scholarly journals Effects of Lactobacillus plantarum 15-1 and fructooligosaccharide on the response of broilers to pathogenic Escherichia coli O78 challenge

2019 ◽  
Author(s):  
Sujuan Ding ◽  
Yongwei Wang ◽  
Wenxin Yan ◽  
Aike Li ◽  
Hongmei Jiang ◽  
...  
Keyword(s):  
Immune Responses ◽  
Diamine Oxidase ◽  
Short Chain Fatty Acid ◽  
Average Daily Gain ◽  
Basal Diet ◽  
Positive Control ◽  
Negative Control ◽  
Intestinal Morphology ◽  
Pathogenic Escherichia Coli ◽  
Daily Gain

AbstractOne-day-old broilers were randomly allocated to 5 treatments: basal diet challenged by saline (negative control, n-control); basal diet and challenged by E.coil O78 (positive control, p-control); supplementation with L. plantarum 15-1 at 1×108 CFU/kg challenged with E.coil O78 (LP); supplementation with FOS at 5 g/kg challenged with E.coil O78 (FOS); supplementation with L. plantarum 15-1 and FOS challenged with E.coil O78 (LP+FOS). L. plantarum 15-1 or FOS had a lowered effect (P<0.05) on crypt depth on d 14 compared with two controls, and L. plantarum 15-1, FOS and L. plantarum 15-1+FOS also reduced relative to p-control on d 21. L. plantarum 15-1 reduced the level of diamine oxidase (DAO) at d 14 and 21 compared with p-control (P<0.05), the broilers with L. plantarum 15-1 and FOS increased the concentration of IgA and IgG relative to two control, and decreased diamine oxidase (DAO) compared with p-control (P 0.05). L. plantarum 15-1 increased the concentration of acetic acid and total short-chain fatty acid (SCFA) in comparison with p-control at d 14 (P<0.05), FOS improved the level of valeric acid and total SCFA relative to p-control at d 21 (P<0.001), the broilers fed L. plantarum 15-1 and FOS were increased the level of butyric acid at d 14 (P<0.05). FOS enhanced bursal index of broilers at d 21 (P<0.05). L. plantarum 15-1 and FOS did no effect on the growth performance. In conclusion, FOS can promote average daily gain, L. plantarum 15-1 and FOS can improve intestinal morphology, and increase the concentration of SCFA in cecal contents in broilers challenged with E.coil O78. These results suggest that L. plantarum 15-1 and FOS have effective mitigation to E. coil O78 via lowing reducing the intestinal injury and enhancing the immune responses.

scholarly journals Effects of inorganic minerals replaced by complexed glycinates on growth, blood profiles, immune responses, intestinal morphology, and mineral excretion in piglets

2020 ◽  
Author(s):  
Xun Pei ◽  
Geng Wang ◽  
Lujie Liu ◽  
Wanjing Sun ◽  
Zhiping Xiao ◽  
...  
Keyword(s):  
Immune Responses ◽  
Low Dose ◽  
Average Daily Gain ◽  
Basal Diet ◽  
Intestinal Morphology ◽  
Trace Minerals ◽  
Control Group ◽  
Trace Mineral ◽  
Mineral Excretion ◽  
Blood Profiles

