scholarly journals Challenges in estimating the impact of vaccination with sparse data

2018 ◽  
Author(s):  
Kayoko Shioda ◽  
Cynthia Schuck-Paim ◽  
Robert J. Taylor ◽  
Roger Lustig ◽  
Lone Simonsen ◽  
...  
Keyword(s):  
Time Series ◽  
Time Series Data ◽  
Simulation Analysis ◽  
Principal Component ◽  
Population Level ◽  
Series Data ◽  
Synthetic Control ◽  
Vaccine Impact ◽  
Pca Method ◽  
The Impact

ABSTRACTBackgroundThe synthetic control (SC) model is a powerful tool to quantify the population-level impact of vaccines, because it can adjust for trends unrelated to vaccination using a composite of control diseases. Because vaccine impact studies are often conducted using smaller subnational datasets, we evaluated the performance of SC models with sparse time series data. To obtain more robust estimates of vaccine effects from noisy time series, we proposed a possible alternative approach, “STL+PCA” method (seasonal-trend decomposition plus principal component analysis), which first extracts smoothed trends from the control time series and uses them to adjust the outcome.MethodsUsing both the SC and STL+PCA models, we estimated the impact of 10-valent pneumococcal conjugate vaccine (PCV10) on pneumonia hospitalizations among cases <12 months and 80+ years of age during 2004-2014 at the subnational level in Brazil. The performance of these models was also compared using simulation analyses.ResultsThe SC model was able to adjust for trends unrelated to PCV10 in larger states but not in smaller states. The simulation analysis confirmed that the SC model failed to select an appropriate set of control diseases when the time series were sparse and noisy, thereby generating biased estimates of the impact of vaccination when secular trends were present. The STL+PCA approach decreased bias in the estimates for smaller populations.ConclusionsEstimates from the SC model might be biased when data are sparse. The STL+PCA model provides more accurate evaluations of vaccine impact in smaller populations.

scholarly journals Symplectic Principal Component Analysis: A New Method for Time Series Analysis

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Min Lei ◽  
Guang Meng
Keyword(s):  
Dynamical System ◽  
Principal Component Analysis ◽  
Time Series ◽  
Symplectic Geometry ◽  
Time Series Data ◽  
Principal Component ◽  
Component Analysis ◽  
Series Data ◽  
Pca Method ◽  
Value Decomposition

Experimental data are often very complex since the underlying dynamical system may be unknown and the data may heavily be corrupted by noise. It is a crucial task to properly analyze data to get maximal information of the underlying dynamical system. This paper presents a novel principal component analysis (PCA) method based on symplectic geometry, called symplectic PCA (SPCA), to study nonlinear time series. Being nonlinear, it is different from the traditional PCA method based on linear singular value decomposition (SVD). It is thus perceived to be able to better represent nonlinear, especially chaotic data, than PCA. Using the chaotic Lorenz time series data, we show that this is indeed the case. Furthermore, we show that SPCA can conveniently reduce measurement noise.

EFFECTS OF TREND AND PERIODICITY ON THE CORRELATION DIMENSION AND THE LYAPUNOV EXPONENTS

2008 ◽  
Vol 18 (12) ◽  
pp. 3679-3687 ◽  
Author(s):  
AYDIN A. CECEN ◽  
CAHIT ERKAL
Keyword(s):  
Time Series ◽  
Lyapunov Exponent ◽  
Lyapunov Exponents ◽  
Correlation Dimension ◽  
Time Series Data ◽  
Logistic Map ◽  
Model Identification ◽  
Series Data ◽  
Largest Lyapunov Exponent ◽  
The Impact

We present a critical remark on the pitfalls of calculating the correlation dimension and the largest Lyapunov exponent from time series data when trend and periodicity exist. We consider a special case where a time series Zi can be expressed as the sum of two subsystems so that Zi = Xi + Yi and at least one of the subsystems is deterministic. We show that if the trend and periodicity are not properly removed, correlation dimension and Lyapunov exponent estimations yield misleading results, which can severely compromise the results of diagnostic tests and model identification. We also establish an analytic relationship between the largest Lyapunov exponents of the subsystems and that of the whole system. In addition, the impact of a periodic parameter perturbation on the Lyapunov exponent for the logistic map and the Lorenz system is discussed.

scholarly journals A Comparison of Time-Series Predictions for Healthcare Emergency Department Indicators and the Impact of COVID-19

