scholarly journals “Risk Factors for Visceral Leishmaniasis in Selected High Endemic Areas of Morang District, Nepal”: A case control study

2019 ◽  
Author(s):  
Punam Kumari Mandal ◽  
Rajendra Raj Wagle ◽  
Ajoy Kumar Thakur ◽  
Surendra Uranw
Keyword(s):  
Risk Factors ◽  
Socioeconomic Status ◽  
Visceral Leishmaniasis ◽  
Case Control Study ◽  
Health Sector ◽  
Case Control ◽  
Extensive Study ◽  
Control Measures ◽  
Health Concern ◽  
Control Study

AbstractVisceral leishmaniasis is a major public health concern in Nepal. During the last few years, several KA outbreaks have been reported from Tarai region including Morang district. A case control study was conducted to assess the risk factors associated with VL in 5 endemic VDC of Morang district with 62 cases already treated from BPKIHS and Koshi zonal hospital and 248 controls selected randomly from the same village. Data collected using semi structured questionnaire from September to November 2013. This study revealed that people living in thatched house, sleeping in ground floor, ownership of animal, history of migration to India (Bihar and Jharkhand) and proximity to other KA cases within 50 m distance of household were strong risk factors for VL. Education remains protective (OR 0.39,95 % CI 0.19-0.79). The association with socioeconomic status showed clear dose – response effect. The odds for VL consistently decreased as the level of socioeconomic status increased (OR 4.26, 3.81). Strengthening surveillance system for early diagnosis and treatment, awareness programme and further extensive study is needed on risk factor, vector and control measures.Author SummaryThis study aims to explore the risk factors for visceral leishmaniasis. Based on findings there is a need to educate people in high-transmission areas how to realize, reduce or avoid environmental factors that favor the survival of the vector in the community. Similarly introduction of more exact surveillance tools in order to improve morbidity and mortality surveillance by health sector. People living in mud thatched houses need to be aware about cracks and crevices in the mud walls, their function as breeding places and how they can be controlled, for example by plastering with lime and mud․. However, a primary condition is that people need to understand the purpose of all these efforts in order to be motivated to put them into practice.

scholarly journals Risk factors for sporadic Campylobacter infection: an all-Ireland case-control study

2009 ◽  
Vol 14 (7) ◽  
Author(s):  
K Danis ◽  
M Di Renzi ◽  
W O’Neill ◽  
B Smyth ◽  
P McKeown ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Population Attributable Fraction ◽  
Case Control ◽  
Control Measures ◽  
Safety Education ◽  
First Case ◽  
The Republic ◽  
Campylobacter Infection ◽  
Control Study

We report the findings of the first case-control study conducted in both the Republic of Ireland and Northern Ireland to determine risk factors for sporadic Campylobacter infections. A total of 197 cases and 296 case-nominated controls matched for age, were included. Based on Population Attributable Fraction (PAF), the most important risk factors were consuming chicken [adjusted matched (am) OR 6.8; 95%CI 2.1-21.9], consuming lettuce (amOR 3.3; 95%CI 1.5-7.1) and eating in takeaways (amOR=3.1; 95%CI 1.4-6.6). Contact with sheep (amOR=11; 95%CI 1.6-78), peptic ulcer (amOR=19; 95%CI 3.8-93.7), hiatus hernia (amOR=20.3; 95%CI 2.3-183.3), lower bowel problems (amOR=4.5; 95%CI 1.2-16.8) were also independently associated with infection. Mains water supply showed protective effect (amOR=0.2; 95 CI 0.1-0.9). The findings highlight the continued need for consumer food safety education and further control measures throughout the food chain on the island of Ireland.

scholarly journals Predictors of delayed recovery following pediatric sports-related concussion: a case-control study

2016 ◽  
Vol 17 (4) ◽  
pp. 491-496 ◽  
Author(s):  
Joseph H. Miller ◽  
Clarence Gill ◽  
Elizabeth N. Kuhn ◽  
Brandon G. Rocque ◽  
Joshua Y. Menendez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Symptom Severity ◽  
Case Control Study ◽  
Case Control ◽  
Health Concern ◽  
Female Sex ◽  
Prolonged Recovery ◽  
History Of ◽  
Delayed Recovery ◽  
Control Study