Abstract BACKGROUND: The effects of inorganic trace minerals (ITM) replaced by low-dose glycine-complexed trace minerals (GCM) on growth, serum parameters, immunity, intestinal morphology, and mineral excretion in piglets were investigated. One hundred and twenty-eight weaned piglets (14.18 ± 0.33kg body weight (BW)) were randomly assigned to 4 treatments with 4 replicates, 8 piglets per replicate. Treatments consist of: (T1) basal diet + 100% inorganic trace mineral (ITM) as the control group (20 ppm Cu, 150 ppm Fe, 150 ppm Zn, and 30 ppm Mn from sulfates); (T2) basal diet + 50% ITM (Cu, Fe, Zn, and Mn from sulfates, 50% of control) + 50% organic trace minerals (OTM, Cu, Fe, Zn, and Mn from glycine complexed trace minerals (GCM), 50% of control); (T3) basis diet + 50% OTM from GCM; (T4) basal diet + 70% OTM from GCM. The feeding period lasted 28 d and was divided into 2 stages (0 to 14 d and 15 to 28 d). After feeding trial , 6 pigs per treatment were randomly selected to slaughter for sampling. RESULTS: Average daily gain, feed intake, and G:F were not affected by dietary treatments during the overall period. During the second, and the overall feeding phases, the digestibility of Zn and Fe in T3 and T4 was higher than that of T1 ( P < 0.05). The concentration of serum ferritin in T2 was significantly higher than T3 and T4. Serum immunoglobulin A concentration in the ileal mucosa of T2 was higher than that of T1 ( P < 0.05), and the higher duodenum villus height was observed in T4 compared with the rest treatments ( P < 0.05). The lowest trace mineral excretion was overserved in T3 ( P < 0.01); in addition, the urinary concentrations of Zn and Fe in T2 were lower than that in T1 ( P < 0.05). CONCLUSION: These results indicate that GCM have higher bioavailability than ITM, and that supplementation of low-dose GCM to replace full dose ITM could reduce mineral excretion without affecting performance, blood profiles, immune responses, and intestinal morphology in piglets.

scholarly journals PSVI-1 Improvement of gut morphology and meat quality of broiler chickens by encapsulated citral and cinnamaldehyde

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 195-195
Author(s):  
Chongwu Yang ◽  
Janghan Choi ◽  
Marion Mogire ◽  
Argenis Rodas-González ◽  
Moussa S Diarra ◽  
...  
Keyword(s):  
Growth Performance ◽  
Meat Quality ◽  
Ph Value ◽  
Basal Diet ◽  
Positive Control ◽  
Negative Control ◽  
Intestinal Morphology ◽  
Post Mortem ◽  
Gut Morphology

Abstract This study investigated the effects of encapsulated citral (CIT) and cinnamaldehyde (CIN) on growth performance, intestinal morphology and meat quality in broilers. A total of 320 0-day-age male broilers (Cobb 500) were allocated 32 pens with 8 pens per treatment. The treatments included: 1) Corn-wheat-SBM basal diet (negative control); 2) basal diet with 30 ppm avilamycin premix (positive control); 3) basal diet with 50 ppm encapsulated CIT and CIN (CCL); 4) basal diet with 100 ppm encapsulated CIT and CIN (CCH). There were no significant differences between treatments in growth performance (P &gt; 0.05) at each feeding stage. Additionally, birds had similar relative organ weights of heart, liver, spleen and bursa (P &gt; 0.05). The higher ratios of villus height to crypt depth (VCR; P ≤ 0.05) were detected in broilers fed either CCL or CCH, with an average being 14.67 and 15.13 in the duodenum, and 15.13 and 13.58 in the jejunum, respectively. Regarding meat quality, a higher pH value (pH = 6.21) in the breast was observed in 24-h post mortem chickens fed CCL (P ≤ 0.05). No significant differences of pH were detected in the breast in 96-h post mortem birds. The breast color (redness, yellowness, and lightness) in either 24-h or 96-h post mortem chickens was not significantly different among treatments (P &gt; 0.05). No change in purge loss (%) was observed in the breast after 48 h. The severity of white striping (WS) or woody meat (WB) was higher in the positive control (WS = 0.58; WB = 0.15) than in other treatments (P ≤ 0.05). In conclusion, dietary treatment with encapsulated CIT and CIN improved gut morphology and meat quality of broilers by increasing VCR in the small intestine and reducing the severity of WS/WB in the breast, respectively, without affecting growth performance.

