scholarly journals A general mathematical framework for understanding the behavior of heterogeneous stem cell regeneration

2019 ◽  
Author(s):  
Jinzhi Lei
Keyword(s):  
Stem Cell ◽  
Tumor Development ◽  
Cell Regeneration ◽  
Mathematical Framework ◽  
Cell Heterogeneity ◽  
Tissue Development ◽  
Cell Behaviors ◽  
Abnormal Growth ◽  
Random Transition ◽  
Conditional Beta

AbstractStem cell heterogeneity is essential for the homeostasis in tissue development. This paper established a general formulation for understanding the dynamics of stem cell regeneration with cell heterogeneity and random transitions of epigenetic states. The model generalizes the classical G0 cell cycle model, and incorporates the epigenetic states of stem cells that are represented by a continuous multidimensional variable and the kinetic rates of cell behaviors, including proliferation, differentiation, and apoptosis, that are dependent on their epigenetic states. Moreover, the random transition of epigenetic states is represented by an inheritance probability that can be described as a conditional beta distribution. This model can be extended to investigate gene mutation-induced tumor development. The proposed formula is a generalized formula that helps us to understand various dynamic processes of stem cell regeneration, including tissue development, degeneration, and abnormal growth.

scholarly journals Role of Stromal Cells in Determining Tumor and Cancer Stem Cell Behaviors and Therapeutic Response

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3162
Author(s):  
Stephan J. Reshkin ◽  
Rosa Angela Cardone
Keyword(s):  
Stem Cell ◽  
Tumor Microenvironment ◽  
Cancer Stem Cell ◽  
Treatment Response ◽  
Tumor Cells ◽  
Stromal Cells ◽  
Therapeutic Response ◽  
Tumor Development ◽  
Cell Behaviors

While research previously focused extensively on the tumor cells, over the last two decades, the tumor microenvironment (TME) has received increasing attention with a particular emphasis in its role in tumor development, metabolism, progression, and treatment response [...]

scholarly journals Induction of Stem Cell Like Cells from Mouse Embryonic Fibroblast by Short-Term Shear Stress and Vitamin C

2021 ◽  
Vol 11 (4) ◽  
pp. 1941
Author(s):  
Seungmin Yeom ◽  
Myung Chul Lee ◽  
Shambhavi Pandey ◽  
Jaewoon Lim ◽  
Sangbae Park ◽  
...  
Keyword(s):  
Stem Cells ◽  
Shear Stress ◽  
Stem Cell ◽  
Vitamin C ◽  
Suspension Culture ◽  
Small Molecules ◽  
Tumor Development ◽  
Embryonic Stem ◽  
Short Term ◽  
External Stimuli

Induced pluripotent stem cells (iPSCs) are a good medicine source because of their potential to differentiate into various tissues or cells. However, traditionally, iPSCs made by specific transgenes and virus vectors are not appropriate for clinical use because of safety concerns and risk of tumor development. The goal of this research was to develop an alternative method for reprogramming, using small molecules and external stimuli. Two groups were established: short-term shear stress (STSS) under suspension culture and a combination of short-term shear stress and vitamin C (SSVC) under suspension culture. For STSS, the pipetting was carried out for cells twice per day for 2 min for 14 days in the embryonic stem cell (ES) medium. In the case of SSVC, the procedure was the same as for STSS however, its ES medium included 10 µM of vitamin C. After 14 days, all spheroids were picked and checked for pluripotency by ALP (alkaline phosphatase) assay and immunocytochemistry. Both groups partially showed the characteristics of stem cells but data demonstrated that the spheroids under shear stress and vitamin C had improved stem cell-like properties. This research showed the possibility of external stimuli and small molecules to reprogram the somatic cells without the use of transgenes.

scholarly journals The cancer stem cell paradigm: a new understanding of tumor development and treatment

2010 ◽  
Vol 14 (6) ◽  
pp. 621-632 ◽  
Author(s):  
Johnathan D Ebben ◽  
Daniel M Treisman ◽  
Michael Zorniak ◽  
Raman G Kutty ◽  
Paul A Clark ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Tumor Development

scholarly journals Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity

Development ◽  
2015 ◽  
Vol 142 (16) ◽  
pp. 2840-2849 ◽  
Author(s):  
D. Cannon ◽  
A. M. Corrigan ◽  
A. Miermont ◽  
P. McDonel ◽  
J. R. Chubb
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cell ◽  
Population Level ◽  
Cell Heterogeneity ◽  
Multiple Cell

scholarly journals A Biological Global Positioning System: Considerations for Tracking Stem Cell Behaviors in the Whole Body

2010 ◽  
Vol 6 (2) ◽  
pp. 317-333 ◽  
Author(s):  
Shengwen Calvin Li ◽  
Lisa May Ling Tachiki ◽  
Jane Luo ◽  
Brent A. Dethlefs ◽  
Zhongping Chen ◽  
...  
Keyword(s):  
Stem Cell ◽  
Global Positioning System ◽  
Whole Body ◽  
Positioning System ◽  
Cell Behaviors ◽  
Global Positioning
Sign in / Sign up

Export Citation Format

Share Document