scholarly journals Photo-inactivation ofNeisseria gonorrhoeae: A paradigm changing approach for combating antibiotic-resistant gonococcal infection

2018 ◽  
Author(s):  
Ying Wang ◽  
Raquel Ferrer-Espada ◽  
Yan Baglo ◽  
Xueping S. Goh ◽  
Kathryn D. Held ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Sexually Transmitted Disease ◽  
Transmitted Disease ◽  
Ultra Performance Liquid Chromatography ◽  
Potential Treatment ◽  
Gonococcal Infection ◽  
Antibiotic Resistant ◽  
Sexually Transmitted ◽  
Vaginal Epithelial Cells ◽  
Ofneisseria Gonorrhoeae

ABSTRACTNeisseria gonorrhoeaeis the causative pathogen of the sexually transmitted disease gonorrhea, a disease at risk of becoming untreatable due to increasing antibiotic resistance. There is a critical need for the development of new anti-gonococcal therapies. In this study, we investigated the effectiveness of antimicrobial blue light (aBL), an innovative non-antibiotic approach, for the inactivation of antibiotic-resistantN.gonorrhoeae. Our findings indicated that aBL at 405 nm preferentially inactivated antibiotic-resistantN. gonorrhoeaeover the vaginal epithelial cells. Furthermore, no genotoxicity of aBL to the vaginal epithelial cells was observed at the exposure for inactivatingN. gonorrhoeae. aBL also effectively inactivatedN. gonorrhoeaethat had invaded into the vaginal epithelial cells. No gonococcal resistance to aBL developed after 15 successive cycles of sub-therapeutic inactivation. Endogenous aBL-active photosensitizing chromophores (porphyrins and flavins) inN. gonorrhoeaewere identified and quantified using ultra performance liquid chromatography, with coproporphyrin being the most abundant endogenous porphyrin species. Taken together, aBL at 405 nm represents a potent potential treatment for gonococcal infections.One Sentence SummaryaBL selectively inactivated antibiotic-resistantNeisseria gonorrhoeaenover normal vaginal epithelial cells.

scholarly journals Photoinactivation of Neisseria gonorrhoeae: A Paradigm-Changing Approach for Combating Antibiotic-Resistant Gonococcal Infection

2019 ◽  
Vol 220 (5) ◽  
pp. 873-881 ◽  
Author(s):  
Ying Wang ◽  
Raquel Ferrer-Espada ◽  
Yan Baglo ◽  
Xueping S Goh ◽  
Kathryn D Held ◽  
...  
Keyword(s):  
Public Health ◽  
Epithelial Cells ◽  
Neisseria Gonorrhoeae ◽  
Abundant Species ◽  
Gonococcal Infection ◽  
Antibiotic Resistant ◽  
Radiant Exposure ◽  
Vaginal Epithelial Cells ◽  
Resistant Strains

AbstractAntimicrobial resistance in Neisseria gonorrhoeae is a major issue of public health, and there is a critical need for the development of new antigonococcal strategies. In this study, we investigated the effectiveness of antimicrobial blue light (aBL; wavelength, 405 nm), an innovative nonpharmacological approach, for the inactivation of N. gonorrhoeae. Our findings indicated that aBL preferentially inactivated N. gonorrhoeae, including antibiotic-resistant strains, over human vaginal epithelial cells in vitro. Furthermore, no aBL-induced genotoxicity to the vaginal epithelial cells was observed at the radiant exposure used to inactivate N. gonorrhoeae. aBL also effectively inactivated N. gonorrhoeae that had attached to and invaded into the vaginal epithelial cells in their cocultures. No gonococcal resistance to aBL developed after 15 successive cycles of inactivation induced by subtherapeutic exposure to aBL. Endogenous aBL-activatable photosensitizing porphyrins in N. gonorrhoeae were identified and quantified using ultraperformance liquid chromatography, with coproporphyrin being the most abundant species in all N. gonorrhoeae strains studied. Singlet oxygen was involved in aBL inactivation of N. gonorrhoeae. Together, these findings show that aBL represents a potential potent treatment for antibiotic-resistant gonococcal infection.

Sexually Transmitted Diseases in Sexually Abused Children

PEDIATRICS ◽  
1983 ◽  
Vol 72 (1) ◽  
pp. 16-21
Author(s):  
Susanne T. White ◽  
Frank A. Loda ◽  
David L. Ingram ◽  
Anna Pearson
Keyword(s):  
Sexual Abuse ◽  
Sexually Transmitted Disease ◽  
Sexually Abused ◽  
Extended Family ◽  
Transmitted Disease ◽  
Gonococcal Infection ◽  
Abused Children ◽  
Sexually Transmitted ◽  
History Of ◽  
Sexually Abused Children

Over a 4-year period, 409 cases of suspected sexual abuse of children were reviewed to study sexually transmitted disease (STD). Sexually transmitted disease was identified in 54 (13%) of the 409 children: 46 cases of gonorrhea, six cases of syphilis, four cases of trichomoniasis, and three cases of condyloma acuminata. Nine of the 46 children with cultures positive for gonorrhea did not have a history of discharge. Four of the six children with syphilis also had a gonococcal infection. One child with syphilis had condyloma. Only one child had clinical features of syphilis. Sexually transmitted disease was more likely to be transmitted by an extended family member or a nonfamily member than by a father/stepfather (P < .001). Laboratory tests that identify sexually transmitted disease may aid in the diagnosis of sexual abuse.

Syphilis

2018 ◽  
Author(s):  
Samuel K. Cohn, Jr.
Keyword(s):  
Sixteenth Century ◽  
Sexually Transmitted Disease ◽  
Transmitted Disease ◽  
New Disease ◽  
Medical Texts ◽  
Sexually Transmitted ◽  
New Name ◽  
The Poor ◽  
Wide Range ◽  
Tit For Tat

By exploring the wide range of names given to the ‘new’ sexually transmitted disease—the Great Pox—this chapter dispels notions held for two centuries or more. Instead, no tit-for-tat-naming war among nations accused of carrying the disease ensued. The ‘French disease’ alone became standard in medical texts, but not among commoners and not after the late sixteenth century for physicians. The chapter challenges a second truism of the historiography: that naming meant blaming. Although the disease was named after the French, no laws or pogroms ensued against them or any other ‘other’. However, physicians increasingly identified humans as the essential carriers of this new disease and became concerned with tracking human contacts. By the end of the sixteenth century, medical texts had renamed it the territorially neutral lues venerea. Coincidently, with the rise of this new name, blame placed on women, the poor, and victims of the disease increased.

MCQs in Travel Medicine

2012 ◽  
Author(s):  
Dom Colbert
Keyword(s):  
International Society ◽  
Sexually Transmitted Disease ◽  
Transmitted Disease ◽  
Travel Medicine ◽  
Multiple Choice ◽  
Multiple Choice Questions ◽  
Sexually Transmitted ◽  
Adventure Travel ◽  
Self Test

Specifically written for those preparing for examinations and practitioners in travel medicine, MCQs in Travel Medicine contains over 600 multiple choice questions with detailed explanations which both teach and challenge the reader. Questions are group by topic which is ideal for revision, enabling you to focus on specific areas including adventure travel, travellers' diarrhoea, malaria, sexually transmitted disease, and drugs used in travel medicine. The style and format of the questions mirror the format of the exam questions, and the book includes a self-test to aid revision. This easy-to-read comprehensive book is ideally suited for those in busy day-to-day practices and those preparing for examinations in travel medicine including the Certificate Exam of the International Society of Travel Medicine.

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