scholarly journals Effects of Increasing Doses of Lactobacillus Pre-Fermented Rapeseed Product with or without Inclusion of Macroalgae Product on Weaner Piglet Performance and Intestinal Development

Animals ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 559
Author(s):  
Gizaw Dabessa Satessa ◽  
Paulina Tamez-Hidalgo ◽  
Søren Kjærulff ◽  
Einar Vargas-Bello-Pérez ◽  
Rajan Dhakal ◽  
...  
Keyword(s):  
Average Daily Gain ◽  
Rapeseed Meal ◽  
Ascophyllum Nodosum ◽  
Positive Control ◽  
Negative Control ◽  
Intestinal Development ◽  
Gut Development ◽  
Brown Macroalgae ◽  
Inclusion Level ◽  
Daily Gain

This study evaluated the effects of increasing doses of pre-fermented rapeseed meal (FRM) without or with inclusion of the brown macroalgae Ascophyllum nodosum (AN) on weaner piglets’ performance and gut development. Ten days pre-weaning, standardized litters were randomly assigned to one of nine isoenergetic and isoproteic diets comprising (on DM basis): no supplement (negative control, NC), 2500 ppm ZnO (positive control, PC), 8, 10, 12, 15 or 25% FRM, and 10% FRM plus 0.6 or 1.0% AN. Fifty piglets receiving the same pre-weaning diets were weaned at 28 days of age and transferred to one pen, where they continued on the pre-weaning diet until day 92. At 41 days, six piglets per treatment were sacrificed for blood and intestinal samplings. The average daily gain was at least sustained at any dose of FRM (increased at 8% FRM, 28–41 days) from 18–41 days similar to PC but unaffected by inclusion of AN. The percentage of piglets that completed the experiment was increased by FRM compared to NC, despite detection of diarrhea symptoms. FRM showed quadratic dose-response effects on colon and mid-jejunum crypts depth, and enterocyte and mid-jejunum villus heights with optimum development at 8% or 10% FRM, respectively, but this was abolished when AN was also added. In conclusion, FRM sustained piglet growth performance and intestinal development similar to ZnO with an optimum inclusion level of 8–10% of dietary DM.

scholarly journals Efficacy of organic acids as an alternative to antibiotic growth promoters in weaned pigs

2018 ◽  
Vol 17 (06) ◽  
pp. 8-14
Author(s):  
Tung M. Che
Keyword(s):  
Organic Acids ◽  
Antibiotic Treatment ◽  
Average Daily Gain ◽  
Basal Diet ◽  
Positive Control ◽  
Negative Control ◽  
Growth Promoters ◽  
Weaned Pigs ◽  
E Coli ◽  
Diarrhea Incidence

The objective of the experiment was to compare effects of dietary supplementation of organic acids (ProHacid Advance, PRO) and antibiotics on growth performance, diarrhea incidence, frequency of antibiotic treatment, and E. coli shedding in weaned pigs. A total of 224 crossbred weaned pigs [(Yorkshire x Landrace) x Duroc; 29 days old)] were allotted to 1 of 4 treatments with 7 replicate pens of 8 pigs each according to sex, litter origin and weight in an RCBD. The 4 dietary treatments included (1) basal diet + 50 mg/kg neomycin and 10 mg/kg enramycin (positive control, PC), (2) basal diet without antibiotics (negative control, NC), (3) As 2 + 0.25% PRO, and (4) As 2 + 0.5% PRO. Over a 4-week study, the results showed that there were no differences in the average daily gain and average daily feed intake of pigs among the 4 treatments (P = 0.328). However, pigs fed the PC diet (1.642) and 0.25% PRO-supplemented diet (1.641) had a lower feed to gain ratio (P < 0.05) than those fed the NC diet (1.808). The diarrhea incidence of pigs fed the 0.25% PRO-supplemented diet (7.36%) was lower (P < 0.01) than that of pigs fed the PC diet (11.61%), NC diet (16.70%), and 0.5% PRO-supplemented diet (10.08%). The frequency of antibiotic treatment of pigs consuming the 0.25% PRO-supplemented diet (4.67%) was lower (P < 0.01) than that of pigs consuming the PC diet (7.33%), NC diet (9.53%) and 0.5% PRO-supplemented diet (7.65%). No differences were found in the number of fecal E. coli among the 4 treatments. In brief, 0.25% PRO added to a nursery pig diet would be considered a potential alternative to the use of antibiotics in feed, but further research on this aspect is needed

