scholarly journals An Exclusively Skewed Distribution of Pediatric Immune Reconstitution Inflammatory Syndrome Towards the Female Sex is Associated with Advanced Acquired Immune Deficiency Syndrome

2019 ◽  
Author(s):  
Regina Célia de Souza Campos Fernandes ◽  
Thaís Louvain de Souza ◽  
Thiago da Silva Barcellos ◽  
Enrique Medina-Acosta
Keyword(s):  
Immune Deficiency ◽  
Immune Reconstitution ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Skewed Distribution ◽  
Female Sex ◽  
Inflammatory Syndrome ◽  
Acquired Immune Deficiency ◽  
Hiv Aids

AbstractIn human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) patients with very low CD4 cell counts, there is a temporal relationship between administration of antiretroviral therapy (ART) and an increased inflammatory response state known as the immune reconstitution inflammatory syndrome (IRIS). The predominant clinical presentation of IRIS is an infectious disease that can be life-threatening. IRIS-related infectious events are distributed similarly between adult males and females, albeit a few studies have shown a skewing towards the male sex in pediatric IRIS. Here, we assessed sex-specific differences in the causes and extent of IRIS infectious events in HIV-infected pediatric patients on ART. We carried out a prospective clinical analysis (from 2000 to 2018) of IRIS-related infectious events after ART in a cohort of 82 Brazilian children and adolescents infected with HIV-1 through mother-to-child transmission as well as a comprehensive cross-referencing with public records on IRIS-related infectious causes in pediatric HIV/AIDS. Twelve events fulfilling the criteria of IRIS occurred exclusively in eleven females in our cohort. The median age at IRIS events was 3.6 years. The infectious causes included Mycobacterium bovis, varicella-zoster virus, molluscum contagiosum virus, human papillomavirus, cytomegalovirus, and Mycobacterium tuberculosis. In one female, there was regional bacillus Calmette-Guérin dissemination and cytomegalovirus esophagitis. There was complete health recovery after ten IRIS events without the use of corticosteroids or ART interruption. One case of IRIS-associated miliary tuberculosis was fatal. The biological female sex was a significant risk factor for IRIS events (odds ratio: 23.67; 95% confidence interval 95%: 1.341 – 417.7; P = 0.0016). We observed an effect of the advanced HIV/AIDS variable in IRIS females as compared with non-IRIS females (mean CD4+ T cell percentage 13.36% versus 18.63%; P = 0.0489), underpinning the exclusively skewed distribution towards the female sex of this cohort. Moreover, the IRIS females in our cohort had higher mean CD4+ T cell percentages before (13.36%) and after IRIS (26.56%) than those of the IRIS females (before IRIS, 4.978%; after IRIS, 13.81%) in previous studies conducted worldwide. We concluded that the exclusively skewed distribution of pediatric IRIS towards females is associated with more advanced AIDS.

scholarly journals Case Report: Tuberculosis IRIS: a mediastinal problem

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 54 ◽  
Author(s):  
Leonardo Valentin ◽  
Andrew DiNardo ◽  
Elizabeth Chiao ◽  
Laila Woc-Colburn ◽  
Arun Nachiappan
Keyword(s):  
Immune Deficiency ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Esophageal Wall ◽  
Highly Active ◽  
Inflammatory Syndrome ◽  
Acquired Immune Deficiency

We present a case of a 39-year-old male patient with Acquired Immune Deficiency Syndrome (AIDS) who developed Mycobacterium tuberculosis related Immune Reconstitution Inflammatory Syndrome (IRIS) after initiation of Highly Active Antiretroviral Therapy (HAART) treatment. The inflammatory response resulted in mediastinal necrotic lymphadenopathy and subsequent perforation of the esophageal wall.

scholarly journals Case Report: Tuberculosis IRIS : a mediastinal problem

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 54
Author(s):  
Leonardo Valentin ◽  
Andrew DiNardo ◽  
Elizabeth Chiao ◽  
Laila Woc-Colburn ◽  
Arun Nachiappan
Keyword(s):  
Immune Deficiency ◽  
Highly Active Antiretroviral Therapy ◽  
Immune Reconstitution ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Esophageal Wall ◽  
Highly Active ◽  
Inflammatory Syndrome ◽  
Acquired Immune Deficiency

