scholarly journals An introduction to MPEG-G, the new ISO standard for genomic information representation

2018 ◽  
Author(s):  
Claudio Albert ◽  
Tom Paridaens ◽  
Jan Voges ◽  
Daniel Naro ◽  
Junaid J. Ahmad ◽  
...  

AbstractThe MPEG-G standardization initiative is a coordinated international effort to specify a compressed data format that enables large scale genomic data to be processed, transported and shared. The standard consists of a set of specifications (i.e., a book) describing: i) a nor-mative format syntax, and ii) a normative decoding process to retrieve the information coded in a compliant file or bitstream. Such decoding process enables the use of leading-edge com-pression technologies that have exhibited significant compression gains over currently used formats for storage of unaligned and aligned sequencing reads. Additionally, the standard provides a wealth of much needed functionality, such as selective access, data aggregation, ap-plication programming interfaces to the compressed data, standard interfaces to support data protection mechanisms, support for streaming and a procedure to assess the conformance of implementations. ISO/IEC is engaged in supporting the maintenance and availability of the standard specification, which guarantees the perenniality of applications using MPEG-G. Fi-nally, the standard ensures interoperability and integration with existing genomic information processing pipelines by providing support for conversion from the FASTQ/SAM/BAM file formats.In this paper we provide an overview of the MPEG-G specification, with particular focus on the main advantages and novel functionality it offers. As the standard only specifies the decoding process, encoding performance, both in terms of speed and compression ratio, can vary depending on specific encoder implementations, and will likely improve during the lifetime of MPEG-G. Hence, the performance statistics provided here are only indicative baseline examples of the technologies included in the standard.

2021 ◽  
Vol 11 (7) ◽  
pp. 3165
Author(s):  
Zhigang Wang ◽  
Yu Yang

A seamless and smooth morphing leading edge has remarkable potential for noise abatement and drag reduction of civil aircraft. Variable-stiffness compliant skin based on tailored composite laminate is a concept with great potential for morphing leading edge, but the currently proposed methods have difficulty in taking the manufacturing constraints or layup sequence into account during the optimization process. This paper proposes an innovative two-step design method for a variable-stiffness compliant skin of a morphing leading edge, which includes layup optimization and layup adjustment. The combination of these two steps can not only improve the deformation accuracy of the final profile of the compliant skin but also easily and effectively determine the layup sequence of the composite layup. With the design framework, an optimization model is created for a variable-stiffness compliant skin, and an adjustment method for its layups is presented. Finally, the deformed profiles between the directly optimized layups and the adjusted ones are compared to verify its morphing ability and accuracy. The final results demonstrate that the obtained deforming ability and accuracy are suitable for a large-scale aircraft wing.


1984 ◽  
Vol 106 (1) ◽  
pp. 222-228 ◽  
Author(s):  
M. L. Marziale ◽  
R. E. Mayle

An experimental investigation was conducted to examine the effect of a periodic variation in the angle of attack on heat transfer at the leading edge of a gas turbine blade. A circular cylinder was used as a large-scale model of the leading edge region. The cylinder was placed in a wind tunnel and was oscillated rotationally about its axis. The incident flow Reynolds number and the Strouhal number of oscillation were chosen to model an actual turbine condition. Incident turbulence levels up to 4.9 percent were produced by grids placed upstream of the cylinder. The transfer rate was measured using a mass transfer technique and heat transfer rates inferred from the results. A direct comparison of the unsteady and steady results indicate that the effect is dependent on the Strouhal number, turbulence level, and the turbulence length scale, but that the largest observed effect was only a 10 percent augmentation at the nominal stagnation position.


1998 ◽  
Vol 120 (4) ◽  
pp. 705-713 ◽  
Author(s):  
S. T. Hsu ◽  
A. M. Wo

This paper demonstrates reduction of stator unsteady loading due to forced response in a large-scale, low-speed, rotor/stator/rotor axial compressor rig by clocking the downstream rotor. Data from the rotor/stator configuration showed that the stator response due to the upstream vortical disturbance reaches a maximum when the wake impinges against the suction surface immediately downstream of the leading edge. Results from the stator/rotor configuration revealed that the stator response due to the downstream potential disturbance reaches a minimum with a slight time delay after the rotor sweeps pass the stator trailing edge. For the rotor/stator/rotor configuration, with Gap1 = 10 percent chord and Gap2 = 30 percent chord, results showed a 60 percent reduction in the stator force amplitude by clocking the downstream rotor so that the time occurrence of the maximum force due to the upstream vortical disturbance coincides with that of the minimum force due to the downstream potential disturbance. This is the first time, the authors believe, that beneficial use of flow unsteadiness is definitively demonstrated to reduce the blade unsteady loading.


