scholarly journals Nutritional Supplementation during Pulmonary Rehabilitation in COPD: A Systematic Review

2019 ◽  
Author(s):  
Abdulelah M Aldhahir ◽  
Ahmed M Al Rajah ◽  
Yousef S Aldabayan ◽  
Salifu Drammeh ◽  
Vanitha Subbu ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
Pulmonary Rehabilitation ◽  
Nutritional Supplementation ◽  
Systematic Search ◽  
Current Evidence ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Cochrane Database ◽  
Registration Number ◽  
Meta Analyses

ABSTRACTBackgroundUptake of nutritional supplementation during pulmonary rehabilitation (PR) for people with chronic obstructive pulmonary disease (COPD) has been limited by an absence of rigorous evidence-based studies supporting use. Our objective were to report and summarise the current evidence supporting use of nutritional supplementation to improve outcomes during pulmonary rehabilitation in stable COPD patients.MethodsA systematic search was conducted up to May 7th, 2019 (registration number CRD42018089142). The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used. Six databases were included: Medical Literature Analysis and Retrieval System Online or MEDLARS Online (Medline), Allied and Complementary Medicine Database (AMED), the Cochrane Database of Systematic Reviews, Excerpta Medica dataBASE (Embase), Cumulative Index of Nursing and Allied Health Literature (CINAHL), and Web of Science.ResultsThis systematic search generated 580 initial matches, of which 24 studies (1035 COPD participants) met the pre-specified criteria and were included. Our analysis does not confirm an impact of nutritional supplementation during PR, but studies, supplements and PR programmes were heterogeneous in nature.ConclusionThere is currently insufficient evidence on the effect of nutritional supplementation on improving outcomes during PR in patients with COPD. Therefore, controversy remains and further research is needed.

scholarly journals Nutritional supplementation during pulmonary rehabilitation in COPD: A systematic review

2020 ◽  
Vol 17 ◽  
pp. 147997312090495 ◽  
Author(s):  
Abdulelah M Aldhahir ◽  
Ahmed M Al Rajeh ◽  
Yousef S Aldabayan ◽  
Salifu Drammeh ◽  
Vanitha Subbu ◽  
...  
Keyword(s):  
Systematic Reviews ◽  
Pulmonary Rehabilitation ◽  
Handgrip Strength ◽  
Nutritional Supplements ◽  
Quadriceps Muscle ◽  
Nutritional Supplementation ◽  
Systematic Search ◽  
Current Evidence ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Uptake of nutritional supplementation during pulmonary rehabilitation (PR) for people with chronic obstructive pulmonary disease (COPD) has been limited by an absence of rigorous evidence-based studies supporting use. The objective was to report and summarise the current evidence supporting the use of nutritional supplementation to improve outcomes during PR in stable COPD patients. A systematic search was conducted up to 7 August 2019 (registration number CRD42018089142). The preferred reporting items for systematic reviews and meta-analyses guidelines were used. Six databases were included: Medical Literature Analysis and Retrieval System Online or MEDLARS Online, Allied and Complementary Medicine Database, the Cochrane Database of Systematic Reviews, Excerpta Medica dataBASE, Cumulative Index of Nursing and Allied Health Literature and Web of Science. This systematic search generated 580 initial matches, of which 22 studies (917 COPD participants) met the pre-specified criteria and were included. Sixteen of 19 studies that used nutritional supplements in addition to PR did not show additional benefit compared to PR alone when measuring exercise capacity. Nutritional supplements significantly increased body weight in 7 of 11 studies. Body mass index increased significantly in two of six studies. Handgrip strength did not improve, while quadriceps muscle strength significantly improved in 3 of 11 studies. Four of eight studies showed a significant improvement in inspiratory muscle function. Only 2 of 14 studies demonstrated a significant improvement in quality of life with supplementation in addition to PR. There remains insufficient evidence on the effect of nutritional supplementation on improving outcomes during PR in patients with COPD due to heterogeneity in supplements, outcome measures and PR programmes. Therefore, controversy remains and further research is needed.

scholarly journals Effects of AntagomiRs on Different Lung Diseases in Human, Cellular, and Animal Models

2019 ◽  
Vol 20 (16) ◽  
pp. 3938 ◽  
Author(s):  
Giuseppe Murdaca ◽  
Alessandro Tonacci ◽  
Simone Negrini ◽  
Monica Greco ◽  
Matteo Borro ◽  
...  
Keyword(s):  
Animal Models ◽  
Lung Diseases ◽  
Single Case ◽  
Case Reports ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Mesh Terms ◽  
Pubmed Database ◽  
Registration Number ◽  
Meta Analyses

