scholarly journals Early Life Trauma Predicts Affective Phenomenology and the Effects are Partly Mediated by Staging Coupled with Lowered Lipid-Associated Antioxidant Defences

2018 ◽  
Author(s):  
Michael Maes ◽  
Ana Congio ◽  
Juliana Brum Moraes ◽  
Kamila Landucci Bonifacio ◽  
Decio Sabbatini Barbosa ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Mood Disorders ◽  
Semantic Memory ◽  
Affective Disorders ◽  
Early Life ◽  
Hdl Cholesterol ◽  
Paraoxonase 1 ◽  
Antioxidant Defences ◽  
Early Life Trauma ◽  
The Impact

AbstractBackgroundEarly life trauma (ELT) may drive mood disorder phenomenology, neuro-oxidative and neuro-immune pathways and impairments in semantic memory. Nevertheless, there are no data regarding the impact of ELT on affective phenomenology and whether these pathways are mediated by staging or lowered lipid-associated antioxidant defences.MethodsThis study examined healthy controls (n=54) and patients with affective disorders including major depression, bipolar disorder and anxiety disorders (n=118). ELT was assessed using the Child Trauma Questionnaire. In addition, we measured affective phenomenology and assayed advanced oxidation protein products; malondialdehyde, paraoxonase 1 (CMPAase) activity, high-sensitivity C-reactive protein (hsCRP), and high-density lipoprotein (HDL) cholesterol.ResultsELT was associated with increased risk for mood and comorbid anxiety disorders and a more severe phenomenology, including staging characteristics (number of mood episodes), severity of depression and anxiety, suicide attempts, suicidal ideation, type of treatments received, disabilities, body mass index, smoking behaviour and hsCRP, as well as lowered health-related quality of life, socio-economic status, antioxidant defences and semantic memory. The number of mood episodes and CMPAase/HDL-cholesterol levels could be reliably combined into a new vulnerability staging-biomarker index, which mediates in part the effects of ELT on affective phenomenology, while lowered antioxidant defences are associated with increased oxidative stress. Moreover, the effects of female sex on mood disorders and affective phenomenology are mediated by ELT.DiscussionThe cumulative effects of different types of ELT drive many aspects of affective phenomenology either directly or indirectly through effects of staging and/or lipid–associated antioxidant defences. The results show that children, especially girls, with ELT are at great risk to develop mood disorders and more severe phenotypes of affective disorders.

scholarly journals Early Life Trauma Predicts Affective Phenomenology and the Effects are Partly Mediated by Staging Coupled with Lowered Lipid-Associated Antioxidant Defences

2018 ◽  
Vol 9 (1) ◽  
pp. 115-130 ◽  
Author(s):  
Michael Maes ◽  
Ana Congio ◽  
Juliana Brum Moraes ◽  
Kamila Landucci Bonifacio ◽  
Decio Sabbatini Barbosa ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Mood Disorders ◽  
Semantic Memory ◽  
Affective Disorders ◽  
Early Life ◽  
Hdl Cholesterol ◽  
Paraoxonase 1 ◽  
Antioxidant Defences ◽  
Early Life Trauma ◽  
The Impact

AbstractBackgroundEarly life trauma (ELT) may drive mood disorder phenomenology, nitro-oxidative pathways and impairments in semantic memory. There are no data regarding the impact of ELT on affective phenomenology and whether these pathways are mediated by staging or lowered lipid-associated antioxidant defences.MethodsThis study examined healthy controls (n=54) and patients with affective disorders including major depression, bipolar disorder and anxiety disorders (n=118). ELT was assessed using the Child Trauma Questionnaire. In addition, we measured affective phenomenology and assayed advanced oxidation protein products; malondialdehyde, paraoxonase 1 (CMPAase) activity, high-sensitivity C-reactive protein (hsCRP), and high-density lipoprotein (HDL) cholesterol.ResultsELT was associated into with increased risk for mood and comorbid anxiety disorders and a more severe phenomenology, including staging characteristics, depression and anxiety severity, suicidal behaviours, type of treatments, disabilities, body mass index, smoking behaviour and hsCRP, as well as lowered health-related quality of life, antioxidant defences and semantic memory. The number of mood episodes and CMPAase/HDL-cholesterol levels could be reliably combined into a new vulnerability staging-biomarker index, which mediates in part the effects of ELT on affective phenomenology and oxidative stress. Moreover, the effects of female sex on mood disorders and affective phenomenology are mediated by ELT.DiscussionThe cumulative effects of different ELT drive many aspects of affective phenomenology either directly or indirectly through effects of staging and/or lipid–associated antioxidant defences. The results show that children, especially girls, with ELT are at great risk to develop mood disorders and more severe phenotypes of affective disorders.