OBJECT Pediatric sports-related concussions are a growing public health concern. The factors that determine injury severity and time to recovery following these concussions are poorly understood. Previous studies suggest that initial symptom severity and diagnosis of attention deficit hyperactivity disorder (ADHD) are predictors of prolonged recovery (> 28 days) after pediatric sports-related concussions. Further analysis of baseline patient characteristics may allow for a more accurate prediction of which patients are at risk for delayed recovery after a sports-related concussion. METHODS The authors performed a single-center retrospective case-control study involving patients cared for at the multidisciplinary Concussion Clinic at Children's of Alabama between August 2011 and January 2013. Patient demographic data, medical history, sport concussion assessment tool 2 (SCAT2) and symptom severity scores, injury characteristics, and patient balance assessments were analyzed for each outcome group. The control group consisted of patients whose symptoms resolved within 28 days. The case group included patients whose symptoms persisted for more than 28 days. The presence or absence of the SCAT2 assessment had a modifying effect on the risk for delayed recovery; therefore, stratum-specific analyses were conducted for patients with recorded SCAT2 scores and for patients without SCAT2 scores. Unadjusted ORs and adjusted ORs (aORs) for an association of delayed recovery outcome with specific risk factors were calculated with logistic regression analysis. RESULTS A total of 294 patients met the inclusion criteria of the study. The case and control groups did not statistically significantly differ in age (p = 0.7). For the patients who had received SCAT2 assessments, a previous history of concussion (aOR 3.67, 95% CI 1.51–8.95), presenting SCAT2 score < 80 (aOR 5.58, 95% CI 2.61–11.93), and female sex (aOR 3.48, 95% CI 1.43–8.49) were all associated with a higher risk for postconcussive symptoms lasting more than 28 days. For patients without SCAT2 scores, female sex and reporting a history of ADHD significantly increased the odds of prolonged recovery (aOR 4.41, 95% CI 1.93–10.07 and aOR 3.87, 95% CI 1.13–13.24, respectively). Concussions resulting from playing a nonhelmet sport were also associated with a higher risk for prolonged symptoms in patients with and without SCAT2 scores (OR 2.59, 95% CI 1.28–5.26 and OR 2.17, 95% CI 0.99–7.73, respectively). Amnesia, balance abnormalities, and a history of migraines were not associated with symptoms lasting longer than 28 days. CONCLUSIONS This case-control study suggests candidate risk factors for predicting prolonged recovery following sports-related concussion. Large prospective cohort studies of youth athletes examined and treated with standardized protocols will be needed to definitively establish these associations and confirm which children are at highest risk for delayed recovery.

scholarly journals Risk factors for depression among elderly in Bangalore urban district: a case control study

2017 ◽  
Vol 4 (8) ◽  
pp. 2696 ◽  
Author(s):  
Ravindra N. R. ◽  
Rashmi M. R. ◽  
R. Maheswaran
Keyword(s):  
Mental Health ◽  
Risk Factors ◽  
Case Control Study ◽  
Depression Scale ◽  
Case Control ◽  
Health Concern ◽  
Elderly Persons ◽  
Urban District ◽  
Prevalence Of Depression ◽  
Control Study

