scholarly journals Deep learning accurately predicts estrogen receptor status in breast cancer metabolomics data

2017 ◽  
Author(s):  
Fadhl M Alakwaa ◽  
Kumardeep Chaudhary ◽  
Lana X Garmire
Keyword(s):  
Breast Cancer ◽  
Machine Learning ◽  
Estrogen Receptor ◽  
Deep Learning ◽  
Support Vector ◽  
Integrated Analysis ◽  
Learning Method ◽  
Learning Methods ◽  
Metabolomics Data ◽  
Machine Learning Methods

ABSTRACTMetabolomics holds the promise as a new technology to diagnose highly heterogeneous diseases. Conventionally, metabolomics data analysis for diagnosis is done using various statistical and machine learning based classification methods. However, it remains unknown if deep neural network, a class of increasingly popular machine learning methods, is suitable to classify metabolomics data. Here we use a cohort of 271 breast cancer tissues, 204 positive estrogen receptor (ER+) and 67 negative estrogen receptor (ER-), to test the accuracies of autoencoder, a deep learning (DL) framework, as well as six widely used machine learning models, namely Random Forest (RF), Support Vector Machines (SVM), Recursive Partitioning and Regression Trees (RPART), Linear Discriminant Analysis (LDA), Prediction Analysis for Microarrays (PAM), and Generalized Boosted Models (GBM). DL framework has the highest area under the curve (AUC) of 0.93 in classifying ER+/ER-patients, compared to the other six machine learning algorithms. Furthermore, the biological interpretation of the first hidden layer reveals eight commonly enriched significant metabolomics pathways (adjusted P-value<0.05) that cannot be discovered by other machine learning methods. Among them, protein digestion & absorption and ATP-binding cassette (ABC) transporters pathways are also confirmed in integrated analysis between metabolomics and gene expression data in these samples. In summary, deep learning method shows advantages for metabolomics based breast cancer ER status classification, with both the highest prediction accurcy (AUC=0.93) and better revelation of disease biology. We encourage the adoption of autoencoder based deep learning method in the metabolomics research community for classification.

scholarly journals Integrating Machine/Deep Learning Methods and Filtering Techniques for Reliable Mineral Phase Segmentation of 3D X-ray Computed Tomography Images

Energies ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4595
Author(s):  
Parisa Asadi ◽  
Lauren E. Beckingham
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Random Forest ◽  
Ct Images ◽  
Ct Imaging ◽  
Learning Method ◽  
Learning Methods ◽  
X Ray ◽  
Machine Learning Methods ◽  
Filtering Techniques

X-ray CT imaging provides a 3D view of a sample and is a powerful tool for investigating the internal features of porous rock. Reliable phase segmentation in these images is highly necessary but, like any other digital rock imaging technique, is time-consuming, labor-intensive, and subjective. Combining 3D X-ray CT imaging with machine learning methods that can simultaneously consider several extracted features in addition to color attenuation, is a promising and powerful method for reliable phase segmentation. Machine learning-based phase segmentation of X-ray CT images enables faster data collection and interpretation than traditional methods. This study investigates the performance of several filtering techniques with three machine learning methods and a deep learning method to assess the potential for reliable feature extraction and pixel-level phase segmentation of X-ray CT images. Features were first extracted from images using well-known filters and from the second convolutional layer of the pre-trained VGG16 architecture. Then, K-means clustering, Random Forest, and Feed Forward Artificial Neural Network methods, as well as the modified U-Net model, were applied to the extracted input features. The models’ performances were then compared and contrasted to determine the influence of the machine learning method and input features on reliable phase segmentation. The results showed considering more dimensionality has promising results and all classification algorithms result in high accuracy ranging from 0.87 to 0.94. Feature-based Random Forest demonstrated the best performance among the machine learning models, with an accuracy of 0.88 for Mancos and 0.94 for Marcellus. The U-Net model with the linear combination of focal and dice loss also performed well with an accuracy of 0.91 and 0.93 for Mancos and Marcellus, respectively. In general, considering more features provided promising and reliable segmentation results that are valuable for analyzing the composition of dense samples, such as shales, which are significant unconventional reservoirs in oil recovery.

