scholarly journals Breathing coordinates limbic network dynamics underlying memory consolidation

2018 ◽  
Author(s):  
Nikolaos Karalis ◽  
Anton Sirota
Keyword(s):  
Memory Consolidation ◽  
Information Transfer ◽  
Large Scale ◽  
Memory Function ◽  
Network Dynamics ◽  
Brain Regions ◽  
Neuronal Dynamics ◽  
Dual Mechanism ◽  
Relationship Of ◽  
The Relationship

The coordinated activity between remote brain regions underlies cognition and memory function. Although neuronal oscillations have been proposed as a mechanistic substrate for the coordination of information transfer and memory consolidation during sleep, little is known about the mechanisms that support the widespread synchronization of brain regions and the relationship of neuronal dynamics with other bodily rhythms, such as breathing. Here we address this question using large-scale recordings from a number of structures, including the medial prefrontal cortex, hippocampus, thalamus, amygdala and nucleus accumbens in mice. We identify a dual mechanism of respiratory entrainment, in the form of an intracerebral corollary discharge that acts jointly with an olfactory reafference to coordinate limbic network dynamics, such as hippocampal ripples and cortical UP and DOWN states, involved in memory consolidation. These results highlight breathing, a perennial rhythmic input to the brain, as an oscillatory scaffold for the functional coordination of the limbic circuit, enabling the segregation and integration of information flow across neuronal networks.

Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE

2021 ◽  
pp. 1-10
Author(s):  
Xiaoqi Wang ◽  
Qiuhui Bi ◽  
Jie Lu ◽  
Piu Chan ◽  
Xiaochen Hu ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Memory Function ◽  
Verbal Learning ◽  
Linear Regression Analysis ◽  
Brain Regions ◽  
Middle Temporal Gyrus ◽  
Subjective Cognitive Decline ◽  
Amyloid Load ◽  
Relationship Of ◽  
The Relationship

Background: Subjective cognitive decline (SCD), an at-risk condition of Alzheimer’s disease (AD), can involve various cognitive domains, such as memory, language, planning, and attention. Objective: We aims to explore the differences in amyloid load between the single memory domain SCD (sd-SCD) and the multidomain SCD (md-SCD) and assess the relationship of amyloid pathology with quantitative SCD scores and objective cognition. Methods: A total of 63 SCD participants from the SILCODE study underwent the clinical evaluation, neuropsychological assessment, and 18F-florbetapir PET scan. Global amyloid standard uptake value ratio (SUVr) was calculated. Additionally, regional amyloid SUVr was quantified in 12 brain regions of interests. A nonparametric rank ANCOVA was used to compare the global and regional amyloid SUVr between the md-SCD (n = 34) and sd-SCD (n = 29) groups. A multiple linear regression analysis was conducted to test the relationship of amyloid SUVr with quantitative SCD scores and objective cognition. Results: Compared with individuals with sd-SCD, individuals with md-SCD had increased global amyloid SUVr (F = 5.033, p = 0.029) and regional amyloid SUVr in the left middle temporal gyrus (F = 12.309, p = 0.001; Bonferroni corrected), after controlling for the effects of age, sex, and education. When pooling all SCD participants together, the increased global amyloid SUVr was related with higher SCD-plus sum scores and lower Auditory Verbal Learning Test-delayed recall scores. Conclusion: According to our findings, individuals with md-SCD showed higher amyloid accumulation than individuals with sd-SCD, suggesting that md-SCD may experience a more advanced stage of SCD. Additionally, increased global amyloid load was predictive of a poorer episodic memory function in SCD individuals.

scholarly journals Dynamical consequences of regional heterogeneity in the brain’s transcriptional landscape

2020 ◽  
Author(s):  
Gustavo Deco ◽  
Kevin Aquino ◽  
Aurina Arnatkevičiūtė ◽  
Stuart Oldham ◽  
Kristina Sabaroedin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Large Scale ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Global Gene Expression ◽  
Brain Regions ◽  
Biophysical Model ◽  
Neuronal Dynamics ◽  
Regional Heterogeneity ◽  
Magnetic Resonance Imaging Mri

