Early detection of seasonality and second-wave prediction in the COVID-19 pandemic
AbstractSeasonality plays an essential role in the dynamics of many infectious diseases. Its confirmation in an emerging infectious disease is usually done using time series data from several years. By using statistical regression methods for time-series data pooled from more than 50 countries from both hemispheres, we show how to determine its presence in a pandemic at the onset of the seasonal period. We measure its expected effect in the mean transmission rate of SARS-coV-2 and predict when further epidemic outbreaks of COVID-19 will occur. The obtained result in the Northern Hemisphere shows that seasonality reduced the mean growth rate in 222.5% in April 2020. A relative reduction greater than 100% should be interpreted as a reduction changing an increasing rate to a decreasing one. In contrast, at the same moment, the seasonal effect in the Southern Hemisphere increased the mean growth rate in 740.3%. Our analysis simultaneously considers other confounding factors to properly separate them from seasonal effects and, in addition, we measure the mean global effect of social-distancing interventions and its relation with income. Future COVID-19 waves are expected to occur in autumn/winter seasons, typically between September and March in the Northern Hemisphere, and between April and September in the Southern Hemisphere. Simulations of a seasonal SEIR model with a social distancing effect are shown to describe the behavior of COVID-19 outbreaks in several countries. These results provide vital information for policy makers to plan their actions against the new coronavirus disease, particularly in the optimization of social-distancing interventions and vaccination schedules. Ultimately, our methods can be used to identify and measure seasonal effects in a future pandemic.