Detecting a keystone species European aspen in boreal forests with airborne hyperspectral, LiDAR and UAV data with machine learning methods

2021 ◽  
Author(s):  
Timo Kumpula ◽  
Janne Mäyrä ◽  
Anton Kuzmin ◽  
Arto Viinikka ◽  
Sonja Kivinen ◽  
...  
Keyword(s):  
Machine Learning ◽  
Remote Sensing ◽  
Deep Learning ◽  
High Resolution ◽  
Boreal Forests ◽  
Tree Level ◽  
Support Vector ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
European Aspen

&lt;p&gt;Sustainable forest management increasingly highlights the maintenance of biological diversity and requires up-to-date information on the occurrence and distribution of key ecological features in forest environments. Different proxy variables indicating species richness and quality of the sites are essential for efficient detecting and monitoring forest biodiversity. European aspen (Populus tremula L.) is a minor deciduous tree species with a high importance in maintaining biodiversity in boreal forests. Large aspen trees host hundreds of species, many of them classified as threatened. However, accurate fine-scale spatial data on aspen occurrence remains scarce and incomprehensive.&lt;/p&gt;&lt;p&gt;&amp;#160;&lt;/p&gt;&lt;p&gt;We studied detection of aspen using different remote sensing techniques in Evo, southern Finland. Our study area of 83 km&lt;sup&gt;2&lt;/sup&gt; contains both managed and protected southern boreal forests characterized by Scots pine (Pinus sylvestris L.), Norway spruce (Picea abies (L.) Karst), and birch (Betula pendula and pubescens L.), whereas European aspen has a relatively sparse and scattered occurrence in the area. We collected high-resolution airborne hyperspectral and airborne laser scanning data covering the whole study area and ultra-high resolution unmanned aerial vehicle (UAV) data with RGB and multispectral sensors from selected parts of the area. We tested the discrimination of aspen from other species at tree level using different machine learning methods (Support Vector Machines, Random Forest, Gradient Boosting Machine) and deep learning methods (3D convolutional neural networks).&lt;/p&gt;&lt;p&gt;&amp;#160;&lt;/p&gt;&lt;p&gt;Airborne hyperspectral and lidar data gave excellent results with machine learning and deep learning classification methods The highest classification accuracies for aspen varied between 91-92% (F1-score). The most important wavelengths for discriminating aspen from other species included reflectance bands of red edge range (724&amp;#8211;727 nm) and shortwave infrared (1520&amp;#8211;1564 nm and 1684&amp;#8211;1706 nm) (Viinikka et al. 2020; M&amp;#228;yr&amp;#228; et al 2021). Aspen detection using RGB and multispectral data also gave good results (highest F1-score of aspen = 87%) (Kuzmin et al 2021). Different remote sensing data enabled production of a spatially explicit map of aspen occurrence in the study area. Information on aspen occurrence and abundance can significantly contribute to biodiversity management and conservation efforts in boreal forests. Our results can be further utilized in upscaling efforts aiming at aspen detection over larger geographical areas using satellite images.&lt;/p&gt;

scholarly journals Evaluation of Different Machine Learning Methods and Deep-Learning Convolutional Neural Networks for Landslide Detection

2019 ◽  
Vol 11 (2) ◽  
pp. 196 ◽  
Author(s):  
Omid Ghorbanzadeh ◽  
Thomas Blaschke ◽  
Khalil Gholamnia ◽  
Sansar Meena ◽  
Dirk Tiede ◽  
...  
Keyword(s):  
Machine Learning ◽  
Neural Networks ◽  
Deep Learning ◽  
Expert Knowledge ◽  
Accuracy Assessment ◽  
Window Size ◽  
Optical Data ◽  
Support Vector ◽  
Learning Methods ◽  
Machine Learning Methods

