scholarly journals Slow peak alpha frequency and corticomotor depression linked to high pain susceptibility in transition to sustained pain

2018 ◽  
Author(s):  
DA Seminowicz ◽  
T Thapa ◽  
AJ Furman ◽  
SJ Summers ◽  
R Cavaleri ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Resting State ◽  
Severe Pain ◽  
Central Peak ◽  
Healthy Individuals ◽  
Pain Model ◽  
Corticomotor Excitability ◽  
Alpha Frequency

AbstractMechanisms that predict an individual’s susceptibility to pain, before pain is present or in the first few days following pain onset, are unknown. We utilised a clinically-relevant human transitional pain model (intramuscular injections of nerve growth factor) to examine brain mechanisms that predict pain susceptibility. Resting state EEG and corticomotor excitability measured by TMS were evaluated longitudinally in healthy individuals as pain developed and resolved over 21 days. Whereas pre-pain central peak alpha frequency (PAF) correlated with peak pain occurring 4-6 days later, altered corticomotor excitability developed several days after pain onset and showed two distinct patterns (facilitation, depression). Individuals with combined slow PAF and corticomotor depression developed more severe pain. These data provide the first evidence of the temporal profile of key brain mechanisms as pain progressively develops. PAF and corticomotor excitability could represent biomarkers for susceptibility to high pain severity and subsequently, the development of chronic pain.

A possible role for nerve growth factor in the augmentation of sodium channels in models of chronic pain

2000 ◽  
Vol 854 (1-2) ◽  
pp. 19-29 ◽  
Author(s):  
Harry J. Gould ◽  
Trevor N. Gould ◽  
John D. England ◽  
Dennis Paul ◽  
Z.P. Liu ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sodium Channels ◽  
Nerve Growth

scholarly journals Antagonism of Nerve Growth Factor-TrkA Signaling and the Relief of Pain

2011 ◽  
Vol 115 (1) ◽  
pp. 189-204 ◽  
Author(s):  
Patrick W. Mantyh ◽  
Martin Koltzenburg ◽  
Lorne M. Mendell ◽  
Leslie Tive ◽  
David L. Shelton ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Pain Relief ◽  
Adverse Events ◽  
Tissue Injury ◽  
Sympathetic Neurons ◽  
Nerve Growth ◽  
Cognate Receptor ◽  
Kinase A

Nerve growth factor (NGF) was originally discovered as a neurotrophic factor essential for the survival of sensory and sympathetic neurons during development. However, in the adult NGF has been found to play an important role in nociceptor sensitization after tissue injury. The authors outline mechanisms by which NGF activation of its cognate receptor, tropomyosin-related kinase A receptor, regulates a host of ion channels, receptors, and signaling molecules to enhance acute and chronic pain. The authors also document that peripherally restricted antagonism of NGF-tropomyosin-related kinase A receptor signaling is effective for controlling human pain while appearing to maintain normal nociceptor function. Understanding whether there are any unexpected adverse events and how humans may change their behavior and use of the injured/degenerating tissue after significant pain relief without sedation will be required to fully appreciate the patient populations that may benefit from these therapies targeting NGF.

Masseter corticomotor excitability is decreased after intramuscular administration of nerve growth factor

2019 ◽  
Vol 23 (9) ◽  
pp. 1619-1630
Author(s):  
Yuri M. Costa ◽  
Fernando G. Exposto ◽  
Mohit Kothari ◽  
Eduardo E. Castrillon ◽  
Paulo César R. Conti ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Intramuscular Administration ◽  
Nerve Growth ◽  
Corticomotor Excitability

scholarly journals A Virus-Like Particle-Based Anti-Nerve Growth Factor Vaccine Reduces Inflammatory Hyperalgesia: Potential Long-Term Therapy for Chronic Pain

2010 ◽  
Vol 186 (3) ◽  
pp. 1769-1780 ◽  
Author(s):  
Till A. Röhn ◽  
William T. Ralvenius ◽  
Jolly Paul ◽  
Petra Borter ◽  
Marcela Hernandez ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Term Therapy ◽  
Inflammatory Hyperalgesia ◽  
Nerve Growth ◽  
Virus Like Particle ◽  
Long Term Therapy

scholarly journals Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats

2018 ◽  
Vol 184 (1) ◽  
pp. 23-23 ◽  
Author(s):  
Masataka Enomoto ◽  
Patrick W Mantyh ◽  
Joanna Murrell ◽  
John F Innes ◽  
B Duncan X Lascelles
Keyword(s):  
Chronic Pain ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Sympathetic Neurons ◽  
Critical Role ◽  
Current Status ◽  
Effective Control ◽  
Novel Therapy ◽  
Nerve Growth ◽  
Species Specific

Nerve growth factor (NGF) is essential for the survival of sensory and sympathetic neurons during development. However, in the adult, NGF and its interaction with tropomyosin receptor kinase A receptor (TrkA) has been found to play a critical role in nociception and nervous system plasticity in pain conditions. Thus, various monoclonal antibody (mAb) therapies targeting this pathway have been investigated in the development of new pharmacotherapies for chronic pain. Although none of the mAbs against NGF are yet approved for use in humans, they look very promising for the effective control of pain. Recently, species-specific anti-NGF mAbs for the management of osteoarthritis (OA)-associated pain in dogs and cats has been developed, and early clinical trials have been conducted. Anti-NGF therapy looks to be both very effective and very promising as a novel therapy against chronic pain in dogs and cats. This review outlines the mechanism of action of NGF, the role of NGF in osteoarthritis, research in rodent OA models and the current status of the development of anti-NGF mAbs in humans. Furthermore, we describe and discuss the recent development of species-specific anti-NGF mAbs for the treatment of OA-associated pain in veterinary medicine.

scholarly journals Efficacy of nerve growth factor antibody in a knee osteoarthritis pain model in mice

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Masayuki Miyagi ◽  
Tetsuhiro Ishikawa ◽  
Hiroto Kamoda ◽  
Miyako Suzuki ◽  
Gen Inoue ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Knee Osteoarthritis ◽  
Pain Model ◽  
Nerve Growth ◽  
Osteoarthritis Pain
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