scholarly journals Impact of temperature and photoperiod on survival and biomarkers of senescence in common woodlouse

2018 ◽  
Author(s):  
Charlotte Depeux ◽  
Ascel Samba-Louaka ◽  
Christine Braquart-Varnier ◽  
Jérôme Moreau ◽  
Jean-François Lemaître ◽  
...  
Keyword(s):  
Experimental Design ◽  
Environmental Factors ◽  
Environmental Conditions ◽  
Opposite Effect ◽  
Experimental Approach ◽  
Galactosidase Activity ◽  
Age Related ◽  
Living Organisms ◽  
The Impact

AbstractMost living organisms display a decline in physiological performances when ageing, a process called senescence that is most often associated with increased mortality risk. Previous researches have shown that both the timing and the intensity of senescence vary a lot within and among species, but the role of environmental factors in this variation is still poorly understood. To fill this knowledge gap, we investigated the impact of environmental conditions on the strength of senescence using an experimental design applied to a population of common woodlouse Armadillidium vulgare intensively monitored in the lab. Cellular senescence biomarkers are available in woodlouse and are age-related. These biomarkers provide relevant biomarkers to test the impact of environmental conditions, through changes in temperature and photoperiod, on individuals of the same age maintained in different environmental conditions. We found different effects of the environmental changing: the increasing of day light modification leaded the same effect as age on our senescence biomarkers while temperature modifications leaded the opposite effect as age on the β-galactosidase activity and cell size. We also demonstrated the existence of sex-specific responses to changes in environmental conditions. By using an experimental approach and biomarkers of senescence in woodlouse, we show that environmental conditions and sex both shape the diversity observed in senescence patterns of woodlouse and underline the importance of identifying senescence biomarkers to understand how environmental conditions influence the evolution of senescence.

scholarly journals Adolescence as a “critical period” in the heritage language use. Polish in Germany

2021 ◽  
Vol 7 (1) ◽  
pp. 301-315
Author(s):  
Hanna Pułaczewska
Keyword(s):  
Role Models ◽  
Personal Development ◽  
Critical Period ◽  
Growing Up ◽  
Age Related ◽  
The Media ◽  
Role Of Parents ◽  
Qualitative Part ◽  
The Impact

Abstract In the article, we consider the impact of adolescence upon the usage of Polish in Polish-German bilinguals raised and living in Germany and demonstrate how adolescence surfaces as a socially based “critical period” in this usage using results from a survey and interviews conducted with 30 teenagers. In the quantitative part of the study, we seek to establish whether adolescents’ age affected the pattern and quantity of their usage of Polish in the media and contacts with age peers, whether the latter two facets of growing up with Polish were interrelated, and which other factors affected peer-relevant activities in Polish. Both age and peer contact turned out to significantly affect the use of the media in Polish, while peer contact in Polish was affected by the parental use of Polish in parent-child communication. The qualitative part presents the context and motivation for using Polish by the youths in peer-relevant activities. We integrate the results with insights provided by child development psychology from the perspective of language socialisation theory and interpret the age-related decline of interest in the Polish media as an effect of a diminishing role of parents and the increasing role of age peers as role models in personal development.

UNDERSTANDING THE GREY ENTREPRENEUR

2004 ◽  
Vol 12 (02) ◽  
pp. 147-164 ◽  
Author(s):  
PAULL WEBER ◽  
MICHAEL SCHAPER
Keyword(s):  
Female Entrepreneurs ◽  
Role Of Government ◽  
Related Data ◽  
Age Related ◽  
Individual Enterprise ◽  
Management Experience ◽  
Productive Ageing ◽  
Developed World ◽  
The Impact

Demographic trends in the developed world indicate that older entrepreneurs will play an increasingly important part of economic activity as populations age, yet this cohort has been largely ignored in entrepreneurship research. This paper provides an overview of current research about the so-called "grey entrepreneur" (also known as senior, older, third age or elderly entrepreneurs), drawing on research from a number of nations. The extant literature indicates that a majority of older entrepreneurs are male, although the number of older female entrepreneurs is increasing; they are also less likely to possess formal educational qualifications than younger entrepreneurs. Some of the advantages that such entrepreneurs possess include greater levels of technical, industrial and management experience; superior personal networks; and a stronger financial asset base. Some of the disadvantages or potential barriers faced by older entrepreneurs can include lower levels of health, energy and productivity; ageism; and the value that his or her society places on active ("productive") ageing. Numerous issues still remain to be investigated in this field of research. These include the differences between younger and older entrepreneurs; their motives and success criteria; the impact of financial, knowledge and other resources on venturing behaviour; the role of government policies in fostering or hampering individual enterprise; and the significance of cultural differences amongst older entrepreneurs. Research in this field is currently also hampered by a multiplicity of terms and definitions, a lack of age-related data about different entrepreneurial cohorts, and the problems inherent in operationalising the concept of the "grey entrepreneur."

