scholarly journals Exploring the mechanistic link between corticosterone and insulinlike growth factor-1 in a wild passerine bird

2018 ◽  
Author(s):  
Zsófia Tóth ◽  
Jenny Q. Ouyang ◽  
Ádám Z. Lendvai
Keyword(s):  
Life History ◽  
Stress Response ◽  
Growth Factor ◽  
Physiological Stress ◽  
Passerine Bird ◽  
Handling Stress ◽  
Trade Offs ◽  
Physiological Stress Response ◽  
Panurus Biarmicus ◽  
Response To Stress

AbstractBackgroundPhysiological regulators of life history trade-offs need to be responsive to sudden changes of resource availability. When homeostasis is challenged by unpredictable stressors, vertebrates respond through a set of physiological reactions, which can promote organismal survival. Glucocorticoids have been traditionally recognized as one of the main regulators of the physiological stress response, but the role of an evolutionarily more conserved pathway, the hypothalamic-pituitary-somatotropic (HPS) axis producing insulin-like growth factor-1 (IGF-1) has received much less attention. Although IGF-1 is known to affect several life history traits, little is known about its role in the physiological stress response and it has never been studied directly in adult wild animals.MethodsIn this study, we combined field observations with a controlled experiment to investigate how circulating levels of IGF-1 change in response to stress and whether this change is due to concomitant change in glucocorticoids in a free-living songbird, the bearded reedling Panurus biarmicus. We used a standard capture-restraint protocol in field observation, in which we took first and second (stress induced: 15 minutes later) samples. In a follow-up experiment, we used a minimally invasive oral corticosterone manipulation.ResultsWe showed that corticosterone levels significantly increased while IGF-1 levels significantly decreased during capture and handling stress. However, change in corticosterone levels were not related to change in IGF-1 levels. We found that experimentally elevated corticosterone levels did not affect IGF-1 levels.DiscussionOur results are the first to highlight that circulating IGF-1 levels are responsive to stress independently from glucocorticoids and suggest that the HPS axis is an autonomous physiological pathway that may play an important role as regulator of life-history decisions.

scholarly journals Exploring the mechanistic link between corticosterone and insulin-like growth factor-1 in a wild passerine bird

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e5936 ◽  
Author(s):  
Zsófia Tóth ◽  
Jenny Q. Ouyang ◽  
Ádám Z. Lendvai
Keyword(s):  
Life History ◽  
Stress Response ◽  
Growth Factor ◽  
Physiological Stress ◽  
Passerine Bird ◽  
Insulin Like Growth Factor ◽  
Handling Stress ◽  
Trade Offs ◽  
Physiological Stress Response ◽  
Panurus Biarmicus

Background Physiological regulators of life history trade-offs need to be responsive to sudden changes of resource availability. When homeostasis is challenged by unpredictable stressors, vertebrates respond through a set of physiological reactions, which can promote organismal survival. Glucocorticoids have been traditionally recognized as one of the main regulators of the physiological stress response, but the role of an evolutionarily more conserved pathway, the hypothalamic-pituitary-somatotropic (HPS) axis producing insulin-like growth factor-1 (IGF-1) has received much less attention. Although IGF-1 is known to affect several life history traits, little is known about its role in the physiological stress response and it has never been studied directly in adult wild animals. Methods In this study, we combined field observations with a controlled experiment to investigate how circulating levels of IGF-1 change in response to stress and whether this change is due to concomitant change in glucocorticoids in a free-living songbird, the bearded reedling Panurus biarmicus. We used a standard capture-restraint protocol in field observation, in which we took first and second (stress induced: 15 minutes later) samples. In a follow-up experiment, we used a minimally invasive oral corticosterone manipulation. Results We showed that corticosterone levels significantly increased while IGF-1 levels significantly decreased during capture and handling stress. However, change in corticosterone levels were not related to change in IGF-1 levels. We found that experimentally elevated corticosterone levels did not affect IGF-1 levels. Discussion Our results are the first to highlight that circulating IGF-1 levels are responsive to stress independently from glucocorticoids and suggest that the HPS axis is an autonomous physiological pathway that may play an important role as regulator of life-history decisions.

scholarly journals “The stressed bird in the hand”: Influence of sampling design on the physiological stress response in a free-living songbird

2020 ◽  
Author(s):  
Nikolaus Huber ◽  
Katharina Mahr ◽  
Zsófia Tóth ◽  
Endre Z. Szarka ◽  
Yusuf Ulaş Çınar ◽  
...  
Keyword(s):  
Stress Response ◽  
Sampling Design ◽  
Physiological Stress ◽  
Parus Major ◽  
Blood Sampling ◽  
Short Term ◽  
Free Living ◽  
Coping Capacity ◽  
Handling Stress ◽  
Physiological Stress Response

AbstractDespite the widely used application of standardized capture-handling protocols to collect blood and assess the physiological stress response, the effect of the actual sampling design (e.g. timing and the number of blood samples) often differs between studies, and the potential implications for the measured physiological endpoints remain understudied. We, therefore, experimentally tested the effects of repeated handling and multiple blood sampling on the stress response in wintering free-living great tits (Parus major). We modified a well-established sampling protocol of avian studies by adding either an additional blood sample or a “sham-manipulation” (i.e. handling associated with the blood sampling procedure without venepuncture), to disentangle the effects of handling stress and blood loss. We combined three different stress metrics along the endocrine-immune interface to investigate the acute short-term stress response: total corticosterone levels (CORT), the heterophil/lymphocyte ratio (H:L), and the Leukocyte Coping Capacity (LCC). Our study provided three key results: i) no relationship between CORT-levels, LCC and H:L, confirming that these three parameters represent different physiological endpoints within the stress response; ii) contrasting dynamics in response to stress by the measured parameters and iii) no difference in stress levels 30 minutes after capture due to one additional blood sampling or handling event. By optimising the sampling design, our results provide implications for animal welfare and planning experimental procedures on stress physiology in passerine species.Summary StatementWhen testing the short-term stress response in free living passerines, both – the scientist and the bird may be better off with a 15-minute stress protocol.