AbstractBrain regions vary in their molecular and cellular composition, but how this heterogeneity shapes neuronal dynamics is unclear. Here, we investigate the dynamical consequences of regional heterogeneity using a biophysical model of whole-brain functional magnetic resonance imaging (MRI) dynamics in humans. We show that models in which transcriptional variations in excitatory and inhibitory receptor (E:I) gene expression constrain regional heterogeneity more accurately reproduce the spatiotemporal structure of empirical functional connectivity estimates than do models constrained by global gene expression profiles and MRI-derived estimates of myeloarchitecture. We further show that regional heterogeneity is essential for yielding both ignition-like dynamics, which are thought to support conscious processing, and a wide variance of regional activity timescales, which supports a broad dynamical range. We thus identify a key role for E:I heterogeneity in generating complex neuronal dynamics and demonstrate the viability of using transcriptional data to constrain models of large-scale brain function.

scholarly journals The power of materialism among young adults: exploring the effects of values on impulsiveness and responsible financial behavior

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Andrea Lučić ◽  
Marija Uzelac ◽  
Andrea Previšić
Keyword(s):  
Young Adults ◽  
Large Scale ◽  
Brand Management ◽  
Mediating Effect ◽  
Financial Behavior ◽  
Purchase Decisions ◽  
Content Type ◽  
Financial Behaviour ◽  
Relationship Of ◽  
The Relationship

Purpose The purpose of this paper is to investigate the effects of values of materialism on cognitive and affective impulsiveness and responsible financial behavior among young adults. Design/methodology/approach A large-scale study (n = 483) was conducted on a sample of young adults 18 to 25 years of age in Croatia. Findings The research found that materialism has no direct effect on responsible financial behaviour (RFB), however, cognitive impulsiveness fully mediates the relationship of all three there three elements of materialism, centrality, success and happiness and RFB. Affective impulsiveness has no effect on the relationship. Furthermore, only materialism as centrality strongly and positively influences cognitive and affective impulsiveness. Practical implications Presented conclusions could be used by policymakers as guidelines for developing educational plans and curriculum to build financial capability and consumer protection among young adults and could be helpful for brand management activities targeting young people purchase decisions. Originality/value This paper’s ultimate purpose is to uncover the mechanism and the power of materialism on impulsiveness and responsible financial behavior. The paper’s originality is established by the focus on the investigation of materialism as an antecedent factor of impulsiveness and by questioning the nature of the relationship between materialism and responsible financial behavior through the mediating effect of impulsiveness.

scholarly journals Governance and Financial Difficulties of Conventional Banks

2019 ◽  
Vol 2 (2) ◽  
pp. 121-134
Author(s):  
La Ode Sumail
Keyword(s):  
Fixed Effects ◽  
Large Scale ◽  
Lagrange Multiplier Test ◽  
Fixed Effects Model ◽  
Insider Ownership ◽  
Financial Difficulties ◽  
Private Banks ◽  
Conventional Banks ◽  
Relationship Of ◽  
The Relationship

This study examines the connection between governance, financial performance, and financial difficulties of 27 conventional private banks during the pe3riod of 2015-2018. In order to meet the accuracy of the model in the regression analysis, the Lagrange Multiplier test was previously performed so that the Fixed Effects model was chosen. The relationship of insider ownership with ROA tends to be in the shape of inversed-U and the relationship between institutional ownership and ROA is significantly positive. The relationship between ROA and financial difficulties is significantly negative. Older or established large scale banks tend to have high ROA. This happens because the greater the assets, the healthier the cash flow of the bank, so that the potential for return of asset is quite high and financial difficulties tend to be low or avoidable.

CREATING KIN: NEW FAMILY ASSOCIATIONS AS WELFARE PROVIDERS IN LIBERALIZING JORDAN

2006 ◽  
Vol 38 (3) ◽  
pp. 349-368 ◽  
Author(s):  
Anne Marie Baylouny
Keyword(s):  
Large Scale ◽  
Family Relations ◽  
The State ◽  
National Politics ◽  
New Family ◽  
Traditional Elite ◽  
Family Associations ◽  
Relationship Of ◽  
Social Provisioning ◽  
The Relationship

