scholarly journals Magnetic resonance imaging of the regenerating neonatal mouse heart

2018 ◽  
Author(s):  
Mala Gunadasa-Rohling ◽  
Megan Masters ◽  
Mahon L. Maguire ◽  
Sean C. Smart ◽  
Jürgen E. Schneider ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Regenerative Process ◽  
Neonatal Mouse ◽  
Therapeutic Interventions ◽  
Mouse Heart ◽  
Coronary Artery Ligation ◽  
Heart Regeneration ◽  
Resonance Imaging ◽  
Artery Ligation

We present longitudinal magnetic resonance imaging (MRI) of neonatal mouse hearts during the first three weeks following coronary artery ligation to mimic heart attack. We confirm heart regeneration in individual animals injured on post-natal day 1 (P1) while those injured on P7 show the adult response of fibrosis, scarring and impaired heart performance. We document heart growth and development of the principal functional cardiac parameters, and also remodeling during tissue regeneration as compared to fibrosis when imaging repeatedly up to 21 days after myocardial infarction (MI). We reveal compensatory changes in cardiac function with the restoration of tissue and resolution of injury for the P1 cohort and sustained injury responses for the P7 cohort. This study resolves the controversy surrounding neonatal mouse heart regeneration and establishes a functional platform for live capture of the regenerative process and for the future testing of genetic or therapeutic interventions.

scholarly journals Magnetic Resonance Imaging of the Regenerating Neonatal Mouse Heart

Circulation ◽  
2018 ◽  
Vol 138 (21) ◽  
pp. 2439-2441 ◽  
Author(s):  
Mala Gunadasa-Rohling ◽  
Megan Masters ◽  
Mahon L. Maguire ◽  
Sean C. Smart ◽  
Jürgen E. Schneider ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Neonatal Mouse ◽  
Mouse Heart ◽  
Resonance Imaging

Magnetic resonance imaging of renal ischemia experimentally induced by renal artery ligation

1992 ◽  
Vol 28 (1) ◽  
pp. 8
Author(s):  
Chang Hee Suh ◽  
Jae Hyung Park ◽  
Moon Hee Han ◽  
Joon Koo Han ◽  
Seung Hyup Kim ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Renal Artery ◽  
Renal Ischemia ◽  
Resonance Imaging ◽  
Artery Ligation ◽  
Experimentally Induced

Magnetic Resonance Imaging and Ultrasound-Guided Percutaneous Interventional Radiology Procedures

2018 ◽  
Author(s):  
Sharath K. Bhagavatula ◽  
Bijal Patel ◽  
Kemal Tuncali ◽  
Stuart G. Silverman ◽  
Paul B. Shyn
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Interventional Procedures ◽  
Therapeutic Interventions ◽  
Resonance Imaging ◽  
Invasive Procedures ◽  
Us Guidance ◽  
Clinical Considerations ◽  
Magnetic Resonance Imaging Mri ◽  
Interventional Radiology Procedures

Diagnostic and therapeutic interventions guided by magnetic resonance imaging (MRI) are performed in clinical practice with increasing frequency and for an increasing number of indications. Ultrasound (US) guidance remains a very common, relatively inexpensive, and versatile option for guiding percutaneous interventions. The need for procedural sedation and anesthesia for minimally invasive procedures continues to grow as the number of procedures and interventional applications increase. This trend will continue as the population ages and the complexity and array of imaging-guided interventional procedures expand. This chapter discusses common interventional procedures that are performed under MRI and US guidance and outlines patient issues, procedural techniques, safety, and other clinical considerations that pertain to both interventionalists and anesthesiologists.

scholarly journals A piglet model for detection of hypoxic-ischemic brain injury with magnetic resonance imaging

2008 ◽  
Vol 49 (9) ◽  
pp. 1049-1057 ◽  
Author(s):  
B. H. Munkeby ◽  
C. De Lange ◽  
K. E. Emblem ◽  
A. Bjørnerud ◽  
G. A. B. Kro ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Basal Ganglia ◽  
Magnetic Resonance ◽  
Diffusion Tensor ◽  
Therapeutic Interventions ◽  
Resonance Imaging ◽  
Prognostic Information ◽  
Proton Mrs ◽  
Apparent Diffusion ◽  
Magnetic Resonance Imaging Mri

Background: Early detection of hypoxic-ischemic (HI) injury in the asphyxic newborn is important because present prognostic factors are inadequate. Furthermore, therapeutic interventions may have additional benefit if initiated in time. Purpose: To assess whether the use of a combined protocol including conventional magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI), and proton MR spectroscopy (MRS) could detect pathological findings in a piglet model 7 hours after HI. Material and Methods: Ten piglets were submitted to HI for 30 min followed by reoxygenation with 21% O2 for 7 hours. MRI at 1.5T was done prior to and 7 hours after the HI. Single-voxel proton MRS was performed, and apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured in the basal ganglia. MRS identified N-acetylaspartate (NAA), choline (Cho), creatine (Cr), and lactate (Lac). Histology and microtubule-associated protein 2 (MAP-2) staining was performed in the basal ganglia at the end of the experiment. Results: Compared to baseline, ADC, NAA/Cho, and NAA/Cr were significantly reduced after 7 hours ( P<0.001, P=0.01, and P=0.05, respectively) and FA values were increased ( P<0.025). The ratios of Lac/Cho and Lac/NAA were significantly higher after 7 hours compared to baseline ( P<0.001). Presence of necrosis correlated well with reduced ADC ( RS=0.91) and presence of Lac ( RS=0.80). Histology and MAP-2 staining showed more than 90% necrosis in eight piglets, 60% in one piglet, and no necrosis in one piglet. Conclusion: Diffusion MRI and proton MRS can detect HI injury in the piglet brain 7 hours after hypoxia. DWI and MRS can be used to give useful prognostic information. This piglet model may potentially be used to mimic clinical situations and is suitable for further research investigating HI injury.

Black blood gradient echo cine magnetic resonance imaging of the mouse heart

2005 ◽  
Vol 53 (5) ◽  
pp. 1074-1079 ◽  
Author(s):  
Stuart S. Berr ◽  
Rene Jack Roy ◽  
Brent A. French ◽  
Zequan Yang ◽  
Wesley Gilson ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Cine Magnetic Resonance Imaging ◽  
Mouse Heart ◽  
Black Blood ◽  
Resonance Imaging ◽  
Gradient Echo
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