We present a case of a 39-year-old male patient with Acquired Immune Deficiency Syndrome (AIDS) who developed Mycobacterium tuberculosis related Immune Reconstitution Inflammatory Syndrome (IRIS) after initiation of Highly Active Antiretroviral Therapy (HAART) treatment. The inflammatory response resulted in mediastinal necrotic lymphadenopathy and subsequent perforation of the esophageal wall.

scholarly journals FAKTOR YANG MEMPENGARUHI TINGKAT KEPATUHAN IBU HAMIL DALAM SKRENING HIV/AIDS

2020 ◽  
Author(s):  
VISIA LUH GITA
Keyword(s):  
Immune Deficiency ◽  
Human Immunodeficiency Virus ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Millenium Development Goals ◽  
Immunodeficiency Virus ◽  
Development Goals ◽  
Acquired Immune Deficiency ◽  
Hiv Aids

Human immunodeficiency virus (HIV) dan Acquired immune deficiency syndrome (AIDS) merupakan salah satu sorotan dalam pencapaian target Millenium Development Goals (MDGs). Ibu hamil dengan HIV akan berisiko menularkan kepada bayinya. Tes HIV merupakan gerbang pembuka status HIV yang sangat penting dilakukan pada ibu hamil. Ada banyak faktor yang mempengaruhi kenapa ibu hamil banyak yang tidak melakukan test HIV/AIDS pada masa kehamilannya , ini tentunya merupakan tantangan terberat bagi pemerintah khususnya petugas kesehatan, untuk itu perlu adanya kerjasama yang baik anatara pemerintah, petugas kesehatan dan lintas sektor terkait dalam pencapaian target Millenium Development Goals (MDGs).

scholarly journals Hambatan Pencegahan Penularan Human Immunodeficiency Virus (HIV) / Acquired Immune Deficiency Syndrome (AIDS) Oleh Pekerja Seks Komersial (PSK) Di Lokalisasi

2018 ◽  
Vol 2 (2) ◽  
Author(s):  
Fahruddin Kurdi
Keyword(s):  
Immune Deficiency ◽  
Human Immunodeficiency Virus ◽  
Bargaining Power ◽  
Immune Deficiency Syndrome ◽  
Acquired Immune Deficiency Syndrome ◽  
Deficiency Syndrome ◽  
Immunodeficiency Virus ◽  
Acquired Immune Deficiency ◽  
Hiv Aids

Pekerja Seks Komersial (PSK) merupakan kelompok yang sangat beresiko tertular dan menularkan HIV/AIDS. Tujuan penelitian adalah mengeksplorasi hambatan pencegahan penularan HIV/AIDS oleh PSK di Lokalisasi Klubuk Jombang. Penelitian ini menggunakan metode kualitatif dengan pendekatan fenomenologi. Subjek penelitian ini adalah Pekerja Seks Komersial di Lokalisasi Klubuk Kabupaten Jombang pada tahun 2016, dengan kriteria telah bekerja sebagai Pekerja Seks Komersial selama minimal 1 (satu) tahun di Lokalisasi. Jumlah partisipan yang diambil adalah 5 (lima) PSK yang berumur 19-38 tahun pada saat pengambilan data dari 130 (seratus tiga puluh) orang Pekerja Seks di lokasi penelitian. Hasil penelitian menunjukkan bahwa Pekerja Seks Komersial mengakui bahwa mereka paham bahwa pemakaian kondom dapat mencegah penularan, tetapi ketika beraktivitas seksual kondom tidak selalu mereka gunakan. Kekerasan fisik dan psikologis kadang mereka dapatkan. Bargaining power mereka masih lemah dalam negosiasi pemakaian kondom dengan pelanggannya. Dukungan dalam upaya pencegahan HIV/AIDS mereka dapat dari kelompok sebaya dan petugas. Perlu kerjasama lintas sektoral dan dinas terkait untuk memberikan intervensi pada komunitas Pekerja Seks Komersial ini sehingga peningkatan kasus HIV/AIDS di Jombang dapat ditekan.

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