Background: With a rapidly aging society, geriatric mental health is emerging as an important public health concern. According to the WHO, prevalence of depression in adults aged ≥60 years in developed and developing countries was 0.5 million and 4.8 million respectively in 2004. The objective of this study is to estimate the prevalence of depression and to assess risk factors of depression among elderly in an urban population. Methods: A case control study was conducted in May-June 2016 in the Bagalgunte area in Bangalore urban district. Purposive sampling technique was employed and all elderly persons (≥60 years) residing in that area were included. Participants were assessed for depression using validated 15 item (short version) geriatric depression scale (GDS).Those with GDS score >5 were considered as cases and those with GDS score ≤5 as controls. Final sample size was 201. Study variables included socio-demographic parameters and all possible risk factors of depression. Results: Of the 201 respondents interviewed, 90 (44.8%) were cases and 111 (55.2%) were controls. 159 (79.1%) were aged 60–69 years and 116 (58%) were male. Low socioeconomic status, elderly who were living alone (single/divorced/death of spouse), h/o dependency on others for daily living, negligence, abuse, economic loss in last 5 years, substance abuse, change of residence, insomnia and anorexia were found to be significantly associated with depression among elderly. Conclusions: In this study, depression among elderly was found to be high. These study findings can help programme managers to focus on mental health of elderly and implement practical and comprehensive strategiesand timely interventions to promote mental health and prevent depression.  

scholarly journals Risk factors of visceral leishmaniasis: a case control study in north-western Ethiopia

2014 ◽  
Vol 7 (1) ◽  
Author(s):  
Solomon Yared ◽  
Kebede Deribe ◽  
Araya Gebreselassie ◽  
Wessenseged Lemma ◽  
Essayas Akililu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Visceral Leishmaniasis ◽  
Case Control Study ◽  
Case Control ◽  
North Western ◽  
Western Ethiopia ◽  
Control Study

scholarly journals Is severe visceral leishmaniasis a systemic inflammatory response syndrome? A case control study

2010 ◽  
Vol 43 (4) ◽  
pp. 386-392 ◽  
Author(s):  
Carlos Henrique Nery Costa ◽  
Guilherme Loureiro Werneck ◽  
Dorcas Lamounier Costa ◽  
Thiago Ayres Holanda ◽  
Guilherme Brasileiro Aguiar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bone Marrow ◽  
Visceral Leishmaniasis ◽  
Systemic Inflammatory Response Syndrome ◽  
Bacterial Infection ◽  
Case Control Study ◽  
Parasite Load ◽  
Case Control ◽  
Severe Anemia ◽  
Control Study

INTRODUCTION: The objective of the study is to identify the main risk factors for death by New World visceral leishmaniasis and establish a coherent pathogenic substrate of severe disease based on clinical findings. METHODS: Seventy-six deceased inpatients and 320 successfully treated inpatients with VL were studied in a case control study. RESULTS: Bacterial infection and bleeding were mutually exclusive events leading to death. Five risk factors were unique for death by bacterial infection (malnutrition, pulmonary rales, severe anemia, severe absolute neutropenia and higher neutrophil count), while another six were unique for death by bleeding (jaundice, severe relative neutropenia, severe thrombocytopenia, liver injury, kidney failure, higher bone marrow parasite load). Bacterial infection, bleeding, severe anemia, diarrhea, dyspnea, edema, jaundice and bone marrow parasite load were the main syndromes of visceral leishmaniasis among successfully treated patients. CONCLUSIONS: The data support the idea that bacterial infections are due to immune paralysis. Broad organ and system involvement is plausibly due to the high production of proinflammatory cytokines, whose actions fit well with visceral leishmaniasis. The syndromes and causative mediators are typical of a slowly developing systemic inflammatory response syndrome.

scholarly journals Predictors for vancomycin resistant Enterococcus faecium transforming from colonization to infection: a case control study

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Pao-Yu Chen ◽  
Yu-Chung Chuang ◽  
Jann-Tay Wang ◽  
Wang-Huei Sheng ◽  
Yee-Chun Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Enterococcus Faecium ◽  
Case Control Study ◽  
Case Control ◽  
Control Measures ◽  
Fourth Generation ◽  
Surveillance Culture ◽  
Icu Admission ◽  
Vancomycin Resistant ◽  
Control Study