Introduction: MiRNAs have been shown to play a crucial role among lung cancer, pulmonary fibrosis, tuberculosis (TBC) infection, and bronchial hypersensitivity, thus including chronic obstructive pulmonary disease (COPD) and asthma. The oncogenic effect of several miRNAs has been recently ruled out. In order to act on miRNAs turnover, antagomiRs have been developed. Materials and methods: The systematic review was conducted under the PRISMA guidelines (registration number is: CRD42019134173). The PubMed database was searched between 1 January 2000 and 30 April 2019 under the following search strategy: (((antagomiR) OR (mirna antagonists) OR (mirna antagonist)) AND ((lung[MeSH Terms]) OR (“lung diseases”[MeSH Terms]))). We included original articles, published in English, whereas exclusion criteria included reviews, meta-analyses, single case reports, and studies published in a language other than English. Results and Conclusions: A total of 68 articles matching the inclusion criteria were retrieved. Overall, the use of antagomiR was seen to be efficient in downregulating the specific miRNA they are conceived for. The usefulness of antagomiRs was demonstrated in humans, animal models, and cell lines. To our best knowledge, this is the first article to encompass evidence regarding miRNAs and their respective antagomiRs in the lung, in order to provide readers a comprehensive review upon major lung disorders.

scholarly journals Telemonitoring to Manage Chronic Obstructive Pulmonary Disease: Systematic Literature Review (Preprint)

2018 ◽  
Author(s):  
Clemens Kruse ◽  
Brandon Pesek ◽  
Megan Anderson ◽  
Kacey Brennan ◽  
Hilary Comfort
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Literature Review ◽  
Pulmonary Disease ◽  
Systematic Reviews ◽  
The United States ◽  
Quality Data ◽  
Future Research ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Meta Analyses

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a leading cause of death throughout the world. Telemedicine has been utilized for many diseases and its prevalence is increasing in the United States. Telemonitoring of patients with COPD has the potential to help patients manage disease and predict exacerbations. OBJECTIVE The objective of this review is to evaluate the effectiveness of telemonitoring to manage COPD. Researchers want to determine how telemonitoring has been used to observe COPD and we are hoping this will lead to more research in telemonitoring of this disease. METHODS This review was conducted in accordance with the Assessment for Multiple Systematic Reviews (AMSTAR) and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Authors performed a systematic review of the PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases to obtain relevant articles. Articles were then accepted or rejected by group consensus. Each article was read and authors identified barriers and facilitators to effectiveness of telemonitoring of COPD. RESULTS Results indicate that conflicting information exists for the effectiveness of telemonitoring of patients with COPD. Primarily, 13 out of 29 (45%) articles stated that patient outcomes were improved overall with telemonitoring, while 11 of 29 (38%) indicated no improvement. Authors identified the following facilitators: reduced need for in-person visits, better disease management, and bolstered patient-provider relationship. Important barriers included low-quality data, increased workload for providers, and cost. CONCLUSIONS The high variability between the articles and the ways they provided telemonitoring services created conflicting results from the literature review. Future research should emphasize standardization of telemonitoring services and predictability of exacerbations.

Telehealth Interventions for COPD Management: An Umbrella Review (Preprint)

2021 ◽  
Author(s):  
Jin Hean Koh ◽  
Lydia Ching Yee Chong ◽  
Gerald Choon Huat Koh ◽  
Shilpa Tyagi
Keyword(s):  
Physical Activity ◽  
Systematic Reviews ◽  
Standard Of Care ◽  
Dropout Rate ◽  
Hospitalisation Rate ◽  
Chronic Obstructive ◽  
Umbrella Review ◽  
Obstructive Pulmonary Disease ◽  
Meta Analyses ◽  
Respiratory Exacerbations

BACKGROUND Chronic obstructive pulmonary disease (COPD) is a growing epidemic, with a heavy associated economic burden. Education, physical activity, and pulmonary rehabilitation programs are important aspects of the management of COPD. These interventions are commonly delivered remotely as part of telemedicine interventions. Several systematic reviews and meta-analyses have been conducted to assess the effectiveness of these interventions. However, these reviews often have conflicting conclusions. OBJECTIVE We thus sought to conduct an umbrella review to critically appraise and summarise the available evidence on telemedicine interventions for the management of COPD. METHODS Medline, Embase, Scopus, Web of Science, PsycINFO and Cochrane databases were searched for articles relating to telemedicine interventions for the management of COPD. We included systematic reviews and meta-analyses of randomised controlled trials which compared telemedicine interventions to usual care. A narrative synthesis was performed. RESULTS We identified 10 systematic reviews which met the inclusion criteria. Telemedicine interventions used in these reviews were tele treatment, telemonitoring and tele support. Tele support interventions significantly reduced the number of inpatient days and quality of life. Tele monitoring interventions were associated with significant reductions in respiratory exacerbations and hospitalisation rate. Tele treatment showed significant effectiveness in reducing respiratory exacerbations, respiratory exacerbations, hospitalisation rate, compliance (acceptance and dropout rate) and physical activity. Among studies which used integrated telemedicine interventions, there was a significant improvement in physical activity. CONCLUSIONS Telemedicine interventions showed non-inferiority or superiority over standard of care for the management of COPD. Telemedicine interventions should be considered as a supplement to usual methods of care for the outpatient management of COPD, with the aim of reducing the burden on healthcare systems.

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