There is a growing demand for detailed and accurate landslide maps and inventories around the globe, but particularly in hazard-prone regions such as the Himalayas. Most standard mapping methods require expert knowledge, supervision and fieldwork. In this study, we use optical data from the Rapid Eye satellite and topographic factors to analyze the potential of machine learning methods, i.e., artificial neural network (ANN), support vector machines (SVM) and random forest (RF), and different deep-learning convolution neural networks (CNNs) for landslide detection. We use two training zones and one test zone to independently evaluate the performance of different methods in the highly landslide-prone Rasuwa district in Nepal. Twenty different maps are created using ANN, SVM and RF and different CNN instantiations and are compared against the results of extensive fieldwork through a mean intersection-over-union (mIOU) and other common metrics. This accuracy assessment yields the best result of 78.26% mIOU for a small window size CNN, which uses spectral information only. The additional information from a 5 m digital elevation model helps to discriminate between human settlements and landslides but does not improve the overall classification accuracy. CNNs do not automatically outperform ANN, SVM and RF, although this is sometimes claimed. Rather, the performance of CNNs strongly depends on their design, i.e., layer depth, input window sizes and training strategies. Here, we conclude that the CNN method is still in its infancy as most researchers will either use predefined parameters in solutions like Google TensorFlow or will apply different settings in a trial-and-error manner. Nevertheless, deep-learning can improve landslide mapping in the future if the effects of the different designs are better understood, enough training samples exist, and the effects of augmentation strategies to artificially increase the number of existing samples are better understood.

scholarly journals Modulation Classification of Underwater Communication with Deep Learning Network

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Yan Wang ◽  
Hao Zhang ◽  
Zhanliang Sang ◽  
Lingwei Xu ◽  
Conghui Cao ◽  
...  
Keyword(s):  
Machine Learning ◽  
Feature Extraction ◽  
Deep Learning ◽  
Language Processing ◽  
Communication Process ◽  
Underwater Acoustic Communication ◽  
Learning Method ◽  
Modulation Recognition ◽  
Learning Methods ◽  
Machine Learning Methods

Automatic modulation recognition has successfully used various machine learning methods and achieved certain results. As a subarea of machine learning, deep learning has made great progress in recent years and has made remarkable progress in the field of image and language processing. Deep learning requires a large amount of data support. As a communication field with a large amount of data, there is an inherent advantage of applying deep learning. However, the extensive application of deep learning in the field of communication has not yet been fully developed, especially in underwater acoustic communication. In this paper, we mainly discuss the modulation recognition process which is an important part of communication process by using the deep learning method. Different from the common machine learning methods that require feature extraction, the deep learning method does not require feature extraction and obtains more effects than common machine learning.

scholarly journals 24-hour cloud cover calculation using ground-based imager with machine learning

2021 ◽  
Author(s):  
Bu-Yo Kim ◽  
Joo Wan Cha ◽  
Ki-Ho Chang
Keyword(s):  
Machine Learning ◽  
Support Vector Regression ◽  
Cloud Cover ◽  
Image Data ◽  
Support Vector ◽  
Machine Learning Method ◽  
Learning Method ◽  
Learning Methods ◽  
Human Eye ◽  
Machine Learning Methods

Abstract. In this study, image data features and machine learning methods were used to calculate 24-h continuous cloud cover from image data obtained by a camera-based imager on the ground. The image data features were the time (Julian day and hour), solar zenith angle, and statistical characteristics of the red-blue ratio, blue–red difference, and luminance. These features were determined from the red, green, and blue brightness of images subjected to a pre-processing process involving masking removal and distortion correction. The collected image data were divided into training, validation, and test sets and were used to optimize and evaluate the accuracy of each machine learning method. The cloud cover calculated by each machine learning method was verified with human-eye observation data from a manned observatory. Supervised machine learning models suitable for nowcasting, namely, support vector regression, random forest, gradient boosting machine, k-nearest neighbor, artificial neural network, and multiple linear regression methods, were employed and their results were compared. The best learning results were obtained by the support vector regression model, which had an accuracy, recall, and precision of 0.94, 0.70, and 0.76, respectively. Further, bias, root mean square error, and correlation coefficient values of 0.04 tenth, 1.45 tenths, and 0.93, respectively, were obtained for the cloud cover calculated using the test set. When the difference between the calculated and observed cloud cover was allowed to range between 0, 1, and 2 tenths, high agreement of approximately 42 %, 79 %, and 91 %, respectively, were obtained. The proposed system involving a ground-based imager and machine learning methods is expected to be suitable for application as an automated system to replace human-eye observations.

scholarly journals Comparison of Soil Total Nitrogen Content Prediction Models Based on Vis-NIR Spectroscopy

