scholarly journals A Human Tissue-Specific Transcriptomic Analysis Reveals that Ageing Hinders Cancer and Boosts Cellular Senescence

2019 ◽  
Author(s):  
Kasit Chatsirisupachai ◽  
Daniel Palmer ◽  
Susana Ferreira ◽  
João Pedro de Magalhães
Keyword(s):  
Cellular Senescence ◽  
Opposite Direction ◽  
Meta Analysis ◽  
Differentially Expressed ◽  
Complex Relationship ◽  
Human Tissues ◽  
Gene Sets ◽  
Ageing Processes ◽  
Transcriptomic Changes ◽  
The Relationship

AbstractAgeing is the biggest risk factor for cancer, but the mechanisms linking these two processes remain unclear. We compared genes differentially expressed with age and genes differentially expressed in cancer among nine human tissues. In most tissues, ageing and cancer gene expression surprisingly changed in the opposite direction. These overlapping gene sets were related to several processes, mainly cell cycle and the immune system. Moreover, cellular senescence signatures derived from a meta-analysis changed in the same direction as ageing and in the opposite direction of cancer signatures. Therefore, transcriptomic changes in ageing and cellular senescence might relate to a decrease in cell proliferation, while cancer transcriptomic changes shift towards an increase in cell division. Our results highlight the complex relationship between ageing, cancer and cellular senescence and suggest that in most human tissues ageing processes and senescence act in tandem while being detrimental to cancer. Our work challenges the traditional view concerning the relationship between cancer and ageing and suggests that ageing processes may hinder cancer development.

scholarly journals CELLULAR SENESCENCE AND CHRONOLOGICAL AGE IN VARIOUS HUMAN TISSUES: A SYSTEMATIC REVIEW AND META-ANALYSIS

2018 ◽  
Vol 2 (suppl_1) ◽  
pp. 94-94
Author(s):  
M Waaijer ◽  
C Tuttle ◽  
M Slee-Valentijn ◽  
T Stijnen ◽  
R Westendorp ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cellular Senescence ◽  
Meta Analysis ◽  
Chronological Age ◽  
Human Tissues

scholarly journals Differential Transcriptomic Profiling Between Patients With Sepsis-Induced Ards And Sepsis Without Ards 

2021 ◽  
Author(s):  
George Kasotakis ◽  
Wei Chen ◽  
David L. Corcoran ◽  
Judie A. Howrylak ◽  
Joshua Englert ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Distress Syndrome ◽  
Differentially Expressed ◽  
Transcriptomic Data ◽  
Gene Sets ◽  
Common Causes ◽  
Geo Dataset ◽  
Transcriptomic Changes

Abstract Introduction: Acute Respiratory Distress Syndrome (ARDS) develops in the lungs as a response to potent inflammatory triggers, and sepsis represents one of the most common causes of ARDS. It is a highly lethal syndrome with no effective therapies, and little is known about the pathways that trigger it. In this project we combine publicly available sepsis and ARDS patient datasets to identify early transcriptomic changes that may be targeted therapeutically in the future. Hypothesis: Proinflammatory, neutrophil-centric pathways are central to the pathogenesis of ARDS in septic patients.Methods: The GEO dataset repository was searched and available human transcriptomic data from patients with Sepsis and Sepsis+ARDS were combined and analyzed. Genes, gene sets and significant pathways that were differentially expressed or activated at a statistically significant level between the two groups were identified.Results: No independent genes were identified to be differentially expressed across the three studies. There were 6 gene sets that were up- or down-regulated across all studies (four and two respectively), and the Sphingosine-1-Phophate (S1P) pathway was the only pathway seen to become activated in septic patients with ARDS compared to those with sepsis alone. Conclusions: Limited consistent gene and gene set transcription hinders our ability to identify viable biomarkers or therapeutic targets in ARDS in the setting of sepsis, but S1P pathway intermediaries may be viable candidates.

scholarly journals Cellular senescence and chronological age in various human tissues: A systematic review and meta‐analysis

Aging Cell ◽  
2019 ◽  
Vol 19 (2) ◽  
Author(s):  
Camilla S. L. Tuttle ◽  
Mariette E. C. Waaijer ◽  
Monique S. Slee‐Valentijn ◽  
Theo Stijnen ◽  
Rudi Westendorp ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cellular Senescence ◽  
Meta Analysis ◽  
Chronological Age ◽  
Human Tissues

scholarly journals Transcriptomic Characterization Reveals Blood-based Molecular Signatures of NSCLC Patients in Response to Anti-PD-1 Therapy Combined with Chemotherapy

2021 ◽  
Author(s):  
Xi Tom Zhang ◽  
Rui Aaron Chen ◽  
Wenqing Sherry Li ◽  
Runpeng Harris Han ◽  
Guodong Gordon Su ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Enrichment Analysis ◽  
Differentially Expressed ◽  
First Line ◽  
Tissue Samples ◽  
Real Time Quantitative Pcr ◽  
Gene Sets ◽  
Pre Treatment ◽  
High Level ◽  
Nsclc Patients

