scholarly journals Overlaps in Brain Dynamic Functional Connectivity between Schizophrenia and Autism Spectrum Disorder

2018 ◽  
Author(s):  
Andry Andriamananjara ◽  
Rayan Muntari ◽  
Alessandro Crimi
Keyword(s):  
Functional Connectivity ◽  
Brain Regions ◽  
Autism Spectrum ◽  
Machine Learning Techniques ◽  
Imaging Biomarkers ◽  
Dynamic Functional Connectivity ◽  
Direct Reports ◽  
Functional Flexibility ◽  
Learning Techniques ◽  
Window Technique

AbstractSchizophrenia and autism share some genotipic and phenotypic aspects as connectome miswiring and common cognitive deficits. Currently, there are no medical tests available for either disorders, and diagnostics for both of them include direct reports of relatives and clinical evaluation by a psychiatrist. Despite several medical imaging biomarkers have been proposed in the past, novel effective biomarkers or improvements of the existing ones is still need. This work proposes a dynamic functional connectome analysis combined with machine learning techniques to complement the present diagnostic procedure. We used the moving window technique to locate a set of dynamic functional connectivity states, and then use them as features to classify subjects as autism/schizophrenia or control. Moreover, by using dynamic functional connectivity measures we investigate the question whether those two disorders overlap, namely whether schizophrenia is part of the autism spectrum and which brain region could be involved in both disorders. The results reveal that both static and dynamic functional connectivity can be used to classify subjects with schizophrenia or autism. Lastly, some brain regions show similar functional flexibility in both autism and schizophrenia cohorts giving further possible proofs of their overlaps.

scholarly journals A Novel Unit-Based Personalized Fingerprint Feature Selection Strategy for Dynamic Functional Connectivity Networks

2021 ◽  
Vol 15 ◽  
Author(s):  
Feng Zhao ◽  
Zhiyuan Chen ◽  
Islem Rekik ◽  
Peiqiang Liu ◽  
Ning Mao ◽  
...  
Keyword(s):  
Feature Selection ◽  
Functional Connectivity ◽  
Evaluation Method ◽  
Brain Regions ◽  
Autism Spectrum ◽  
Superior Performance ◽  
Selection Strategy ◽  
Dynamic Functional Connectivity ◽  
Discriminative Feature ◽  
Fingerprint Feature

The sliding-window-based dynamic functional connectivity networks (SW-D-FCN) derive from resting-state functional Magnetic Resonance Imaging has become an increasingly useful tool in the diagnosis of various neurodegenerative diseases. However, it is still challenging to learn how to extract and select the most discriminative features from SW-D-FCN. Conventionally, existing methods opt to select a single discriminative feature set or concatenate a few more from the SW-D-FCN. However, such reductionist strategies may fail to fully capture the personalized discriminative characteristics contained in each functional connectivity (FC) sequence of the SW-D-FCN. To address this issue, we propose a unit-based personalized fingerprint feature selection (UPFFS) strategy to better capture the most discriminative feature associated with a target disease for each unit. Specifically, we regard the FC sequence between any pair of brain regions of interest (ROIs) is regarded as a unit. For each unit, the most discriminative feature is identified by a specific feature evaluation method and all the most discriminative features are then concatenated together as a feature set for the subsequent classification task. In such a way, the personalized fingerprint feature derived from each FC sequence can be fully mined and utilized in classification decision. To illustrate the effectiveness of the proposed strategy, we conduct experiments to distinguish subjects diagnosed with autism spectrum disorder from normal controls. Experimental results show that the proposed strategy can select relevant discriminative features and achieve superior performance to benchmark methods.

scholarly journals Identification of Alzheimer’s Disease using Functional Connectivity Measures

2019 ◽  
Vol 9 (2) ◽  
pp. 1452-1456
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Functional Connectivity ◽  
Correlation Method ◽  
Brain Regions ◽  
Cognitive Disorder ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Functional Connections ◽  
Learning Techniques

Alzheimer’s disease (AD) is a gradual neuro cognitive disorder caused by the damage of brain cells over a certain period of time. One non-invasive and efficient technique to investigate AD is to use functional magnetic resonance imaging (fMRI). Functional connectivity is a change in the functional connections between brain regions when an activity takes place. The correlation value gives the strength of functional connectivity. Pearson’s correlation method was used to calculate the correlation coefficient between two time series. Mutual information which denotes the information successfully transmitted through a channel was also considered. In this paper, these two measures are compared and their performance and suitability is assessed for fMRI connectivity modelling based on the classification accuracy. Machine learning techniques such as support vector machine (SVM) is employed for connectivity analysis and classification of Alzheimer’s from control population

scholarly journals Dissecting Static and Dynamic Functional Connectivity: Example From the Autism Spectrum