Sensors ◽  
2020 ◽  
Vol 20 (24) ◽  
pp. 7078
Author(s):  
Yueting Wang ◽  
Minzan Li ◽  
Ronghua Ji ◽  
Minjuan Wang ◽  
Lihua Zheng
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Prediction Model ◽  
Total Nitrogen ◽  
Nir Spectroscopy ◽  
Learning Method ◽  
Learning Methods ◽  
Data Set ◽  
Machine Learning Methods ◽  
Conventional Machine

Visible-near-infrared spectrum (Vis-NIR) spectroscopy technology is one of the most important methods for non-destructive and rapid detection of soil total nitrogen (STN) content. In order to find a practical way to build STN content prediction model, three conventional machine learning methods and one deep learning approach are investigated and their predictive performances are compared and analyzed by using a public dataset called LUCAS Soil (19,019 samples). The three conventional machine learning methods include ordinary least square estimation (OLSE), random forest (RF), and extreme learning machine (ELM), while for the deep learning method, three different structures of convolutional neural network (CNN) incorporated Inception module are constructed and investigated. In order to clarify effectiveness of different pre-treatments on predicting STN content, the three conventional machine learning methods are combined with four pre-processing approaches (including baseline correction, smoothing, dimensional reduction, and feature selection) are investigated, compared, and analyzed. The results indicate that the baseline-corrected and smoothed ELM model reaches practical precision (coefficient of determination (R2) = 0.89, root mean square error of prediction (RMSEP) = 1.60 g/kg, and residual prediction deviation (RPD) = 2.34). While among three different structured CNN models, the one with more 1 × 1 convolutions preforms better (R2 = 0.93; RMSEP = 0.95 g/kg; and RPD = 3.85 in optimal case). In addition, in order to evaluate the influence of data set characteristics on the model, the LUCAS data set was divided into different data subsets according to dataset size, organic carbon (OC) content and countries, and the results show that the deep learning method is more effective and practical than conventional machine learning methods and, on the premise of enough data samples, it can be used to build a robust STN content prediction model with high accuracy for the same type of soil with similar agricultural treatment.

scholarly journals A stacking ensemble deep learning approach to cancer type classification based on TCGA data

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mohanad Mohammed ◽  
Henry Mwambi ◽  
Innocent B. Mboya ◽  
Murtada K. Elbashir ◽  
Bernard Omolo
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Feature Selection Method ◽  
Morphological Characteristics ◽  
Support Vector ◽  
Cancer Type ◽  
Learning Methods ◽  
Machine Learning Methods ◽  
Proposed Model ◽  
Significant Difference

AbstractCancer tumor classification based on morphological characteristics alone has been shown to have serious limitations. Breast, lung, colorectal, thyroid, and ovarian are the most commonly diagnosed cancers among women. Precise classification of cancers into their types is considered a vital problem for cancer diagnosis and therapy. In this paper, we proposed a stacking ensemble deep learning model based on one-dimensional convolutional neural network (1D-CNN) to perform a multi-class classification on the five common cancers among women based on RNASeq data. The RNASeq gene expression data was downloaded from Pan-Cancer Atlas using GDCquery function of the TCGAbiolinks package in the R software. We used least absolute shrinkage and selection operator (LASSO) as feature selection method. We compared the results of the new proposed model with and without LASSO with the results of the single 1D-CNN and machine learning methods which include support vector machines with radial basis function, linear, and polynomial kernels; artificial neural networks; k-nearest neighbors; bagging trees. The results show that the proposed model with and without LASSO has a better performance compared to other classifiers. Also, the results show that the machine learning methods (SVM-R, SVM-L, SVM-P, ANN, KNN, and bagging trees) with under-sampling have better performance than with over-sampling techniques. This is supported by the statistical significance test of accuracy where the p-values for differences between the SVM-R and SVM-P, SVM-R and ANN, SVM-R and KNN are found to be p = 0.003, p =  < 0.001, and p =  < 0.001, respectively. Also, SVM-L had a significant difference compared to ANN p = 0.009. Moreover, SVM-P and ANN, SVM-P and KNN are found to be significantly different with p-values p =  < 0.001 and p =  < 0.001, respectively. In addition, ANN and bagging trees, ANN and KNN were found to be significantly different with p-values p =  < 0.001 and p = 0.004, respectively. Thus, the proposed model can help in the early detection and diagnosis of cancer in women, and hence aid in designing early treatment strategies to improve survival.

