scholarly journals Theta and gamma oscillations in the rat hippocampus during attentive lever pressing

2018 ◽  
Author(s):  
A Lipponen ◽  
H Tanila ◽  
K Gurevicius
Keyword(s):  
Gamma Oscillations ◽  
Water Port ◽  
Lever Pressing ◽  
Gamma Rhythms ◽  
Frequency Coupling ◽  
Theta Phase ◽  
Hippocampal Theta ◽  
Dentate Hilus ◽  
Cross Frequency Coupling

AbstractThe hippocampus is known to be pivotal for spatial memory but emerging evidence suggests its contribution to temporal memories as well. However, it is not clear how the hippocampus represents time and how it synchronizes spatial and temporal presentations into a coherent memory. We assessed the specific role of hippocampal theta and gamma oscillations and their interaction in short-term timing of motor reactions. Rats were trained to maintain lever pressing for 2.5 s and then to quickly release the lever and retrieve water reward from a nearby water port guided by a cue light. In essence, this task allows observation of hippocampal rhythms during timed anticipation when no overt movements take place. Then we implanted wire electrodes to five hippocampal layers for recording local field potentials during the task. Consistent with earlier reports, theta showed a declining trend during the lever press. We also found that fast-gamma declined in tandem with theta while slow-gamma showed an opposite trend. Theta-phase to gamma-amplitude cross-frequency coupling measured with modulation index (MI) varied significantly between the three task phases. Interestingly, also changes in MI were opposite for fast- and slow-gamma. The MI was also related to the task performance, so that during omission trials the MI for fast-gamma in CA1 was smaller than during trials with premature lever release. In addition, the MI in dentate hilus was higher during all error trials than during correctly performed trials. Collectively, these data suggest an important role of synchronization of hippocampal theta and gamma rhythms to timing of cued motor reactions.

scholarly journals Thalamic theta phase alignment predicts human memory formation and anterior thalamic cross-frequency coupling

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Catherine M Sweeney-Reed ◽  
Tino Zaehle ◽  
Jürgen Voges ◽  
Friedhelm C Schmitt ◽  
Lars Buentjen ◽  
...  
Keyword(s):  
Human Memory ◽  
Gamma Oscillations ◽  
Memory Formation ◽  
Anterior Thalamic Nucleus ◽  
Memory Processing ◽  
Phase Alignment ◽  
Theta Frequency ◽  
Frequency Coupling ◽  
Theta Phase ◽  
Cross Frequency Coupling

Previously we reported electrophysiological evidence for a role for the anterior thalamic nucleus (ATN) in human memory formation (<xref ref-type="bibr" rid="bib29">Sweeney-Reed et al., 2014</xref>). Theta-gamma cross-frequency coupling (CFC) predicted successful memory formation, with the involvement of gamma oscillations suggesting memory-relevant local processing in the ATN. The importance of the theta frequency range in memory processing is well-established, and phase alignment of oscillations is considered to be necessary for synaptic plasticity. We hypothesized that theta phase alignment in the ATN would be necessary for memory encoding. Further analysis of the electrophysiological data reveal that phase alignment in the theta rhythm was greater during successful compared with unsuccessful encoding, and that this alignment was correlated with the CFC. These findings support an active processing role for the ATN during memory formation.

scholarly journals Communication through coherence by means of cross-frequency coupling

2020 ◽  
Author(s):  
Joaquín González ◽  
Matias Cavelli ◽  
Alejandra Mondino ◽  
Nicolás Rubido ◽  
Adriano BL Tort ◽  
...  
Keyword(s):  
Information Transfer ◽  
Screening Method ◽  
Gamma Oscillations ◽  
Critical Question ◽  
Long Distance ◽  
Frequency Coupling ◽  
Communication Through Coherence ◽  
The Cross ◽  
Hippocampal Theta ◽  
Cross Frequency Coupling

The theory of communication through coherence (CTC) posits the synchronization of brain oscillations as a key mechanism for information sharing and perceptual binding. In a parallel literature, hippocampal theta activity (4 – 10 Hz) has been shown to modulate the appearance of neocortical fast gamma oscillations (100 – 150 Hz), a phenomenon known as cross-frequency coupling (CFC). Even though CFC has also been previously associated with information routing, it remains to be determined whether it directly relates to CTC. In particular, for the theta-fast gamma example at hand, a critical question is to know if the phase of the theta cycle influences gamma synchronization across the neocortex. To answer this question, we designed a new screening method for detecting the modulation of the cross-regional high-frequency synchronization by the phase of slower oscillations. Upon applying the method, we found that the long-distance synchronization of neocortical fast gamma during REM sleep depends on the instantaneous phase of the theta rhythm. These results show that CFC is likely to aid long-range information transfer by facilitating the cross-regional synchronization of faster rhythms, thus consistent with classical CTC views.