2019 ◽  
Vol 13 ◽  
pp. 117906951985180 ◽  
Author(s):  
Tonya White ◽  
Vince D. Calhoun
Keyword(s):  
Functional Connectivity ◽  
Brain Connectivity ◽  
Brain Regions ◽  
Autism Spectrum ◽  
Dynamic Functional Connectivity ◽  
Age Related ◽  
Autistic Symptoms ◽  
Magnetic Resonance Imaging Mri ◽  
Dynamic Measures ◽  
The Brain

The ability to measure the intrinsic functional architecture of the brain has grown exponentially over the last 2 decades. Measures of intrinsic connectivity within the brain, typically measured using resting-state functional magnetic resonance imaging (MRI), have evolved from primarily “static” approaches, to include dynamic measures of functional connectivity. Measures of dynamic functional connectivity expand the assumptions to allow brain regions to have temporally different patterns of communication between different regions. That is, connections within the brain can differentially fire between different regions at different times, and these differences can be quantified. Applying approaches that measure the dynamic characteristics of functional brain connectivity have been fruitful in identifying differences during brain development and psychopathology. We provide a brief overview of static and dynamic measures of functional connectivity and illustrate the synergy in applying these approaches to identify both age-related differences in children and differences between typically developing children and children with autistic symptoms.

Autism Spectrum Disorder Identification Using Polynomial Distribution based Convolutional Neural Network

2021 ◽  
Vol 19 (2) ◽  
pp. 19-30
Author(s):  
G. Nagarajan ◽  
Dr.A. Mahabub Basha ◽  
R. Poornima
Keyword(s):  
Neural Network ◽  
Prediction Models ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Machine Learning Techniques ◽  
Hybrid Technique ◽  
Learning Techniques ◽  
Chicken Swarm Optimization ◽  
Sensitivity Specificity ◽  
Polynomial Distribution

One main psychiatric disorder found in humans is ASD (Autistic Spectrum Disorder). The disease manifests in a mental disorder that restricts humans from communications, language, speech in terms of their individual abilities. Even though its cure is complex and literally impossible, its early detection is required for mitigating its intensity. ASD does not have a pre-defined age for affecting humans. A system for effectively predicting ASD based on MLTs (Machine Learning Techniques) is proposed in this work. Hybrid APMs (Autism Prediction Models) combining multiple techniques like RF (Random Forest), CART (Classification and Regression Trees), RF-ID3 (RF-Iterative Dichotomiser 3) perform well, but face issues in memory usage, execution times and inadequate feature selections. Taking these issues into account, this work overcomes these hurdles in this proposed work with a hybrid technique that combines MCSO (Modified Chicken Swarm Optimization) and PDCNN (Polynomial Distribution based Convolution Neural Network) algorithms for its objective. The proposed scheme’s experimental results prove its higher levels of accuracy, precision, sensitivity, specificity, FPRs (False Positive Rates) and lowered time complexity when compared to other methods.

Dynamic Functional Connectivity Reveals Abnormal Variability and Hyper‐connected Pattern in Autism Spectrum Disorder

2019 ◽  
Vol 13 (2) ◽  
pp. 230-243 ◽  
Author(s):  
Yu Li ◽  
Yuying Zhu ◽  
Benedictor Alexander Nguchu ◽  
Yanming Wang ◽  
Huijuan Wang ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Functional Connectivity ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Dynamic Functional Connectivity

scholarly journals Linear Input as a Fundamental Motif of Brain Connectivity Organization

2019 ◽  
Author(s):  
Jonathan F. O’Rawe ◽  
Hoi-Chung Leung
Keyword(s):  
Functional Connectivity ◽  
Information Transfer ◽  
Brain Connectivity ◽  
Brain Regions ◽  
Fundamental Aspect ◽  
Biased Sampling ◽  
Whole Brain ◽  
3 Dimensional ◽  
Face Area ◽  
Learning Techniques