Influence of Isoamylase Supplementation on Performance and α-Amylase Activities of Broilers Fed Maize-Soybean Meal Diets

2013 ◽  
Vol 295-298 ◽  
pp. 104-108
Author(s):  
Ling Yun Liu ◽  
De Fa Sun ◽  
Jun Jun Li ◽  
Xiang Hua Tang ◽  
Yue Lin Mu ◽  
...  
Keyword(s):  
Soybean Meal ◽  
Amylase Activity ◽  
Average Daily Gain ◽  
Positive Control ◽  
Negative Control ◽  
Conversion Ratio ◽  
Feed Conversion Ratio ◽  
Feed Conversion ◽  
The Difference ◽  
Daily Gain

An experiment was conducted to study the influence of isoamylase supplementation to maize-soybean diets on productive performance and amylase activities of broilers from 1 to 42 d of age.The results showed that different dose of isoamylase（300g/T,600 g/T,900 g/T, containing 3000IU of isoamylase/g）in the maize - soybean meal diet significantly affected the performance of broilers within 1-42 days. Within 1-21 days , the average daily gain(ADG) of experimental groups( experiment I (E I) experiment II (E II) experiment III (E III) ) improved by 3.2% -10.32%(P>0.05) compared with the control groups(negative control(NC) and positive control(PC)), average daily feed intake(ADFI) improved by 0.63%-7.43%(P>0.05), while feed conversion ratio decreased by 0.55%-4.43%(P>0.05); Within 21-42 days , the ADG of experimental groups decreased by 1.38%-4.84% and ADFI by 11.89%-15.58% (P<0.05), feed conversion ratio by 5.41%-7.54% compared with that in the NC group; Within 1-42 days , the ADG of experimental groups improved by 0.54%-4.06%(P>0.05), while ADFI decreased by 0.75%-11.83% (P<0.05), and feed conversion ratio by 3.97%-7.52% (P>0.05) compared with those in the negative control. Isoamylase supplementation influenced amylase activity of various parts of the chyme in digestive tract and the tissues of small intestine and pancreas. 21 d, the amylase activity in experimental groups improved by 4.67%-79.29%(P<0.05) compared with PC, α-amylase activity in the majority experimental groups were lower than PC group, but the difference was not significant(P>0.05).

164 Effect of Supplemental Dl-met Above Requirement on Performance and Serum Concentration of Amino Acids in Heat Stressed Pigs

2021 ◽  
Vol 99 (Supplement_1) ◽  
pp. 59-60
Author(s):  
Adriana Morales Trejo ◽  
Verónica Sánchez ◽  
Bayron Pérez ◽  
Lucero R Camacho ◽  
J Caroline González-Vega ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Average Daily Gain ◽  
Basal Diet ◽  
Intestinal Morphology ◽  
Free Access ◽  
Oxygen Species ◽  
Negative Effect ◽  
Quadratic Effects ◽  
Performance Results ◽  
Daily Gain

