scholarly journals The association between 25(OH)D levels, frailty status and adiposity indices in older adults

2018 ◽  
Author(s):  
Ana Rita Sousa-Santos ◽  
Cláudia Afonso ◽  
Alejandro Santos ◽  
Nuno Borges ◽  
Pedro Moreira ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Multinomial Logistic Regression ◽  
Positive Association ◽  
Serum Levels ◽  
Shape Index ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Adiposity Indices

AbstractBackgroundVitamin D deficiency is common in older adults and has been linked with frailty and obesity, but it remains to be studied whether frail obese older adults are at higher risk of vitamin D deficiency. Therefore, the aim of this study is to explore the association between frailty, adiposity indices and serum 25(OH)D concentrations.Methods1447 individuals with 65 years or older, participating in a cross-sectional study (Nutrition UP 65). Frailty, according to Fried et al., body mass index (BMI), waist circumference (WC), body roundness index (BRI) and body shape index (ABSI) were evaluated. A stepwise multinomial logistic regression was carried out to quantify the association between 25(OH)D quartiles and independent variables.ResultsMedian 25(OH)D levels were lower in individuals presenting both frailty and obesity (p<0.001). In the multivariate analysis, pre-frailty (OR 2.65; 95% CI 1.63-4.32) and frailty (OR 3.76; 95% CI 2.08-6.81) were associated with increased odds of lower 25(OH)D serum levels (first quartile). Regarding adiposity indices, obesity (OR 1.75; 95% CI 1.07-2.87) and the highest categories of WC (OR 3.46; 95% CI 1.95-6.15), BRI (OR 4.35; 95% CI 2.60-7.29) and ABSI (OR 3.17 95% CI 1.86-5.38) were directly associated with lower 25(OH)D serum levels (first quartile).ConclusionsA positive association between frailty or obesity and lower levels of vitamin D was found. Moreover, besides BMI and WC, other indicators of body adiposity, such as BRI and ABSI, were associated with lower 25(OH)D serum concentrations.

scholarly journals Vitamin D and PTH: data from a cross-sectional study in an equatorial population

2020 ◽  
Vol 9 (7) ◽  
pp. 667-675
Author(s):  
Natércia Neves Marques de Queiroz ◽  
Franciane Trindade Cunha de Melo ◽  
Fabrício de Souza Resende ◽  
Luísa Corrêa Janaú ◽  
Norberto Jorge Kzan de Souza Neto ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Vitamin D Insufficiency ◽  
Institute Of Medicine ◽  
Sectional Study ◽  
Cross Sectional ◽  
Endocrine Society

Objective: Investigate the prevalence of vitamin D deficiency in an equatorial population through a large-sample study. Methods: Cross-sectional study with 30,224 healthy individuals from the North Region, in Brazil (Amazônia – state of Pará), who had 25-hydroxy-vitamin D (25(OH)D) and intact parathyroid hormone (PTH) serum levels measured by immunoassay method. Those with history of acute or chronic diseases were excluded. Abnormal levels of calcium, creatinine, glycemia and albumin were also exclusion criteria. Results: 25(OH)D levels were 29.1 ± 8.2 ng/mL and values <12.7 ng/mL were equal to < −2 s.d. below average. Hypovitaminosis D was present in 10% of subjects according to the Institute of Medicine (values <20 ng/mL) and in 59%, in consonance with Endocrine Society (values 20–30 ng/mL as insufficiency and <20 ng/mL as deficiency) criteria. Individuals were divided according to four age brackets: children, adolescents, adults and elderly, and their 25(OH)D levels were: 33 ± 9; 28.5 ± 7.4; 28.3 ± 7.7; 29.3 ± 8.5 ng/mL, respectively. All groups differed in 25(OH)D, except adolescents vs adults. Regression model showed BMI, sex, living zone (urban or rural) and age as independent variables to 25(OH)D levels. Comparing subjects with vitamin D deficiency (<20 ng/mL) to those with vitamin D insufficiency (20–30 ng/mL), a difference between PTH levels in these two groups was observed (95.9 ± 24.7 pg/mL vs 44.2 ± 64.5 pg/mL; P < 0.01). Additionally, the most accurate predictive vitamin D level for subclinical hyperparathyroidism in ROC curve was 26 ng/mL. Conclusion: Our equatorial population showed low prevalence of vitamin D hypovitaminosis ranging with age bracket. The insufficient category by Endocrine Society was corroborated by our PTH data.