AbstractBackgroundFor patients with non-small cell lung cancer (NSCLC), the PD-1/PD-L1 blockade treatment were incorporated into first-line treatment commonly. Despite the improved survival observed in PD-1 blockade treatment, a large proportion of patients do not respond while others actually progress during treatment.MethodTranscriptomic profiling was performed on whole blood samples from 30 patients received anti-PD-1 (Tislelizumab) plus chemotherapy. Expression levels of differentially expressed genes (DEGs) identified from two comparisons (post-and pre-treatment, responders and non-responders) were validated by real-time quantitative PCR, analyzed within tissue database and meta-analysis database, then followed by enrichment analysis in high-level representations and in silico leukocyte deconvolution.ResultsA panel of blood-based gene signatures (FDR p<0.05, fold change<-2 or >2) were identified (DEG n=155 and 112 in two comparisons) and validated that not only differentially expressed between post- and pre- treatment or responders and non-responders but also in tissue samples between normal and tumor. Genes DLG5 and H3C10 were found negatively associated with overall survival (p<0.05). Enrichment of immunological and metabolism pathways and gene sets indicating activated circulating leukocytes were observed.ConclusionThe molecular and cellular signatures characterized in this study may provide potential blood-based predictors of the response to PD-1 blockade treatment in NSCLC patients.

Relationship between total plasma homocysteine and the risk of aneurysms – a meta-analysis

VASA ◽  
2020 ◽  
pp. 1-6
Author(s):  
Hanji Zhang ◽  
Dexin Yin ◽  
Yue Zhao ◽  
Yezhou Li ◽  
Dejiang Yao ◽  
...  
Keyword(s):  
Large Scale ◽  
Meta Analysis ◽  
Single Species ◽  
Total Plasma ◽  
Control Groups ◽  
Randomized Controlled ◽  
Randomized Controlled Studies ◽  
The Difference ◽  
The Relationship ◽  
Healthy Participants

Summary: Our meta-analysis focused on the relationship between homocysteine (Hcy) level and the incidence of aneurysms and looked at the relationship between smoking, hypertension and aneurysms. A systematic literature search of Pubmed, Web of Science, and Embase databases (up to March 31, 2020) resulted in the identification of 19 studies, including 2,629 aneurysm patients and 6,497 healthy participants. Combined analysis of the included studies showed that number of smoking, hypertension and hyperhomocysteinemia (HHcy) in aneurysm patients was higher than that in the control groups, and the total plasma Hcy level in aneurysm patients was also higher. These findings suggest that smoking, hypertension and HHcy may be risk factors for the development and progression of aneurysms. Although the heterogeneity of meta-analysis was significant, it was found that the heterogeneity might come from the difference between race and disease species through subgroup analysis. Large-scale randomized controlled studies of single species and single disease species are needed in the future to supplement the accuracy of the results.

A Meta-Analysis of Interviews and Cognitive Ability

2013 ◽  
Vol 12 (4) ◽  
pp. 157-169 ◽  
Author(s):  
Philip L. Roth ◽  
Allen I. Huffcutt
Keyword(s):  
Cognitive Ability ◽  
Meta Analysis ◽  
Incremental Validity ◽  
Employment Interviews ◽  
Moderator Analysis ◽  
The Future ◽  
Research Questions ◽  
Meta Analyses ◽  
The Relationship

The topic of what interviews measure has received a great deal of attention over the years. One line of research has investigated the relationship between interviews and the construct of cognitive ability. A previous meta-analysis reported an overall corrected correlation of .40 ( Huffcutt, Roth, & McDaniel, 1996 ). A more recent meta-analysis reported a noticeably lower corrected correlation of .27 ( Berry, Sackett, & Landers, 2007 ). After reviewing both meta-analyses, it appears that the two studies posed different research questions. Further, there were a number of coding judgments in Berry et al. that merit review, and there was no moderator analysis for educational versus employment interviews. As a result, we reanalyzed the work by Berry et al. and found a corrected correlation of .42 for employment interviews (.15 higher than Berry et al., a 56% increase). Further, educational interviews were associated with a corrected correlation of .21, supporting their influence as a moderator. We suggest a better estimate of the correlation between employment interviews and cognitive ability is .42, and this takes us “back to the future” in that the better overall estimate of the employment interviews – cognitive ability relationship is roughly .40. This difference has implications for what is being measured by interviews and their incremental validity.

The Relationship Between Immorality and Cleansing

2018 ◽  
Vol 49 (5) ◽  
pp. 303-309 ◽  
Author(s):  
Jedidiah Siev ◽  
Shelby E. Zuckerman ◽  
Joseph J. Siev
Keyword(s):  
Effect Size ◽  
Meta Analysis ◽  
Weighted Mean ◽  
The Relationship

Abstract. In a widely publicized set of studies, participants who were primed to consider unethical events preferred cleansing products more than did those primed with ethical events ( Zhong & Liljenquist, 2006 ). This tendency to respond to moral threat with physical cleansing is known as the Macbeth Effect. Several subsequent efforts, however, did not replicate this relationship. The present manuscript reports the results of a meta-analysis of 15 studies testing this relationship. The weighted mean effect size was small across all studies (g = 0.17, 95% CI [0.04, 0.31]), and nonsignificant across studies conducted in independent laboratories (g = 0.07, 95% CI [−0.04, 0.19]). We conclude that there is little evidence for an overall Macbeth Effect; however, there may be a Macbeth Effect under certain conditions.

A Systematic Review and a Meta-Analysis of the Relationship Between Problem Finding and Creativity

2017 ◽  
Author(s):  
Ahmed M. Abdulla ◽  
Sue Hyeon Paek ◽  
Rodney Dishman ◽  
Bonnie Cramond ◽  
Mark A. Runco
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Problem Finding ◽  
The Relationship
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