scholarly journals Functional connectivity alterations in Parkinson’s disease during the stop-signal task

2018 ◽  
Author(s):  
Chris Vriend ◽  
Douglas T. Leffa ◽  
James P. Trujillo ◽  
Niels J.H.M. Gerrits ◽  
Femke E. de Boer ◽  
...  
Keyword(s):  
Reaction Time ◽  
Functional Connectivity ◽  
Response Inhibition ◽  
Functional Activity ◽  
Brain Regions ◽  
Anterior Insula ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Healthy Controls ◽  
Dopaminergic Medication

AbstractAlthough deficits in response inhibition are common in Parkinson’s disease (PD), studies on their neural correlates are relatively scarce. In our previous study, medication-naïve PD patients showed, among others, lower activation of the inhibition-related bilateral inferior frontal gyrus (IFG) compared with healthy controls while performing the stop-signal task. Here we report on a follow-up study in the same cohort.Fourteen medicated PD patients and 16 healthy controls performed the same stop-signal task during MRI; 3.1±1.0 years after our previous study. During that time, all PD patients had started to use dopaminergic medication. We analyzed task-related functional activity and connectivity in the bilateral IFG and anterior insula, brain regions that are important response inhibition. Task-related functional connectivity was analyzed with generalized psychophysiological interaction.PD patients were significantly slower on response initiation (GO reaction time) and response inhibition (stop-signal reaction time) than healthy controls. There were no between-group differences in functional activity. On the other hand, functional connectivity of the IFG and anterior insula was significantly lower in PD compared with healthy controls. Mainly the inferior parietal lobule and dorsolateral prefrontal cortex were less connected with these seed regions.These results show that early-stage medicated PD patients show lower task-related functional connectivity but not activity of brain regions that are important for response inhibition; the IFG and anterior insula. We tentatively speculate that the use of dopaminergic medication upheld task-related activity but not connectivity.

scholarly journals Stop Signal Reaction Time Deficits in a Lifetime Obsessive-Compulsive Disorder Sample

2016 ◽  
Vol 22 (7) ◽  
pp. 785-789 ◽  
Author(s):  
Nicole C.R. McLaughlin ◽  
Jason Kirschner ◽  
Hallee Foster ◽  
Chloe O’Connell ◽  
Steven A. Rasmussen ◽  
...  
Keyword(s):  
Reaction Time ◽  
Obsessive Compulsive Disorder ◽  
Response Inhibition ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Control Group ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Stop Signal Reaction Time

AbstractObjectives: Several studies have found impaired response inhibition, measured by a stop-signal task (SST), in individuals who are currently symptomatic for obsessive-compulsive disorder (OCD). The aim of this study was to assess stop-signal reaction time (SSRT) performance in individuals with a lifetime diagnosis of OCD, in comparison to a healthy control group. This is the first study that has examined OCD in participants along a continuum of OCD severity, including approximately half of whom had sub-syndromal symptoms at the time of assessment. Methods: OCD participants were recruited primarily from within the OCD clinic at a psychiatric hospital, as well as from the community. Healthy controls were recruited from the community. We used the stop signal task to examine the difference between 21 OCD participants (mean age, 42.95 years) and 40 healthy controls (mean age, 35.13 years). We also investigated the relationship between SST and measures of OCD, depression, and anxiety severity. Results: OCD participants were significantly slower than healthy controls with regard to mean SSRT. Contrary to our prediction, there was no correlation between SSRT and current levels of OCD, anxiety, and depression severity. Conclusions: Results support prior studies showing impaired response inhibition in OCD, and extend the findings to a sample of patients with lifetime OCD who were not all currently above threshold for diagnosis. These findings indicate that response inhibition deficits may be a biomarker of OCD, regardless of current severity levels. (JINS, 2016, 22, 785–789)

Emotional Stop Cues Facilitate Inhibitory Control in Schizophrenia

2019 ◽  
Vol 26 (3) ◽  
pp. 286-293
Author(s):  
Qi Zheng ◽  
Tian-Xiao Yang ◽  
Zheng Ye
Keyword(s):  
Reaction Time ◽  
Inhibitory Control ◽  
Significant Influence ◽  
Response Inhibition ◽  
Stop Signal Task ◽  
Enhancement Effect ◽  
Healthy Controls ◽  
Inhibitory Process ◽  
After Effects ◽  
Effective Interventions

