scholarly journals Age-related changes in MEG theta and alpha oscillatory signatures of attentional control

2018 ◽  
Author(s):  
Eleanor Huizeling ◽  
Hongfang Wang ◽  
Carol Holland ◽  
Klaus Kessler
Keyword(s):  
Attentional Control ◽  
Age Groups ◽  
Visual Presentation ◽  
Theta Oscillations ◽  
Older Individuals ◽  
Middle Aged ◽  
Attention Task ◽  
Age Related ◽  
Middle Aged Adults ◽  
Age Related Changes

AbstractIn our recent behavioural research (Callaghan et al., 2017), we reported age-related changes in the costs of switching between from a temporal (rapid serial visual presentation) to a spatial (visual search) attention task. Using magnetoencephalography, we have now compared the neural signatures of attention refocusing between three age groups (19-30, 40-49 and 60+ years) and found differences in task-related modulation and cortical localisation of alpha and theta oscillations. Efficient, faster switching between the temporal and spatial attention tasks in the youngest group compared to both older groups was reflected in parietal theta effects that were significantly reduced in the older groups. Residual parietal theta activity in older individuals was, however, beneficial to attentional switching, and could reflect the preservation of attention mechanisms. Difficulties in refocusing attention in the older and middle-aged adults (slowed response times) were accompanied by reduced theta power modulation in occipital and cerebellar regions. In addition to this posterior theta deficit, older and middle-aged adults presented with increased recruitment of frontal (both groups) and temporal (older group) areas. Theta oscillations therefore demonstrated a posterior to anterior processing shift, which may reflect the engagement of alternative strategies in older- and middle-age, such as top-down attentional control in an attempt to compensate for posterior processing deficits. Additional frontal theta recruitment indeed appeared to be beneficial for faster performance, as reflected by correlational analysis. Temporal theta (in older-age), however, did not correlate with performance, but could reflect strategies unrelated to speeded performance (e.g. silent vocalisation to maintain task goals). Alpha oscillations did not significantly correlate with task performance, possibly reflecting decreased neural precision or de-differentiation, but require further investigation.

Effect of aging on tracheal mucociliary clearance in beagle dogs

1987 ◽  
Vol 62 (3) ◽  
pp. 1331-1334 ◽  
Author(s):  
S. L. Whaley ◽  
B. A. Muggenburg ◽  
F. A. Seiler ◽  
R. K. Wolff
Keyword(s):  
Young Adult ◽  
Gamma Camera ◽  
Mucociliary Clearance ◽  
Age Groups ◽  
Beagle Dogs ◽  
Velocity Measurements ◽  
Middle Aged ◽  
Age Related ◽  
Age Related Changes ◽  
Made In

Tracheal mucous velocity measurements were made in 24 beagle dogs in five age groups, using a gamma camera to detect movement of instilled 99mTc-macroaggregated albumin. Age groups were defined as immature (9–10 mo), young adult (2.8–3.0 yr), middle aged (6.7–6.9 yr), mature (9.6–9.8 yr), and aged dogs (13.6–16.2 yr). Mean velocities were 3.6 +/- 0.4 (SE) mm/min in the immature dogs, 9.7 +/- 0.6 mm/min in the young adults, 6.9 +/- 0.5 mm/min in the middle-aged dogs, 3.5 +/- 0.8 mm/min in the mature dogs, and 2.9 +/- 0.5 mm/min in the aged dogs. Tracheal mucous velocity was significantly (P less than 0.05) greater in the young adult and middle-aged groups compared with the immature, mature, and aged dogs. This pattern of age-related changes was noted to be similar to age-related changes described for certain pulmonary function measurements.

scholarly journals Event Centrality of Positive and Negative Autobiographical Memories in Older Adulthood

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 712-712
Author(s):  
Justina Pociunaite ◽  
Tabea Wolf
Keyword(s):  
Older Adults ◽  
Individual Differences ◽  
Life Experience ◽  
Age Groups ◽  
Openness To Experience ◽  
Middle Aged ◽  
Younger Adults ◽  
Age Related ◽  
Middle Aged Adults ◽  
Positive Memories