Abstract Background Little is known about risk factors for subsequent infections among vancomycin resistant Enterococcus faecium (VREfm) colonizers, especially characterized by concordant pulsotypes (CP) of paired colonization and infection-related isolates. Methods This case-control study was conducted at a teaching hospital between 2011 and 2014. Targeted patients received active surveillance culture for VREfm by anal swabs at admission. Cases were those who developed VREfm infection within 180 days after colonization of VREfm. Controls were those colonized with VREfm without subsequent VREfm infection. CP were defined by similarities ≥86.7% using pulsed-field gel electrophoresis between paired colonization and infection-related isolates. Results Ninety-seven cases and 194 controls were enrolled. By conditional multivariable logistic regression analysis, the risk factors for subsequent infection among VREfm colonizers were intensive care unit (ICU) admission (adjusted odds ratio [aOR], 9.32; 95% CI, 3.61–24.02), receipt of central venous catheters (CVC) (aOR, 3.38; 95% CI, 1.30–8.82), and utilization of third- and fourth-generation cephalosporins (aOR, 4.06; 95% CI, 1.79–9.20, and aOR, 5.32; 95% CI, 1.85– 10.29, respectively) (all P ≤ 0.01). Fifty-six (57.7%) of case patients belonged to the CP group, which were associated with ICU admission (aOR, 3.74; 95% CI, 1.38–10.13), and infection developing within 30 days after colonization (aOR, 3.34; 95% CI, 1.25–8.91). Conclusions Among VREfm colonizers, being admitted to ICU and receiving CVC or broad spectrum cephalosporins, were the risk factors for subsequent infections. These findings highlight the importance of conducting more strict infection control measures on specific groups of VREfm colonizers.

scholarly journals Risk factors of visceral leishmaniasis in East Africa: a case-control study in Pokot territory of Kenya and Uganda

2008 ◽  
Vol 37 (2) ◽  
pp. 344-352 ◽  
Author(s):  
J. H Kolaczinski ◽  
R. Reithinger ◽  
D. T Worku ◽  
A. Ocheng ◽  
J. Kasimiro ◽  
...  
Keyword(s):  
Risk Factors ◽  
Visceral Leishmaniasis ◽  
East Africa ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

scholarly journals A case-control study of microenvironmental risk factors for urban visceral leishmaniasis in a large city in Brazil, 1999-2000

2006 ◽  
Vol 20 (6) ◽  
pp. 369-376 ◽  
Author(s):  
Claudia Di Lorenzo Oliveira ◽  
Ana Diez-Roux ◽  
Cibele Comini César ◽  
Fernando Augusto Proietti
Keyword(s):  
Risk Factors ◽  
Visceral Leishmaniasis ◽  
Case Control Study ◽  
Large City ◽  
Case Control ◽  
Control Study

scholarly journals Behavioral, Nutritional, and Genetic Risk Factors of Colorectal Cancers in Morocco: Protocol for a Multicenter Case-Control Study (Preprint)

2019 ◽  
Author(s):  
Meimouna Mint Sidi Ould Deoula ◽  
Inge Huybrechts ◽  
Khaoula El Kinany ◽  
Hanae Boudouaya ◽  
Zineb Hatime ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Logistic Regression ◽  
Genetic Factors ◽  
Case Control Study ◽  
Case Control ◽  
Health Concern ◽  
Mediterranean Country ◽  
Genetic Traits ◽  
Control Study

