scholarly journals Deep learning of quality control for stereotaxic registration of human brain MRI

2018 ◽  
Author(s):  
Vladimir S. Fonov ◽  
Mahsa Dadar ◽  
D. Louis Collins ◽  
Keyword(s):  
Image Processing ◽  
Quality Control ◽  
Deep Learning ◽  
Human Brain ◽  
Control Method ◽  
False Positive Rate ◽  
Brain Mri ◽  
Brain Scans ◽  
Positive Rate ◽  
Mri Scans

AbstractLinear registration to stereotaxic space is a common first step in many automated image-processing tools for analysis of human brain MRI scans. This step is crucial for the success of the following image-processing steps. Several well-established algorithms are commonly used in the field of neuroimaging for this task, but none of them has a 100% success rate. Manual assessment of the registration is commonly used as part of quality control.We propose a completely automatic quality control method based on deep learning that replaces human rater and accurately performs quality control assessment for stereotaxic registration of T1w brain scans.In a recently published study from our group comparing linear registration methods, we used a database of 9693 MRI scans from several publically available datasets and applied five linear registration tools. In this study, the resulting images that were assessed and labeled by a human rater are used to train a deep neural network to detect cases when registration failed.Our method was able to achieve 88% accuracy and 11% false positive rate in detecting scans that should pass quality control, better than a manual QC rater.

scholarly journals DARQ: Deep learning of quality control for stereotaxic registration of human brain MRI

2021 ◽  
Author(s):  
Vladimir Fonov ◽  
Mahsa Dadar ◽  
D. Louis Collins ◽  
◽  
Keyword(s):  
Image Processing ◽  
Quality Control ◽  
Deep Learning ◽  
Human Brain ◽  
Brain Mri ◽  
True Negative ◽  
Available N ◽  
True Negative Rate ◽  
Negative Rate ◽  
Mri Scans

Linear registration to stereotaxic space is a common first step in many automated image-processing tools for analysis of human brain MRI scans. This step is crucial for the success of the subsequent image-processing steps. Several well-established algorithms are commonly used in the field of neuroimaging for this task, but none have a 100% success rate. Manual assessment of the registration is commonly used as part of quality control. To reduce the burden of this time-consuming step, we propose Deep Automated Registration Qc (DARQ), a fully automatic quality control method based on deep learning that can replace the human rater and accurately perform quality control assessment for stereotaxic registration of T1w brain scans. In a recently published study from our group comparing linear registration methods, we used a database of 9325 MRI scans from several publicly available datasets and applied seven linear registration tools to them. In this study, the resulting images that were assessed and labeled by a human rater are used to train a deep neural network to detect cases when registration failed. We further validated the results on an independent dataset of patients with multiple sclerosis, with manual QC labels available (n=1200). In terms of agreement with a manual rater, our automated QC method was able to achieve 89% accuracy and 85% true negative rate (equivalently 15% false positive rate) in detecting scans that should pass quality control in a balanced cross-validation experiments, and 96.1% accuracy and 95.5% true negative rate (or 4.5% FPR) when evaluated in a balanced independent sample, similar to manual QC rater (test-retest accuracy of 93%). The results show that DARQ is robust, fast, accurate, and generalizable in detecting failure in linear stereotaxic registrations and can substantially reduce QC time (by a factor of 20 or more) when processing large datasets.

scholarly journals IoT Botnet Anomaly Detection Using Unsupervised Deep Learning

Electronics ◽  
2021 ◽  
Vol 10 (16) ◽  
pp. 1876
Author(s):  
Ioana Apostol ◽  
Marius Preda ◽  
Constantin Nila ◽  
Ion Bica
Keyword(s):  
Deep Learning ◽  
Detection System ◽  
False Positive Rate ◽  
Empirical Evaluation ◽  
Learning Approaches ◽  
Promising Alternative ◽  
Positive Rate ◽  
Unsupervised Deep Learning ◽  
Attack Surface ◽  
Iot Devices