scholarly journals Evaluation of the Relationship Between Vitamin D Levels and Related Serum Markers as Well as Disease Activity in Patients With Rheumatoid Arthritis: A Cross-sectional Study in Western Iran

2020 ◽  
Author(s):  
Nasrin Moghimi ◽  
Ali Faridfar ◽  
Reza Shahriarirad ◽  
Mohsen Nikandish ◽  
Amirhossein Salimi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Serum Marker ◽  
Sectional Study ◽  
Cross Sectional ◽  
Vitamin D Levels ◽  
The Relationship

Abstract Introduction: Many studies have reported the role of vitamin D in rheumatoid arthritis (RA) which is related to several serum autoantibodies such as RF and Anti CCP. It also has been shown that vitamin D deficiency affect the DAS28 and VAS score inversely. Therefore, we aim to assess the relationship between vitamin D deficiency and RA-related autoantibodies including Anti CCP and RF levels and also evaluate the association between these parameters and the severity of disease.Methods: In this cross-sectional study, RA patients over 16 years of age were enrolled. The severity of diseases was assessed via the DAS28 scoring system. Serum levels of 25(OH) vitamin D were determined by the ELISA method, along with other rheumatoid related laboratory evaluations including Anti CCP, RF and CRPResults: A total of 100 patients with a mean age of 45.27± 14.14 were included and evaluated; of them, 75% were female and 77% lived in the city. Most of the patients (66%) had moderate DAS28 levels; however, no substantial relationship was observed between DAS28 and vitamin D levels. A significant positive relation between serum 25(OH)D level and disease duration, as well as the level of education, was observed. There was also no significant correlation between RA-related autoantibodies and inflammatory serum marker with 25(OH)D.Conclusion: Due to vitamin deficiency in the majority of cases (73%) and the relationship between serum 25(OH)D levels and the duration of disease, it can be concluded that vitamin D levels should be checked in those patients.

scholarly journals Serum Levels of Vitamin D in Diabetic Patients With and Without Retinopathy

2020 ◽  
Author(s):  
Mehrdad Afarid ◽  
Naghme Ghattavi ◽  
Mohammad Karim Johari
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Proliferative Retinopathy ◽  
Diabetic Patients ◽  
Cross Sectional ◽  
Serum Vitamin D ◽  
25 Hydroxy Vitamin D

Purpose: To evaluate the levels of vitamin D in the serum of diabetic patients with and without diabetic retinopathy (DR). Methods: Thirty patients with DR and thirty diabetic patients without retinopathy were included in this cross-sectional study. Based on ophthalmic examination, patients with DR were categorized into having non-proliferative retinopathy (NPDR) and proliferative retinopathy (PDR). Patients were tested for fasting blood sugar (FBS), hemoglobin A1C (HbA1C), 25-hydroxy vitamin D (25 (OH) D), and creatinine levels in the serum, and for urine protein. Vitamin D deficiency was defined as a serum 25 (OH) D level < 20 ng/mL. Results: We found that all diabetic patients had mild vitamin D deficiency (serum 25 (OH) D level = 10–20 ng/mL). The mean serum 25 (OH) D concentration in patients with DR was lower than in those without DR (12.10 ± 14.62 ng/mL vs 15.61 ± 9.40 ng/mL, respectively, P = 0.012). Trace or more proteinuria was frequently present in patients with DR than in those without DR (56% in DR vs 30% in non-DR; P = 0.037). There were no significant differences in the FBS, HbA1C, and serum creatinine levels between patients with or without retinopathy. Conclusion: The present study demonstrated that patients with DR had lower levels of serum vitamin D compared with those without retinopathy.

scholarly journals Correlation of Vitamin D Serum Level of Mothers and Their Newborns

2021 ◽  
Vol 18 (2) ◽  
Author(s):  
Hassan Boskabadi ◽  
Elahe Heidari
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Vitamin D Supplementation ◽  
High Rate ◽  
Cross Sectional ◽  
Maternal Vitamin ◽  
Premature Newborns ◽  
Vitamin D Levels

