scholarly journals A Connectome Wide Functional Signature of Transdiagnostic Risk for Mental Illness

2017 ◽  
Author(s):  
Maxwell L. Elliott ◽  
Adrienne Romer ◽  
Annchen R. Knodt ◽  
Ahmad R. Hariri

AbstractBackgroundHigh rates of comorbidity, shared risk, and overlapping therapeutic mechanisms have led psychopathology research towards transdiagnostic dimensional investigations of clustered symptoms. One influential framework accounts for these transdiagnostic phenomena through a single general factor, sometimes referred to as the ‘p’ factor, associated with risk for all common forms of mental illness.MethodsHere we build on past research identifying unique structural neural correlates of the p factor by conducting a data-driven analysis of connectome wide intrinsic functional connectivity (n = 605).ResultsWe demonstrate that higher p factor scores and associated risk for common mental illness maps onto hyper-connectivity between visual association cortex and both frontoparietal and default mode networks.ConclusionsThese results provide initial evidence that the transdiagnostic risk for common forms of mental illness is associated with patterns of inefficient connectome wide intrinsic connectivity between visual association cortex and networks supporting executive control and self-referential processes, networks which are often impaired across categorical disorders.

2021 ◽  
pp. 089020702110129
Author(s):  
Joshua K Wood ◽  
Jeromy Anglim ◽  
Sharon Horwood

Researchers and practitioners have long been concerned about detrimental effects of socially desirable responding on the structure and criterion validity of personality assessments. The current research examined the effect of reducing evaluative item content of a Big Five personality assessment on test structure and criterion validity. We developed a new public domain measure of the Big Five called the Less Evaluative Five Factor Inventory (LEFFI), adapted from the standard 50-item IPIP NEO, and intended to be less evaluative. Participants ( n = 3164) then completed standard (IPIP) and neutralized (LEFFI) measures of personality. Criteria were also collected, including academic grades, age, sex, smoking, alcohol consumption, exercise, protesting, religious worship, music preferences, dental hygiene, blood donation, other-rated communication styles, other-rated HEXACO personality, and cognitive ability (ICAR). Evaluativeness of items was reduced in the neutralized measure. Cronbach's alpha and test-retest reliability were maintained. Correlations between the Big Five were reduced in the neutralized measure and criterion validity was similar or slightly reduced in the neutralized measure. The large sample size and use of objective criteria extend past research. The study also contributes to debates about whether the general factor of personality and agreement with socially desirable content reflect substance or bias.


Author(s):  
Robbie Duschinsky ◽  
Sarah Foster

The theory of mentalizing and epistemic trust introduced by Peter Fonagy and colleagues at the Anna Freud Centre has been an important perspective on mental health and illness. This book is the first comprehensive account and evaluation of this perspective. The book explores 20 primary concepts that organize the contributions of Fonagy and colleagues: adaptation, aggression, the alien self, culture, disorganized attachment, epistemic trust, hypermentalizing, reflective function, the p-factor, pretend mode, the primary unconscious, psychic equivalence, mental illness, mentalizing, mentalization-based therapy, non-mentalizing, the self, sexuality, the social environment, and teleological mode. The biographical and social context of the development of these ideas is examined. The book also specifies the current strengths and limitations of the theory of mentalizing and epistemic trust, with attention to the implications for both clinicians and researchers.


2019 ◽  
Author(s):  
Ashley L. Watts ◽  
Holly Poore ◽  
Irwin Waldman

We advanced several “riskier tests” of the validity of bifactor models of psychopathology, which included that the general and specific factors should be reliable and well-represented by their indicators, and that including a general factor should improve the correlated factor model’s external validity. We compared bifactor and correlated factors models using data from a community sample of youth (N=2498) whose parents provided ratings on psychopathology and external criteria (i.e., temperament, aggression, antisociality). Bifactor models tended to yield either general or specific factors that were unstable and difficult to interpret. The general factor appeared to reflect a differentially-weighted amalgam of psychopathology rather than a liability for psychopathology broadly construed. With rare exceptions, bifactor models did not explain additional variance in psychopathology symptom dimensions or external criteria compared with correlated factors models. Together, our findings call into question the validity of bifactor models of psychopathology, and the p-factor more broadly.