The Internet of Things has become a cutting-edge technology that is continuously evolving in size, connectivity, and applicability. This ecosystem makes its presence felt in every aspect of our lives, along with all other emerging technologies. Unfortunately, despite the significant benefits brought by the IoT, the increased attack surface built upon it has become more critical than ever. Devices have limited resources and are not typically created with security features. Lately, a trend of botnet threats transitioning to the IoT environment has been observed, and an army of infected IoT devices can expand quickly and be used for effective attacks. Therefore, identifying proper solutions for securing IoT systems is currently an important and challenging research topic. Machine learning-based approaches are a promising alternative, allowing the identification of abnormal behaviors and the detection of attacks. This paper proposes an anomaly-based detection solution that uses unsupervised deep learning techniques to identify IoT botnet activities. An empirical evaluation of the proposed method is conducted on both balanced and unbalanced datasets to assess its threat detection capability. False-positive rate reduction and its impact on the detection system are also analyzed. Furthermore, a comparison with other unsupervised learning approaches is included. The experimental results reveal the performance of the proposed detection method.

scholarly journals Detection and classification of unilateral cleft alveolus with and without cleft palate on panoramic radiographs using a deep learning system

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chiaki Kuwada ◽  
Yoshiko Ariji ◽  
Yoshitaka Kise ◽  
Takuma Funakoshi ◽  
Motoki Fukuda ◽  
...  
Keyword(s):  
Deep Learning ◽  
Cleft Palate ◽  
Panoramic Radiography ◽  
False Positive Rate ◽  
Normal Subjects ◽  
Learning System ◽  
Panoramic Radiographs ◽  
Positive Rate ◽  
Aided Diagnosis

AbstractAlthough panoramic radiography has a role in the examination of patients with cleft alveolus (CA), its appearances is sometimes difficult to interpret. The aims of this study were to develop a computer-aided diagnosis system for diagnosing the CA status on panoramic radiographs using a deep learning object detection technique with and without normal data in the learning process, to verify its performance in comparison to human observers, and to clarify some characteristic appearances probably related to the performance. The panoramic radiographs of 383 CA patients with cleft palate (CA with CP) or without cleft palate (CA only) and 210 patients without CA (normal) were used to create two models on the DetectNet. The models 1 and 2 were developed based on the data without and with normal subjects, respectively, to detect the CAs and classify them into with or without CP. The model 2 reduced the false positive rate (1/30) compared to the model 1 (12/30). The overall accuracy of Model 2 was higher than Model 1 and human observers. The model created in this study appeared to have the potential to detect and classify CAs on panoramic radiographs, and might be useful to assist the human observers.

scholarly journals Automated claustrum segmentation in human brain MRI using deep learning

2021 ◽  
Author(s):  
Hongwei Li ◽  
Aurore Menegaux ◽  
Benita Schmitz‐Koep ◽  
Antonia Neubauer ◽  
Felix J. B. Bäuerlein ◽  
...  
Keyword(s):  
Deep Learning ◽  
Human Brain ◽  
Brain Mri

Epileptic Seizure Prediction Using Deep Transformer Model

2021 ◽  
Author(s):  
Abhijeet Bhattacharya ◽  
Tanmay Baweja ◽  
S. P. K. Karri
Keyword(s):  
Signal Processing ◽  
Deep Learning ◽  
False Positive Rate ◽  
Superior Performance ◽  
Seizure Prediction ◽  
Advantages And Disadvantages ◽  
Positive Rate ◽  
Benchmark Datasets ◽  
Automated Screening ◽  
Transformer Model

The electroencephalogram (EEG) is the most promising and efficient technique to study epilepsy and record all the electrical activity going in our brain. Automated screening of epilepsy through data-driven algorithms reduces the manual workload of doctors to diagnose epilepsy. New algorithms are biased either towards signal processing or deep learning, which holds subjective advantages and disadvantages. The proposed pipeline is an end-to-end automated seizure prediction framework with a Fourier transform feature extraction and deep learning-based transformer model, a blend of signal processing and deep learning — this imbibes the potential features to automatically identify the attentive regions in EEG signals for effective screening. The proposed pipeline has demonstrated superior performance on the benchmark dataset with average sensitivity and false-positive rate per hour (FPR/h) as 98.46%, 94.83% and 0.12439, 0, respectively. The proposed work shows great results on the benchmark datasets and a big potential for clinics as a support system with medical experts monitoring the patients.

