scholarly journals Carbon monoxide, a retrograde messenger generated in post-synaptic mushroom body neurons evokes non-canonical dopamine release

2018 ◽  
Author(s):  
Kohei Ueno ◽  
Johannes Morstein ◽  
Kyoko Ofusa ◽  
Shintaro Naganos ◽  
Ema Suzuki-Sawano ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Mushroom Body ◽  
Ryanodine Receptors ◽  
Memory Formation ◽  
Presynaptic Terminals ◽  
Modes Of Transmission ◽  
Brain Functions ◽  
Wide Range ◽  
Retrograde Messenger ◽  
Da Release

ABSTRACTDopaminergic neurons innervate extensive areas of the brain and release dopamine (DA) onto a wide range of target neurons. However, DA release is also precisely regulated, and inDrosophila,DA is released specifically onto mushroom body (MB) neurons, which have been coincidentally activated by cholinergic and glutamatergic inputs. The mechanism for this precise release has been unclear. Here we found that coincidentally activated MB neurons generate carbon monoxide (CO) which functions as a retrograde signal evoking local DA release from presynaptic terminals. CO production depends on activity of heme oxygenase in post-synaptic MB neurons, and CO-evoked DA release requires Ca2+efflux through ryanodine receptors in DA terminals. CO is only produced in MB areas receiving coincident activation, and removal of CO using scavengers blocks DA release. We propose that DA neurons utilize two distinct modes of transmission to produce global and local DA signaling.SIGNIFICANCE STATEMENTDopamine (DA) is needed for various higher brain functions including memory formation. However, DA neurons form extensive synaptic connections, while memory formation requires highly specific and localized DA release. Here we identify a mechanism through which DA release from presynaptic terminals is controlled by postsynaptic activity. Postsynaptic neurons activated by cholinergic and glutamatergic inputs generate carbon monoxide, which acts as a retrograde messenger inducing presynaptic DA release. Released DA is required for memory-associated plasticity. Our work identifies a novel mechanism that restricts DA release to the specific postsynaptic sites that require DA during memory formation.

scholarly journals Carbon Monoxide, a Retrograde Messenger Generated in Postsynaptic Mushroom Body Neurons, Evokes Noncanonical Dopamine Release

2020 ◽  
Vol 40 (18) ◽  
pp. 3533-3548 ◽  
Author(s):  
Kohei Ueno ◽  
Johannes Morstein ◽  
Kyoko Ofusa ◽  
Shintaro Naganos ◽  
Ema Suzuki-Sawano ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Mushroom Body ◽  
Dopamine Release ◽  
Retrograde Messenger

scholarly journals Feedforward and feedback frequency-dependent interactions in a large-scale laminar network of the primate cortex

2016 ◽  
Vol 2 (11) ◽  
pp. e1601335 ◽  
Author(s):  
Jorge F. Mejias ◽  
John D. Murray ◽  
Henry Kennedy ◽  
Xiao-Jing Wang
Keyword(s):  
Large Scale ◽  
Complex Dynamics ◽  
Predictive Coding ◽  
Causality Analysis ◽  
Frequency Dependent ◽  
Brain Functions ◽  
Wide Range ◽  
Cortical Laminar ◽  
Feedback Frequency ◽  
Visual Cortical

Interactions between top-down and bottom-up processes in the cerebral cortex hold the key to understanding attentional processes, predictive coding, executive control, and a gamut of other brain functions. However, the underlying circuit mechanism remains poorly understood and represents a major challenge in neuroscience. We approached this problem using a large-scale computational model of the primate cortex constrained by new directed and weighted connectivity data. In our model, the interplay between feedforward and feedback signaling depends on the cortical laminar structure and involves complex dynamics across multiple (intralaminar, interlaminar, interareal, and whole cortex) scales. The model was tested by reproducing, as well as providing insights into, a wide range of neurophysiological findings about frequency-dependent interactions between visual cortical areas, including the observation that feedforward pathways are associated with enhanced gamma (30 to 70 Hz) oscillations, whereas feedback projections selectively modulate alpha/low-beta (8 to 15 Hz) oscillations. Furthermore, the model reproduces a functional hierarchy based on frequency-dependent Granger causality analysis of interareal signaling, as reported in recent monkey and human experiments, and suggests a mechanism for the observed context-dependent hierarchy dynamics. Together, this work highlights the necessity of multiscale approaches and provides a modeling platform for studies of large-scale brain circuit dynamics and functions.