2021 ◽  
Author(s):  
◽  
Sophie Hedley

<p>Creativity is hugely important in our everyday lives. Understanding what makes some people more creative than others is not just important in traditional creative fields. Creative problem solving is the key to solving all significant challenges we face as a society, including but not limited to technological, political and environmental challenges. Mental illness, in both popular culture and in psychological science, have long been linked to creative thought. Many eminent creatives, both past and current, attribute their success to their mental illness. For example, in schizophrenia, the grandiose thinking and florid hallucinations that characterise this disorder may be supportive of creative thinking.   However, schizophrenia is characterised by severe cognitive deficits that, according to models of creativity, would be disadvantageous to creative thinking. Schizotypy is a personality trait that is characterised by some features of schizophrenia (unusual thinking, poor interpersonal communication), but is not accompanied by the same severe cognitive deficits seen in schizophrenia. Based on this view, it is reasonable to assume that people high on schizotypal traits may be more creative than those who are low on schizotypal traits.   While there a number of studies examining this relationship, findings are inconsistent, with effect sizes ranging from -.42 to .8. In my thesis, I explored a) whether there was a relationship between schizotypy and creativity and b) whether that relationship could be explained by underlying differences in cognitive processing (associative processing and executive control). I predicted that positive schizotypy in particular (typified by unusual thinking, superstitious beliefs) would be positively correlated with schizotypy in three different measures of creativity (two performance based tasks and one self-report measure) in two different samples of participants.   In Chapters 3 + 4, I tested the relationship between schizotypy and creativity using two different methods. In chapter 3, I found no evidence for the predicted effect. In fact, I found a negative association between positive schizotypy and scores on one measure of creativity (the Remote Associates test) and a positive association between negative schizotypy (characterised by interpersonal deficits) and performance on the RAT. These effects did not replicate in the second sample. Finally, there was a positive association between disorganised schizotypy and creativity on the Alternate Uses task. The results of Chapter 4, using a latent profile analytic approach, mirrored the results of Chapter 3. Finally, Chapter 5 found no support for any relationship being mediated by associative processing or executive control; however, there was partial support for two models of creativity. Overall, evidence suggests that schizotypal traits are not helpful for creativity. These results shed light on some of the challenges when conducting research regarding both schizotypy and creativity.</p>


2020 ◽  
Vol 16 (1) ◽  
pp. 75-98 ◽  
Author(s):  
Gregory T. Smith ◽  
Emily A. Atkinson ◽  
Heather A. Davis ◽  
Elizabeth N. Riley ◽  
Joshua R. Oltmanns

An important advance in understanding and defining mental disorders has been the development of empirical approaches to mapping dimensions of dysfunction and their interrelatedness. Such empirical approaches have consistently observed intercorrelations among the many forms of psychopathology, leading to the identification of a general factor of psychopathology (the p factor). In this article, we review empirical support for p, including evidence for the stability and criterion validity of p. Further, we discuss the strong relationship between p and both the general factor of personality and the general factor of personality disorder, substantive interpretations of p, and the potential clinical utility of p. We posit that proposed substantive interpretations of p do not explain the full range of symptomatology typically included in p. The most plausible explanation is that p represents an index of impairment that has the potential to inform the duration and intensity of a client's mental health treatment.


2003 ◽  
Vol 90 (2) ◽  
pp. 1279-1294 ◽  
Author(s):  
Ralph M. Siegel ◽  
Milena Raffi ◽  
Raymond E. Phinney ◽  
Jessica A. Turner ◽  
Gábor Jandó

In the behaving monkey, inferior parietal lobe cortical neurons combine visual information with eye position signals. However, an organized topographic map of these neurons' properties has never been demonstrated. Intrinsic optical imaging revealed a functional architecture for the effect of eye position on the visual response to radial optic flow. The map was distributed across two subdivisions of the inferior parietal lobule, area 7a and the dorsal prelunate area, DP. Area 7a contains a representation of the lower eye position gain fields while area DP represents the upper eye position gain fields. Horizontal eye position is represented orthogonal to the vertical eye position across the medial lateral extents of the cortices. Similar topographies were found in three hemispheres of two monkeys; the horizontal and vertical gain field representations were not isotropic with a greater modulation found with the vertical. Monte Carlo methods demonstrated the significance of the maps, and they were verified in part using multiunit recordings. The novel topographic organization of this association cortex area provides a substrate for constructing representations of surrounding space for perception and the guidance of motor behaviors.