2021 ◽  
Vol 11 (8) ◽  
pp. 3561
Author(s):  
Diego Duarte ◽  
Chris Walshaw ◽  
Nadarajah Ramesh
Keyword(s):  
Time Series ◽  
Time Series Data ◽  
Moving Average ◽  
General Regression Neural Network ◽  
Series Data ◽  
Machine Learning Model ◽  
Hospital Patients ◽  
Major Incidents ◽  
General Regression ◽  
The Impact

Across the world, healthcare systems are under stress and this has been hugely exacerbated by the COVID pandemic. Key Performance Indicators (KPIs), usually in the form of time-series data, are used to help manage that stress. Making reliable predictions of these indicators, particularly for emergency departments (ED), can facilitate acute unit planning, enhance quality of care and optimise resources. This motivates models that can forecast relevant KPIs and this paper addresses that need by comparing the Autoregressive Integrated Moving Average (ARIMA) method, a purely statistical model, to Prophet, a decomposable forecasting model based on trend, seasonality and holidays variables, and to the General Regression Neural Network (GRNN), a machine learning model. The dataset analysed is formed of four hourly valued indicators from a UK hospital: Patients in Department; Number of Attendances; Unallocated Patients with a DTA (Decision to Admit); Medically Fit for Discharge. Typically, the data exhibit regular patterns and seasonal trends and can be impacted by external factors such as the weather or major incidents. The COVID pandemic is an extreme instance of the latter and the behaviour of sample data changed dramatically. The capacity to quickly adapt to these changes is crucial and is a factor that shows better results for GRNN in both accuracy and reliability.

scholarly journals Assessing Stream-Aquifer Connectivity in a Coastal California Watershed

Water ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 416
Author(s):  
Bwalya Malama ◽  
Devin Pritchard-Peterson ◽  
John J. Jasbinsek ◽  
Christopher Surfleet
Keyword(s):  
Time Series ◽  
Spectral Analysis ◽  
Water Level ◽  
Time Series Data ◽  
Series Data ◽  
Low Permeability ◽  
Pumping Tests ◽  
Stream Flows ◽  
The Impact

We report the results of field and laboratory investigations of stream-aquifer interactions in a watershed along the California coast to assess the impact of groundwater pumping for irrigation on stream flows. The methods used include subsurface sediment sampling using direct-push drilling, laboratory permeability and particle size analyses of sediment, piezometer installation and instrumentation, stream discharge and stage monitoring, pumping tests for aquifer characterization, resistivity surveys, and long-term passive monitoring of stream stage and groundwater levels. Spectral analysis of long-term water level data was used to assess correlation between stream and groundwater level time series data. The investigations revealed the presence of a thin low permeability silt-clay aquitard unit between the main aquifer and the stream. This suggested a three layer conceptual model of the subsurface comprising unconfined and confined aquifers separated by an aquitard layer. This was broadly confirmed by resistivity surveys and pumping tests, the latter of which indicated the occurrence of leakage across the aquitard. The aquitard was determined to be 2–3 orders of magnitude less permeable than the aquifer, which is indicative of weak stream-aquifer connectivity and was confirmed by spectral analysis of stream-aquifer water level time series. The results illustrate the importance of site-specific investigations and suggest that even in systems where the stream is not in direct hydraulic contact with the producing aquifer, long-term stream depletion can occur due to leakage across low permeability units. This has implications for management of stream flows, groundwater abstraction, and water resources management during prolonged periods of drought.

Welfare Use in Japan: Trends and Determinants

2007 ◽  
pp. 88
Author(s):  
Wataru Suzuki ◽  
Yanfei Zhou
Keyword(s):  
Time Series ◽  
Longitudinal Data ◽  
Time Series Data ◽  
Positive Impact ◽  
Series Data ◽  
Negative Effects ◽  
Long Time ◽  
Welfare Use ◽  
The Impact

This article represents the first step in filling a large gap in knowledge concerning why Public Assistance (PA) use recently rose so fast in Japan. Specifically, we try to address this problem not only by performing a Blanchard and Quah decomposition on long-term monthly time series data (1960:04-2006:10), but also by estimating prefecturelevel longitudinal data. Two interesting findings emerge from the time series analysis. The first is that permanent shock imposes a continuously positive impact on the PA rate and is the main driving factor behind the recent increase in welfare use. The second finding is that the impact of temporary shock will last for a long time. The rate of the use of welfare is quite rigid because even if the PA rate rises due to temporary shocks, it takes about 8 or 9 years for it to regain its normal level. On the other hand, estimations of prefecture-level longitudinal data indicate that the Financial Capability Index (FCI) of the local government2 and minimum wage both impose negative effects on the PA rate. We also find that the rapid aging of Japan's population presents a permanent shock in practice, which makes it the most prominent contribution to surging welfare use.