Abstract Centrality of an event (CE) is a characteristic denoting how important a life experience is to one’s identity. Usually, positive memories are more central than negative ones in the community samples. Nevertheless, there is emerging evidence showing substantial individual differences in how one perceives CE. Especially regarding age, one could expect pronounced differences due to age-related changes in personal goals. In this study, we investigated how older adults differ from young and middle-aged adults. Apart from age, we tested whether personality traits such as neuroticism and openness to experience influence the CE ratings among age groups. The sample comprised of 363 German participants, age ranging from 18 to 89 (M=49.57, SD=17.087), 67.2 % of the sample were women. Using multilevel analysis, we found the CE of positive memories to be higher in all age groups. The CE of positive events significantly differed for older adults compared to younger adults but not to the middle-aged group. With respect to personality, neuroticism had an impact only on the CE of negative memories in younger and middle-aged adults. For older adults, neither neuroticism, nor openness to experience had an impact on CE ratings. This shows that while older adults significantly differ from younger adults in the CE of positive memories, other individual differences characteristics do not have an impact on the way older adults perceive memories as central to their identity.

scholarly journals Age-related changes of neutrophil characteristics, potential of activation, DNA release and NET formation

2020 ◽  
Author(s):  
Moritz Krall ◽  
Lisa-Marie Mauracher ◽  
Johanna Roiss ◽  
Lena Hell ◽  
Anna S Ondracek ◽  
...  
Keyword(s):  
Age Groups ◽  
Membrane Receptors ◽  
Lower Amount ◽  
Older Individuals ◽  
Activation Markers ◽  
Disease States ◽  
Age Related ◽  
Release Assay ◽  
Dna Release ◽  
Age Related Changes

Abstract Background: Neutrophils are a heterogeneous population of leukocytes, which can be subdivided into high and low density neutrophils (HDNs/LDNs). They are known to fight intruders with different mechanisms, including the release of neutrophil extracellular traps (NETs), which have also been associated with thrombosis. Risks of infection and thrombosis increase with age. Differences in neutrophil subpopulations and functionality have been shown in various disease states, but investigations in healthy subjects and their dependence on age are lacking. The aim of this study was to investigate age-related changes in neutrophils regarding neutrophil subpopulations, their potential of activation, DNA release and NET formation.Methods: Neutrophil subpopulations (HDNs and LDNs) were isolated from 25 healthy individuals subdivided into 3 groups (<45 years, n=8; 45-54, n=9; >54, n=8). Neutrophil characteristics, potential of activation and the ability of NET formation was investigated using flow cytometry. Externalisation of DNA was detected by a DNA release assay.Results: HDN and LDN counts did not differ between age-groups. However, with increasing age we observed a shift in neutrophil subpopulations towards a lower amount of mature LDNs, characterized by their expression of membrane receptors CD62L and CD16. Upon stimulation, neutrophils of older individuals showed significantly higher release of DNA. HDNs of younger participants increased activation markers (CD66b and CD11b) to a higher extent compared to those of older individualsConclusion: Neutrophils and their ability of activation, DNA release and NET formation change with age and this might contribute to the higher risk of infection and thrombosis at advanced age. Furthermore, these results highlight the importance and necessity of age-matching in studies that focus on neutrophil characteristics.

The emergence of age-related changes in recognition memory in healthy middle-aged adults using the CVLT-II

2019 ◽  
Vol 27 (6) ◽  
pp. 854-863 ◽  
Author(s):  
Mckenna E. Williams ◽  
Lisa V. Graves ◽  
Emily J. Van Etten ◽  
Heather M. Holden ◽  
Lisa Delano-Wood ◽  
...  
Keyword(s):  
Recognition Memory ◽  
Middle Aged ◽  
Age Related ◽  
Middle Aged Adults ◽  
Age Related Changes

scholarly journals Age-related changes of neutrophil characteristics, potential of activation, DNA release and NET formation

2020 ◽  
Author(s):  
Moritz Krall ◽  
Lisa-Marie Mauracher ◽  
Johanna Roiss ◽  
Lena Hell ◽  
Anna S Ondracek ◽  
...  
Keyword(s):  
Age Groups ◽  
Membrane Receptors ◽  
Lower Amount ◽  
Older Individuals ◽  
Activation Markers ◽  
Disease States ◽  
Age Related ◽  
Thrombosis Risk ◽  
Dna Release ◽  
Age Related Changes