AbstractDescribing the pattern of region-to-region functional connectivity is an important step towards understanding information transfer and transformation between brain regions. Although fMRI data are limited in spatial resolution, recent advances in technology afford more precise mapping. Here, we extended previous methods, connective field mapping, to 3 dimensions to provide a more concise estimate of the organization and potential information transformation from one region to another. We first replicated previous work with the 3 dimensional model by showing that the topology of functional connectivity between early visual regions maintained along their eccentricity axis or the anterior-posterior dimension. We then examined higher order visual regions (e,g, fusiform face area) and showed that their pattern of connectivity, the convergence and biased sampling, seem to contribute to some of their core receptive field properties. We further demonstrated that linearity of input is a fundamental aspect of functional connectivity of the whole brain, with higher linearity between regions within a network than across networks; that is, high connective linearity was evident between early visual areas, and between prefrontal areas, but less evident between them. By decomposing the whole brain linearity matrix with manifold learning techniques, we found that the principle mode of the linearity maps onto decompositions in both functional connectivity and genetic expression reported in previous studies. The current work provides evidence supporting that linearity of input is likely a fundamental motif of functional connectivity between regions for information processing across the brain, with high linearity preserving the integrity of information from one region to another within a network.

scholarly journals Sex-dependent and sex-independent brain resting-state functional connectivity in children with autism spectrum disorder

2016 ◽  
Author(s):  
Xin Di ◽  
Bharat B Biswal
Keyword(s):  
Autism Spectrum Disorder ◽  
Functional Connectivity ◽  
Resting State ◽  
Data Exchange ◽  
Brain Regions ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Imaging Data ◽  
Resting State Functional Connectivity ◽  
Main Effects

Background: Males are more likely to suffer from autism spectrum disorder (ASD) than females. As to whether females with ASD have similar brain alterations remain an open question. The current study aimed to examine sex-dependent as well as sex-independent alterations in resting-state functional connectivity in individuals with ASD compared with typically developing (TD) individuals. Method: Resting-state functional MRI data were acquired from the Autism Brain Imaging Data Exchange (ABIDE). Subjects between 6 to 20 years of age were included for analysis. After matching the intelligence quotient between groups for each dataset, and removing subjects due to excessive head motion, the resulting effective sample contained 28 females with ASD, 49 TD females, 129 males with ASD, and 141 TD males, with a two (diagnosis) by two (sex) design. Functional connectivity among 153 regions of interest (ROIs) comprising the whole brain was computed. Two by two analysis of variance was used to identify connectivity that showed diagnosis by sex interaction or main effects of diagnosis. Results: The main effects of diagnosis were found mainly between visual cortex and other brain regions, indicating sex-independent connectivity alterations. We also observed two connections whose connectivity showed diagnosis by sex interaction between the precuneus and medial cerebellum as well as the precunes and dorsal frontal cortex. While males with ASD showed higher connectivity in these connections compared with TD males, females with ASD had lower connectivity than their counterparts. Conclusions: Both sex-dependent and sex-independent functional connectivity alterations are present in ASD.

scholarly journals An Autism Spectrum Disorder Adaptive Identification Based on the Elimination of Brain Connections: A Proof of Long-Range Underconnectivity

2021 ◽  
Author(s):  
Fatima zahra Benabdallah ◽  
Ahmed Drissi El Maliani ◽  
Dounia Lotfi ◽  
Rachid Jennane ◽  
Mohammed El hassouni
Keyword(s):  
Autism Spectrum Disorder ◽  
Functional Connectivity ◽  
Long Range ◽  
Data Exchange ◽  
Brain Connectivity ◽  
Brain Regions ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Imaging Data ◽  
Brain Imaging Data

Abstract Autism spectrum disorder (ASD) is theoretically characterized by alterations in functional connectivity between brain regions. Many works presented approaches to determine informative patterns that help to predict autism from typical development. However, most of the proposed pipelines are not specifically designed for the autism problem, i.e they do not corroborate with autism theories about functional connectivity. In this paper, we propose a framework that takes into account the properties of local connectivity and long range under-connectivity in the autistic brain. The originality of the proposed approach is to adopt elimination as a technique in order to well emerge the autistic brain connectivity alterations, and show how they contribute to differentiate ASD from controls. Experimental results conducted on the large multi-site Autism Brain Imaging Data Exchange (ABIDE) show that our approach provides accurate prediction up to 70% and succeeds to prove the existence of deficits in the long-range connectivity in the ASD subjects brains.

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