Chronic inflammatory pain drives alcohol drinking in a sex-dependent manner

Mapping Intimacies ◽

10.1101/379362 ◽

2018 ◽

Author(s):

Waylin Yu ◽

Lara S. Hwa ◽

Viren H. Makhijani ◽

Joyce Besheer ◽

Thomas L. Kash

Keyword(s):

Chronic Pain ◽

Alcohol Consumption ◽

Alcohol Abuse ◽

Alcohol Drinking ◽

Plasma Corticosterone ◽

Dependent Manner ◽

Total Alcohol ◽

Drinking Session ◽

The Relationship ◽

Drinking Outcomes

AbstractSex differences in chronic pain and alcohol abuse are not well understood. The development of rodent models is imperative for investigating the underlying changes behind these pathological states. However, past attempts have failed to produce drinking outcomes similar to those reported in humans. In the present study, we investigated whether hind paw treatment with the inflammatory agent Complete Freund’s Adjuvant (CFA) could generate hyperalgesia and alter alcohol consumption in male and female C57BL/6J mice. CFA treatment led to greater nociceptive sensitivity for both sexes in the Hargreaves test, and increased alcohol drinking for males in a continuous access two-bottle choice (CA2BC) paradigm. Regardless of treatment, female mice exhibited greater alcohol drinking than males. Following a 2-hour terminal drinking session, CFA treatment failed to produce changes in alcohol drinking, blood ethanol concentration (BEC), and plasma corticosterone (CORT) for both sexes. 2-hr alcohol consumption and CORT was higher in females than males, irrespective of CFA treatment. Taken together, these findings have established that male mice are more susceptible to escalations in alcohol drinking when undergoing pain, despite higher levels of total alcohol drinking and CORT in females. Furthermore, the exposure of CFA-treated C57BL/6J mice to the CA2BC drinking paradigm has proven to be a useful model for studying the relationship between chronic pain and alcohol abuse. Future applications of the CFA/CA2BC model should incorporate manipulations of stress signaling and other related biological systems to improve our mechanistic understanding of pain and alcohol interactions.

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Effect of the Covid-19 Italian lockdown on human health: the analysis of alcohol consumption for aware quarantine (Preprint)

10.2196/preprints.25366 ◽

2020 ◽

Author(s):

Chiara Mazzarella ◽

Annamaria Spina ◽

Marcello Dallio ◽

Antonietta Gerarda Gravina ◽

Mario Romeo ◽

...

Keyword(s):

Alcohol Consumption ◽

Alcohol Abuse ◽

Psychosocial Factors ◽

Alcohol Drinking ◽

Psychosocial Support ◽

Human Life ◽

Stressful Event ◽

Drinking Behaviour ◽

Drinking Habits ◽

Specific Subset

BACKGROUND Italy has been one of the first western countries seriously involved in the COVID-19 pandemic in the first months of 2020 and so that the national government was forced to impose a long lockdown period, stopping all the people aggregation outdoor and indoor activities. From a social point of view this period of domestic confinement resulted in deep changes of behaviours and lifestyles, promoting in many people the onset of psychological symptoms and signs (including anxiety, depression, insomnia, and irritability among others) already known as associated with drug and alcohol abuse OBJECTIVE this study aims to assess the variation of alcohol drinking habits in a sample of Italian citizens during the COVID-19 lockdown and to identify the psychosocial factors surrounding it, in order to assess the specific subset of the population that could need psychosocial support during these events METHODS An online anonymous questionnaire was created and submitted from 9th April 2020 to 28th April 2020 using social medias and e-mails. Questions were related to personal details such as age, work, instruction, and, moreover, to alcohol drinking habits during the lockdown, including Alcohol Use Disorders Identification Test (AUDIT C) test questions RESULTS A total of 1234 surveys were filled out by subjects with an age range from 18 to 80 years old. An increase in both anxiety and fear has been detected in most of the participants (63% and 61% respectively) with a direct (r=0.652; p<0.001) relationship between them. Participants older than 50 years showed the strongest correlation between alcohol consumption, fear, and anxiety, (r=0.830, P <0.001 and r=0.741, P<0.001, respectively). Subjects living alone experienced a stronger association between anxiety, fear, and higher level of alcohol consumption (r: 0.529; P<0.001; r: 0.628, P<0.001 respectively). Moreover, 18% of participants increased alcohol consumption drinking during the lockdown. These subjects showed a lower frequency of alcohol consumption before the lockdown in comparison to the rest of the study population (2.5±0.96 vs 3±1.03, P<0.0001 respectively). Moreover, comparing the abovementioned groups, the percentage of subjects who experienced higher alcohol assumption before the 11th of March was higher in those that didn't change their drinking behaviour during the lockdown in comparison to that portion of them that experienced a worsening of alcohol abuse (r: 30.422, P<0.0001) CONCLUSIONS according to these data, during the Italian lockdown due to COVID 19 pandemic, different kind of people experienced an increase in alcohol drinking. Several psychosocial factors are involved in determining the increase in harmful alcohol consumption during this extraordinary stressful event and they must be addressed by the healthcare support in order to avoid awful lockdown impact on human life

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Relevance of the body mass index in the cognitive status of diabetic patients with different alcohol-drinking patterns

Archives of Biological Sciences ◽

10.2298/abs1401347t ◽

2014 ◽

Vol 66 (1) ◽

pp. 347-353

Author(s):

Serban Lacramioara ◽

Cristina Toarba ◽

Simona Hogas ◽

A. Covic ◽

A. Ciobica ◽

...