2019 ◽  
Vol 34 (7) ◽  
pp. 1248-1248
Author(s):  
S Del Corral Winder ◽  
A J Cook ◽  
M Poulakis

Abstract Objective This poster will focus on findings pertaining to the relationship between bilingualism and Attention Deficit/Hyperactivity Disorder (ADHD), a gap that currently exists in cultural neuropsychology. This poster will introduce the literature regarding bilingualism and the development of individuals’ executive functioning throughout their lifespan. Bilingual individuals often have enhanced executive functioning. This review will provide a foundation for the present study. Then, we will compare racial and ethnic differences in ADHD diagnosis and treatment. ADHD diagnoses tend to be higher for White children than for Hispanics raised in a non-English household. These findings suggest that bilingualism may affect the diagnosis and the expression of ADHD. Participants and Method This poster will consider the acquisition of executive control skills and language. Since ADHD and language develop before adolescence, this poster will focus on individuals between the ages of 3 and 12. This will allow us to better understand how language acquisition and the factors that surround language affect the expression of ADHD. Results The poster will present results from the literature review to better understand the results of bilingualism on ADHD. Bilinguals tend to outperform monolinguals in tasks related to reasoning and problem solving. However, bilinguals tend to struggle in tasks related to vocabulary retrieval. This is key because individuals with ADHD tend to perform worse on tasks related to executive functioning. The poster will display different methods used in past research in order to expand future implications. Conclusions ADHD appears to interrupt some skills that bilingual individuals possess. This interference may affect ADHD symptom expression and performance on neuropsychological testing. This may lead to misdiagnoses and a resulting lag in the provision of effective treatments for bilingual children. Thus, this poster will propose alternatives and implications for practice.


NeuroImage ◽  
1998 ◽  
Vol 7 (4) ◽  
pp. S358 ◽  
Author(s):  
J. Kassubek ◽  
M. Otte ◽  
T. Wolter ◽  
M.W. Greenlee ◽  
T. Mergner ◽  
...  

2018 ◽  
Vol 30 (3) ◽  
pp. 365-380 ◽  
Author(s):  
Maya L. Rosen ◽  
Margaret A. Sheridan ◽  
Kelly A. Sambrook ◽  
Matthew R. Peverill ◽  
Andrew N. Meltzoff ◽  
...  

Associative learning underlies the formation of new episodic memories. Associative memory improves across development, and this age-related improvement is supported by the development of the hippocampus and pFC. Recent work, however, additionally suggests a role for visual association cortex in the formation of associative memories. This study investigated the role of category-preferential visual processing regions in associative memory across development using a paired associate learning task in a sample of 56 youths (age 6–19 years). Participants were asked to bind an emotional face with an object while undergoing fMRI scanning. Outside the scanner, participants completed a memory test. We first investigated age-related changes in neural recruitment and found linear age-related increases in activation in lateral occipital cortex and fusiform gyrus, which are involved in visual processing of objects and faces, respectively. Furthermore, greater activation in these visual processing regions was associated with better subsequent memory for pairs over and above the effect of age and of hippocampal and pFC activation on performance. Recruitment of these visual processing regions mediated the association between age and memory performance, over and above the effects of hippocampal activation. Taken together, these findings extend the existing literature to suggest that greater recruitment of category-preferential visual processing regions during encoding of associative memories is a neural mechanism explaining improved memory across development.


2006 ◽  
Vol 2 ◽  
pp. S10-S10
Author(s):  
Ann C. McKee ◽  
Rhoda Au ◽  
Howard J. Cabral ◽  
Neil W. Kowall ◽  
Sudha Seshadri ◽  
...  

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