BACKGROUND Colorectal cancer (CRC) has been reported as the third most commonly diagnosed cancer worldwide and is currently considered as a major public health concern. A peak increase in incidence has been noted in economically transitioning countries like Morocco where industrialization started shifting from a traditional lifestyle and diet toward a more westernized diet and lifestyle. OBJECTIVE This paper aims to present the protocol of a large-scale Moroccan case-control study that aims at investigating associations of diet, other lifestyle factors, and genetic traits with CRC risk in Morocco. METHODS A case-control study was conducted between 2009 and 2017, including 3032 case-control pairs (1516 cases and 1516 controls) matched on sex, age, and center in 5 major public health hospitals in Morocco. Questionnaires on sociodemographic data, lifestyle, family history of CRC, and nonsteroidal anti-inflammatory drugs (NSAIDs) were completed by trained investigators during face-to-face interviews. In addition, participants completed a semiquantitative food-frequency questionnaire, developed to assess food intake in the Moroccan population. Information regarding genetic factors was recorded for cases, and paraffin blocks (with embedded tumor tissues) are available in 3 collaborating hospitals. Conditional logistic regression analysis is planned to assess associations between diet and CRC risk. Binary logistic regression is considered to predict associations between mutations and nutritional risk factors including only CRC case series. RESULTS Altogether, 2966 cases-control pairs (1483 cases and 1483 controls) were considered eligible and included in this study. Both cases and controls did not differ significantly with respect to age (<italic>P</italic>=.36), sex (<italic>P</italic>=.51), center (<italic>P</italic>&gt;.99), marital status (<italic>P</italic>=.30), and NSAID use (<italic>P</italic>=.08). However, participants in the control group were significantly more likely to have a high income level and live in urban areas and to have a high level of education than cases. CONCLUSIONS This is the first study investigating potential risk factors of CRC such as lifestyle, diet, and genetic factors, originating from a southern Mediterranean country with low but increasing CRC prevalence. Identified risk factors allow the establishment of evidence-based preventive actions regarding nutrition and other lifestyle habits adapted to the Moroccan context. In brief, this study will promote cancer research and prevention in Morocco. INTERNATIONAL REGISTERED REPORT RR1-10.2196/13998

scholarly journals Another dengue fever outbreak in Eastern Ethiopia—An emerging public health threat

2021 ◽  
Vol 15 (1) ◽  
pp. e0008992
Author(s):  
Mulugeta Asefa Gutu ◽  
Alemayehu Bekele ◽  
Yimer Seid ◽  
Yusuf Mohammed ◽  
Fekadu Gemechu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Dengue Fever ◽  
Case Control Study ◽  
Larval Density ◽  
Case Control ◽  
Control Measures ◽  
Severe Dengue ◽  
Vector Surveillance ◽  
Eastern Ethiopia ◽  
Control Study

Background Dengue Fever (DF) is a viral disease primarily transmitted by Aedes (Ae.) aegypti mosquitoes. Outbreaks in Eastern Ethiopia were reported during 2014–2016. In May 2017, we investigated the first suspected DF outbreak from Kabridahar Town, Somali region (Eastern Ethiopia) to describe its magnitude, assess risk factors, and implement control measures. Methods Suspected DF cases were defined as acute febrile illness plus ≥2 symptoms (headache, fever, retro-orbital pain, myalgia, arthralgia, rash, or hemorrhage) in Kabridahar District residents. All reported cases were identified through medical record review and active searches. Severe dengue was defined as DF with severe organ impairment, severe hemorrhage, or severe plasma leakage. We conducted a neighborhood-matched case-control study using a subset of suspected cases and conveniently-selected asymptomatic community controls and interviewed participants to collect demographic and risk factor data. We tested sera by RT-PCR to detect dengue virus (DENV) and identify serotypes. Entomologists conducted mosquito surveys at community households to identify species and estimate larval density using the house index (HI), container index (CI) and Breteau index (BI), with BI≥20 indicating high density. Results We identified 101 total cases from May 12–31, 2017, including five with severe dengue (one death). The attack rate (AR) was 17/10,000. Of 21 tested samples, 15 (72%) were DENV serotype 2 (DENV 2). In the case-control study with 50 cases and 100 controls, a lack of formal education (AOR [Adjusted Odds Ratio] = 4.2, 95% CI [Confidence Interval] 1.6–11.2) and open water containers near the home (AOR = 3.0, 95% CI 1.2–7.5) were risk factors, while long-lasting insecticide treated-net (LLITN) usage (AOR = 0.21, 95% CI 0.05–0.79) was protective. HI and BI were 66/136 (49%) and 147 per 100 homes (147%) respectively, with 151/167 (90%) adult mosquitoes identified as Ae. aegypti. Conclusion The epidemiologic, entomologic, and laboratory investigation confirmed a DF outbreak. Mosquito indices were far above safe thresholds, indicating inadequate vector control. We recommended improved vector surveillance and control programs, including best practices in preserving water and disposal of open containers to reduce Aedes mosquito density.

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