Brain Tumor Segmentation Based on Region of Interest-Aided Localization and Segmentation U-Net

2021 ◽  
Author(s):  
Shidong Li ◽  
Jianwei Liu ◽  
Zhanjie Song
Keyword(s):  
Image Processing ◽  
Deep Learning ◽  
Brain Tumor ◽  
Medical Image ◽  
Brain Mri ◽  
Medical Image Processing ◽  
Tumor Segmentation ◽  
Dice Similarity Coefficient ◽  
Brain Tumor Segmentation ◽  
The Impact

Abstract Since magnetic resonance imaging (MRI) has superior soft tissue contrast, contouring (brain) tumor accurately by MRI images is essential in medical image processing. Segmenting tumor accurately is immensely challenging, since tumor and normal tissues are often inextricably intertwined in the brain. It is also extremely time consuming manually. Late deep learning techniques start to show reasonable success in brain tumor segmentation automatically. The purpose of this study is to develop a new region-ofinterest-aided (ROI-aided) deep learning technique for automatic brain tumor MRI segmentation. The method consists of two major steps. Step one is to use a 2D network with U-Net architecture to localize the tumor ROI, which is to reduce the impact of normal tissue’s disturbance. Then a 3D U-Net is performed in step 2 for tumor segmentation within identified ROI. The proposed method is validated on MICCAI BraTS 2015 Challenge with 220 high Gliomas grade (HGG) and 54 low Gliomas grade (LGG) patients’ data. The Dice similarity coefficient and the Hausdorff distance between the manual tumor contour and that segmented by the proposed method are 0.876 ±0.068 and 3.594±1.347 mm, respectively. These numbers are indications that our proposed method is an effective ROI-aided deep learning strategy for brain MRI tumor segmentation, and a valid and useful tool in medical image processing.

scholarly journals Convolutional Neural Networks for the Segmentation of Microcalcification in Mammography Imaging

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Gabriele Valvano ◽  
Gianmarco Santini ◽  
Nicola Martini ◽  
Andrea Ripoli ◽  
Chiara Iacconi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neural Networks ◽  
Deep Learning ◽  
Convolutional Neural Networks ◽  
False Positive ◽  
False Positive Rate ◽  
Novel Approach ◽  
Positive Rate ◽  
Microcalcification Detection ◽  
Microcalcification Clusters

Cluster of microcalcifications can be an early sign of breast cancer. In this paper, we propose a novel approach based on convolutional neural networks for the detection and segmentation of microcalcification clusters. In this work, we used 283 mammograms to train and validate our model, obtaining an accuracy of 99.99% on microcalcification detection and a false positive rate of 0.005%. Our results show how deep learning could be an effective tool to effectively support radiologists during mammograms examination.

scholarly journals OTHR-13. A DEEP LEARNING APPROACH TO DETECT CANCER METASTASES TO THE BRAIN IN MRI

2019 ◽  
Vol 1 (Supplement_1) ◽  
pp. i20-i21
Author(s):  
Min Zhang ◽  
Geoffrey Young ◽  
Huai Chen ◽  
Lei Qin ◽  
Xinhua Cao ◽  
...  
Keyword(s):  
Neural Network ◽  
Deep Learning ◽  
Brain Metastases ◽  
False Positive ◽  
False Positive Rate ◽  
Brain Mri ◽  
Ground Truth ◽  
Learning Approach ◽  
Cancer Metastases ◽  
The Brain

Abstract BACKGROUND AND OBJECTIVE: Brain metastases have been found to account for one-fourth of all cancer metastases seen in clinics. Magnetic resonance imaging (MRI) is widely used for detecting brain metastases. Accurate detection of the brain metastases is critical to design radiotherapy to treat the cancer and monitor their progression or response to the therapy and prognosis. However, finding metastases on brain MRI is very challenging as many metastases are small and manifest as objects of weak contrast on the images. In this work we present a deep learning approach integrated with a classification scheme to detect cancer metastases to the brain on MRI. MATERIALS AND METHODS: We retrospectively extracted 101 metastases patients, equal to 1535 metastases on 10192 slices of images in a total of 336 scans from our PACS and manually marked the lesions on T1-weighted contrast enhanced MRI as the ground-truth. We then randomly separated the cases into training, validation, and test sets for developing and optimizing the deep learning neural network. We designed a 2-step computer-aided detection (CAD) pipeline by first applying a fast region-based convolutional neural network method (R-CNN) to sequentially process each slice of an axial brain MRI to find abnormal hyper-intensity that may correspond to a brain metastasis and, second, applying a random under sampling boost (RUSBoost) classification method to reduce the false positive metastases. RESULTS: The computational pipeline was tested on real brain images. A sensitivity of 97.28% and false positive rate of 36.25 per scan over the images were achieved by using the proposed method. CONCLUSION: Our results demonstrated the deep learning-based method can detect metastases in very challenging cases and can serve as CAD tool to help radiologists interpret brain MRIs in a time-constrained environment.

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