In the decade and a half since economic liberalization began in Jordan, a little noticed but large-scale organizing trend has taken over the formal provision of social welfare, redefining the institutional conception of familial identity in the process. For over one third of the population, kin solidarities have been reorganized, formalized, and registered as nongovernmental organizations in an attempt to cope with the removal of basic social provisioning by the state. Although kinship clearly has been a major element in Jordan's history, the present phenomena alter traditional familial institutions, change kin lineages, and institutionalize the economic salience of family relations. In turn, the relationship of the populace to the state has changed, marginalizing previously regime-supporting groups and facilitating the implementation of economic neoliberalism without significant protest. Repackaged as charitable elements of civil society, these family associations are sanctioned and encouraged by the state and international community. Although they are not regime creations, family associations reinforce the Jordanian regime's efforts at political deliberalization. The new elites who head the organizations have been placated through indirect incorporation into the regime; they now wield significant economic power over fellow kin and have enhanced social status backed by the new group. Furthermore, the trend mainly consists of families without immediate ambitions of entering national politics. These are not the traditional elite families.

Normative Sexual Behavior in Children

PEDIATRICS ◽  
1991 ◽  
Vol 88 (3) ◽  
pp. 456-464 ◽  
Author(s):  
William N. Friedrich ◽  
Patricia Grambsch ◽  
Daniel Broughton ◽  
James Kuiper ◽  
Robert L. Beilke
Keyword(s):  
Sexual Behavior ◽  
Sexual Behaviors ◽  
Large Scale ◽  
Older Children ◽  
Community Based ◽  
History Of ◽  
Family Variables ◽  
Relationship Of ◽  
The Relationship ◽  
Internalizing And Externalizing

A large-scale, community-based survey was done to assess the frequency of a wide variety of sexual behaviors in normal preadolescent children and to measure the relationship of these behaviors to age, gender, and socioeconomic and family variables. A sample of 880 2-through 12-year-old children screened to exclude those with a history of sexual abuse were rated by their mothers using several questionnaire measures. The frequency of different behaviors varied widely, with more aggressive sexual behaviors and behaviors imitative of adults being rare. Older children (both boys and girls) were less sexual than younger children. Sexuality was found to be related to the level of general behavior problems, as measured by the Achenbach Internalizing and Externalizing T scores and to a measure of family nudity. It was not related to socioeconomic variables.

Setting the Scene

2021 ◽  
pp. 1-8
Author(s):  
John Zerilli
Keyword(s):  
Neural Circuits ◽  
Brain Regions ◽  
Basic Assumptions ◽  
The Subject ◽  
Basic Argument ◽  
The Mind ◽  
Relationship Of ◽  
The Relationship

The modularity of mind has been understood in various ways, amended as evidence from neuroscience has forced the theory to shed various structural assumptions. Neuroplasticity has, for better or worse, challenged many of the orthodox conceptions of the mind that originally led cognitive scientists to postulate mental modules. Similarly, rapidly accumulating neuroscientific evidence of the reuse or redeployment of neural circuits, revealing the integrated and interactive structure of brain regions, has upset basic assumptions about the relationship of function to structure upon which modularity—not to say neuroscience itself—originally depended. These movements, developments, and cross-currents are the subject of this book. This chapter outlines the basic argument of the book and its motivation.

scholarly journals Altered topology of large-scale structural brain networks in chronic stroke

2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Bastian Cheng ◽  
Eckhard Schlemm ◽  
Robert Schulz ◽  
Marlene Boenstrup ◽  
Arnaud Messé ◽  
...  
Keyword(s):  
Information Transfer ◽  
Large Scale ◽  
Neuronal Degeneration ◽  
Brain Networks ◽  
Brain Regions ◽  
Local Network ◽  
Structural Connectome ◽  
The Impact ◽  
Structural Brain ◽  
Topological Changes