Abstract Background: Neutrophils are a heterogeneous population of leukocytes, which can be subdivided into high and low density neutrophils (HDNs/LDNs). They are known to fight intruders with different mechanisms, including the release of neutrophil extracellular traps (NETs), which have also been associated with thrombosis. Risk of both, thrombosis and infections, increase with age. Differences in neutrophil subpopulations and functionality have been shown in various disease states, but investigations in healthy subjects and their dependence on age are lacking. The aim of this study was to investigate age-related changes in neutrophils regarding neutrophil subpopulations, their potential of activation, DNA release and NET formation. Methods: Neutrophil subpopulations (HDNs and LDNs) were isolated from 25 healthy individuals subdivided into 3 groups (<45 years, n=8; 45-54, n=9; >54, n=8). Neutrophil characteristics, potential of activation and the ability of NET formation were investigated using flow cytometry. Externalisation of DNA was detected by a DNA release assay. Results: HDN and LDN counts did not differ between age-groups. However, with increasing age we observed a shift in neutrophil subpopulations towards a lower amount of mature LDNs, characterized by their expression of membrane receptors CD62L and CD16. Upon stimulation, neutrophils of older individuals showed significantly higher release of DNA. NET formation was associated with increasing age. HDNs of younger participants increased activation markers (CD66b and CD11b) to a higher extent compared to those of older individuals. Conclusion: Neutrophils and their ability of activation, DNA release and NET formation change with age and this might contribute to the higher risk of infection and thrombosis at advanced age. Furthermore, these results highlight the importance and necessity of age-matching in studies that focus on neutrophil characteristics.

scholarly journals Effect of Age on the Touchscreen Manipulation Ability of Community-Dwelling Adults

2021 ◽  
Vol 18 (4) ◽  
pp. 2094
Author(s):  
Michal Elboim-Gabyzon ◽  
Patrice L. Weiss ◽  
Alexandra Danial-Saad
Keyword(s):  
Older Adults ◽  
Assessment Tool ◽  
Low Cost ◽  
Age Groups ◽  
Community Dwelling ◽  
Older Individuals ◽  
Middle Aged ◽  
Usability Assessment ◽  
System Usability Scale ◽  
Middle Aged Adults

Assessment of touchscreen manipulation skills is essential for determining the abilities of older individuals and the extent to which they may benefit from this technology as a means to enhance participation, self-esteem, and quality of life. The aim of this study was to compare the touchscreen manipulation ability between community-dwelling older adults and middle-aged adults using a newly developed Touchscreen Assessment Tool (TATOO) and to determine the usability of this instrument. Convenience samples of two age groups were considered, one including 28 independent community-living older adults aged 81.9 ± 4.2 years with intact or corrected vision and with the abilities to walk independently with or without a walking aid and to understand and follow simple commands, and the other including 25 healthy middle-age adults aged 53.4 ± 5.9 years. The usability assessment was conducted during a single session using the System Usability Scale (SUS). Older adults demonstrated poorer touchscreen skills compared to middle-aged adults. Previous experience in manipulating a smartphone by the older adults did not affect their performance. The SUS results indicated good usability of the TATOO by both age groups. The TATOO shows promise as a user-friendly tool for assessing the specific skills needed to operate touchscreens. The outcomes of this study support the suitability of touchscreen devices and applications as well as the need for adapted accessibility for older adults. Researchers and clinicians will benefit from the availability of a rapid, low-cost, and objective tool to assess the skills required for touchscreen use.

scholarly journals THE UNCANNY VALLEY REVISITED: AGE-RELATED DIFFERENCE AND THE EFFECT OF FUNCTION TYPE

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S330-S330
Author(s):  
Yun-Chen Tu ◽  
Sung-En Chien ◽  
Yueh-Yi Lai ◽  
Jen-Chi Liu ◽  
Su-Ling Yeh
Keyword(s):  
Older Adults ◽  
Age Groups ◽  
Uncanny Valley ◽  
Middle Aged ◽  
Function Type ◽  
Younger Adults ◽  
Assistive Robots ◽  
The Uncanny ◽  
Age Related ◽  
Middle Aged Adults

