scholarly journals Downregulation of insulin-like growth factor binding protein 5 is involved in intervertebral disc degeneration via the ERK signaling pathway

2018 ◽  
Keyword(s):  
Growth Factor ◽  
Intervertebral Disc ◽  
Signaling Pathway ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Binding Protein ◽  
Erk Signaling ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Effects of suppressing bioavailability of insulin‐like growth factor on age‐associated intervertebral disc degeneration

JOR Spine ◽  
2020 ◽  
Vol 3 (4) ◽  
Author(s):  
Rebecca Kritschil ◽  
Zhongying Zhang ◽  
Changbin Lei ◽  
Jiongbiao Zhong ◽  
Qing Dong ◽  
...  
Keyword(s):  
Growth Factor ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Insulin Like Growth Factor

scholarly journals The microRNA-302b-inhibited insulin-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor IA

PLoS ONE ◽  
2017 ◽  
Vol 12 (3) ◽  
pp. e0173890 ◽  
Author(s):  
Chin-Cheng Lee ◽  
Peng-Hsu Chen ◽  
Kuo-Hao Ho ◽  
Chwen-Ming Shih ◽  
Chia-Hsiung Cheng ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Cell Apoptosis ◽  
Glioma Cell ◽  
Binding Protein ◽  
Nuclear Factor ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Platelet-Derived Growth Factor-BB Inhibits Intervertebral Disc Degeneration via Suppressing Pyroptosis and Activating the MAPK Signaling Pathway

2022 ◽  
Vol 12 ◽  
Author(s):  
Weikang Zhang ◽  
Yuhang Gong ◽  
Xiaohang Zheng ◽  
Jianxin Qiu ◽  
Ting Jiang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Intervertebral Disc ◽  
Protective Effect ◽  
Signaling Pathway ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Platelet Derived Growth Factor ◽  
Nucleus Pulposus Cells

Platelet-derived growth factor-BB (PDGF-BB) is a cytokine involved in tissue repair and tumor progression. It has been found to have expression differences between normal and degenerative intervertebral discs. However, it is not clear whether PDGF-BB has a protective effect on intervertebral disc degeneration (IDD). In this experiment, we treated nucleus pulposus cells (NPCs) with IL-1β to simulate an inflammatory environment and found that the extracellular matrix (ECM) anabolic function of NPCs in an inflammatory state was inhibited. Moreover, the induction of IL-1β also enhanced the expression of NLRP3 and the cleavage of caspase-1 and IL-1β, which activated the pyroptosis of NPCs. In this study, we studied the effect of PDGF-BB on IL-1β-treated NPCs and found that PDGF-BB not only significantly promotes the ECM anabolism of NPCs, but also inhibits the occurrence of pyroptosis and the production of pyroptosis products of NPCs. Consistent with this, when we used imatinib to block the PDGF-BB receptor, the above-mentioned protective effect disappeared. In addition, we found that PDGF-BB can also promote the ECM anabolism of NPCs by regulating the ERK, JNK, PI3K/AKT signaling pathways, but not the P38 signaling pathway. In vivo studies, mice that blocked PDGF-BB receptors showed more severe histological manifestations of intervertebral disc degeneration. In summary, our results indicate that PDGF-BB participates in inhibiting the occurrence and development of IDD by inhibiting pyroptosis and regulating the MAPK signaling pathway.

Sign in / Sign up

Export Citation Format

Share Document