scholarly journals Feasibility, Acceptability, and Clinical Trends of a Mindfulness-Informed Child Welfare Intervention: Implications for Trauma-Focused Practice

2017 ◽  
Vol 18 (1) ◽  
pp. 369-386 ◽  
Author(s):  
Samantha M. Brown ◽  
Jennifer Bellamy
Keyword(s):  
Child Welfare ◽  
Early Life ◽  
Substance Misuse ◽  
Child Welfare System ◽  
Stress Coping ◽  
Early Life Trauma ◽  
Trauma Informed ◽  
Underlying Causes ◽  
Single Intervention ◽  
The Impact

Exposure to stress and early life trauma have been linked to child maltreatment and parental substance misuse. These issues often co-occur, yet few child welfare services target their shared underlying causes in a single intervention. Teaching mindfulness-informed strategies to substance-misusing families in the child welfare system may be one promising trauma-informed approach. As part of a larger pilot study testing the initial efficacy of a mindfulness-informed intervention for parents in public child welfare, this study explored the feasibility, acceptability, and clinical trends of the intervention using weekly reports of stress, coping, and mindfulness. Findings show support for the feasibility and acceptability of the intervention as well as positive responses to the intervention on measures of stress and mindfulness. However, the impact of the intervention varied with regard to improving weekly coping among participants. Implications for the integration of mindfulness into child welfare practice as a trauma-informed approach are discussed.

scholarly journals The impact of interpersonal early life trauma on cardio-metabolic health in post-9/11 veterans.

2019 ◽  
Vol 38 (2) ◽  
pp. 113-121
Author(s):  
Hannah M. Franz ◽  
Vincent Corbo ◽  
Jennifer R. Fonda ◽  
Laura K. Levin ◽  
William P. Milberg ◽  
...  
Keyword(s):  
Early Life ◽  
Metabolic Health ◽  
Early Life Trauma ◽  
The Impact

scholarly journals ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ МЕЛАТОНИНА В ТЕРАПИИ РАЗЛИЧНЫХ ПСИХИЧЕСКИХ РАССТРОЙСТВ (ОБЗОР ЛИТЕРАТУРЫ)

2017 ◽  
Vol 9 (1) ◽  
pp. 131 ◽  
Author(s):  
Angelina Nailevna Hannanova ◽  
Yuriy Vitalevich Bykov ◽  
Roman Aleksandrovich Bekker
Keyword(s):  
Anxiety Disorders ◽  
Mood Disorders ◽  
Affective Disorders

Цель исследования: Обзор и обобщение существующих литературных данных о применении мелатонина в терапии различных психических расстройств, формулирование выводов о качестве доказательной базы для его применения, о перспективах его применения в терапии психических расстройств и перспективности дальнейшего его исследования в этом направлении.Методология проведения работы. Авторами был проведен поиск по публичным базам данных PubMed / MedLine / EmBASE / UpToDate с использованием ключевого слова melatonin в конъюнкции с ключевыми словами cognition, cognitive, mood disorders, affective disorders, insomnia, psychosis, schizophrenia, anxiety disorders. Найденные результаты подвергались сортировке в соответствии с критериями доказательности (РКИ, открытые проспективные исследования, сообщения серий случаев, единичных случаев, гипотетические предположения о возможной эффективности). Затем проводилось обобщение полученных данных.Результаты. Полученные нами в результате настоящего обзора литературы данные свидетельствуют о перспективности применения мелатонина в комплексной терапии диссомнических состояний, алкоголизма, тревожных и аффективных расстройств, шизофрении и других психозов, в лечении и профилактике таких побочных эффектов психофармакотерапии, как метаболический синдром, поздние дискинезии, акатизия, инсомния, а также о перспективности дальнейшего исследования мелатонина в этом направлении.Область применения результатов. Полученные нами результаты заслуживают широкого применения в психиатрии, наркологии и неврологии.

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