scholarly journals Prefrontal pathways provide top down control of memory for sequences of events

2018 ◽  
Author(s):  
Maanasa Jayachandran ◽  
Stephanie Linley ◽  
Maximilian Schlecht ◽  
Stephen V. Mahler ◽  
Robert P. Vertes ◽  
...  
Keyword(s):  
Memory Retrieval ◽  
Perirhinal Cortex ◽  
Prelimbic Cortex ◽  
Control Sequence ◽  
Retrieval Strategy ◽  
Top Down ◽  
Nucleus Reuniens ◽  
Retrieval Strategies ◽  
Sequence Memory ◽  
Context Memory

SummaryWe remember our lives as sequences of events, but it is unclear how these memories are controlled during retrieval. In rats, prelimbic cortex (PL) is positioned to influence sequence memory through extensive top down inputs to the nucleus reuniens of the thalamus (RE) and perirhinal cortex (PER), regions heavily interconnected with the hippocampus. Here, we tested the hypothesis that specific PL➔RE and PL➔PER projections regulate sequence memory retrieval using an hM4Di synaptic-silencing approach. First, we show that the suppression of PL activity impairs sequence memory. Second, we show that inhibiting PL➔RE and PL➔PER pathways effectively eliminated sequence memory. Last, we performed a sequential lag analysis showing that the PL➔RE pathway contributes to a working memory retrieval strategy, and the PL➔PER pathway contributes to a temporal context memory retrieval strategy. These results demonstrate that the PL➔RE and PL➔PER pathways serve as top down mechanisms that control sequence memory retrieval strategies.

scholarly journals Distributed learning episodes create a context fear memory outside the hippocampus that depends on perirhinal and anterior cingulate cortices

2021 ◽  
Vol 28 (11) ◽  
pp. 405-413
Author(s):  
Elizabeth H. Shepherd ◽  
Neil M. Fournier ◽  
Robert J. Sutherland ◽  
Hugo Lehmann
Keyword(s):  
Retrograde Amnesia ◽  
Memory Retrieval ◽  
Distributed Learning ◽  
Perirhinal Cortex ◽  
Contextual Fear Conditioning ◽  
Anterior Cingulate ◽  
Contextual Fear ◽  
Combined Lesions ◽  
Cortical Regions ◽  
Context Memory

Damage to the hippocampus (HPC) typically causes retrograde amnesia for contextual fear conditioning. Repeating the conditioning over several sessions, however, can eliminate the retrograde amnesic effects. This form of reinstatement thus permits modifications to networks that can support context memory retrieval in the absence of the HPC. The present study aims to identify cortical regions that support the nonHPC context memory. Specifically, the contribution of the perirhinal cortex (PRH) and the anterior cingulate cortex (ACC) were examined because of their established importance to context memory. The findings show that context memories established through distributed reinstatement survive damage limited only to the HPC, PRH, or ACC. Combined lesions of the HPC and PRH, as well as the HPC and ACC, caused retrograde amnesia, suggesting that network modifications in the PRH and ACC enable context fear memories to become resistant to HPC damage.

Medial temporal lobe activation during autobiographical context memory retrieval of time and place and its dependency upon recency

Neurocase ◽  
2013 ◽  
Vol 21 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Silke Lux ◽  
Valeska N. Bindrich ◽  
Hans J. Markowitsch ◽  
Gereon R. Fink
Keyword(s):  
Temporal Lobe ◽  
Memory Retrieval ◽  
Medial Temporal Lobe ◽  
Context Memory

A hippocampal indexing model of memory retrieval based on state trajectory reconstruction

2013 ◽  
Vol 36 (6) ◽  
pp. 615-616
Author(s):  
Peter Ford Dominey
Keyword(s):  
Memory Retrieval ◽  
Cortical Activity ◽  
Memory Storage ◽  
Trajectory Reconstruction ◽  
Storage And Retrieval ◽  
State Trajectory ◽  
Indexing Model ◽  
Sequence Memory

AbstractA method is proposed where static patterns or snapshots of cortical activity that could be stored as hyperassociative indices in hippocampus can subsequently be retrieved and reinjected into the neocortex in order to enable neocortex to then proceed to unfold the corresponding sequence, thus implementing an index-based sequence memory storage and retrieval capability.

scholarly journals Age-related changes in neural oscillations supporting context memory retrieval

Cortex ◽  
2017 ◽  
Vol 91 ◽  
pp. 40-55 ◽  
Author(s):  
Jonathan Strunk ◽  
Taylor James ◽  
Jason Arndt ◽  
Audrey Duarte
Keyword(s):  
Memory Retrieval ◽  
Neural Oscillations ◽  
Age Related ◽  
Age Related Changes ◽  
Context Memory

scholarly journals The Paraventricular Thalamus is a Critical Mediator of Top-down Control of Cue-motivated Behavior in Rats

2019 ◽  
Author(s):  
Paolo Campus ◽  
Ignacio R. Covelo ◽  
Youngsoo Kim ◽  
Aram Parsegian ◽  
Brittany N. Kuhn ◽  
...  
Keyword(s):  
Maladaptive Behavior ◽  
Incentive Salience ◽  
Prelimbic Cortex ◽  
Emotional States ◽  
Nucleus Accumbens Shell ◽  
Top Down ◽  
Incentive Value ◽  
Motivated Behavior ◽  
Paraventricular Thalamus ◽  
Stimulation Of

AbstractCues in the environment can elicit complex emotional states, and thereby maladaptive behavior, as a function of their ascribed value. Here we capture individual variation in the propensity to attribute motivational value to reward-cues using the sign-tracker/goal-tracker animal model. Goal-trackers attribute predictive value to reward-cues, and sign-trackers attribute both predictive and incentive value. Using chemogenetics and microdialysis, we show that, in sign-trackers, stimulation of the neuronal pathway from the prelimbic cortex (PrL) to the paraventricular nucleus of the thalamus (PVT) decreases the incentive value of a reward-cue. In contrast, in goal-trackers, inhibition of the PrL-PVT pathway increases both the incentive value and dopamine levels in the nucleus accumbens shell. The PrL-PVT pathway, therefore, exerts top-down control over the dopamine-dependent process of incentive salience attribution. These results highlight PrL-PVT pathway as a potential target for treating psychopathologies associated with the attribution of excessive incentive value to reward-cues, including addiction.

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