scholarly journals The Origin and Evolution of Language and the Propagation of Organization

1970 ◽  
Vol 5 (2) ◽  
pp. 75-81 ◽  
Author(s):  
Robert K. Logan
Keyword(s):  
Knowledge Management ◽  
New Media ◽  
Evolution Of Language ◽  
Origin And Evolution ◽  
Language And Culture ◽  
Origin Of Language ◽  
Engineering Problems ◽  
Living Organisms ◽  
The Impact

In this presentation we will study propagating organization. We begin by examining the evolution and origin of language by briefly reviewing the impact of the phonetic alphabet (Logan 2004a), the evolution of notated language (Logan 2004b), the origin of language and culture (Logan 2006, 2007), the role of collaboration in knowledge management (Logan and Stokes 2004), the impact of “new media” (Logan in preparation). We will then connect this work to the propagating organization of all living organisms (Kauffman et al. in press) where we will show that information in biotic systems are the constraints that instruct living organisms how to operate. We will demonstrate that instructional or biotic information is quite different than the classical notion of information Shannon developed for addressing engineering problems in telecommunications. We also will show that biosemiosis is in some sense equivalent to propagating organization (Kauffman et al. in press). We then conclude our presentation with the speculation that there exist at least seven levels of biosemiosis.

scholarly journals Estrogen Receptor and Vascular Aging

2021 ◽  
Vol 2 ◽  
Author(s):  
Morgane Davezac ◽  
Melissa Buscato ◽  
Rana Zahreddine ◽  
Patrick Lacolley ◽  
Daniel Henrion ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cardiovascular Diseases ◽  
Experimental Studies ◽  
Hormonal Treatment ◽  
Protective Effects ◽  
Age Related ◽  
Nuclear Receptor Family ◽  
The Impact ◽  
Receptor Family

Cardiovascular diseases remain an age-related pathology in both men and women. These pathologies are 3-fold more frequent in men than in women before menopause, although this difference progressively decreases after menopause. The vasculoprotective role of estrogens are well established before menopause, but the consequences of their abrupt decline on the cardiovascular risk at menopause remain debated. In this review, we will attempt to summarize the main clinical and experimental studies reporting the protective effects of estrogens against cardiovascular diseases, with a particular focus on atherosclerosis, and the impact of aging and estrogen deprivation on their endothelial actions. The arterial actions of estrogens, but also part of that of androgens through their aromatization into estrogens, are mediated by the estrogen receptor (ER)α and ERβ. ERs belong to the nuclear receptor family and act by transcriptional regulation in the nucleus, but also exert non-genomic/extranuclear actions. Beside the decline of estrogens at menopause, abnormalities in the expression and/or function of ERs in the tissues, and particularly in arteries, could contribute to the failure of classic estrogens to protect arteries during aging. Finally, we will discuss how recent insights in the mechanisms of action of ERα could contribute to optimize the hormonal treatment of the menopause.

scholarly journals Interactions between Climate and Nutrient Cycles on Forest Response to Global Change: The Role of Mixed Forests

Forests ◽  
2019 ◽  
Vol 10 (8) ◽  
pp. 609 ◽  
Author(s):  
Ester González de Andrés
Keyword(s):  
Climate Change ◽  
Global Change ◽  
Environmental Conditions ◽  
Species Interactions ◽  
N Deposition ◽  
Elemental Ratios ◽  
Nutrient Mineralization ◽  
Carbon Dioxide Co2 ◽  
The Impact

Forest ecosystems are undergoing unprecedented changes in environmental conditions due to global change impacts. Modification of global biogeochemical cycles of carbon and nitrogen, and the subsequent climate change are affecting forest functions at different scales, from physiology and growth of individual trees to cycling of nutrients. This review summarizes the present knowledge regarding the impact of global change on forest functioning not only with respect to climate change, which is the focus of most studies, but also the influence of altered nitrogen cycle and the interactions among them. The carbon dioxide (CO2) fertilization effect on tree growth is expected to be constrained by nutrient imbalances resulting from high N deposition rates and the counteractive effect of increasing water deficit, which interact in a complex way. At the community level, responses to global change are modified by species interactions that may lead to competition for resources and/or relaxation due to facilitation and resource partitioning processes. Thus, some species mixtures can be more resistant to drought than their respective pure forests, albeit it depends on environmental conditions and species’ functional traits. Climate change and nitrogen deposition have additional impacts on litterfall dynamics, and subsequent decomposition and nutrient mineralization processes. Elemental ratios (i.e., stoichiometry) are associated with important ecosystem traits, including trees’ adaptability to stress or decomposition rates. As stoichiometry of different ecosystem components are also influenced by global change, nutrient cycling in forests will be altered too. Therefore, a re-assessment of traditional forest management is needed in order to cope with global change. Proposed silvicultural systems emphasize the key role of diversity to assure multiple ecosystem services, and special attention has been paid to mixed-species forests. Finally, a summary of the patterns and underlying mechanisms governing the relationships between diversity and different ecosystems functions, such as productivity and stability, is provided.