Keyword(s):

Cognitive Function ◽

Alcohol Consumption ◽

Alcohol Drinking ◽

The Body ◽

Control Group ◽

Diabetic Patients ◽

Inverse Association ◽

Drinking Patterns ◽

Alcohol Drinking Patterns ◽

The Relationship

Nowadays the general relevance of alcohol consumption in diabetes is extremely controversial. There are recent reports that alcohol consumption could result in a decreased incidence of diabetes, as well as other studies demonstrating a positive association between alcohol consumption and type 2 diabetes; there are also reports arguing for an inverse association between the two or for no correlation at all. The different results obtained in these studies could be explained by the existence of several confounders that could influence the outcome of the aforementioned studies. In this paper, we studied the possible relevance of BMI as a confounder in the relationship between alcohol consumption in diabetes and cognitive function, by analyzing the correlations between BMI values in diabetic patients with different alcohol drinking patterns and the subdomains from some main psychometric tests, such as MMSE (Mini-Mental State Examination) and MOCA (Montreal Cognitive Assessment). Our results provide evidence for BMI as a possible confounder of the relationship between alcohol consumption in diabetes and cognitive function. We found a significant increase (p<0.0001) in BMI values in patients with diabetes compared to our control group. Most importantly, significant correlations between BMI parameters in alcohol-consuming diabetic patients and most of the subdomains for psychometric testing.

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O Abuso de Álcool na Gestação e a Saúde Física e Psicológica do Bebê: Um Olhar Psicanalítico

REVISTA PLURI ◽

10.26843/rpv122019p241-244 ◽

2019 ◽

Vol 1 (2) ◽

pp. 241

Author(s):

Veridiana Canezin Guimarães ◽

Regiane Ribeiro ◽

Tuanne Sousa ◽

Audinéia Pereira

Keyword(s):

Alcohol Consumption ◽

Alcohol Abuse ◽

Pregnant Women ◽

Psychological Health ◽

Psychological Consequences ◽

Treatment And Prevention ◽

Excessive Consumption ◽

Physical And Psychological Health ◽

The Relationship

O presente estudo tem como objetivo pesquisar o consumo excessivo de álcool pelas gestantes e o comportamento dos bebês recém-nascidos, abordando consequências fisiológicas e psicológicas, visando também o tratamento e a prevenção. Trata-se de uma pesquisa de cunho bibliográfico, que investigou a relação entre o consumo de álcool pelas gestantes e a saúde física e psicológica dos bebês, tendo como referência teórica estudos psicanalíticos da relação mãe-bebê.Palavras-Chave: Abuso de álcool. Gravidez. PsicanáliseAbstractThe present study aims to investigate the excessive consumption of alcohol by pregnant women and the behavior of newborn babies, addressing physiological and psychological consequences, as well as treatment and prevention. This is a bibliographical research that will investigate the relationship between alcohol consumption by pregnant women and the physical and psychological health of the babies, having as theoretical reference psychoanalytic studies of the mother-baby relationship.Keywords: Alcohol abuse. Pregnancy. Psychoanalysis.

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Sexual Violence and Major Depression among Women: Evidence for Reciprocal Relationships

Social Currents ◽

10.1177/2329496519857095 ◽

2019 ◽

Vol 6 (6) ◽

pp. 575-589

Author(s):

Jason Schnittker

Keyword(s):

Major Depression ◽

Alcohol Consumption ◽

Alcohol Abuse ◽

Sexual Violence ◽

Stress Generation ◽

Generation Process ◽

Reciprocal Relationships ◽

The Relationship ◽

Shed Light

Using two waves of the National Comorbidity Survey, this study examines the relationship between sexual violence and major depression among women, focusing on rape. It uncovers evidence for two-way relationships that, among other things, shed light on who is at risk of sexual assault. Although rape increases the risk of developing major depression in a prospective fashion, depressed women are also at a higher risk of being raped. These pathways inflate the unadjusted prospective relationship between rape and major depression, though they do not explain it altogether. Comparisons between disorders indicate that major depression plays as significant a role as alcohol abuse disorder, and that depressed women are not at a higher risk only because of associated alcohol consumption. This study encourages further research not only on the effects of sexual violence on depression but also the role of common psychiatric disorders in the stress generation process, including how perpetrators target victims.

