scholarly journals Characterizing the effects of sex, APOE ɛ4, and literacy on mid-life cognitive trajectories: Application of Information-Theoretic model-averaging and multi-model inference techniques to the Wisconsin Registry for Alzheimer’s Prevention Study

2017 ◽  
Author(s):  
Rebecca L. Koscik ◽  
Derek L. Norton ◽  
Samantha L. Allison ◽  
Erin M. Jonaitis ◽  
Lindsay R. Clark ◽  
...  
Keyword(s):  
Model Selection ◽  
Cognitive Decline ◽  
Model Averaging ◽  
Parameter Estimates ◽  
Theoretic Model ◽  
Traditional Model ◽  
Test Model ◽  
Prevention Study ◽  
Information Theoretic ◽  
Modifiable Factors

ObjectiveIn this paper we apply Information-Theoretic (IT) model averaging to characterize a set of complex interactions in a longitudinal study on cognitive decline. Prior research has identified numerous genetic (including sex), education, health and lifestyle factors that predict cognitive decline. Traditional model selection approaches (e.g., backward or stepwise selection) attempt to find models that best fit the observed data; these techniques risk interpretations that only the selected predictors are important. In reality, several models may fit similarly well but result in different conclusions (e.g., about size and significance of parameter estimates); inference from traditional model selection approaches can lead to overly confident conclusions.MethodHere we use longitudinal cognitive data from ~1550 late-middle aged adults the Wisconsin Registry for Alzheimer’s Prevention study to examine the effects of sex, Apolipoprotein E (APOE) ɛ4 allele (non-modifiable factors), and literacy achievement (modifiable) on cognitive decline. For each outcome, we applied IT model averaging to a model set with combinations of interactions among sex, APOE, literacy, and age.ResultsFor a list-learning test, model-averaged results showed better performance for women vs men, with faster decline among men; increased literacy was associated with better performance, particularly among men. APOE had less of an effect on cognitive performance in this age range (~40-70).ConclusionsThese results illustrate the utility of the IT approach and point to literacy as a potential modifier of decline. Whether the protective effect of literacy is due to educational attainment or intrinsic verbal intellectual ability is the topic of ongoing work.

scholarly journals Characterizing the Effects of Sex, APOE ɛ4, and Literacy on Mid-life Cognitive Trajectories: Application of Information-Theoretic Model Averaging and Multi-model Inference Techniques to the Wisconsin Registry for Alzheimer’s Prevention Study

2018 ◽  
Vol 25 (2) ◽  
pp. 119-133 ◽  
Author(s):  
Rebecca L. Koscik ◽  
Derek L. Norton ◽  
Samantha L. Allison ◽  
Erin M. Jonaitis ◽  
Lindsay R. Clark ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Sex Education ◽  
Model Averaging ◽  
Intellectual Ability ◽  
Parameter Estimates ◽  
Theoretic Model ◽  
Test Model ◽  
Prevention Study ◽  
Information Theoretic ◽  
Modifiable Factors

AbstractObjectives: Prior research has identified numerous genetic (including sex), education, health, and lifestyle factors that predict cognitive decline. Traditional model selection approaches (e.g., backward or stepwise selection) attempt to find one model that best fits the observed data, risking interpretations that only the selected predictors are important. In reality, several predictor combinations may fit similarly well but result in different conclusions (e.g., about size and significance of parameter estimates). In this study, we describe an alternative method, Information-Theoretic (IT) model averaging, and apply it to characterize a set of complex interactions in a longitudinal study on cognitive decline. Methods: Here, we used longitudinal cognitive data from 1256 late–middle aged adults from the Wisconsin Registry for Alzheimer’s Prevention study to examine the effects of sex, apolipoprotein E (APOE) ɛ4 allele (non-modifiable factors), and literacy achievement (modifiable) on cognitive decline. For each outcome, we applied IT model averaging to a set of models with different combinations of interactions among sex, APOE, literacy, and age. Results: For a list-learning test, model-averaged results showed better performance for women versus men, with faster decline among men; increased literacy was associated with better performance, particularly among men. APOE had less of an association with cognitive performance in this age range (∼40–70 years). Conclusions: These results illustrate the utility of the IT approach and point to literacy as a potential modifier of cognitive decline. Whether the protective effect of literacy is due to educational attainment or intrinsic verbal intellectual ability is the topic of ongoing work. (JINS, 2019, 25, 119–133)

scholarly journals How to improve parameter estimates in GLM-based fMRI data analysis: cross-validated Bayesian model averaging