OPTIMIZATION OF GAS-DIESEL ENGINE REGULATION AS A METHOD OF IMPROVING ITS ECOLOGICAL CHARACTERISTICS

2021 ◽  
pp. 28-32
Author(s):  
VALERIY L. CHUMAKOV ◽  
Keyword(s):  
Carbon Monoxide ◽  
Diesel Engine ◽  
Nitrogen Oxides ◽  
Diesel Fuel ◽  
Hydrocarbon Fuel ◽  
Load Range ◽  
Engine Operation ◽  
Exhaust Gases ◽  
Wide Range ◽  
Diesel Cycle

The paper shows some ways to improve the environmental characteristics of a diesel engine using gaseous hydrocarbon fuel and operating the engine in a gas-diesel cycle mode. Some possibilities to reduce toxic components of exhaust gases in a gas-diesel engine operating on liquefi ed propane-butane mixtures have been studied. Experiments carried out in a wide range of load from 10 to 100% and speed from 1400 to 2000 rpm showed that the gas-diesel engine provides a suffi ciently high level of diesel fuel replacement with gas hydrocarbon fuel. The authors indicate some eff ective ways to reduce the toxicity of exhaust gases. The engine power should be adjusted by the simultaneous supply of fuel, gas and throttling the air charge in the intake manifold. This method enriches the fi rst combusting portions to reduce nitrogen oxides and maintains the depletion of the main charge within the fl ammability limits of the gas-air charge to reduce carbon monoxide and hydrocarbons. The authors found that when the engine operates in a gas-diesel cycle mode, the power change provides a decrease in nitrogen oxide emissions of gas-diesel fuel only due to gas supply in almost the entire load range as compared to the pure diesel. At high loads (more than 80%) stable engine operation is ensured up to 90% of diesel fuel replaced by gas. Even at 10% of diesel fuel used the concentration of nitrogen oxides decreases by at least 15…20% as compared with a diesel engine in the entire load range. However, there is an increased emission of hydrocarbons and carbon monoxide in the exhaust gases. Further experimental studies have shown that optimization of the gas diesel regulation can reduce the mass emission of nitrogen oxides contained in exhaust gases in 2…3 times and greatly reduce the emission of incomplete combustion products – carbon monoxide and hydrocarbons.

scholarly journals The Role of Host-Generated H2S in Microbial Pathogenesis: New Perspectives on Tuberculosis

2020 ◽  
Vol 10 ◽  
Author(s):  
Md. Aejazur Rahman ◽  
Joel N. Glasgow ◽  
Sajid Nadeem ◽  
Vineel P. Reddy ◽  
Ritesh R. Sevalkar ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Hydrogen Sulfide ◽  
Host Immunity ◽  
Microbial Pathogens ◽  
Microbial Pathogenesis ◽  
Enzymatic Production ◽  
Growth And Survival ◽  
Wide Range

For centuries, hydrogen sulfide (H2S) was considered primarily as a poisonous gas and environmental hazard. However, with the discovery of prokaryotic and eukaryotic enzymes for H2S production, breakdown, and utilization, H2S has emerged as an important signaling molecule in a wide range of physiological and pathological processes. Hence, H2S is considered a gasotransmitter along with nitric oxide (•NO) and carbon monoxide (CO). Surprisingly, despite having overlapping functions with •NO and CO, the role of host H2S in microbial pathogenesis is understudied and represents a gap in our knowledge. Given the numerous reports that followed the discovery of •NO and CO and their respective roles in microbial pathogenesis, we anticipate a rapid increase in studies that further define the importance of H2S in microbial pathogenesis, which may lead to new virulence paradigms. Therefore, this review provides an overview of sulfide chemistry, enzymatic production of H2S, and the importance of H2S in metabolism and immunity in response to microbial pathogens. We then describe our current understanding of the role of host-derived H2S in tuberculosis (TB) disease, including its influences on host immunity and bioenergetics, and on Mycobacterium tuberculosis (Mtb) growth and survival. Finally, this review discusses the utility of H2S-donor compounds, inhibitors of H2S-producing enzymes, and their potential clinical significance.

Nitric oxide — a retrograde messenger for carbon monoxide signaling in ischemic heart

1996 ◽  
pp. 75-86
Author(s):  
Nilanjana Maulik ◽  
Daniel T. Engelman ◽  
Masazumi Watanabe ◽  
Richard M. Engelman ◽  
Dipak K. Das
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Ischemic Heart ◽  
Retrograde Messenger

scholarly journals Climatology and long-term evolution of ozone and carbon monoxide in the UTLS at northern mid-latitudes, as seen by IAGOS from 1995 to 2013

2017 ◽  
Author(s):  
Yann Cohen ◽  
Hervé Petetin ◽  
Valérie Thouret ◽  
Virginie Marécal ◽  
Béatrice Josse ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Lower Stratosphere ◽  
Boreal Summer ◽  
Brazilian Coast ◽  
Seasonal Cycles ◽  
Western Coast ◽  
Data Set ◽  
Upper Troposphere ◽  
North East ◽  
Wide Range