2011 ◽  
Vol 672 ◽  
pp. 451-476 ◽  
Author(s):  
ERICH SCHÜLEIN ◽  
VICTOR M. TROFIMOV

Large-scale longitudinal vortices in high-speed turbulent separated flows caused by relatively small irregularities at the model leading edges or at the model surfaces are investigated in this paper. Oil-flow visualization and infrared thermography techniques were applied in the wind tunnel tests at Mach numbers 3 and 5 to investigate the nominally 2-D ramp flow at deflection angles of 20°, 25° and 30°. The surface contour anomalies have been artificially simulated by very thin strips (vortex generators) of different shapes and thicknesses attached to the model surface. It is shown that the introduced streamwise vortical disturbances survive over very large downstream distances of the order of 104 vortex-generator heights in turbulent supersonic flows without pressure gradients. It is demonstrated that each vortex pair induced in the reattachment region of the ramp is definitely a child of a vortex pair, which was generated originally, for instance, by the small roughness element near the leading edge. The dependence of the spacing and intensity of the observed longitudinal vortices on the introduced disturbances (thickness and spanwise size of vortex generators) and on the flow parameters (Reynolds numbers, boundary-layer thickness, compression corner angles, etc.) has been shown experimentally.


Author(s):  
Wei Ma ◽  
Feng Gao ◽  
Xavier Ottavy ◽  
Lipeng Lu ◽  
A. J. Wang

Recently bimodal phenomenon in corner separation has been found by Ma et al. (Experiments in Fluids, 2013, doi:10.1007/s00348-013-1546-y). Through detailed and accurate experimental results of the velocity flow field in a linear compressor cascade, they discovered two aperiodic modes exist in the corner separation of the compressor cascade. This phenomenon reflects the flow in corner separation is high intermittent, and large-scale coherent structures corresponding to two modes exist in the flow field of corner separation. However the generation mechanism of the bimodal phenomenon in corner separation is still unclear and thus needs to be studied further. In order to obtain instantaneous flow field with different unsteadiness and thus to analyse the mechanisms of bimodal phenomenon in corner separation, in this paper detached-eddy simulation (DES) is used to simulate the flow field in the linear compressor cascade where bimodal phenomenon has been found in previous experiment. DES in this paper successfully captures the bimodal phenomenon in the linear compressor cascade found in experiment, including the locations of bimodal points and the development of bimodal points along a line that normal to the blade suction side. We infer that the bimodal phenomenon in the corner separation is induced by the strong interaction between the following two facts. The first is the unsteady upstream flow nearby the leading edge whose angle and magnitude fluctuate simultaneously and significantly. The second is the high unsteady separation in the corner region.


Author(s):  
A. Samson ◽  
S. Sarkar

The dynamics of separation bubble under the influence of continuous jets ejected near the semi-circular leading edge of a flat plate is presented. Two different streamwise injection angles 30° and 60° and velocity ratios 0.5 and 1 for Re = 25000 and 55000 (based on the leading-edge diameter) are considered here. The flow visualizations illustrating jet and separated layer interactions have been carried out with PIV. The objective of this study is to understand the mutual interactions of separation bubble and the injected jets. It is observed that flow separates at the blending point of semi-circular arc and flat plate. The separated shear layer is laminar up to 20% of separation length after which perturbations are amplified and grows in the second-half of the bubble leading to breakdown and reattachment. Blowing has significantly affected the bubble length and thus, turbulence generation. Instantaneous flow visualizations supports the unsteadiness and development of three-dimensional motions leading to formation of Kelvin-Helmholtz rolls and shedding of large-scale vortices due to jet and bubble interactions. In turn, it has been seen that both the spanwise and streamwise dilution of injected air is highly influenced by the separation bubble.