AbstractObjective:Inhibitory control is a key deficit in patients with schizophrenia. This study aims to test whether emotions can facilitate inhibition in patients with schizophrenia when they increase attention to inhibitory process.Method:A total of 36 patients with schizophrenia and 36 healthy controls completed an emotional stop-signal task. The task involved selective responses to “Go” stimuli and stopped response when emotional or neutral stop cues occurred.Results:In all conditions, patients with schizophrenia took longer time to inhibit response compared with healthy controls, indicating an overall impairment in response inhibition. Importantly, patients with schizophrenia and controls acquired similar size of benefit from the negative stop cues, showing as reduced reaction time to negative than neutral stop cues. However, the negative stop cues impaired subsequent Go performance only in patients with schizophrenia, indicating additional cost of the negative stop cues for patients with schizophrenia. In both groups, the positive stop cues did not have any significant influence on response inhibition.Conclusions:These findings provide novel evidence for the benefit of emotional stop cues on inhibitory control in patients with schizophrenia and reveal different after-effects of emotional enhancement effect in patients and healthy populations. The findings may help develop effective interventions for improving inhibitory control in patients with schizophrenia and other clinical populations.

Proactive and Reactive Motor Inhibition in Top Athletes Versus Nonathletes

2018 ◽  
Vol 125 (2) ◽  
pp. 289-312 ◽  
Author(s):  
Damien Brevers ◽  
Etienne Dubuisson ◽  
Fabien Dejonghe ◽  
Julien Dutrieux ◽  
Mathieu Petieau ◽  
...  
Keyword(s):  
Reaction Time ◽  
Response Inhibition ◽  
Motor Response ◽  
Proactive Inhibition ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Reactive Inhibition ◽  
Stop Signal Reaction Time ◽  
Motor Response Inhibition ◽  
Inhibition Performance

We examined proactive (early restraint in preparation for stopping) and reactive (late correction to stop ongoing action) motor response inhibition in two groups of participants: professional athletes ( n = 28) and nonathletes ( n = 25). We recruited the elite athletes from Belgian national taekwondo and fencing teams. We estimated proactive and reactive inhibition with a modified version of the stop-signal task (SST) in which participants inhibited categorizing left/right arrows. The probability of the stop signal was manipulated across blocks of trials by providing probability cues from the background computer screen color (green = 0%, yellow =17%, orange = 25%, red = 33%). Participants performed two sessions of the SST, where proactive inhibition was operationalized with increased go-signal reaction time as a function of increased stop-signal probability and reactive inhibition was indicated by stop-signal reaction time latency. Athletes exhibited higher reactive inhibition performance than nonathletes. In addition, athletes exhibited higher proactive inhibition than nonathletes in Session 1 (but not Session 2) of the SST. As top-level athletes exhibited heightened reactive inhibition and were faster to reach and maintain consistent proactive motor response inhibition, these results confirm an evaluative process that can discriminate elite athleticism through a fine-grained analysis of inhibitory control.

scholarly journals Obsessive Compulsive Disorder and Response Inhibition: Meta-analysis of the Stop-Signal Task

2021 ◽  
Author(s):  
Kendall Mar ◽  
Parker Townes ◽  
Petros Pechlivanoglou ◽  
Paul Arnold ◽  
Russell James Schachar
Keyword(s):  
Reaction Time ◽  
Obsessive Compulsive Disorder ◽  
Response Inhibition ◽  
Meta Analysis ◽  
Stop Signal ◽  
Mean Difference ◽  
Stop Signal Task ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Stop Signal Reaction Time

