scholarly journals The association of plasma lipids with white blood cell counts: Results from the Multi-Ethnic Study of Atherosclerosis

2018 ◽  
Author(s):  
Yong Chang Lai ◽  
Kevin J. Woollard ◽  
Robyn L. McClelland ◽  
Matthew A. Allison ◽  
Kerry-Anne Rye ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Ldl Cholesterol ◽  
Plasma Lipids ◽  
Hdl Cholesterol ◽  
Lipid Lowering ◽  
Total White Blood Cell ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

AbstractBackground and aimsPrevious studies have demonstrated that elevated cholesterol results in increased white blood cell counts in mouse models. However, there is insufficient evidence to support this in humans. We, therefore, investigated the relationship of plasma lipids with white blood cell counts (basophils, eosinophils, monocytes, neutrophils and lymphocytes) in the Multi-Ethnic Study of Atherosclerosis (MESA).MethodsThe analysis included 2873 MESA participants at visit 5 with a complete white blood count and differential analysis. The cross-sectional association of total cholesterol, LDL cholesterol, HDL cholesterol and triglyceride levels with different white blood cell counts was analyzed by multivariable linear regression.ResultsAfter adjusting sociodemographic and confounding factors including red blood cells counts, platelet counts, use of lipid-lowering medication, CVD risk factors and other lipid measures, and multiple testing correction, a 1-SD increment in total cholesterol and LDL cholesterol was associated with 2.8% and 2.3% (both p<0.001) lower total white blood cell counts. The same increment in ln-transformed triglyceride levels was associated with 2.3% higher total white blood cell counts, 2.9% higher lymphocyte counts and 2.7% lower monocyte counts (all p<0.001). HDL cholesterol was not associated with any white blood cell counts. Similar results were obtained after excluding participants taking lipid-lowering medication.ConclusionsWhilst significant associations were observed, the heterogenous and modest nature of the relationships between plasma lipid levels and white blood cell populations make it hard to support the hypothesis that lipids are in the causal pathway for leukogenesis.

scholarly journals Low HDL (High-Density Lipoprotein) Cholesterol and High White Blood Cell Counts

2020 ◽  
Author(s):  
Mads Harsløf ◽  
Kasper M. Pedersen ◽  
Børge G. Nordestgaard ◽  
Shoaib Afzal
Keyword(s):  
Blood Cell ◽  
High Density Lipoprotein ◽  
White Blood Cell ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Density ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Low Hdl ◽  
White Blood Cell Counts

Objective: Animal studies suggest that HDL (high-density lipoprotein) regulates proliferation and differentiation of hematopoietic stem cells. Using a Mendelian randomization approach, we tested the hypothesis that low HDL cholesterol is associated with high white blood cell counts. Approach and Results: We included 107 952 individuals aged 20 to 100 years from the Copenhagen General Population Study with information on HDL cholesterol, white blood cell counts, and 9 genetic variants associated with HDL cholesterol. In multivariable-adjusted observational analyses, HDL cholesterol was inversely associated with white blood cell counts. On a continuous scale, a 1-mmol/L (39 mg/dL) lower HDL cholesterol was associated with 5.1% (95% CI, 4.7%–5.4%) higher leukocytes, 4.5% (95% CI, 4.0%–4.9%) higher neutrophils, 5.7% (95% CI, 5.3%–6.1%) higher lymphocytes, 5.7% (95% CI, 5.3%–6.2%) higher monocytes, 14.8% (95% CI, 13.9%–15.8%) higher eosinophils, and 3.9% (95% CI, 3.1%–4.7%) higher basophils. In age- and sex-adjusted genetic analyses using the inverse-variance weighted analysis, a 1-mmol/L (39 mg/dL) genetically determined lower HDL cholesterol was associated with 2.2% (95% CI, 0.3%–4.1%) higher leukocytes, 4.3% (95% CI, 1.6%–7.1%) higher lymphocytes, 4.3% (95% CI, 2.6%–6.1%) higher monocytes, and 4.8% (95% CI, 1.2%–8.5%) higher eosinophils. Overall, the genetic associations were robust across sensitivity analyses and replicated using summary statistics from the UK Biobank with up to 350 470 individuals. Conclusions: Genetic and hence lifelong low HDL cholesterol was associated with high peripheral blood leukocytes, including high lymphocytes, monocytes, and eosinophils. The concordance between observational and genetic estimates and independent replication suggest a potential causal relationship.

scholarly journals The association of plasma lipids with white blood cell counts: Results from the Multi-Ethnic Study of Atherosclerosis

2019 ◽  
Vol 13 (5) ◽  
pp. 812-820 ◽  
Author(s):  
Yong Chang Lai ◽  
Kevin J. Woollard ◽  
Robyn L. McClelland ◽  
Matthew A. Allison ◽  
Kerry-Anne Rye ◽  
...  
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Plasma Lipids ◽  
Ethnic Study ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

scholarly journals PC160. Elevated Postoperative Neutrophil and Total White Blood Cell Counts Predict Wound Formation After Below-Knee Amputation

2019 ◽  
Vol 69 (6) ◽  
pp. e247
Author(s):  
Braden Palanuk ◽  
Nasibeh Vatankhah ◽  
Sheena K. Harris ◽  
Gregory Landry ◽  
Amir F. Azarbal
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Total White Blood Cell ◽  
Knee Amputation ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

scholarly journals Baseline haematological, serum biochemical and some urine parameters in Nigerian indigenous dogs

2018 ◽  
pp. 48-52
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Whole Blood ◽  
Clinicopathological Parameters ◽  
Total White Blood Cell ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Serum Biochemical ◽  
Healthy Dogs ◽  
White Blood Cell Counts

Introduction: Haematological and serum biochemical profiles of dogs are essential in the diagnosis and monitoring of systemic disease in veterinary medicine. The aim of this study was to determine the baseline haematological, serum biochemical and some urine parameters in clinically healthy dogs presented to the Veterinary teaching hospital (VTH), Ahmadu Bello University (A.B.U.), Zaria, Nigeria. Methods: Thirty apparently healthy dogs comprising of 19 males and 11 females aged between 9 to 36 months were sampled in this study. Whole blood was collected via cephalic venepuncture for determination of haematological parameters. Serum was processed from the whole blood to determine the concentrations of serum metabolites, serum electrolytes, blood urea nitrogen (BUN)/creatinine ratio, anion gap (AG) as well as serum activities of liver enzymes. Urinalysis was done using urine. Data was analysed using Graph pad prism version 5.2. Mean values were determined. Results: No significant (p > 0.05) differences related to sex were observed in the values of packed cell volume (PCV), haemoglobin (Hb) concentration, red blood cell counts (RBC), mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCHC), differential and total white blood cell counts. The PCV (p < 0.005), Hb (p < 0.05) and Hb (p < 0.01) of the adults were significantly higher in the young Nigerian indigenous dogs. However, the MCV, MCHC, differential and total white blood cell counts were insignificant in both age groups. Significance: These baseline data would help clinicians to recognize deviations from normal clinicopathological parameters especially in Nigerian Indigenous dogs.

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