Abstract The intestinal morphology can be compromised in pigs when exposed to heat stress (HS), partly due to increased production of reactive-oxygen species. Because methionine (Met) functions as intracellular antioxidant, requirement of Met may be increased in HS-pigs. The effect of dietary supplementation with DL-Met above requirement on performance and serum concentration (SC) of free AA in HS-pigs was evaluated. A basal wheat-soybean meal diet was formulated to meet 100% Met requirement with the other indispensable AA exceeding at least 20% their requirement. Sixty individually housed pigs (23.0 ± 2.4 kg BW, 12 pigs/treatment) were randomly assigned to 5 treatments: TN100, thermal-neutral (22.7 °C) housed pigs fed the basal diet; HS100, HS120, HS140, HS160; HS pigs (29.6 to 39.4°C) fed the basal diet supplemented with DL-Met to contain 0, 20, 40, and 60% DL-Met above the requirement, respectively. Pigs had free access to feed and water during the 21-d trial. Blood samples were collected on d18 to analyze the absorptive AA-SC. The effect of ambient temperature (HS100 vs. TN100), as well as the linear and quadratic effects of increasing Met levels in the diets for HS pigs were analyzed. The performance results for the TN100, HS100, HS120, HS140, HS160 pigs were: Average daily gain (ADG), 728, 612, 720, 716, 719 g/d; average daily feed intake, 1.40, 1.34, 1.30, 1.30, 1.29 kg/d; gain:feed, 0.522, 0.474, 0.569, 0.563, 0.562, respectively. The ADG reduced (P &lt; 0.01) in HS100 compared with TN100 pigs, but linearly increased in HS-pigs, besides gain:feed (P ≤ 0.05), in response to DL-Met supplementation. The SC of Ile, Leu, Lys, Phe, and Val were higher in HS100 pigs than in TN100 pigs (P &lt; 0.05). Graded supplemental DL-Met in diets for HS-pigs linearly decreased SC of Ile, Leu, and Val (P &lt; 0.05), tended to decrease His, Lys, and Thr (P &lt; 0.10), and increased Met (P &lt; 0.01). In conclusion, HS had negative effect on weight gain; however, it was ameliorated by adding 20% Met above the requirement.

PSVI-4 Effect of phytase on mineral digestibility and growth performance of pigs fed diets with pharmacological levels of Zn

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 400-401
Author(s):  
Charmaine D Espinosa ◽  
Deepak Velayudhan ◽  
Yueming Dersjant-Li ◽  
Janet Remus ◽  
Hans-Henrik H Stein
Keyword(s):  
Growth Performance ◽  
Block Design ◽  
Average Daily Gain ◽  
Positive Control ◽  
Negative Control ◽  
Metabolizable Energy ◽  
Randomized Complete Block Design ◽  
Quadratic Effects ◽  
Digestible Amino Acids ◽  
Daily Gain

Abstract An experiment was conducted to test the hypothesis that increasing levels of phytase increases mineral digestibility and growth performance of pigs fed diets with 3,000 mg/kg of Zn. A positive control (PC) diet that met nutrient requirements and a negative control (NC) diet that was deficient in total Ca (-0.16%), digestible P (-0.14%), metabolizable energy (-50 kcal/kg), and digestible amino acids (-0.02%) were formulated. Eight additional diets were formulated by adding 500, 1,000, 1,500, or 2,000 phytase units/kg of a novel bacterial 6-phytase (PhyG) or a commercial Buttiauxella phytase (PhyB) to the NC diet. A randomized complete block design with 400 weanling pigs (5.82 ± 0.70 kg), 10 diets, 4 pigs per pen, and 10 replicate pens per diet was used. Pigs were fed the experimental diets for 28 d. Fecal samples were collected from 1 pig per pen on d 26 to 28. Linear and quadratic effects of PhyG and PhyB were determined using polynomial contrast statements. Contrast statements were used to compare effects of PC diet with NC diet, and to compare effects of PhyG diets with PhyB diets. Overall, pigs fed the NC diet had reduced growth performance (P &lt; 0.05) compared with pigs fed the NC diet (Table 1). Linear (P &lt; 0.01) and quadratic (P &lt; 0.05) increases in overall average daily gain and average daily feed intake of pigs were observed as dietary concentrations of PhyG or PhyB increased. Increasing levels of PhyG or PhyB linearly increased (P &lt; 0.01) the apparent total tract digestibility (ATTD) of P and Ca. PhyG increased ATTD of P more (P &lt; 0.05) than PhyB. In conclusion, both phytases are effective in increasing mineral digestibility and growth performance in pigs fed diets with pharmacological levels of Zn; however, PhyG improved P digestibility more than PhyB.

