scholarly journals Testing Equality of Curves after Covariate Adjustment

2017 ◽  
Author(s):  
Parichoy Pal Choudhury ◽  
Prosenjit Kundu ◽  
Qian-Li Xue ◽  
Reyhan Westbrook ◽  
Ciprian M. Crainiceanu
Keyword(s):  
Covariate Adjustment ◽  
Functional Regression ◽  
Test Statistic ◽  
Nonparametric Bootstrap ◽  
Difference Curve ◽  
Regression Methods ◽  
Highly Sensitive ◽  
And Control ◽  
Relationship Of ◽  
Global And Local

SummaryThis paper is concerned with providing simple methodological approaches for global and local tests of difference between the mean of treatment and control groups when the measured outcome is a function. The added complexity is that for every subject we have repeated samples for the same curve and additional covariates of interest. We propose a permutation based approach to test for a global difference between the averages of two functional processes after covariate adjustment. The within group averages are estimated by modeling the relationship of the functional outcome on the covariate using functional regression methods and then averaging with respect to the covariate distribution in each group. The test statistic is the L2 area under the squared difference curve. We also test for the localized differences between the two average curves using a nonparametric bootstrap of subjects to obtain the 95% pointwise and joint confidence intervals for the estimated covariate-adjusted difference curve. Extensive simulation studies illustrate that the proposed tests preserve the type one error and are highly sensitive to detecting departures from the null assumption. We illustrate our method by studying the differences in time varying oxygen consumption between the frail Interleukin 10tm1Cgn (IL10tm) mice and the wildtype mice after adjusting for body composition measures.

ACCESS TO AND CONTROL OVER LAND AS GENDERED: CONTEXTUALIZING WOMEN’S ACCESS AND OWNERSHIP RIGHTS OF LAND IN RURAL GHANA

2016 ◽  
Vol 45 (2) ◽  
pp. 28-48 ◽  
Author(s):  
Isaac Dery
Keyword(s):  
Thematic Analysis ◽  
Rural Women ◽  
Rural Poor ◽  
Rural Ghana ◽  
Secure Access ◽  
Key Factor ◽  
Access Rights ◽  
Ownership Rights ◽  
And Control ◽  
Relationship Of

Women’s access to and control over productive resources, including land, has increasingly been recognized in global discussions as a key factor in reducing poverty, ensuring food security and promoting gender equality. Indeed, this argument has been widely accepted by both feminists and development theorists since the 1980s. Based on qualitative research with 50 purposively selected men and women, this study explored the complexity of women’s access to and control over land within a specific relationship of contestations, negotiations, and manipulations with men. Data were analyzed using thematic analysis. While theoretically, participants showed that women’s [secure] access to and control over land has beneficial consequences to women themselves, households and the community at large, in principle, women's access and control status was premised in the traditional framework which largely deprives women, equal access and/or control over the land. The study indicates that even though land is the most revered resource and indeed, the dominant source of income for the rural poor, especially women, gender-erected discrimination and exclusion lie at the heart of many rural women in gaining access to land. This study argues that women's weak access rights and control over land continue to perpetuate the feminization of gender inequality–while men were reported to possess primary access and control over land as the heads of households, women were argued to have secondary rights due to their ‘stranger statuses’ in their husbands’ families. Overall, the degree of access to land among women was reported to be situated within two broad contexts–marriage and inheritance.

scholarly journals Real-Time In Vivo Bioluminescent Imaging for Evaluating the Efficacy of Antibiotics in a Rat Staphylococcus aureus Endocarditis Model

2005 ◽  
Vol 49 (1) ◽  
pp. 380-387 ◽  
Author(s):  
Yan Q. Xiong ◽  
Julie Willard ◽  
Jagath L. Kadurugamuwa ◽  
Jun Yu ◽  
Kevin P. Francis ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Real Time ◽  
Imaging System ◽  
Bioluminescent Imaging ◽  
Vancomycin Therapy ◽  
Treatment Groups ◽  
Highly Sensitive ◽  
Relevant Animal Model ◽  
And Control

ABSTRACT Therapeutic options for invasive Staphylococcus aureus infections have become limited due to rising antimicrobial resistance, making relevant animal model testing of new candidate agents more crucial than ever. In the present studies, a rat model of aortic infective endocarditis (IE) caused by a bioluminescently engineered, biofilm-positive S. aureus strain was used to evaluate real-time antibiotic efficacy directly. This strain was vancomycin and cefazolin susceptible but gentamicin resistant. Bioluminescence was detected and quantified daily in antibiotic-treated and control animals with IE, using a highly sensitive in vivo imaging system (IVIS). Persistent and increasing cardiac bioluminescent signals (BLS) were observed in untreated animals. Three days of vancomycin therapy caused significant reductions in both cardiac BLS (>10-fold versus control) and S. aureus densities in cardiac vegetations (P < 0.005 versus control). However, 3 days after discontinuation of vancomycin therapy, a greater than threefold increase in cardiac BLS was observed, indicating relapsing IE (which was confirmed by quantitative culture). Cefazolin resulted in modest decreases in cardiac BLS and bacterial densities. These microbiologic and cardiac BLS differences during therapy correlated with a longer time-above-MIC for vancomycin (>12 h) than for cefazolin (∼4 h). Gentamicin caused neither a reduction in cardiac S. aureus densities nor a reduction in BLS. There were significant correlations between cardiac BLS and S. aureus densities in vegetations in all treatment groups. These data suggest that bioluminescent imaging provides a substantial advance in the real-time monitoring of the efficacy of therapy of invasive S. aureus infections in live animals.