scholarly journals Political Stability and its Impact on Economic Growth of Pakistan (1988-2018): A Time Series Analysis

2020 ◽  
Vol 6 (1) ◽  
pp. 273-282
Author(s):  
Majid Hussain Phul ◽  
Muhammad Saleem Rahpoto ◽  
Ghulam Muhammad Mangnejo
Keyword(s):  
Economic Growth ◽  
Time Series ◽  
Time Series Data ◽  
Political Stability ◽  
Series Data ◽  
Explanatory Variables ◽  
Long Run ◽  
Short Run ◽  
The Impact ◽  
Positive Effect

This research paper empirically investigates the outcome of Political stability on economic growth (EG) of Pakistan for the period of 1988 to 2018. Political stability (PS), gross fixed capital formation (GFCF), total labor force (TLF) and Inflation (INF) are important explanatory variables. Whereas for model selection GDPr is used as the dependent variable. To check the stationary of time series data Augmented Dickey Fuller (ADF) unit root (UR) test has been used,  and whereas to find out the long run relationship among variables, OLS method has been used. The analysis the impact of PS on EG (EG) in the short run, VAR model has been used. The outcomes show that all the variables (PS, GFCF, TLF and INF) have a significantly positive effect on the EG of Pakistan in the long run period. But the effect of PS on GDP is smaller. Further, in this research we are trying to see the short run relationship between GDP and other explanatory variables. The outcomes show that PS does not have such effect on GDP in the short run analysis. While GFCF, TLF and INF have significantly positive effect on GDP of Pakistan in the short run period.

scholarly journals The Effect of IJ-EPA to Indonesia Export: Interupted Time Series (ITS) Approach

2020 ◽  
Vol 2 (1) ◽  
pp. 128-145
Author(s):  
Yuafanda Kholfi Hartono ◽  
Sumarto Eka Putra
Keyword(s):  
Time Series ◽  
Free Trade ◽  
Free Trade Agreement ◽  
Time Series Data ◽  
Current Account Deficit ◽  
Trade Agreement ◽  
Export Market ◽  
Series Data ◽  
The Government ◽  
The Impact

Indonesia Japan Economic Partnership Agreement (IJ-EPA) is a bilateral free-trade agreement between Indonesia and Japan that has been started from July 1st, 2008. After more than a decade of its implementation, there is a question that we need to be addressed: Does liberalization of IJ-EPA make Indonesia’s export to Japan increase? This question is important since the government gives a trade-off by giving lower tariff for certain commodities agreed in agreement to increase export. Using Interrupted time series (ITS) analysis based on time-series data from Statistics Indonesia (BPS), this article found that the impact of IJ-EPA decreased for Indonesia export to Japan. Furthermore, this paper proposed some potential commodities that can increase the effectiveness of this FTA. The importance of this topic is that Indonesia will maximize the benefit in implementing of agreement that they made from the third biggest destination export of their total export value, so it will be in line with the government's goal to expand export market to solve current account deficit. In addition, the method that used in this paper can be implemented to other countries so that they can maximize the effect of Free Trade Agreement, especially for their export.

Exploratory Time Series Data Mining by Genetic Clustering

2011 ◽  
pp. 157-178
Author(s):  
T. Warren Liao
Keyword(s):  
Data Mining ◽  
Time Series ◽  
Time Series Data ◽  
Distance Measures ◽  
Series Data ◽  
Synthetic Control ◽  
Data Set ◽  
Univariate Time Series ◽  
Genetic Clustering ◽  
Data Objects

In this chapter, we present genetic algorithm (GA) based methods developed for clustering univariate time series with equal or unequal length as an exploratory step of data mining. These methods basically implement the k-medoids algorithm. Each chromosome encodes in binary the data objects serving as the k-medoids. To compare their performance, both fixed-parameter and adaptive GAs were used. We first employed the synthetic control chart data set to investigate the performance of three fitness functions, two distance measures, and other GA parameters such as population size, crossover rate, and mutation rate. Two more sets of time series with or without known number of clusters were also experimented: one is the cylinder-bell-funnel data and the other is the novel battle simulation data. The clustering results are presented and discussed.

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