This systematic review and meta-analysis updates evidence pertaining to deficient response inhibition in obsessive-compulsive disorder (OCD) as measured by the stop-signal task (SST). We conducted a meta-analysis of the literature to compare response inhibition in patients with OCD and healthy controls, meta-regressions to determine relative influences of age and sex on response inhibition impairment, and a risk of bias assessment for included studies using the Newcastle-Ottawa Scale (NOS). Stop-signal reaction time (SSRT), which estimates the latency of the stopping process deficit, was significantly longer in OCD samples than in controls, reflecting inferior inhibitory control (Raw mean difference = 23.43ms; p = <0.001; 95% CI = [17.42, 29.45]). We did not observe differences in mean reaction time (MRT) in OCD compared to controls (Raw mean difference = 2.51ms; p = 0.755; 95% CI = [-13.27, 18.30]). Age impacted effect size of SSRT, indicating a greater deficit in older patients than younger ones. We did not observe a significant effect of sex on SSRT or MRT scores.

scholarly journals Response inhibition alterations in migraine: evidence from event-related potentials and evoked oscillations

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Guoliang Chen ◽  
Yansong Li ◽  
Zhao Dong ◽  
Rongfei Wang ◽  
Dengfa Zhao ◽  
...  
Keyword(s):  
Inhibitory Control ◽  
Response Inhibition ◽  
Event Related Potentials ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Healthy Controls ◽  
Conflict Monitoring ◽  
Time Frequency ◽  
Related Potentials ◽  
Prepotent Responses

Abstract Background Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mechanisms giving rise to this abnormality, the presence of deficient inhibitory cortical processes has been proposed to be one possible mechanism underlying its pathogenesis. Empirical evidence supporting this claim is mainly based on previous accounts showing functional cortical disexcitability in the sensory domain. Considering that a general inhibitory control process can play an important role across early to later stage of information processing, this may indicate the important role other dimensions of inhibitory control can play in migraine disability. The present study examined the pathophysiological features of inhibitory control that takes place during suppression of prepotent responses in migraineurs. Methods Twenty-two patients with migraine without aura (mean age = 30.86 ± 5.69 years; 19 females) during the interictal period and 25 healthy controls (mean age = 30.24 ± 3.52 years; 18 females) were recruited. We used a stop signal task in combination with event-related potentials (ERPs) to examine participants’ neural activity supporting response inhibition. Results Behaviorally, migraineurs exhibited prolonged stop signal reaction times relative to healthy controls. At the neural level, the amplitude of the stop-N2 over fronto-central, central and centro-parietal scalp regions, a component of the ERPs related to conflict monitoring during early, non-motoric stages of inhibition, was significantly increased in migraineurs. Meanwhile, the amplitude of the stop-P3 over central and centro-parietal scalp regions, a component of the ERPs reflecting late-stage inhibition of the motor system and cognitive evaluation of motor inhibition, was also significantly increased in migraineurs. Ultimately, our time-frequency analysis further revealed increased delta activity in migraineurs. Conclusions Consistent with the theory that alterations in cognitive cortical processes are a key signature of migraine, our findings revealed an abnormal state of suppressing prepotent responses in migraineurs, which can be attributed to cortical disexcitability of the pre-frontal executive network and centro-parietal sensorimotor network. These novel findings extend to show the existence of dysfunctional inhibition control that occurs during suppression of prepotent responses in migraneurs.

scholarly journals An ERP study on proactive and reactive response inhibition in individuals with schizotypy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lu-xia Jia ◽  
Xiao-jing Qin ◽  
Ji-fang Cui ◽  
Qi Zheng ◽  
Tian-xiao Yang ◽  
...  
Keyword(s):  
Reaction Time ◽  
Response Inhibition ◽  
Proactive Inhibition ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Signal Probability ◽  
Reactive Inhibition ◽  
Eeg Data ◽  
Stop Signal Reaction Time ◽  
Stop Condition

AbstractSchizotypy, a subclinical group at risk for schizophrenia, has been found to show impairments in response inhibition. However, it remains unclear whether this impairment is accompanied by outright stopping (reactive inhibition) or preparation for stopping (proactive inhibition). We recruited 20 schizotypy and 24 non-schizotypy individuals to perform a modified stop-signal task with electroencephalographic (EEG) data recorded. This task consists of three conditions based on the probability of stop signal: 0% (no stop trials, only go trials), 17% (17% stop trials), and 33% (33% stop trials), the conditions were indicated by the colour of go stimuli. For proactive inhibition (go trials), individuals with schizotypy exhibited significantly lesser increase in go response time (RT) as the stop signal probability increasing compared to non-schizotypy individuals. Individuals with schizotypy also exhibited significantly increased N1 amplitude on all levels of stop signal probability and increased P3 amplitude in the 17% stop condition compared with non-schizotypy individuals. For reactive inhibition (stop trials), individuals with schizotypy exhibited significantly longer stop signal reaction time (SSRT) in both 17% and 33% stop conditions and smaller N2 amplitude on stop trials in the 17% stop condition than non-schizotypy individuals. These findings suggest that individuals with schizotypy were impaired in both proactive and reactive response inhibition at behavioural and neural levels.