Development of a Ring Permeability Test System

2010 ◽  
Vol 136 ◽  
pp. 153-157
Author(s):  
Yu Hong Du ◽  
Xiu Ming Jiang ◽  
Xiu Ren Li
Keyword(s):  
Control System ◽  
Control Method ◽  
Dynamic Performance ◽  
Experimental Tests ◽  
Measuring Method ◽  
Test System ◽  
Fluid Theory ◽  
And Control ◽  
Relationship Of ◽  
The Mathematical Model

To solve the problem of detecting the permeability of the textile machinery, a dedicated test system has been developed based on the pressure difference measuring method. The established system has a number of advantages including simple, fast and accurate. The mathematical model of influencing factors for permeability is derived based on fluid theory, and the relationship of these parameters is achieved. Further investigations are directed towards the inherent characteristics of the control system. Based on the established model and measuring features, an information fusion based clustering control system is proposed to implement the measurement. Using this mechanical structure, a PID control system and a cluster control system have been developed. Simulation and experimental tests are carried out to examine the performance of the established system. It is noted that the clustering method has a high dynamic performance and control accuracy. This cluster fusion control method has been successfully utilized in powder metallurgy collar permeability testing.

Overview of Path-Planning and Obstacle Avoidance Algorithms for UAVs: A Comparative Study

2018 ◽  
Vol 06 (02) ◽  
pp. 95-118 ◽  
Author(s):  
Mohammadreza Radmanesh ◽  
Manish Kumar ◽  
Paul H. Guentert ◽  
Mohammad Sarim
Keyword(s):  
Path Planning ◽  
Comparative Study ◽  
Operating Conditions ◽  
Computational Time ◽  
Safe Operation ◽  
Sense And Avoid ◽  
Planning Algorithms ◽  
And Control ◽  
Global And Local ◽  
Further Development

Unmanned aerial vehicles (UAVs) have recently attracted the attention of researchers due to their numerous potential civilian applications. However, current robot navigation technologies need further development for efficient application to various scenarios. One key issue is the “Sense and Avoid” capability, currently of immense interest to researchers. Such a capability is required for safe operation of UAVs in civilian domain. For autonomous decision making and control of UAVs, several path-planning and navigation algorithms have been proposed. This is a challenging task to be carried out in a 3D environment, especially while accounting for sensor noise, uncertainties in operating conditions, and real-time applicability. Heuristic and non-heuristic or exact techniques are the two solution methodologies that categorize path-planning algorithms. The aim of this paper is to carry out a comprehensive and comparative study of existing UAV path-planning algorithms for both methods. Three different obstacle scenarios test the performance of each algorithm. We have compared the computational time and solution optimality, and tested each algorithm with variations in the availability of global and local obstacle information.

THE HORMONAL COMPOSITION OF MILK IN PRODUCTIVE ANIMALS AND ITS SAFETY FOR HUMANS

2020 ◽  
Vol 1 (3) ◽  
pp. 313-321
Author(s):  
P.A. Popov ◽  
◽  
V.S. Babunova ◽  
Keyword(s):  
Trace Elements ◽  
Growth Factor ◽  
Dairy Products ◽  
The Body ◽  
The Other ◽  
Raw Material ◽  
Important Food ◽  
The Past ◽  
Highly Sensitive ◽  
And Control

Hormones are an integral part of milk and throughout lactation, the content of certain hormones is unstable. Hormones regulate the process of starting lactation of animals, the lactation process itself, and also the other functions of the body. Milk is of great importance for the growth of young animals and the formation of immunity. Milk is a special product in the diet and is an important food and raw material for the production of dairy products for people. It contains a large amount of protein, fat, carbohydrates, vitamins and trace elements in biologically available form. But at the same time, over the past few years, more and more evidence has emerged that hormones in dairy products can impact on human health. Thus, some estrogens and insulin-like growth factor IGF-1 are involved in the initiation and provocation of breast, prostate and endometrial tumors. That’s why, it is necessary to normalize and control the content of certain hormones in milk with highly sensitive methods.

scholarly journals Elections and the Regression Discontinuity Design: Lessons from Close U.S. House Races, 1942–2008

2011 ◽  
Vol 19 (4) ◽  
pp. 385-408 ◽  
Author(s):  
Devin Caughey ◽  
Jasjeet S. Sekhon
Keyword(s):  
Regression Discontinuity ◽  
Covariate Adjustment ◽  
Regression Discontinuity Design ◽  
Present Evidence ◽  
Model Based ◽  
Covariate Balance ◽  
Ex Ante ◽  
And Control

