scholarly journals Spatial cell firing during virtual navigation of open arenas by head-restrained mice

2018 ◽  
Author(s):  
Guifen Chen ◽  
John A King ◽  
Yi Lu ◽  
Francesca Cacucci ◽  
Neil Burgess
Keyword(s):  
Translational Motion ◽  
Grid Cell ◽  
Place Cell ◽  
Head Movements ◽  
Neuronal Firing ◽  
Firing Patterns ◽  
Firing Rates ◽  
Theta Frequency ◽  
Cell Firing ◽  
Horizontal Rotations

AbstractWe present a mouse virtual reality (VR) system which restrains head-movements to horizontal rotations, potentially compatible with multi-photon imaging. We show that this system allows expression of the spatial navigational behaviour and neuronal firing patterns characteristic of real open arenas (R). Place and grid, but not head-direction, cell firing had broader spatial tuning in VR than R. Theta frequency increased less with running speed in VR than in R, while firing rates increased similarly in both. Place, but not grid, cell firing was more directional in VR than R. These results suggest that the scale of grid and place cell firing patterns, and the frequency of theta, reflect translational motion inferred from both virtual (visual and proprioceptive) cues and uncontrolled static (vestibular translation and extra-maze) cues, while firing rates predominantly reflect visual and proprioceptive motion. They also suggest that omni-directional place cell firing in R reflects local-cues unavailable in VR.

scholarly journals Spatial cell firing during virtual navigation of open arenas by head-restrained mice

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Guifen Chen ◽  
John Andrew King ◽  
Yi Lu ◽  
Francesca Cacucci ◽  
Neil Burgess
Keyword(s):  
Place Cell ◽  
Head Movements ◽  
Running Speed ◽  
Firing Patterns ◽  
Firing Rates ◽  
Theta Frequency ◽  
Phase Precession ◽  
Cell Firing ◽  
Theta Phase ◽  
Theta Phase Precession

We present a mouse virtual reality (VR) system which restrains head-movements to horizontal rotations, compatible with multi-photon imaging. This system allows expression of the spatial navigation and neuronal firing patterns characteristic of real open arenas (R). Comparing VR to R: place and grid, but not head-direction, cell firing had broader spatial tuning; place, but not grid, cell firing was more directional; theta frequency increased less with running speed, whereas increases in firing rates with running speed and place and grid cells' theta phase precession were similar. These results suggest that the omni-directional place cell firing in R may require local-cues unavailable in VR, and that the scale of grid and place cell firing patterns, and theta frequency, reflect translational motion inferred from both virtual (visual and proprioceptive) and real (vestibular translation and extra-maze) cues. By contrast, firing rates and theta phase precession appear to reflect visual and proprioceptive cues alone.

Grids from bands, or bands from grids? An examination of the effects of single unit contamination on grid cell firing fields

2016 ◽  
Vol 115 (2) ◽  
pp. 992-1002 ◽  
Author(s):  
Z. Navratilova ◽  
K. B. Godfrey ◽  
B. L. McNaughton
Keyword(s):  
Single Cell ◽  
Grid Cell ◽  
Cell Isolation ◽  
Recording Technology ◽  
Firing Patterns ◽  
Limiting Step ◽  
Isolation Methods ◽  
Single Cell Isolation ◽  
Cell Firing ◽  
Cell Data

Neural recording technology is improving rapidly, allowing for the detection of spikes from hundreds of cells simultaneously. The limiting step in multielectrode electrophysiology continues to be single cell isolation. However, this step is crucial to the interpretation of data from putative single neurons. We present here, in simulation, an illustration of possibly erroneous conclusions that may be reached when poorly isolated single cell data are analyzed. Grid cells are neurons recorded in rodents, and bats, that spike in equally spaced locations in a hexagonal pattern. One theory states that grid firing patterns arise from a combination of band firing patterns. However, we show here that summing the grid firing patterns of two poorly resolved neurons can result in spurious band-like patterns. Thus, evidence of neurons spiking in band patterns must undergo extreme scrutiny before it is accepted. Toward this aim, we discuss single cell isolation methods and metrics.