Abstract Beyond disruption of neuronal pathways, focal stroke lesions induce structural disintegration of distant, yet connected brain regions via retrograde neuronal degeneration. Stroke lesions alter functional brain connectivity and topology in large-scale brain networks. These changes are associated with the degree of clinical impairment and recovery. In contrast, changes of large scale, structural brain networks after stroke are less well reported. We therefore aimed to analyse the impact of focal lesions on the structural connectome after stroke based on data from diffusion-weighted imaging and probabilistic fibre tracking. In total, 17 patients (mean age 64.5 ± 8.4 years) with upper limb motor deficits in the chronic stage after stroke and 21 healthy participants (mean age 64.9 ± 10.3 years) were included. Clinical deficits were evaluated by grip strength and the upper extremity Fugl-Meyer assessment. We calculated global and local graph theoretical measures to characterize topological changes in the structural connectome. Results from our analysis demonstrated significant alterations of network topology in both ipsi- and contralesional, primarily unaffected, hemispheres after stroke. Global efficiency was significantly lower in stroke connectomes as an indicator of overall reduced capacity for information transfer between distant brain areas. Furthermore, topology of structural connectomes was shifted toward a higher degree of segregation as indicated by significantly higher values of global clustering and modularity. On a level of local network parameters, these effects were most pronounced in a subnetwork of cortico-subcortical brain regions involved in motor control. Structural changes were not significantly associated with clinical measures. We propose that the observed network changes in our patients are best explained by the disruption of inter- and intrahemispheric, long white matter fibre tracts connecting distant brain regions. Our results add novel insights on topological changes of structural large-scale brain networks in the ipsi- and contralesional hemisphere after stroke.

scholarly journals Message-Elicited Brain Response Moderates the Relationship Between Opportunities for Exposure to Anti-Smoking Messages and Message Recall

2019 ◽  
Vol 69 (6) ◽  
pp. 589-611
Author(s):  
Elissa C Kranzler ◽  
Ralf Schmälzle ◽  
Rui Pei ◽  
Robert C Hornik ◽  
Emily B Falk
Keyword(s):  
Large Scale ◽  
Communication Theory ◽  
Brain Regions ◽  
Message Processing ◽  
Memory Encoding ◽  
Brain Response ◽  
Real Cost ◽  
Social Processing ◽  
The Relationship ◽  
The Brain

Abstract Campaign success is contingent on adequate exposure; however, exposure opportunities (e.g., ad reach/frequency) are imperfect predictors of message recall. We hypothesized that the exposure-recall relationship would be contingent on message processing. We tested moderation hypotheses using 3 data sets pertinent to “The Real Cost” anti-smoking campaign: past 30-day ad recall from a rolling national survey of adolescents aged 13–17 (n = 5,110); ad-specific target rating points (TRPs), measuring ad reach and frequency; and ad-elicited response in brain regions implicated in social processing and memory encoding, from a separate adolescent sample aged 14–17 (n = 40). Average ad-level brain activation in these regions moderates the relationship between national TRPs and large-scale recall (p < .001), such that the positive exposure-recall relationship is more strongly observed for ads that elicit high levels of social processing and memory encoding in the brain. Findings advance communication theory by demonstrating conditional exposure effects, contingent on social and memory processes in the brain.

Gold–copper–bismuth mineralization in hedenbergitic skarn, Tombstone Mountains, Yukon

1987 ◽  
Vol 24 (12) ◽  
pp. 2362-2372 ◽  
Author(s):  
Isobel J. Brown ◽  
Bruce E. Nesbitt
Keyword(s):  
Large Scale ◽  
Small Volume ◽  
Gold Mineralization ◽  
Rock Interaction ◽  
The North ◽  
Mineral Assemblages ◽  
Intrusive Rocks ◽  
Porosity And Permeability ◽  
Relationship Of ◽  
The Relationship

Gold mineralization on the Marn property, Yukon, occurs in two pyroxene skarn bodies, which are adjacent to the Mount Brenner Stock in the Ogilvie Mountains. The skarns are separated by a 600 m wide monzonite intrusion and show contrasting mineralogical and geochemical characteristics in addition to quite different metal values. Significant but uneconomic Au, Ag, W, and Cu mineralization is found in skarn on the north side of the intrusion, while very low Au grades (0.052 g/t) occur at the southern contact. The mineral assemblages of both skarns are dominated by iron-rich pyroxenes. The iron content of the pyroxenes varies between Hd40 and Hd80 in the northern location and Hd80 and Hd100 in the southern skarn. A well-developed sequence of retrograde alteration affected only the northern skarn. This was probably the result of porosity and permeability differences in the early, high-temperature pyroxene skarn, which permitted greater fluid–rock interaction in the northern skarn during cooling. A small volume of diopsidic, aluminous, wollastonite-bearing skarn occurs in both the northern and southern localities. The relationship of this type of skarn to the hedenbergitic skarn is ambiguous, since there is no large-scale mineralogical zoning. The Marn is similar to hedenbergitic, auriferous skarns of Japan, where the oxidation state of the intrusive rocks is believed to be the controlling factor in the development of skarn mineralogy.

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