longevity was evaluated by dividing the sample into three age groups: 10-50, 51-85, and 86-98.We observed a significant decrease in the frequency of the GSTT1 null, GSTP G and XPC C alleles in the oldest group with respect to the youngest one and with respect to 51-85 age group. We obtained the same results also subdividing the sample into 1-85 and 86-98 age groups. The general linear model analyses confirmed a significant decreasing trend of the above mentioned alleles with age. We hypothesized that these minor alleles, being important in the sensitivity against the development of different types of cancer, may reflect a reduced life-expectancy in carrier subjects and may explain their significantly lower frequency observed among subjects belonging to oldest age group.

scholarly journals Epidemiological and immunological features of obesity and SARS-CoV-2

2020 ◽  
Author(s):  
Eric J Nilles ◽  
Sameed M Siddiqui ◽  
Stephanie Fischinger ◽  
Yannic C Bartsch ◽  
Michael de Saint Aubin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Immune Response ◽  
Cohort Study ◽  
T Cell ◽  
Body Mass ◽  
Age Groups ◽  
Older Age ◽  
Viral Antigens ◽  
Symptom Phenotype

AbstractObesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response are poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and, remarkably homogenous immune activity across BMI categories suggests natural- and vaccine-induced protection may be similar across these groups.

Age-Group Differences in Body Mass Index, Weight, and Height in Adults With Down Syndrome and Adults With Intellectual Disability From the United States

2021 ◽  
Vol 38 (1) ◽  
pp. 79-94
Author(s):  
Stamatis Agiovlasitis ◽  
Jooyeon Jin ◽  
Joonkoo Yun
Keyword(s):  
United States ◽  
Body Mass Index ◽  
Down Syndrome ◽  
Intellectual Disability ◽  
Body Mass ◽  
Age Groups ◽  
The United States ◽  
Age Group ◽  
Cross Sectional ◽  
Men And Women

The authors examined if body mass index (BMI), weight, and height across age groups differ between adults with Down syndrome (DS) and adults with intellectual disability but without DS. They conducted secondary analyses of cross-sectional data from 45,803 individuals from the United States from 2009 to 2014 of the National Core Indicators Adult Consumer Survey across five age groups: 18–29, 30–39, 40–49, 50–59, and 60+ years. For both men and women with DS, BMI and weight increased between the 18- to 29- and the 30- to 39-year age groups and decreased thereafter. For both men and women with intellectual disability, BMI and weight increased between the 18- to 29- and the 30- to 39-year age groups, stayed about the same until the 50- to 59-year age group, and decreased thereafter. Height demonstrated a small but significant decrease with older age in all groups. These cross-sectional comparisons indicate that BMI and weight may start decreasing at a younger age in adults with DS than in adults with intellectual disability.

scholarly journals Some approaches to dispanserization of patients with hypertensive disease at territorial internist's area

2019 ◽  
Vol 100 (6) ◽  
pp. 905-909
Author(s):  
I E Babushkin ◽  
O V Gataulina ◽  
E I Demina ◽  
D S Bublikov ◽  
N V Duruda ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Creatinine Clearance ◽  
Body Mass ◽  
Age Groups ◽  
Overweight And Obesity ◽  
Age Group ◽  
Class Iii ◽  
Class I Obesity ◽  
Group 2 ◽  
Group 1

Aim. To study creatinine clearance, body mass index and to perform ROSE survey amomg patients with hypertension of different age groups at territorial internist's area. Methods. The study involved 112 patients aged 40 to 75 years. Patients were divided into two groups according to the age: group 1 40 to 61 years, 55 people (15 men and 40 women), the average age 52.67.1 years; group 2 62 to 75 years, 57 people (15 men and 42 women), the average age 69.84.4 years. Creatinine clearance and body mass index were measured, and ROSE survey was conducted. Results. In group 1 creatinine clearance 60 ml/min was in 5 (9%) subjects, in group 2 in 20 (35%; p=0.002). In group 1 15 (27%) subjects had normal body mass, in group 2 5 (9%). In group 1 overweight was registered in 18 (33%) subjects, and in group 2 in 24 (42%; p=0.407). Class I obesity in group 1 was found in 15 (27%) patients, in group 2 in 16 (28%; p=0.907). Class II obesity in group 1 was noted in 5 (9%) patients, in group 2 in 4 (7%; p=0.955). Class III obesity in group 1 was registered in 2 (4%) people and in 8 (14%) in group 2 (p=0.110). According to the results of ROSE questionnaire, signs of angina pectoris were found in 7 (13%) patients in group 1 and 17 (30%) in group 2 (p=0.048). Conclusion. In the territorial internist's area the proportion of cases of overweight and obesity among patients of groups 1 and 2 with hypertension did not differ significantly (p 0.05); in patients from group 2 with hypertension creatinine clearance less than 60 ml/min was identified 3.9 times more often than in the younger age group (p=0.002); in patients of group 2 with hypertension were 2.3 times more likely to have angina, according to ROSE questionnaire than in group 1 (p=0.048).

scholarly journals Epidemiological and Immunological Features of Obesity and SARS-CoV-2

Viruses ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2235
Author(s):  
Eric J. Nilles ◽  
Sameed M. Siddiqui ◽  
Stephanie Fischinger ◽  
Yannic C. Bartsch ◽  
Michael de St. Aubin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Immune Response ◽  
Cohort Study ◽  
T Cell ◽  
Body Mass ◽  
Age Groups ◽  
Immune Protection ◽  
Viral Antigens ◽  
Symptom Phenotype

Obesity is a key correlate of severe SARS-CoV-2 outcomes while the role of obesity on risk of SARS-CoV-2 infection, symptom phenotype, and immune response remain poorly defined. We examined data from a prospective SARS-CoV-2 cohort study to address these questions. Serostatus, body mass index, demographics, comorbidities, and prior COVID-19 compatible symptoms were assessed at baseline and serostatus and symptoms monthly thereafter. SARS-CoV-2 immunoassays included an IgG ELISA targeting the spike RBD, multiarray Luminex targeting 20 viral antigens, pseudovirus neutralization, and T cell ELISPOT assays. Our results from a large prospective SARS-CoV-2 cohort study indicate symptom phenotype is strongly influenced by obesity among younger but not older age groups; we did not identify evidence to suggest obese individuals are at higher risk of SARS-CoV-2 infection; and remarkably homogenous immune activity across BMI categories suggests immune protection across these groups may be similar.

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