Internal Pallidal Neuronal Activity During Mild Drug-Related Dyskinesias in Parkinson's Disease: Decreased Firing Rates and Altered Firing Patterns

2007 ◽  
Vol 97 (4) ◽  
pp. 2627-2641 ◽  
Author(s):  
J. I. Lee ◽  
L. Verhagen Metman ◽  
S. Ohara ◽  
P. M. Dougherty ◽  
J. H. Kim ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Firing Rate ◽  
Spike Trains ◽  
Neuronal Firing ◽  
Low Doses ◽  
Significant Group ◽  
Firing Patterns ◽  
Firing Rates ◽  
Before And After

The neuronal basis of hyperkinetic movement disorders has long been unclear. We now test the hypothesis that changes in the firing pattern of neurons in the globus pallidus internus (GPi) are related to dyskinesias induced by low doses of apomorphine in patients with advanced Parkinson's disease (PD). During pallidotomy for advanced PD, the activity of single neurons was studied both before and after administration of apomorphine at doses just adequate to induce dyskinesias (21 neurons, 17 patients). After the apomorphine injection, these spike trains demonstrated an initial fall in firing from baseline. In nine neurons, the onset of on was simultaneous with that of dyskinesias. In these spike trains, the initial fall in firing rate preceded and was larger than the fall at the onset of on with dyskinesias. Among the three neurons in which the onset of on occurred before that of dyskinesias, the firing rate did not change at the time of onset of dyskinesias. After injection of apomorphine, dyskinesias during on with dyskinesias often fluctuated between transient periods with dyskinesias and those without. Average firing rates were not different between these two types of transient periods. Transient periods with dyskinesias were characterized by interspike interval (ISI) independence, stationary spike trains, and higher variability of ISIs. A small but significant group of neurons demonstrated recurring ISI patterns during transient periods of on with dyskinesias. These results suggest that mild dyskinesias resulting from low doses of apomorphine are related to both low GPi neuronal firing rates and altered firing patterns.

Lipopolysaccharide effects on neuronal activity in rat basal forebrain and hypothalamus during sleep and waking

2000 ◽  
Vol 278 (3) ◽  
pp. R620-R627
Author(s):  
Xinzheng Xi ◽  
Linda A. Toth
Keyword(s):  
Neuronal Activity ◽  
Basal Forebrain ◽  
Preoptic Area ◽  
Intraperitoneal Administration ◽  
Brain Regions ◽  
Neuronal Firing ◽  
Firing Patterns ◽  
Firing Rates ◽  
Neuronal Mechanisms ◽  
The Brain

Peripheral administration of lipopolysaccharide (LPS) is associated with alterations in sleep and the electroencephalogram. To evaluate potential neuronal mechanisms for the somnogenic effects of LPS administration, we used unanesthetized rats to survey the firing patterns of neurons in various regions of rat basal forebrain (BF) and hypothalamus during spontaneous sleep and waking and during the epochs of sleep and waking that occurred after the intraperitoneal administration of LPS. In the brain regions studied, LPS administration was associated with altered firing rates in 39% of the neurons examined. A larger proportion of LPS-responsive units showed vigilance-related alterations in firing rates compared with nonresponsive units. Approximately equal proportions of LPS-responsive neurons showed increased and decreased firing rates after LPS administration, with some units in the lateral preoptic area of the hypothalamus showing particularly robust increases. These findings are consistent with other studies showing vigilance-related changes in neuronal activity in various regions of BF and hypothalamus and further demonstrate that peripheral LPS administration alters neuronal firing rates in these structures during both sleep and waking.

scholarly journals Hippocampal Place Cell Firing Patterns Can Induce Long-Term Synaptic Plasticity In Vitro

2009 ◽  
Vol 29 (21) ◽  
pp. 6840-6850 ◽  
Author(s):  
J. T. R. Isaac ◽  
K. A. Buchanan ◽  
R. U. Muller ◽  
J. R. Mellor
Keyword(s):  
Synaptic Plasticity ◽  
Place Cell ◽  
Firing Patterns ◽  
Cell Firing ◽  
Hippocampal Place Cell

Remapping of place cell firing patterns after maze rotations

2002 ◽  
Vol 143 (4) ◽  
pp. 470-479 ◽  
Author(s):  
Arnaud Cressant ◽  
Robert U. Muller ◽  
Bruno Poucet
Keyword(s):  
Place Cell ◽  
Firing Patterns ◽  
Cell Firing
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