scholarly journals Short-time fractal analysis of biological autoluminescence

2019 ◽  
Author(s):  
Martin Dlask ◽  
Jaromír Kukal ◽  
Michaela Poplová ◽  
Pavel Sovka ◽  
Michal Cifra

AbstractBiological systems manifest continuous weak autoluminescence, which is present even in the absence of external stimuli. Since this autoluminescence arises from internal metabolic and physiological processes, several works suggested that it could carry information in the time series of the detected photon counts. However, there is little experimental work which would show any difference of this signal from random Poisson noise and some works were prone to artifacts due to lacking or improper reference signals. Here we apply rigorous statistical methods and advanced reference signals to test the hypothesis whether time series of autoluminescence from germinating mung beans display any intrinsic correlations. Utilizing the fractional Brownian bridge that employs short samples of time-series in the method kernel, we suggest that the detected autoluminescence signal from mung beans is not totally random, but it seems to involve a process with a negative memory. Our results contribute to the development of the rigorous methodology of signal analysis of photonic biosignals.

Author(s):  
Lyudmyla Kirichenko ◽  
Tamara Radivilova ◽  
Vitalii Bulakh

This paper presents a generalized approach to the fractal analysis of self-similar random processes by short time series. Several stages of the fractal analysis are proposed. Preliminary time series analysis includes the removal of short-term dependence, the identification of true long-term dependence and hypothesis test on the existence of a self-similarity property. Methods of unbiased interval estimation of the Hurst exponent in cases of stationary and non-stationary time series are discussed. Methods of estimate refinement are proposed. This approach is applicable to the study of self-similar time series of different nature.


2016 ◽  
Vol 450 ◽  
pp. 531-540 ◽  
Author(s):  
Ruixue Li ◽  
Jiang Wang ◽  
Haitao Yu ◽  
Bin Deng ◽  
Xile Wei ◽  
...  

Author(s):  
Jonas F. Eichinger ◽  
Maximilian J. Grill ◽  
Iman Davoodi Kermani ◽  
Roland C. Aydin ◽  
Wolfgang A. Wall ◽  
...  

AbstractLiving soft tissues appear to promote the development and maintenance of a preferred mechanical state within a defined tolerance around a so-called set point. This phenomenon is often referred to as mechanical homeostasis. In contradiction to the prominent role of mechanical homeostasis in various (patho)physiological processes, its underlying micromechanical mechanisms acting on the level of individual cells and fibers remain poorly understood, especially how these mechanisms on the microscale lead to what we macroscopically call mechanical homeostasis. Here, we present a novel computational framework based on the finite element method that is constructed bottom up, that is, it models key mechanobiological mechanisms such as actin cytoskeleton contraction and molecular clutch behavior of individual cells interacting with a reconstructed three-dimensional extracellular fiber matrix. The framework reproduces many experimental observations regarding mechanical homeostasis on short time scales (hours), in which the deposition and degradation of extracellular matrix can largely be neglected. This model can serve as a systematic tool for future in silico studies of the origin of the numerous still unexplained experimental observations about mechanical homeostasis.


Author(s):  
Tie Liang ◽  
Qingyu Zhang ◽  
Xiaoguang Liu ◽  
Bin Dong ◽  
Xiuling Liu ◽  
...  

Abstract Background The key challenge to constructing functional corticomuscular coupling (FCMC) is to accurately identify the direction and strength of the information flow between scalp electroencephalography (EEG) and surface electromyography (SEMG). Traditional TE and TDMI methods have difficulty in identifying the information interaction for short time series as they tend to rely on long and stable data, so we propose a time-delayed maximal information coefficient (TDMIC) method. With this method, we aim to investigate the directional specificity of bidirectional total and nonlinear information flow on FCMC, and to explore the neural mechanisms underlying motor dysfunction in stroke patients. Methods We introduced a time-delayed parameter in the maximal information coefficient to capture the direction of information interaction between two time series. We employed the linear and non-linear system model based on short data to verify the validity of our algorithm. We then used the TDMIC method to study the characteristics of total and nonlinear information flow in FCMC during a dorsiflexion task for healthy controls and stroke patients. Results The simulation results showed that the TDMIC method can better detect the direction of information interaction compared with TE and TDMI methods. For healthy controls, the beta band (14–30 Hz) had higher information flow in FCMC than the gamma band (31–45 Hz). Furthermore, the beta-band total and nonlinear information flow in the descending direction (EEG to EMG) was significantly higher than that in the ascending direction (EMG to EEG), whereas in the gamma band the ascending direction had significantly higher information flow than the descending direction. Additionally, we found that the strong bidirectional information flow mainly acted on Cz, C3, CP3, P3 and CPz. Compared to controls, both the beta-and gamma-band bidirectional total and nonlinear information flows of the stroke group were significantly weaker. There is no significant difference in the direction of beta- and gamma-band information flow in stroke group. Conclusions The proposed method could effectively identify the information interaction between short time series. According to our experiment, the beta band mainly passes downward motor control information while the gamma band features upward sensory feedback information delivery. Our observation demonstrate that the center and contralateral sensorimotor cortex play a major role in lower limb motor control. The study further demonstrates that brain damage caused by stroke disrupts the bidirectional information interaction between cortex and effector muscles in the sensorimotor system, leading to motor dysfunction.


Author(s):  
Ruqiang Yan ◽  
Robert X. Gao ◽  
Kang B. Lee ◽  
Steven E. Fick

This paper presents a noise reduction technique for vibration signal analysis in rolling bearings, based on local geometric projection (LGP). LGP is a non-linear filtering technique that reconstructs one dimensional time series in a high-dimensional phase space using time-delayed coordinates, based on the Takens embedding theorem. From the neighborhood of each point in the phase space, where a neighbor is defined as a local subspace of the whole phase space, the best subspace to which the point will be orthogonally projected is identified. Since the signal subspace is formed by the most significant eigen-directions of the neighborhood, while the less significant ones define the noise subspace, the noise can be reduced by converting the points onto the subspace spanned by those significant eigen-directions back to a new, one-dimensional time series. Improvement on signal-to-noise ratio enabled by LGP is first evaluated using a chaotic system and an analytically formulated synthetic signal. Then analysis of bearing vibration signals is carried out as a case study. The LGP-based technique is shown to be effective in reducing noise and enhancing extraction of weak, defect-related features, as manifested by the multifractal spectrum from the signal.


2018 ◽  
Vol 9 ◽  
Author(s):  
Atae Akhrif ◽  
Marcel Romanos ◽  
Katharina Domschke ◽  
Angelika Schmitt-Boehrer ◽  
Susanne Neufang
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