scholarly journals The effects of experimental increase in insulin-like growth factor 1 on feather growth rate, moult intensity and feather quality in a passerine bird

2021 ◽  
Author(s):  
Ádám Z. Lendvai ◽  
Zsófia Tóth ◽  
Katharina Mahr ◽  
Gergely Osváth ◽  
Sarah Vogel-Kindgen ◽  
...  
Keyword(s):  
Growth Rate ◽  
Life History ◽  
Growth Factor ◽  
Somatic Growth ◽  
Peptide Hormone ◽  
Passerine Bird ◽  
Life History Stage ◽  
Insulin Like Growth Factor ◽  
Feather Growth ◽  
Panurus Biarmicus

Moulting is a crucial, yet often overlooked life-history stage in many animals, when they renew their integumental structures. This life-history stage is an energetically demanding somatic growth event that has particular importance in birds because feathers play a crucial role in flight, insulation and communication. Somatic growth processes are regulated by the evolutionarily conserved peptide hormone, insulin-like growth factor 1 (IGF-1). However, the role of IGF-1 in feather growth remains unknown. In this study, we captured 41 juvenile free-living bearded reedlings (Panurus biarmicus) that had started their first complete moult and brought them into captivity. Then we manipulated their circulating IGF-1 levels using poly-(lactid-co-glycolid acid) microparticles (microspheres) that provide a sustained release of IGF-1. The treatment increased IGF-1 levels but did not affect the feather growth rate. However, two weeks after the treatment, birds in the increased IGF-1 group were moulting more feathers simultaneously than the controls and were at a more advanced stage of moult. Birds with experimentally increased IGF-1 levels had better quality feathers (measured by a lower number of fault bars) than the controls. These results suggest that an increase in IGF-1 does not speed up feather growth, but may alter moult intensity by initiating the renewal of several feathers simultaneously. This may shorten the overall moulting time but may imply costs in terms of IGF-1 induced oxidative stress.

scholarly journals Thermal flexibility is a repeatable mechanism to cope with environmental stressors in a passerine bird

2021 ◽  
Author(s):  
Joshua K. Robertson ◽  
Gabriela F. Mastromonaco ◽  
Gary Burness
Keyword(s):  
Stress Response ◽  
Physiological Stress ◽  
Passerine Bird ◽  
Urban Environments ◽  
Environmental Stressors ◽  
List Type ◽  
Physiological Stress Response ◽  
Fight Or Flight Response ◽  
Body Surface Temperature ◽  
Induced Changes

AbstractFor many vertebrates, urban environments are characterised by frequent environmental stressors. Coping with such stressors can demand that urban individuals activate energetically costly physiological pathways (e.g. the fight-or-flight response) more regularly than rural-living conspecifics. However, urban environments also commonly demand appreciable expenditure toward thermoregulation, owing to their often extreme climatic variations. To date, whether and how vertebrates can balance expenditure toward both the physiological stress response and thermoregulation, and thus persist in an urbanising world, remains an unanswered and urgent question among ecologists.In some species, changes in body surface temperature (Ts) and peripheral heat loss (qTot) that accompany the stress response are thought to balance energetic expenditure toward thermoregulation and responding to a stressor. Thus, augmentation of stressinduced thermal responses may be a mechanism by which urban individuals cope with simultaneously high thermoregulatory and stress-physiological demands.We tested whether stress-induced changes in Ts and qTot: (1) differed between urban- and rural-origin individuals, (2) reduce thermoregulatory demands in urban individuals relative to rural conspecifics, and (3) meet an essential first criterion for evolutionary responses to selection (variability among, and consistency within, individuals).Using the black-capped chickadee (Poecile atricapillus; n = 19), we show that neither rapid nor chronic changes in Ts and qTot following exposure to randomised stressors differed between urban- and rural-origin individuals (nurban = 9; nrural = 10). Nevertheless, we do find that stress-induced changes in Ts and qTot are highly repeatable across chronic time periods (RTs = 0.61; RqTot = 0.67) and display signatures of stabilising or directional selection (i.e. reduced variability and increase repeatability relative to controls).Our findings suggest that, although urban individuals appear no more able to balance expenditure toward thermoregulation and the stress response than rural conspecifics, the capacity to do so may be subject to selection in some species. To our knowledge this is also the first study to report repeatability of any theorised stress-induced trade-off.

Reflex impairment and physiological stress response in the Neotropical wolf fish Hoplias malabaricus (Characiformes, Erythrinidae) exposed to catch-and-release angling

2021 ◽  
Vol 239 ◽  
pp. 105940
Author(s):  
Laura Simões Andrade ◽  
Domingos Garrone-Neto ◽  
Manuela Alves Nobre Sales ◽  
Luciana Rodrigues de Souza-Bastos ◽  
Ursulla Pereira Souza ◽  
...  
Keyword(s):  
Stress Response ◽  
Physiological Stress ◽  
Hoplias Malabaricus ◽  
Catch And Release ◽  
Physiological Stress Response

scholarly journals Physiological Stress Response of Captive White-Tailed Deer to Video Collars

2009 ◽  
Vol 73 (4) ◽  
pp. 609-614 ◽  
Author(s):  
Remington J. Moll ◽  
Joshua J. Millspaugh ◽  
Jeff Beringer ◽  
Joel Sartwell ◽  
Rami J. Woods ◽  
...  
Keyword(s):  
Stress Response ◽  
Physiological Stress ◽  
Physiological Stress Response
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