scholarly journals Gamma Oscillations and Their Cross-frequency Coupling in the Primate Hippocampus during Sleep

SLEEP ◽  
2015 ◽  
Vol 38 (7) ◽  
pp. 1085-1091 ◽  
Author(s):  
Saori Takeuchi ◽  
Tatsuya Mima ◽  
Rie Murai ◽  
Hideki Shimazu ◽  
Yoshikazu Isomura ◽  
...  
Keyword(s):  
Gamma Oscillations ◽  
Frequency Coupling ◽  
Cross Frequency Coupling

scholarly journals Theta and gamma hippocampal-neocortical oscillations during the episodic-like memory test: impairment in epileptogenic rats

2021 ◽  
Author(s):  
Anton E Malkov ◽  
Ludmila Shevkova ◽  
Alexandra Latyshkova ◽  
Valentina Kitchigina
Keyword(s):  
Episodic Memory ◽  
Memory Task ◽  
Gamma Oscillations ◽  
High Amplitude ◽  
Memory Test ◽  
Interictal Spikes ◽  
Paroxysmal Activity ◽  
Cortical Oscillations ◽  
Gamma Rhythms ◽  
Hippocampal Theta

Cortical oscillations in different frequency bands have been shown to be intimately involved in exploration of environment and cognition. Here, the local field potentials in the hippocampus, the medial prefrontal cortex (mPFC), and the medial entorhinal cortex (mEC) were recorded simultaneously in rats during the execution of the episodic-like memory task. The power of hippocampal theta (~4-10 Hz), slow gamma (~25-50 Hz), and fast gamma oscillations (~55-100 Hz) was analyzed in all structures examined. Particular attention was paid to the theta coherence between three mentioned structures. The modulation of the power of gamma rhythms by the phase of theta cycle during the execution of the episodic-like memory test by rats was also closely studied. Healthy rats and rats one month after kainate-induced status epilepticus (SE) were examined. Paroxysmal activity in the hippocampus (high amplitude interictal spikes), excessive excitability of animals, and the death of hippocampal and dentate granular cells in rats with kainate-evoked SE were observed, which indicated the development of seizure focus in the hippocampus (epileptogenesis). One month after SE, the rats exhibited a specific impairment of episodic memory for the what-where-when triad: unlike healthy rats, epileptogenic SE animals did not identify the objects during the test. This impairment was associated with the changes in the characteristics of theta and gamma rhythms and specific violation of theta coherence and theta/gamma coupling in these structures in comparison with the healthy animals. We believe that these disturbances in the cortical areas play a role in episodic memory dysfunction in kainate-treated animals. These findings can shed light on the mechanisms of cognitive deficit during epileptogenesis.

Hippocampal-prefrontal theta coupling develops as mice become proficient in associative odorant discrimination learning

2021 ◽  
Author(s):  
Daniel Ramirez-Gordillo ◽  
Andrew A. Parra ◽  
K. Ulrich Bayer ◽  
Diego Restrepo
Keyword(s):  
Learning And Memory ◽  
Discrimination Learning ◽  
Gamma Oscillations ◽  
Oscillatory Activity ◽  
Dependent Protein Kinase ◽  
Dependent Protein ◽  
Theta Phase ◽  
Phase Amplitude ◽  
The Brain

Learning and memory requires coordinated activity between different regions of the brain. Here we studied the interaction between medial prefrontal cortex (mPFC) and hippocampal dorsal CA1 during associative odorant discrimination learning in the mouse. We found that as the animal learns to discriminate odorants in a go-no go task the coupling of high frequency neural oscillations to the phase of theta oscillations (phase-amplitude coupling or PAC) changes in a manner that results in divergence between rewarded and unrewarded odorant-elicited changes in the theta-phase referenced power (tPRP) for beta and gamma oscillations. In addition, in the proficient animal there was a decrease in the coordinated oscillatory activity between CA1 and mPFC in the presence of the unrewarded odorant. Furthermore, the changes in PAC resulted in a marked increase in the accuracy for decoding odorant identity from tPRP when the animal became proficient. Finally, we studied the role of Ca2+/calmodulin-dependent protein kinase II α (CaMKIIα), a protein involved in learning and memory, in oscillatory neural processing in this task. We find that the accuracy for decoding the odorant identity from tPRP decreases in CaMKIIα knockout mice and that this accuracy correlates with behavioral performance. These results implicate a role for PAC and CaMKIIα in olfactory go-no go associative learning in the hippocampal-prefrontal circuit.

scholarly journals Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson’s disease

Brain ◽  
2020 ◽  
Vol 143 (11) ◽  
pp. 3393-3407
Author(s):  
Muthuraman Muthuraman ◽  
Manuel Bange ◽  
Nabin Koirala ◽  
Dumitru Ciolac ◽  
Bogdan Pintea ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Subthalamic Nucleus ◽  
Brain Stimulation ◽  
Gamma Oscillations ◽  
Stimulation Frequency ◽  
Frequency Coupling ◽  
Cross Frequency Coupling ◽  
Deep Brain