scholarly journals Basic Income, Wages, and Productivity: A Laboratory Experiment

2019 ◽  
Vol 14 (2) ◽  
Author(s):  
Veera Amanda Jokipalo
Keyword(s):  
Labor Market ◽  
Experimental Design ◽  
Laboratory Experiment ◽  
Gift Exchange ◽  
Cash Transfers ◽  
Unemployment Benefit ◽  
Basic Income ◽  
Unemployment Benefits ◽  
The Impact

Abstract This paper reports the results of an economic lab experiment designed to test the impact of Basic Income (BI) on wages and productivity. The experimental design is based on the classic gift exchange game. Participants assigned the role of employer were tasked with making wage offers, and those assigned as employees chose how hard they would work in return. In addition to a control without any social security net, BI was compared to unemployment benefits, and both types of cash transfers were tested at two levels. The results are that wage offers were increased in both the BI and unemployment benefit treatments compared to the control. The higher-level BI treatment also significantly increased effort. Further experimentation could shed more light on how the potential extra value created in the labor market through increased productivity would be divided between employers and employees.

scholarly journals The Role of Counter-Ions in Peptides—An Overview

2020 ◽  
Vol 13 (12) ◽  
pp. 442
Author(s):  
Karol Sikora ◽  
Maciej Jaśkiewicz ◽  
Damian Neubauer ◽  
Dorian Migoń ◽  
Wojciech Kamysz
Keyword(s):  
Mobile Phase ◽  
Analytical Techniques ◽  
Drug Formulation ◽  
Biological Processes ◽  
Multiple Functions ◽  
Mobile Phase Additives ◽  
Counter Ions ◽  
Living Organisms ◽  
The Impact

Peptides and proteins constitute a large group of molecules that play multiple functions in living organisms. In conjunction with their important role in biological processes and advances in chemical approaches of synthesis, the interest in peptide-based drugs is still growing. As the side chains of amino acids can be basic, acidic, or neutral, the peptide drugs often occur in the form of salts with different counter-ions. This review focuses on the role of counter-ions in peptides. To date, over 60 peptide-based drugs have been approved by the FDA. Based on their area of application, biological activity, and results of preliminary tests they are characterized by different counter-ions. Moreover, the impact of counter-ions on structure, physicochemical properties, and drug formulation is analyzed. Additionally, the application of salts as mobile phase additives in chromatographic analyses and analytical techniques is highlighted.

scholarly journals Sleep as a Mediator in the Pathway Linking Environmental Factors to Hypertension: A Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Oluwaseun A. Akinseye ◽  
Stephen K. Williams ◽  
Azizi Seixas ◽  
Seithikurippu R. Pandi-Perumal ◽  
Julian Vallon ◽  
...  
Keyword(s):  
African American ◽  
Environmental Factors ◽  
Sleep Quality ◽  
Noise Exposure ◽  
Outcome Variable ◽  
African American Community ◽  
Poor Sleep ◽  
Main Outcome Variable ◽  
The Impact

Environmental factors, such as noise exposure and air pollution, are associated with hypertension. These environmental factors also affect sleep quality. Given the growing evidence linking sleep quality with hypertension, the purpose of this review is to investigate the role of sleep as a key mediator in the association between hypertension and environmental factors. Through this narrative review of the extant literature, we highlight that poor sleep quality mediates the relationship between environmental factors and hypertension. The conceptual model proposed in this review offers opportunities to address healthcare disparities in hypertension among African Americans by highlighting the disparate impact that the predictors (environmental factors) and mediator (sleep) have on the African-American community. Understanding the impact of these factors is crucial since the main outcome variable (hypertension) severely burdens the African-American community.

scholarly journals Mutational Signatures as Sensors of Environmental Exposures: Role of Smoking in COVID-19 Vulnerabilities

2021 ◽  
Author(s):  
Yoo-Ah Kim ◽  
Ermin Hodzic ◽  
Ariella Saslafsky ◽  
Damian Wojtowicz ◽  
Bayarbaatar Amgalan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Environmental Factors ◽  
Disease Progression ◽  
Environmental Exposures ◽  
Biological Processes ◽  
Mutational Signatures ◽  
Mutational Signature ◽  
The Impact ◽  
Pathway Level