2021 ◽  
Vol 143 (4) ◽  
Author(s):  
Teng Cao ◽  
Tadashi Kanzaka ◽  
Liping Xu ◽  
Tobias Brandvik

Abstract In this paper, an unsteady tip leakage flow phenomenon is identified and investigated in a centrifugal compressor with a vaneless diffuser at near-stall conditions. This phenomenon is associated with the inception of a rotating instability in the compressor. The study is based on numerical simulations that are supported by experimental measurements. The study confirms that the unstable flow is governed by a Kelvin–Helmholtz type instability of the shear layer formed between the main-stream flow and the tip leakage flow. The shear layer instability induces large-scale vortex roll-up and forms vortex tubes, which propagate circumferentially, resulting in measured pressure fluctuations with short wavelength and high amplitude which rotate at about half of the blade speed. The 3D vortex tube is also found to interact with the main blade leading edge, causing the reduction of the blade loading identified in the experiment. The paper also reveals that the downstream volute imposes a once-per-rev circumferential nonuniform back pressure at the impeller exit, inducing circumferential loading variation at the impeller inducer, and causing circumferential variation in the unsteady tip leakage flow.


Author(s):  
M. W. Benner ◽  
S. A. Sjolander ◽  
S. H. Moustapha

This paper presents experimental results of the secondary flows from two large-scale, low-speed, linear turbine cascades for which the incidence was varied. The aerofoils for the two cascades were designed for the same inlet and outlet conditions and differed mainly in their leading-edge geometries. Detailed flow field measurements were made upstream and downstream of the cascades and static pressure distributions were measured on the blade surfaces for three different values of incidence: 0, +10 and +20 degrees. The results from this experiment indicate that the strength of the passage vortex does not continue to increase with incidence, as would be expected from inviscid flow theory. The streamwise acceleration within the aerofoil passage seems to play an important role in influencing the strength of the vortex. The most recent off-design secondary loss correlation (Moustapha et al. [1]) includes leading-edge diameter as an influential correlating parameter. The correlation predicts that the secondary losses for the aerofoil with the larger leading-edge diameter are lower at off-design incidence; however, the opposite is observed experimentally. The loss results at high positive incidence have also high-lighted some serious shortcomings with the conventional method of loss decomposition. An empirical prediction method for secondary losses has been developed and will be presented in a subsequent paper.


2018 ◽  
Vol 857 ◽  
pp. 907-936 ◽  
Author(s):  
A. Cimarelli ◽  
A. Leonforte ◽  
D. Angeli

The separating and reattaching flows and the wake of a finite rectangular plate are studied by means of direct numerical simulation data. The large amount of information provided by the numerical approach is exploited here to address the multi-scale features of the flow and to assess the self-sustaining mechanisms that form the basis of the main unsteadinesses of the flows. We first analyse the statistically dominant flow structures by means of three-dimensional spatial correlation functions. The developed flow is found to be statistically dominated by quasi-streamwise vortices and streamwise velocity streaks as a result of flow motions induced by hairpin-like structures. On the other hand, the reverse flow within the separated region is found to be characterized by spanwise vortices. We then study the spectral properties of the flow. Given the strongly inhomogeneous nature of the flow, the spectral analysis has been conducted along two selected streamtraces of the mean velocity field. This approach allows us to study the spectral evolution of the flow along its paths. Two well-separated characteristic scales are identified in the near-wall reverse flow and in the leading-edge shear layer. The first is recognized to represent trains of small-scale structures triggering the leading-edge shear layer, whereas the second is found to be related to a very large-scale phenomenon that embraces the entire flow field. A picture of the self-sustaining mechanisms of the flow is then derived. It is shown that very-large-scale fluctuations of the pressure field alternate between promoting and suppressing the reverse flow within the separation region. Driven by these large-scale dynamics, packages of small-scale motions trigger the leading-edge shear layers, which in turn created them, alternating in the top and bottom sides of the rectangular plate with a relatively long period of inversion, thus closing the self-sustaining cycle.


2016 ◽  
Author(s):  
J. Alakuijala ◽  
Z. Szabadka
Keyword(s):  

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