Abstract The disruption of pathologically enhanced beta oscillations is considered one of the key mechanisms mediating the clinical effects of deep brain stimulation on motor symptoms in Parkinson’s disease. However, a specific modulation of other distinct physiological or pathological oscillatory activities could also play an important role in symptom control and motor function recovery during deep brain stimulation. Finely tuned gamma oscillations have been suggested to be prokinetic in nature, facilitating the preferential processing of physiological neural activity. In this study, we postulate that clinically effective high-frequency stimulation of the subthalamic nucleus imposes cross-frequency interactions with gamma oscillations in a cortico-subcortical network of interconnected regions and normalizes the balance between beta and gamma oscillations. To this end we acquired resting state high-density (256 channels) EEG from 31 patients with Parkinson’s disease who underwent deep brain stimulation to compare spectral power and power-to-power cross-frequency coupling using a beamformer algorithm for coherent sources. To show that modulations exclusively relate to stimulation frequencies that alleviate motor symptoms, two clinically ineffective frequencies were tested as control conditions. We observed a robust reduction of beta and increase of gamma power, attested in the regions of a cortical (motor cortex, supplementary motor area, premotor cortex) and subcortical network (subthalamic nucleus and cerebellum). Additionally, we found a clear cross-frequency coupling of narrowband gamma frequencies to the stimulation frequency in all of these nodes, which negatively correlated with motor impairment. No such dynamics were revealed within the control posterior parietal cortex region. Furthermore, deep brain stimulation at clinically ineffective frequencies did not alter the source power spectra or cross-frequency coupling in any region. These findings demonstrate that clinically effective deep brain stimulation of the subthalamic nucleus differentially modifies different oscillatory activities in a widespread network of cortical and subcortical regions. Particularly the cross-frequency interactions between finely tuned gamma oscillations and the stimulation frequency may suggest an entrainment mechanism that could promote dynamic neural processing underlying motor symptom alleviation.

scholarly journals Dynamic modulation of theta–gamma coupling during rapid eye movement sleep

SLEEP ◽  
2019 ◽  
Vol 42 (12) ◽  
Author(s):  
Mojtaba Bandarabadi ◽  
Richard Boyce ◽  
Carolina Gutierrez Herrera ◽  
Claudio L Bassetti ◽  
Sylvain Williams ◽  
...  
Keyword(s):  
Eye Movement ◽  
Rem Sleep ◽  
Temporal Dynamics ◽  
Brain Structures ◽  
Rapid Eye Movement ◽  
Sleep Episode ◽  
Frequency Coupling ◽  
Theta Phase ◽  
Hippocampal Networks ◽  
Cross Frequency Coupling

Abstract Theta phase modulates gamma amplitude in hippocampal networks during spatial navigation and rapid eye movement (REM) sleep. This cross-frequency coupling has been linked to working memory and spatial memory consolidation; however, its spatial and temporal dynamics remains unclear. Here, we first investigate the dynamics of theta–gamma interactions using multiple frequency and temporal scales in simultaneous recordings from hippocampal CA3, CA1, subiculum, and parietal cortex in freely moving mice. We found that theta phase dynamically modulates distinct gamma bands during REM sleep. Interestingly, we further show that theta–gamma coupling switches between recorded brain structures during REM sleep and progressively increases over a single REM sleep episode. Finally, we show that optogenetic silencing of septohippocampal GABAergic projections significantly impedes both theta–gamma coupling and theta phase coherence. Collectively, our study shows that phase-space (i.e. cross-frequency coupling) coding of information during REM sleep is orchestrated across time and space consistent with region-specific processing of information during REM sleep including learning and memory.

scholarly journals Correction: IhTunes Theta/Gamma Oscillations and Cross-Frequency Coupling In an In Silico CA3 Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
Author(s):  
Samuel A. Neymotin ◽  
Markus M. Hilscher ◽  
Thiago C. Moulin ◽  
Yosef Skolnick ◽  
Maciej T. Lazarewicz ◽  
...  
Keyword(s):  
In Silico ◽  
Gamma Oscillations ◽  
Frequency Coupling ◽  
Cross Frequency Coupling

scholarly journals Ih Tunes Theta/Gamma Oscillations and Cross-Frequency Coupling In an In Silico CA3 Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e76285 ◽  
Author(s):  
Samuel A. Neymotin ◽  
Markus M. Hilscher ◽  
Thiago C. Moulin ◽  
Yosef Skolnick ◽  
Maciej T. Lazarewicz ◽  
...  
Keyword(s):  
In Silico ◽  
Gamma Oscillations ◽  
Frequency Coupling ◽  
Cross Frequency Coupling
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