Comparative effects of low zinc oxide dose with or without probiotics relative to high zinc oxide dose on the performance, nutrient digestibility, blood metabolites, and noxious gases emission in weaned piglets

2019 ◽  
Vol 99 (4) ◽  
pp. 881-889
Author(s):  
Huan Shi ◽  
Santi Devi Upadhaya ◽  
In Ho Kim
Keyword(s):  
Zinc Oxide ◽  
Average Daily Gain ◽  
Basal Diet ◽  
Positive Control ◽  
Negative Control ◽  
Nutrient Digestibility ◽  
Blood Metabolites ◽  
Weaned Piglets ◽  
High Zinc

The objective of this study was to assess the effects of low-dose zinc oxide (ZnO) supplemented with or without probiotic complex compared with pharmacological ZnO (3000 mg kg−1) on the performance, digestibility, blood metabolites, fecal Lactobacillus and enterobacteria counts of weaned piglets. One-hundred and twenty crossbred piglets were randomly allocated to three treatments based on their initial body weight (BW). Treatments consisted of corn–soybean-meal-based basal diet supplemented with 3000 mg kg−1 ZnO as positive control (ZH), basal diet supplemented with 300 mg kg−1 ZnO as negative control (ZL), and ZL + 0.1% probiotic complex (ZLP). At the end of the experiment, fecal samples were collected by direct rectal massage to determine nutrient digestibility, Lactobacillus and enterobacteria counts, and gas emission, whereas blood samples were taken via jugular venipuncture for determination of blood metabolites. The BW of piglets at week 6, and the average daily gain (ADG) at week 6 and during overall period were higher (P < 0.05) in pigs fed ZH diet compared with those fed ZL diet. The supplementation of ZLP increased the ADG during week 6 and overall making it comparable with ZH diet (P < 0.05). However, other parameters described above were comparable with ZH in pigs fed ZLP diet.

scholarly journals Effects of yeast based toxin binder supplementation on growth performance and intestinal microarchitecture in male buffalo calves (Bubalus bubalis) exposed to different concentrations of Aflatoxin B1.

2018 ◽  
Vol 69 (1) ◽  
pp. 853
Author(s):  
O. NASEER ◽  
M. U. SALEEM ◽  
M. L. SOHAIL ◽  
J. NASEER ◽  
J. KHAN ◽  
...  
Keyword(s):  
Growth Performance ◽  
Aflatoxin B1 ◽  
Periodic Acid ◽  
Average Daily Gain ◽  
Basal Diet ◽  
Goblet Cells ◽  
Intestinal Morphology ◽  
Buffalo Calves ◽  
Intestinal Segments ◽  
Daily Gain