scholarly journals Test-Retest Reliability of Neural Correlates of Response Inhibition and Error Monitoring: An fMRI Study of a Stop-Signal Task

2021 ◽  
Vol 15 ◽  
Author(s):  
Ozlem Korucuoglu ◽  
Michael P. Harms ◽  
Serguei V. Astafiev ◽  
Semyon Golosheykin ◽  
James T. Kennedy ◽  
...  
Keyword(s):  
Response Inhibition ◽  
Noise Removal ◽  
Neural Correlates ◽  
Brain Regions ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Error Monitoring ◽  
Retest Reliability ◽  
Dorsolateral Prefrontal ◽  
Test Retest Reliability

Response inhibition (RI) and error monitoring (EM) are important processes of adaptive goal-directed behavior, and neural correlates of these processes are being increasingly used as transdiagnostic biomarkers of risk for a range of neuropsychiatric disorders. Potential utility of these purported biomarkers relies on the assumption that individual differences in brain activation are reproducible over time; however, available data on test-retest reliability (TRR) of task-fMRI are very mixed. This study examined TRR of RI and EM-related activations using a stop signal task in young adults (n = 56, including 27 pairs of monozygotic (MZ) twins) in order to identify brain regions with high TRR and familial influences (as indicated by MZ twin correlations) and to examine factors potentially affecting reliability. We identified brain regions with good TRR of activations related to RI (inferior/middle frontal, superior parietal, and precentral gyri) and EM (insula, medial superior frontal and dorsolateral prefrontal cortex). No subcortical regions showed significant TRR. Regions with higher group-level activation showed higher TRR; increasing task duration improved TRR; within-session reliability was weakly related to the long-term TRR; motion negatively affected TRR, but this effect was abolished after the application of ICA-FIX, a data-driven noise removal method.

scholarly journals Response inhibition alterations in migraine: Evidence from event-related potentials and evoked oscillations

2020 ◽  
Author(s):  
Guoliang Chen ◽  
Yansong Li ◽  
Zhao Dong ◽  
Rongfei Wang ◽  
Dengfa Zhao ◽  
...  
Keyword(s):  
Inhibitory Control ◽  
Response Inhibition ◽  
Event Related Potentials ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Healthy Controls ◽  
Conflict Monitoring ◽  
Time Frequency ◽  
Related Potentials ◽  
Prepotent Responses

Abstract Background: Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mechanisms giving rise to this abnormality, the presence of deficient inhibitory cortical processes has been proposed to be one possible mechanism underlying its pathogenesis. Empirical evidence supporting this claim is mainly based on previous accounts showing functional cortical disexcitability in the sensory domain. Considering that a general inhibitory control process can play an important role across early to later stage of information processing, this may indicate the important role other dimensions of inhibitory control can play in migraine disability. The present study examined the pathophysiological features of inhibitory control that takes place during suppression of prepotent responses in migraineurs.Methods: Twenty-two patients with migraine without aura (mean age = 30.86 ± 5.69 years; 19 females) during the interictal period and 25 healthy controls (mean age = 30.24 ± 3.52 years; 18 females) were recruited. We used a stop signal task in combination with event-related potentials (ERPs) to examine participants’ neural activity supporting response inhibition.Results: Behaviorally, migraineurs exhibited prolonged stop signal reaction times relative to healthy controls. At the neural level, the amplitude of the stop-N2 over fronto-central, central and centro-parietal scalp regions, a component of the ERPs related to conflict monitoring during early, non-motoric stages of inhibition, was significantly increased in migraineurs. Meanwhile, the amplitude of the stop-P3 over central and centro-parietal scalp regions, a component of the ERPs reflecting late-stage inhibition of the motor system and cognitive evaluation of motor inhibition, was also significantly increased in migraineurs. Ultimately, our time-frequency analysis further revealed increased delta activity in migraineurs.Conclusions: Consistent with the theory that alterations in cognitive cortical processes are a key signature of migraine, our findings revealed an abnormal state of suppressing prepotent responses in migraineurs, which can be attributed to cortical disexcitability of the pre-frontal executive network and centro-parietal sensorimotor network. These novel findings extend to show the existence of dysfunctional inhibition control that occurs during suppression of prepotent responses in migraneurs.