2016 ◽  
Author(s):  
Joram Soch ◽  
Achim Pascal Meyer ◽  
John-Dylan Haynes ◽  
Carsten Allefeld
Keyword(s):  
Data Analysis ◽  
Model Selection ◽  
Bayesian Model ◽  
Bayesian Model Averaging ◽  
Model Averaging ◽  
Bayesian Model Selection ◽  
Fmri Data ◽  
Parameter Estimates ◽  
Fmri Data Analysis ◽  
Level Analysis

AbstractIn functional magnetic resonance imaging (fMRI), model quality of general linear models (GLMs) for first-level analysis is rarely assessed. In recent work (Soch et al., 2016: “How to avoid mismodelling in GLM-based fMRI data analysis: cross-validated Bayesian model selection”, NeuroImage, vol. 141, pp. 469-489; DOI: 10.1016/j. neuroimage.2016.07.047), we have introduced cross-validated Bayesian model selection (cvBMS) to infer the best model for a group of subjects and use it to guide second-level analysis. While this is the optimal approach given that the same GLM has to be used for all subjects, there is a much more efficient procedure when model selection only addresses nuisance variables and regressors of interest are included in all candidate models. In this work, we propose cross-validated Bayesian model averaging (cvBMA) to improve parameter estimates for these regressors of interest by combining information from all models using their posterior probabilities. This is particularly useful as different models can lead to different conclusions regarding experimental effects and the most complex model is not necessarily the best choice. We find that cvBMS can prevent not detecting established effects and that cvBMA can be more sensitive to experimental effects than just using even the best model in each subject or the model which is best in a group of subjects.

P3-321: Information-Theoretic Model Averaging to Characterize Effects oOf Age, Gender, And Apoe Ɛ4 on Mid-Life Cognitive Trajectories: Results from the Wisconsin Registry for Alzheimer’s Prevention

2016 ◽  
Vol 12 ◽  
pp. P966-P968
Author(s):  
Rebecca L. Koscik ◽  
Derek L. Norton ◽  
Lindsay R. Clark ◽  
Kimberly D. Mueller ◽  
Bruce P. Hermann ◽  
...  
Keyword(s):  
Model Averaging ◽  
Theoretic Model ◽  
Information Theoretic

scholarly journals A Conceptual Introduction to Bayesian Model Averaging

2020 ◽  
Vol 3 (2) ◽  
pp. 200-215
Author(s):  
Max Hinne ◽  
Quentin F. Gronau ◽  
Don van den Bergh ◽  
Eric-Jan Wagenmakers
Keyword(s):  
Model Selection ◽  
Bayesian Model ◽  
Bayesian Model Averaging ◽  
Selection Process ◽  
Process Analysis ◽  
Meta Analysis ◽  
Model Averaging ◽  
Analysis Of Covariance ◽  
Parameter Estimates ◽  
Data Generating Process

Many statistical scenarios initially involve several candidate models that describe the data-generating process. Analysis often proceeds by first selecting the best model according to some criterion and then learning about the parameters of this selected model. Crucially, however, in this approach the parameter estimates are conditioned on the selected model, and any uncertainty about the model-selection process is ignored. An alternative is to learn the parameters for all candidate models and then combine the estimates according to the posterior probabilities of the associated models. This approach is known as Bayesian model averaging (BMA). BMA has several important advantages over all-or-none selection methods, but has been used only sparingly in the social sciences. In this conceptual introduction, we explain the principles of BMA, describe its advantages over all-or-none model selection, and showcase its utility in three examples: analysis of covariance, meta-analysis, and network analysis.

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