The purpose of study was to analyze the effects of yeast based toxin binder (YTB) on growth performance and intestinal microarchitecture of buffalo calves exposed to different concentrations of aflatoxin B1 (AFB1). Male buffalo calves (n=72) having no disease exposure in the last four months, aged 10 ± 1 months and weighing 150 ± 12.22 kg (Mean ± standard deviation)were purchased from a buffalo calf fattening farm and divided in 8 equal groups (n=9 animals in each group). Animals that were fed common basal diet and basal diet along with yeast cell wall based toxin binder (YTB) and had no exposure to AFB1 were served as controls. Different concentrations of AFB1 (6mg, 8mg and 10mg per kg of feed) were given to 27 animals, similarly 2mg of YTB (per kg of contaminated feed) was added to concentrate with different AFB1 concentrations and fed to another 27 animals. Average daily gain of each animal was recorded. Animals were slaughtered after 27 days and intestinal segments from duodenum, jejunum, ileum and colon were collected which were stained with hematoxylin/eosin or combined alcian blue and periodic acid schiff stain. Average daily gain and intestinal morphometric parameters (villus height, villus width, crypt depth and surface area) in all the selected intestinal segments decreased (P<0.05) whereas, intraepithelial lymphocytes, goblet cells (having acidic and neutral mucins) and proliferative cells increased (P<0.05) with AFB1 exposure. It was also observed that YTB neutralized (P<0.05) the harmful effects of AFB1 on intestinal morphology, boosted activity of goblet cells and decreased (P<0.05) number of proliferative cells. It was concluded that YTB supplementation is advantageous in eliminating the negative effects of AFB1 on gut of buffalo calves.

scholarly journals Evaluation of a novel threonine source for nursery pig diets

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Dalton Humphrey ◽  
Spenser Becker ◽  
Jason Lee ◽  
Keith Haydon ◽  
Laura Greiner
Keyword(s):  
Repeated Measures ◽  
Fixed Effects ◽  
Average Daily Gain ◽  
Covariance Structure ◽  
Treatment Phase ◽  
Positive Control ◽  
Negative Control ◽  
Feed Ratio ◽  
Experimental Unit ◽  
Nursery Pigs

Abstract Four hundred and eighty (PIC 337 X 1050, PIC Genus, Hendersonville, TN) pigs were used to evaluate a novel threonine source (ThrPro, CJ America Bio, Fort Dodge, IA) for nursery pigs from approximately 7 to 20 kg body weight (BW). After weaning, pigs were sorted by sex and fed a common diet for 1 wk. Upon completion of the first week, pigs were sorted into randomized complete blocks, equalized by weight, within 16 replications. Pigs were allocated to one of three dietary treatments: positive control (POS)—standard ileal digestible threonine-to-lysine ratio (SID; Thr:Lys) 0.60, negative control (NEG)—SID Thr:Lys ≤0.46, and alternative Thr source (TEST)—SID Thr:Lys 0.60. The alternative Thr source included fermentative biomass and was assumed to contain 75% Thr and a digestibility coefficient of 100% based on the manufacturer’s specifications. All other nutrients met or exceeded the NRC recommendations. Growth and intake data were analyzed as repeated measures with a compound symmetry covariance structure using the MIXED procedure in SAS 9.4 (SAS Institute Inc., Cary, NC) with pen as the experimental unit. Treatment, phase, the interaction between treatment and phase, and block were included as fixed effects in the model. Differences in total removals were tested using Fisher’s Exact Test of PROC FREQ. Results were considered significant at P ≤ 0.05 and considered a trend at P &gt; 0.05 and P ≤ 0.10. During the first 14 d, pigs fed TEST had decreased gain-to-feed ratio (G:F; 0.77 vs. 0.80, P = 0.022) compared to POS and increased G:F (0.77 vs. 0.73, P &lt; 0.001) compared to NEG. Over days 14–28, pigs fed TEST had similar G:F (0.71 vs. 0.70, P = 0.112) compared to POS and increased G:F (0.71 vs. 0.63, P &lt; 0.001) compared to NEG. Overall (days 0–28), pigs fed TEST had similar average daily gain (ADG; 0.47 vs. 0.47 kg/d, P = 0.982) and G:F (0.76 vs. 0.74, P = 0.395) compared to POS and increased ADG (0.47 vs. 0.43 kg/d, P &lt; 0.001) and G:F (0.76 vs. 0.67, P &lt; 0.001) compared to NEG. The average daily feed intake was not significantly different across treatments for the entirety of the study. In conclusion, the replacement of crystalline L-Thr with a novel Thr source resulted in similar growth performance in nursery pigs from approximately 7 to 20 kg.

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