A Very Large-Scale Bioactivity Comparison of Deep Learning and Multiple Machine Learning Algorithms for Drug Discovery

2020 ◽  
Author(s):  
Thomas R. Lane ◽  
Daniel H. Foil ◽  
Eni Minerali ◽  
Fabio Urbina ◽  
Kimberley M. Zorn ◽  
...  
Keyword(s):  
Machine Learning ◽  
Neural Networks ◽  
Deep Learning ◽  
Drug Discovery ◽  
Deep Neural Networks ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Learning Methods ◽  
Machine Learning Methods

<p>Machine learning methods are attracting considerable attention from the pharmaceutical industry for use in drug discovery and applications beyond. In recent studies we have applied multiple machine learning algorithms, modeling metrics and in some cases compared molecular descriptors to build models for individual targets or properties on a relatively small scale. Several research groups have used large numbers of datasets from public databases such as ChEMBL in order to evaluate machine learning methods of interest to them. The largest of these types of studies used on the order of 1400 datasets. We have now extracted well over 5000 datasets from CHEMBL for use with the ECFP6 fingerprint and comparison of our proprietary software Assay Central<sup>TM</sup> with random forest, k-Nearest Neighbors, support vector classification, naïve Bayesian, AdaBoosted decision trees, and deep neural networks (3 levels). Model performance <a>was</a> assessed using an array of five-fold cross-validation metrics including area-under-the-curve, F1 score, Cohen’s kappa and Matthews correlation coefficient. <a>Based on ranked normalized scores for the metrics or datasets all methods appeared comparable while the distance from the top indicated Assay Central<sup>TM</sup> and support vector classification were comparable. </a>Unlike prior studies which have placed considerable emphasis on deep neural networks (deep learning), no advantage was seen in this case where minimal tuning was performed of any of the methods. If anything, Assay Central<sup>TM</sup> may have been at a slight advantage as the activity cutoff for each of the over 5000 datasets representing over 570,000 unique compounds was based on Assay Central<sup>TM</sup>performance, but support vector classification seems to be a strong competitor. We also apply Assay Central<sup>TM</sup> to prospective predictions for PXR and hERG to further validate these models. This work currently appears to be the largest comparison of machine learning algorithms to date. Future studies will likely evaluate additional databases, descriptors and algorithms, as well as further refining methods for evaluating and comparing models. </p><p><b> </b></p>

scholarly journals Modeling Traders’ Behavior with Deep Learning and Machine Learning Methods: Evidence from BIST 100 Index

Complexity ◽  
2020 ◽  
Vol 2020 ◽  
pp. 1-16
Author(s):  
Afan Hasan ◽  
Oya Kalıpsız ◽  
Selim Akyokuş
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Financial Market ◽  
Performance Metrics ◽  
Confusion Matrix ◽  
Support Vector ◽  
Human Beings ◽  
Learning Methods ◽  
Technical Indicators ◽  
Machine Learning Methods

Although the vast majority of fundamental analysts believe that technical analysts’ estimates and technical indicators used in these analyses are unresponsive, recent research has revealed that both professionals and individual traders are using technical indicators. A correct estimate of the direction of the financial market is a very challenging activity, primarily due to the nonlinear nature of the financial time series. Deep learning and machine learning methods on the other hand have achieved very successful results in many different areas where human beings are challenged. In this study, technical indicators were integrated into the methods of deep learning and machine learning, and the behavior of the traders was modeled in order to increase the accuracy of forecasting of the financial market direction. A set of technical indicators has been examined based on their application in technical analysis as input features to predict the oncoming (one-period-ahead) direction of Istanbul Stock Exchange (BIST100) national index. To predict the direction of the index, Deep Neural Network (DNN), Support Vector Machine (SVM), Random Forest (RF), and Logistic Regression (LR) classification techniques are used. The performance of these models is evaluated on the basis of various performance metrics such as confusion matrix, compound return, and max drawdown.

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