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Excessive alcohol consumption: a challenge for occupational health / El consumo excesivo de alcohol: un reto para la salud laboral

Health and Addictions/Salud y Drogas ◽

10.21134/haaj.v1i1.180 ◽

2003 ◽

Vol 1 (1) ◽

Author(s):

Javier Fernández-Montalvo ◽

Enrique Echeburúa

Keyword(s):

Alcohol Consumption ◽

Alcohol Abuse ◽

Early Detection ◽

Occupational Health ◽

Alcohol Intake ◽

Detection Methods ◽

Prevalence Rates ◽

Excessive Alcohol Consumption ◽

Excessive Alcohol ◽

The Relationship

En este trabajo se analiza la relación existente entre el abuso de alcohol y la actividad laboral. Se comentan las tasas de prevalencia del consumo de alcohol entre los trabajadores obtenidas en diferentes estudios y se describen los principales métodos de detección precoz (biológicos y psicológicos), así como las limitaciones de cada uno de ellos. Por último, se revisan los estudios sobre las principales repercusiones del abuso de alcohol en el ámbito laboral. AbstractThis paper analyses the relationship between alcohol abuse and labour activity. The prevalence rates about alcohol intake in workers are commented and the main early detection methods (biological and psychological) together with its limitations are described. Finally, studies about work consequences of alcohol are reviewed.

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The interplay between cognitive ability, alcohol consumption, and health characteristics

Psychological Medicine ◽

10.1017/s0033291717003543 ◽

2017 ◽

Vol 48 (12) ◽

pp. 2011-2022 ◽

Cited By ~ 2

Author(s):

E. Degerud ◽

E. Ystrom ◽

K. Tambs ◽

I. Ariansen ◽

J. Mørland ◽

...

Keyword(s):

Alcohol Consumption ◽

Cognitive Ability ◽

Mental Distress ◽

Early Adulthood ◽

Full Sample ◽

Current Smoking ◽

Consumption Frequency ◽

Total Alcohol ◽

The Mean ◽

The Relationship

AbstractBackgroundHigher cognitive ability is associated with favourable health characteristics. The relation between ability and alcohol consumption, and their interplay with other health characteristics, is unclear. We aimed to assess the relationship between cognitive ability and alcohol consumption and to assess whether alcohol consumption relates differently to health characteristics across strata of ability.MethodsFor 63 120 Norwegian males, data on cognitive ability in early adulthood were linked to midlife data on alcohol consumption frequency (times per month, 0–30) and other health characteristics, including cardiovascular risk factors and mental distress. Relations were assessed using linear regression and reported as unstandardised beta coefficients [95% confidence interval (CI)].ResultsThe mean ± s.d. frequency of total alcohol consumption in the sample was 4.0 ± 3.8 times per month. In the low, medium, and high group of ability, the frequencies were 3.0 ± 3.3, 3.7 ± 3.5, and 4.7 ± 4.1, respectively. In the full sample, alcohol consumption was associated with physical activity, heart rate, fat mass, smoking, and mental distress. Most notably, each additional day of consumption was associated with a 0.54% (0.44–0.64) and 0.14% (0.09–0.18) increase in the probability of current smoking and mental distress, respectively. In each strata of ability (low, medium, high), estimates were 0.87% (0.57–1.17), 0.48% (0.31–0.66) and 0.49% (0.36–0.62) for current smoking, and 0.44% (0.28–0.60), 0.10% (0.02–0.18), and 0.09% (0.03–0.15) for mental distress, respectively.ConclusionsParticipants with low cognitive ability drink less frequently, but in this group, more frequent alcohol consumption is more strongly associated with adverse health characteristics.

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Symptoms of Alcohol Dependence Predict Suicide Ideation Among Alaskan Undergraduates

Crisis ◽

10.1027/0227-5910/a000373 ◽

2016 ◽

Vol 37 (3) ◽

pp. 232-235 ◽

Cited By ~ 3

Author(s):

Christopher R. DeCou ◽

Monica C. Skewes

Keyword(s):

Depressive Symptoms ◽

Alcohol Consumption ◽

Alcohol Dependence ◽

Suicide Ideation ◽

Alcohol Problems ◽

Future Research ◽

Causal Mechanism ◽

Students At Risk ◽

The Relationship ◽

Alcohol Related Problems

Abstract. Background: Previous research has demonstrated an association between alcohol-related problems and suicidal ideation (SI). Aims: The present study evaluated, simultaneously, alcohol consequences and symptoms of alcohol dependence as predictors of SI after adjusting for depressive symptoms and alcohol consumption. Method: A sample of 298 Alaskan undergraduates completed survey measures, including the Young Adult Alcohol Consequences Questionnaire, the Short Alcohol Dependence Data Questionnaire, and the Beck Depression Inventory – II. The association between alcohol problems and SI status was evaluated using sequential logistic regression. Results: Symptoms of alcohol dependence (OR = 1.88, p < .05), but not alcohol-related consequences (OR = 1.01, p = .95), emerged as an independent predictor of SI status above and beyond depressive symptoms (OR = 2.39, p < .001) and alcohol consumption (OR = 1.08, p = .39). Conclusion: Alcohol dependence symptoms represented a unique risk for SI relative to alcohol-related consequences and alcohol consumption. Future research should examine the causal mechanism behind the relationship between alcohol dependence and suicidality among university students. Assessing the presence of dependence symptoms may improve the accuracy of identifying students at risk of SI.

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