Abstract Due to declined birthrate and the increased aging population, solving the problem of labor shortage has become important. Introducing robotic labors could effectively help older adults’ daily lives. However, older adults’ acceptance of robots was lower than younger adults. Robot’s appearance might be one of the reasons. The Uncanny Valley (UV) refers to the phenomenon that people rate more positively as robots become more humanlike, but only up to a certain point; as it approaches near-perfect similarity of human appearance, likeability drops and forms an uncanny valley. Nonetheless, previous results supporting the UV were mainly from younger adults. We examined whether the UV is also applicable for older and middle-aged adults. We also examined whether the acceptance of function (companion vs. service) would change based on robot appearance, and whether robot-induced traits have any relation with the acceptance of robot function. We asked younger (N= 80, age 18-39), middle-aged (N= 87, age 40-59), and older (N= 88, age 60-87) adults to view each picture of 84 robots and evaluate their impression of each robot and intention of use regarding robot function. Contrary to the UV found for younger and middle-aged adults, older adults did not show UV–they preferred humanlike over non-humanlike robots, regardless of the robot function. Scores on each trait–except for authoritativeness–showed positive correlations with the acceptance of functions. These findings imply that the design of assistive robots should take UV into consideration by customizing robots’ appearances and functions to different age groups.

scholarly journals Age-Related Differences of Rumination on the Loneliness-Depression Relationship: Evidence from a Population-Representative Cohort

2021 ◽  
Author(s):  
Horace Tong ◽  
Wai Kai Hou ◽  
Li Liang ◽  
Tsz Wai Li ◽  
Huinan Liu ◽  
...  
Keyword(s):  
Older Adults ◽  
Depressive Symptoms ◽  
Age Groups ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Middle Aged ◽  
Cross Sectional ◽  
Age Related ◽  
Affective Symptoms ◽  
Middle Aged Adults

Abstract Background and Objective This study examined the association of loneliness with depressive symptoms across various age groups. Loneliness is a significant risk factor for precipitating depressive symptoms. Rumination, a mechanism that underpins depression, can become intense when a person feels lonely. In addition, age is a major factor associated with changes in mental and physical health. Thus, the importance of rumination and age in moderating the loneliness–depression link were investigated. Research Design and Methods This cross-sectional study was conducted during the acute phase of the COVID-19 pandemic in Hong Kong (February 27 to March 17, 2020). A population-representative sample of 2,018 people (1,126 females; 15–92 years of age) was recruited and interviewed via telephone through random digit dialling. This sample included 394 younger adults (18–30 years), 1,106 middle-aged adults (31–64 years), and 472 older adults (65 years or above). Respondents reported depressive symptoms, subjective loneliness, state rumination, and sociodemographic factors. Results Loneliness and rumination were positively associated with depressive symptoms, and they significantly interacted in predicting cognitive-affective symptoms. Further analysis of age showed that the interaction was only significant only in middle-aged adults and older adults. Both rumination and age interacted with loneliness respectively in predicting cognitive-affective symptoms. Discussion and Implications These findings indicate that the strength of the association between loneliness and the cognitive-affective symptoms of depression depends on rumination levels and age. An intervention to regulate rumination offers a feasible direction for health care and social care aimed at improving older adults’ mental health.

Perceptions of Sex Roles of Young and Middle-Aged Women and Men

1982 ◽  
Vol 55 (2) ◽  
pp. 559-562
Author(s):  
Claire Etaugh ◽  
Sharon Weber
Keyword(s):  
College Students ◽  
Sex Roles ◽  
Sex Role ◽  
Middle Aged ◽  
Age Related ◽  
Aged Woman ◽  
Male College ◽  
Middle Aged Woman ◽  
Age Related Changes ◽  
Female Subjects

48 female and 48 male college students used the Bern Sex-role Inventory to describe either a young or middle-aged woman or man. Female subjects perceived that women become increasingly feminine and less androgynous with age. No age-related changes were perceived in men's sex-role behaviors.

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