Background: The possibility of vitamin D deficiency is high among mothers and their premature newborns. Objectives: Due to the high rate of vitamin D deficiency in Iranian women, this study aimed to determine the association between the serum levels of vitamin D in the blood of premature newborns and their mothers in the Iranian population. Methods: This cross-sectional study was conducted on 324 mothers and their 324 newborns with gestational age less than 37 weeks, who were referred to Ghaem Hospital affiliated to Mashhad University of Medical Sciences, Mashhad, Iran, during 2016-2020. After clamping, 1.5 cc blood samples were obtained through the umbilical cord to determine the neonates’ vitamin D levels. Finally, the serum levels of vitamin D were measured, and the correlation between the levels of vitamin D of mothers and their newborns was calculated. Results: The mean vitamin D levels of newborns and mothers were 15.75 ± 11.18 and 20.16 ± 13.41 ng/mL, respectively. Moreover, there was a high correlation between the vitamin D levels of mothers and their newborns (r = 0.672; P < 0.001). Furthermore, a significant correlation was observed between the vitamin D levels of mothers, who used vitamin D supplementation during pregnancy and their neonates’ levels (r = 0.773; P < 0.001). Conclusions: The findings suggest a positive correlation between neonatal and maternal vitamin D levels. Moreover, it seems that maternal vitamin D levels can predict neonatal vitamin D deficiency.

scholarly journals The Association of Disease Activity, BMI and Phase Angle with Vitamin D Deficiency in Patients with IBD

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2583 ◽  
Author(s):  
Maria Chiara Mentella ◽  
Franco Scaldaferri ◽  
Marco Pizzoferrato ◽  
Antonio Gasbarrini ◽  
Giacinto Abele Donato Miggiano
Keyword(s):  
Vitamin D ◽  
Disease Activity ◽  
Vitamin D Deficiency ◽  
Phase Angle ◽  
Alimentary Tract ◽  
Hypovitaminosis D ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Inflammatory Bowel

Hypovitaminosis D is frequently present in inflammatory bowel disease (IBD) with a higher incidence in Crohn’s disease (CD) than in Ulcerative Colitis (UC). Given the involvement of the alimentary tract, many factors can contribute to hypovitaminosis D. The aim of the study was to investigate the association of disease activity, body mass index (BMI) and phase angle with vitamin D deficiency in patients with IBD. A cross-sectional study was conducted on a cohort of 206 IBD patients (October 2016–September 2018). Of these patients, 32.6% were affected by hypovitaminosis D (CD: 38.6%; UC: 25.6%; p < 0.01). Negative and significant associations (p < 0.01) were found between BMI and vitamin D serum levels both in CD and UC patients. BMI represented a determinant of hypovitaminosis D (Odds Ratio (OR) = 1.12, p < 0.01) only in UC patients; phase angle was associated to hypovitaminosis D in both groups (CD: OR = 0.64, p < 0.05; UC: OR = 0.49, p < 0.01). Results of the present study confirm a higher incidence of hypovitaminosis D in patients with CD than in those with UC, and show that nutritional status plays a crucial role in the incidence of vitamin D deficiency in patients with IBD.

Association of Serum 25-(OH)-D3 with Osteosarcopenic Obesity: A Cross-Sectional Study of Older Chinese

2020 ◽  
Author(s):  
Yanan Ma ◽  
Yuyan Liu ◽  
Shen Zhang ◽  
Lu Cao ◽  
Yu He ◽  
...  
Keyword(s):  
Vitamin D ◽  
Serum Level ◽  
Vitamin D Deficiency ◽  
Muscle Mass ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Osteosarcopenic Obesity ◽  
The Relationship

Abstract Background Limited and inconsistent epidemiological evidence for the relationship between vitamin D level and risk of osteosarcopenic obesity. We aimed to find out the relationship between serum level of 25-(OH)-D3 and osteosarcopenic obesity.Methods This study was a cross-sectional study. Residents from nine communities of the Tiexi District of Shenyang City were enrolled from May to October 2017. We included 4,506 eligible participants (1,601 men) for analyses. Participants were asked for an overnight fast. Thereafter, Blood samples were collected, and serum level of 25-(OH)-D3 was estimated using liquid chromatography–tandem mass spectrometry. We undertook logistic regression models adjusted for most known osteosarcopenic obesity risk factors. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.Results Our study included a total of 4,506 participants (2,905 women). In multivariable-adjusted analyses, compared to the lowest tertile, a higher 25-(OH)-D3 level (OR was 0.77, 95% CI was 0.61, 0.98; and P for trend was 0.026) was inversely correlated with osteosarcopenic obesity. A positive association between vitamin D deficiency and osteosarcopenic obesity was found (OR was 1.33, 95% CI was 1.10, 1.62). Inverse relationships between serum level of 25-(OH)-D3 and low bone mass, as well as low muscle mass were found (P values for trend were 0.035 and 0.014, respectively). However, vitamin D deficiency only showed a positive correlation with low muscle mass (OR=1.26, 95 %CI: 1.07, 1.44).Conclusion An independent inverse dose-response association of serum 25-(OH)-D3 level with osteosarcopenic obesity, as well as its compositions was found. Our findings implied that serum 25-(OH)-D3 could be a good predictor of osteosarcopenic obesity in older northeastern Chinese.