Following David Lee's pioneering work, numerous scholars have applied the regression discontinuity (RD) design to popular elections. Contrary to the assumptions of RD, however, we show that bare winners and bare losers in U.S. House elections (1942–2008) differ markedly on pretreatment covariates. Bare winners possess largeex antefinancial, experience, and incumbency advantages over their opponents and are usually the candidates predicted to win byCongressional Quarterly's pre-election ratings. Covariate imbalance actually worsens in the closest House elections. National partisan tides help explain these patterns. Previous works have missed this imbalance because they rely excessively on model-based extrapolation. We present evidence suggesting that sorting in close House elections is due mainly to activities on or before Election Day rather than postelection recounts or other manipulation. The sorting is so strong that it is impossible to achieve covariate balance between matched treated and control observations, making covariate adjustment a dubious enterprise. Although RD is problematic for postwar House elections, this example does highlight the design's advantages over alternatives: RD's assumptions are clear and weaker than model-based alternatives, and their implications are empirically testable.

scholarly journals Effect on lipid profile due to prolong Valproic acid intake

2021 ◽  
Vol 15 (7) ◽  
pp. 1497-1499
Author(s):  
Rao. S Aziz ◽  
Usman Saeed ◽  
Liaqat Ali ◽  
Muhammad Arshad ◽  
Roman Abbas ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Cholesterol Oxidase ◽  
Venous Blood ◽  
Case Group ◽  
Long Duration ◽  
And Control ◽  
Relationship Of

Background: Valproic acid (VA) serve as the antimigraine , anti-mental disturbances agent and antiepileptic medicine. After using va, metabolic rearrangements seen in patients that include alteration in lipoproteins levels; Aim: To discuss the effects of VA after using for long duration on total levels of cholesterol in adult. Methods: About Eighty candidates participated and they were divided into two groups namely, case group (40 candidates) and control groups (40 candidates). All the candidates were asked for collection of venous blood sample in order to determine total cholesterol serum level among them via aid of enzymatic cholesterol oxidase phenol 4-aminoantipyrine peroxidase. Results: By the aid of the logistic regression analysis, the relationship of the long-term VA treatment and the level of total cholesterol was obtained. With respect to our analysis, there is a co relation between total levels of cholestrol and long term usage of VA (P=0.003). Conclusions: In a net shell, by using VA for long duration, the total level of cholesterol in adults reduces. Keywords: Lipid profile, side effects, total cholesterol, valproic acid

scholarly journals PENGARUH SUMBER DAYA MANUSIA TERHADAP PROFESIONALISME PRAJURIT PANGKALAN TNI AL DI PANTAI BARAT

2020 ◽  
Vol 8 (1) ◽  
Author(s):  
Bambang Supriyono ◽  
Prio Budi Leksono ◽  
Devi Erlita
Keyword(s):  
Human Resource ◽  
West Coast ◽  
Task Force ◽  
Command And Control ◽  
Weapon System ◽  
And Control ◽  
Relationship Of ◽  
The Relationship ◽  
Naval Base ◽  
Operating Units

<strong><em>Naval base as one of the integral components of the SSAT is the spearhead of power in carrying out support for the tasks of the operating units both in peacetime and during war. In carrying out its duties the Navy has an Integrated Fleet Weapon System (SSAT) which is the integration of strength of the capabilities of the KRI, Aircraft, Marines and Naval base components. To find out the professional level of the soldier, it is necessary to hold a Test of Combat Naval Base Task Force in order to realize, maintain and improve the skills of both individuals and groups, which in turn will increase the establishment of Operational Command and Control, Operational Procedures and the establishment of mastery of appropriate techniques and tactics. With the implementation of the test, it is expected to know about Naval Base Combat Readiness, a condition where the base can carry out its main tasks. Combat Duty Rehearsal is an exercise carried out by KRI or base to maintain the ability and professionalism of soldiers both programmed and programmed. This study aims to determine whether the relationship of human resource readiness influences the professional abilities of the Naval Base on west coast.</em></strong>

scholarly journals Objective psychology. Academician V. Bekhterev. Issue I. St. Petersburg. 1907 year

1907 ◽  
Vol XIV (3-4) ◽  
pp. 194-196
Author(s):  
V. Osipova
Keyword(s):  
Mental Life ◽  
Subjective Experiences ◽  
The Subject ◽  
And Control ◽  
Relationship Of ◽  
The Relationship ◽  
Living Creature

The author begins his work with the words that the psychology that he will expound bears little resemblance to the psychology that has been the subject of study until now. In objective psychology, there should be no place for questions about subjective processes or processes of consciousness, therefore there should be no place for introspection. Self-observation is not enough even to study one's own mental life. Objective psychology has in mind to study and explain only the relationship of a living creature to the surrounding conditions that affect it in one way or another, without aiming to find out those internal or subjective experiences, which are known as conscious phenomena and which are accessible only to self-observation. All mental items should only be subject to objective registration and control.

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