Abstract. In situ measurements in the upper troposphere – lower stratosphere (UTLS) are performed in the framework of the European research infrastructure IAGOS (In-service Aircraft for a Global Observing System) for ozone since 1994 and for carbon monoxide since 2002. The flight tracks cover a wide range of longitudes in the northern extratropics, extending from the North American western coast (125° W) to the eastern Asian coast (135° E), and more recently over the northern Pacific ocean. Different tropical regions are also sampled frequently, such as the Brazilian coast, central and southern Africa, southeastern Asia and the western Maritime Continent. As a result, a new set of climatologies for O3 (Aug. 1994–Dec. 2013) and CO (Dec. 2001–Dec. 2013) in the upper troposphere (UT), tropopause layer and lower stratosphere (LS) are made available, including quasi-global gridded horizontal distributions, and seasonal cycles over eight well sampled regions of interest in the northern extratropics. The seasonal cycles generally show a summertime maximum in O3 and a springtime maximum in CO in the UT, in contrast with the systematic springtime maximum in O3 and the quasi-absence of seasonal cycle of CO in the LS. This study highlights some regional variabilities in the UT notably (i) a west-east difference of O3 in boreal summer with up to 15 ppb more O3 over central Russia compared with northeast America, (ii) a systematic west-east gradient of CO from 60° E to 140° E (especially noticeable in spring and summer with about 5 ppb by 10 degrees longitude), (iii) a broad spring/summer maximum of CO over North East Asia, and (iv) a spring maximum of O3 over Western North America. Thanks to almost 20 years of O3 and 12 years of CO measurements, the IAGOS database is a unique data set to derive trends in the UTLS. Trends in O3 in the UT are positive and statistically significant in most regions, ranging from +0.25 to +0.45 ppb yr−1, characterized by the significant increase of the lowest values of the distribution. No significant trends of O3 are detected in the LS. Trends of CO in the UT, tropopause and LS are all negative and statistically significant. The estimated slopes range from −1.37 to −0.59 ppb yr−1 , with a nearly homogeneous decrease of the lowest values of the monthly distribution (fifth percentile) contrasting with the high inter-regional variability of the highest values (95th percentile).

Prediction of CO and NOx Pollutants in a Stratified Bluff Body Burner

2017 ◽  
Author(s):  
Pascal Gruhlke ◽  
Fabian Proch ◽  
Andreas M. Kempf ◽  
Enric Illana Mahiques ◽  
Stefan Dederichs ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Monoxide ◽  
Bluff Body ◽  
Combustion Products ◽  
Combustion Model ◽  
Wide Range ◽  
Flame Region ◽  
Numerical Grid ◽  
Nitric Oxide Emissions ◽  
Heavy Duty Gas Turbine

The major exhaust gas pollutants from heavy duty gas turbine engines are CO and NOx. The difficulty of predicting the concentration of these combustion products originates from their wide range of chemical time scales. In this paper, a combustion model that includes the prediction of the carbon monoxide and nitric oxide emissions is tested. Large eddy simulations (LES) are performed using a compressible code (OpenFOAM). A modified flamelet generated manifolds (FGM) approach is applied with a thickened flame approach (ATF) to resolve the flame on the numerical grid, with a flame sensor to ensure that the flame is only thickened in the flame region. For the prediction of the CO and NOx emissions, pollutant species transport equations and a second, CO based, progress variable are introduced for the flame burnout zone to account for slow chemistry effects. For the validation of the models, the Cambridge burner of Sweeney and Hochgreb [1, 2] is employed, as both carbon monoxide and nitric oxide [3] data is available.

scholarly journals Induction of Relaxation by Autonomous Sensory Meridian Response

2021 ◽  
Vol 15 ◽  
Author(s):  
Noriko Sakurai ◽  
Ken Ohno ◽  
Satoshi Kasai ◽  
Kazuaki Nagasaka ◽  
Hideaki Onishi ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Positive Emotions ◽  
Classical Music ◽  
Brain Activation ◽  
Auditory Stimulation ◽  
Brain Functions ◽  
Relaxation Effects ◽  
Wide Range ◽  
Significant Difference

Background: Autonomous sensory meridian response (ASMR) is used by young people to induce relaxation and sleep and to reduce stress and anxiety; it comprises somatosensation caused by audiovisual stimuli (triggers) that lead to positive emotions. Auditory stimuli play the most important role among the triggers involved in ASMR and have been reported to be more triggering than visual stimuli. On the other hand, classical music is also known to have a relaxing effect. This is the first study to clarify the difference in brain activation associated with relaxation effects between ASMR and classical music by limiting ASMR to auditory stimulation alone.Methods: Thirty healthy subjects, all over 20 years of age, underwent fMRI while listening to ASMR and classical music. We compared the differences in brain activation associated with classical music and ASMR stimulation. After the experiment, the subjects were administered a questionnaire on somatosensation and moods. After the experiment, the participants were asked whether they experienced ASMR somatosensation or frisson. They were also asked to rate the intensity of two moods during stimulation: “comfortable mood,” and “tingling mood”.Result: The results of the questionnaire showed that none of the participants experienced any ASMR somatosensation or frisson. Further, there was no significant difference in the ratings given to comfort mood, but there was a significant difference in those given to tingling mood. In terms of brain function, classical music and ASMR showed significant activation in common areas, while ASMR showed activation in more areas, with the medial prefrontal cortex being the main area of activation during ASMR.Conclusion: Both classical music and the ASMR auditory stimulus produced a pleasant and relaxed state, and ASMR involved more complex brain functions than classical music, especially the activation of the medial prefrontal cortex. Although ASMR was limited to auditory stimulation, the effects were similar to those of listening to classical music, suggesting that ASMR stimulation can produce a pleasant state of relaxation even if it is limited to the auditory component, without the somatic sensation of tingling. ASMR stimulation is easy to use, and appropriate for wellness purposes and a wide range of people.

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