Vitamin D deficiency and risk of Helicobacter pylori infection in older adults: a cross-sectional study

2018 ◽  
Vol 31 (7) ◽  
pp. 985-991 ◽  
Author(s):  
Deniz Mut Surmeli ◽  
Zeki Gokhan Surmeli ◽  
Remzi Bahsi ◽  
Tugba Turgut ◽  
Hande Selvi Oztorun ◽  
...  
Keyword(s):  
Older Adults ◽  
Vitamin D ◽  
Helicobacter Pylori ◽  
Vitamin D Deficiency ◽  
Cross Sectional Study ◽  
Helicobacter Pylori Infection ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Vitamin D Serum Levels in Patients with Statin-Induced Musculoskeletal Pain

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Manuela Pennisi ◽  
Giuseppe Di Bartolo ◽  
Giulia Malaguarnera ◽  
Rita Bella ◽  
Giuseppe Lanza ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
Ratio Analysis ◽  
Vitamin D Status ◽  
Sectional Study ◽  
Musculoskeletal Health ◽  
Cross Sectional ◽  
Vitamin D Levels

Introduction. Statin-associated muscle symptoms are common side effects of statin therapy. These symptoms include myopathy, myalgia, and rhabdomyolysis. Vitamin D has been associated with musculoskeletal health; thus, its deficiency may produce detrimental effects in this tissue. Indeed, one symptom of vitamin D deficiency is myalgia, and the normalization of low vitamin D levels can relieve it. Patients and Methods. This cross-sectional study examined 1210 statin-treated patients to assess vitamin D status. These patients were divided into two groups: 287 with statin-associated muscle symptoms (SAMS) and 923 control patients without SAMS. Results. We have found a significant association between deficient and insufficient vitamin D status and statin-associated muscle symptoms (SAMS). Vitamin D deficiency (<30 nmol/L) presents 77% (95% C.I. 71.6% to 81.7%) sensitivity and 63.4% (95% C.I. 60.2% to 66.5%) specificity in diagnosing SAMS. Odds ratio analysis showed that this association is moderate-strong both for deficient and for insufficient status. Conclusion. We found a correlation between vitamin D deficiency and SAMS. Therefore, vitamin D levels may be useful for the diagnosis and management of SAMS.

scholarly journals Vitamin D Deficiency and Psoriasis: A Cross-Sectional study of Iranian Population in Yazd Province

2020 ◽  
Author(s):  
Mohammad Ebrahimzadeh Ardakani ◽  
Mohammad Afkhami-Ardekani ◽  
Mohammad Reza Taghizadeh Yazdi ◽  
Nasim Namiranian ◽  
Farideh Radmehr
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Hypovitaminosis D ◽  
Serum Levels ◽  
Cross Sectional Study ◽  
P Value ◽  
Sectional Study ◽  
Chi Square ◽  
Cross Sectional ◽  
Significant Difference

Objective: Psoriasis is an inflammatory disease of the skin and the joints. Psoriatic patients sometimes suffer from vitamin D deficiency and hypocalcemia. The aim of our study was to evaluate the level of calcium and vitamin D in patients with psoriasis. Materials and Methods: In this analytical cross sectional study, 110 cases of psoriasis that were referred to Shohadaye Mehrab clinic during 2015 and 110 non-psoriatic patients enrolled. Serum levels of calcium, phosphorus, parathyroid hormone (PTH), alkaline phosphatase (ALK) and 25- hydroxy vitamin D3 [(25OH) D3] were measured in both groups. Data were analyzed using SPSS software version 19. Chi square test and T-test were used for statistical analysis. Results: Among110 patients with psoriasis 74 (67.3%) were men and 36 (32.75%) were women. There was no significant difference in the serum level of calcium (P-value: 0.563), phosphorus (P-value: 0.381), PTH (P-value: 0.364) and ALK (P-value: 0.639) between two groups. Vitamin D deficiency was found in 64.5% of psoriatic patients and 60% of the controls (P-value= 0.45); However 30.9% of psoriatic and 17.3% of the controls suffered from severe hypovitaminosis D. This difference was statistically significant (Pvalue= 0.014).Conclusion: We found a significant relationship between severe hypovitaminosis D and psoriasis. This finding revealed the need for evaluation of psoriatic patients for the presence of vitamin D deficiency.

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