scholarly journals Lateralized deficit of response inhibition in early-onset schizophrenia

2005 ◽  
Vol 36 (4) ◽  
pp. 495-505 ◽  
Author(s):  
MARK A. BELLGROVE ◽  
CHRISTOPHER D. CHAMBERS ◽  
ALASDAIR VANCE ◽  
NICOLE HALL ◽  
MARY KARAMITSIOS ◽  
...  
Keyword(s):  
Reaction Time ◽  
Response Inhibition ◽  
Early Onset ◽  
Poor Response ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Early Onset Schizophrenia ◽  
Left Hand ◽  
Stop Signal Reaction Time ◽  
The Right

Background. The ability to inhibit inappropriate or unwanted actions is a key element of executive control. The existence of executive function deficits in schizophrenia is consistent with frontal lobe theories of the disorder. Relatively few studies have examined response inhibition in schizophrenia, and none in adolescent patients with early-onset schizophrenia (EOS).Methods. Twenty-one adolescents with the onset of clinically impairing psychosis before 19 years of age and 16 matched controls performed a stop-signal task to assess response inhibition. The patients with EOS were categorized as paranoid (n=10) and undifferentiated subtypes (n=11). The undifferentiated group had higher levels of negative symptomatology. Stop-signal reaction time (SSRT) and go-signal reaction time (Go-RT) were analysed with respect to hand of response.Results. The undifferentiated early-onset patients had significantly longer SSRTs, indicative of poor response inhibition, for the left hand compared to the paranoid early-onset patients and control participants. No differences existed for inhibitory control with the right hand. The three groups did not differ in Go-RT.Conclusions. Our results indicate a specific lateralized impairment of response inhibition in patients with undifferentiated, but not paranoid, EOS. These findings are consistent with reports of immature frontostriatal networks in EOS and implicate areas such as the pre-motor cortex and supplementary motor area (SMA) that are thought to play a role in both voluntary initiation and inhibition of movement.

Causal Prefrontal Contributions to Stop-Signal Task Performance in Humans

2020 ◽  
pp. 1-14
Author(s):  
Michael K. Yeung ◽  
Ami Tsuchida ◽  
Lesley K. Fellows
Keyword(s):  
Task Performance ◽  
Inhibitory Control ◽  
Cognitive Neuroscience ◽  
Response Inhibition ◽  
Frontal Lobes ◽  
Stop Signal ◽  
Stop Signal Task ◽  
Healthy Controls ◽  
Full Understanding ◽  
Underlying Mechanisms

The frontal lobes have long been implicated in inhibitory control, but a full understanding of the underlying mechanisms remains elusive. The stop-signal task has been widely used to probe instructed response inhibition in cognitive neuroscience. The processes involved have been modeled and related to putative brain substrates. However, there has been surprisingly little human lesion research using this task, with the few existing studies implicating different prefrontal regions. Here, we tested the effects of focal prefrontal damage on stop-signal task performance in a large sample of people with chronic focal damage affecting the frontal lobes ( n = 42) and demographically matched healthy people ( n = 60). Patients with damage to the left lateral, right lateral, dorsomedial, or ventromedial frontal lobe had slower stop-signal RT compared to healthy controls. There were systematic differences in the patterns of impairment across frontal subgroups: Those with damage to the left or right lateral and dorsomedial frontal lobes, but not those with ventromedial frontal damage, were slower than controls to “go” as well as to stop. These findings suggest that multiple prefrontal regions make necessary but distinct contributions to stop-signal task performance. As a consequence, stop-signal RT slowing is not strongly localizing within the frontal lobes.

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