Background: Environmental exposures such as smoking are widely recognized risk factors in the emergence of lung diseases such as lung cancer and acute respiratory distress syndrome (ARDS). However, the strength of environmental exposures is difficult to measure, making it challenging to understand their impacts. On the other hand, some COVID-19 patients develop ARDS in an unfavorable disease progression and smoking has been suggested as a potential risk factor among others. Yet initial studies on COVID-19 cases reported contradictory results on the effects of smoking on the disease. Some suggest that smoking might have a protective effect against it while other studies report an increased risk. A better understanding of how the exposure to smoking and other environmental factors affect biological processes relevant to SARS-CoV-2 infection and unfavorable disease progression is needed. Approach: In this study, we utilize mutational signatures associated with environmental factors as sensors of their exposure level. Many environmental factors including smoking are mutagenic and leave characteristic patterns of mutations, called mutational signatures, in affected genomes. We postulated that analyzing mutational signatures, combined with gene expression, can shed light on the impact of the mutagenic environmental factors to the biological processes. In particular, we utilized mutational signatures from lung adenocarcinoma (LUAD) data set collected in TCGA to investigate the role of environmental factors in COVID-19 vulnerabilities. Integrating mutational signatures with gene expression in normal tissues and using a pathway level analysis, we examined how the exposure to smoking and other mutagenic environmental factors affects the infectivity of the virus and disease progression. Results: By delineating changes associated with smoking in pathway-level gene expression and cell type proportions, our study demonstrates that mutational signatures can be utilized to study the impact of exogenous mutagenic factors on them. Consistent with previous findings, our analysis showed that smoking mutational signature (SBS4) is associated with activation of cytokines mediated singling pathways, leading to inflammatory responses. Smoking related changes in cell composition were also observed, including the correlation of SBS4 with the expansion of goblet cells. On the other hand, increased basal cells and decreased ciliated cells in proportion were associated with the strength of a different mutational signature (SBS5), which is present abundantly but not exclusively in smokers. In addition, we found that smoking increases the expression levels of genes that are upregulated in severe COVID-19 cases. Jointly, these results suggest an unfavorable impact of smoking on the disease progression and also provide novel findings on how smoking impacts biological processes in lung.

scholarly journals Age-related Attenuation of Isoflurane Preconditioning in Human Atrial Cardiomyocytes

2008 ◽  
Vol 108 (4) ◽  
pp. 612-620 ◽  
Author(s):  
Yasushi Mio ◽  
Martin W. Bienengraeber ◽  
Jasna Marinovic ◽  
David D. Gutterman ◽  
Mladen Rakic ◽  
...  
Keyword(s):  
Cell Death ◽  
Respiratory Function ◽  
Right Atrial ◽  
Channel Activity ◽  
Age Related ◽  
Isolated Myocardium ◽  
The Impact ◽  
Mitochondrial Respiratory

Background Clinical trials suggest that anesthetic-induced preconditioning (APC) produces cardioprotection in humans, but the mechanisms of APC and significance of aging for APC in humans are not well understood. Here, the impact of age on the role of two major effectors of APC, mitochondria and sarcolemmal adenosine triphosphate-sensitive potassium (sarcKATP) channels, in preconditioning of the human atrial myocardium were investigated. Methods Right atrial appendages were obtained from adult patients undergoing cardiac surgery and assigned to mid-aged (MA) and old-aged (OA) groups. APC was induced by isoflurane in isolated myocardium and isolated cardiomyocytes. Mitochondrial oxygen consumption measurements, myocyte survival testing, and patch clamp techniques were used to investigate mitochondrial respiratory function and sarcKATP channel activity. Results After in vitro APC with isoflurane, the respiratory function of isolated mitochondria was better preserved after hypoxia-reoxygenation stress in MA than in OA. In isolated intact myocytes, APC significantly decreased oxidative stress-induced cell death in MA but not in OA, and isoflurane protection from cell death was attenuated by the sarcKATP channel inhibitor HMR-1098. Further, the properties of single sarcKATP channels were similar in MA and OA, and isoflurane sensitivity of pinacidil-activated whole cell KATP current was no different between MA and OA myocytes. Conclusion Anesthetic-induced preconditioning with isoflurane decreases stress-induced cell death and preserves mitochondrial respiratory function to a greater degree in MA than in OA myocytes; however, sarcKATP channel activity is not differentially affected by isoflurane. Therefore, effectiveness of APC in humans may decrease with advancing age partly because of altered mitochondrial function of myocardial cells.

Sign in / Sign up

Export Citation Format

Share Document